LeishMANIAdb
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5-demethoxyubiquinone hydroxylase, mitochondrial

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
5-demethoxyubiquinone hydroxylase, mitochondrial
Gene product:
Ubiquinone biosynthesis protein COQ7, putative
Species:
Leishmania mexicana
UniProt:
E9ALI9_LEIMU
TriTrypDb:
LmxM.08_29.2350
Length:
206

Annotations

LeishMANIAdb annotations

Very conserved, homologous to animal COQ7 proteins. Probably perimembrane protein.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0019898 extrinsic component of membrane 2 10
GO:0031312 extrinsic component of organelle membrane 3 10
GO:0031314 extrinsic component of mitochondrial inner membrane 4 10
GO:0110165 cellular anatomical entity 1 10
GO:0005743 mitochondrial inner membrane 5 1
GO:0016020 membrane 2 1
GO:0019866 organelle inner membrane 4 1
GO:0031090 organelle membrane 3 1
GO:0031966 mitochondrial membrane 4 1

Expansion

Sequence features

E9ALI9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALI9

Function

Biological processes
Term Name Level Count
GO:0006743 ubiquinone metabolic process 5 10
GO:0006744 ubiquinone biosynthetic process 6 10
GO:0008152 metabolic process 1 10
GO:0009058 biosynthetic process 2 10
GO:0009987 cellular process 1 10
GO:0042180 cellular ketone metabolic process 3 10
GO:0042181 ketone biosynthetic process 4 10
GO:0044237 cellular metabolic process 2 10
GO:0044249 cellular biosynthetic process 3 10
GO:0044281 small molecule metabolic process 2 10
GO:0044283 small molecule biosynthetic process 3 10
GO:0071704 organic substance metabolic process 2 10
GO:1901576 organic substance biosynthetic process 3 10
GO:1901661 quinone metabolic process 4 10
GO:1901663 quinone biosynthetic process 5 10
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 10
GO:0004497 monooxygenase activity 3 10
GO:0005488 binding 1 10
GO:0008682 3-demethoxyubiquinol 3-hydroxylase activity 4 10
GO:0016491 oxidoreductase activity 2 10
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3 10
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 4 10
GO:0043167 ion binding 2 10
GO:0043169 cation binding 3 10
GO:0046872 metal ion binding 4 10

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 204 206 PF00082 0.352
CLV_PCSK_PC1ET2_1 204 206 PF00082 0.352
CLV_PCSK_SKI1_1 2 6 PF00082 0.546
CLV_PCSK_SKI1_1 61 65 PF00082 0.143
CLV_Separin_Metazoa 27 31 PF03568 0.279
DEG_APCC_DBOX_1 43 51 PF00400 0.360
DEG_Nend_UBRbox_1 1 4 PF02207 0.509
DEG_SPOP_SBC_1 83 87 PF00917 0.308
DOC_MAPK_gen_1 21 31 PF00069 0.315
DOC_MAPK_MEF2A_6 2 11 PF00069 0.438
DOC_PP4_FxxP_1 16 19 PF00568 0.427
DOC_WW_Pin1_4 48 53 PF00397 0.243
LIG_14-3-3_CanoR_1 84 89 PF00244 0.249
LIG_BIR_III_2 55 59 PF00653 0.360
LIG_FHA_1 101 107 PF00498 0.180
LIG_FHA_1 58 64 PF00498 0.390
LIG_FHA_1 83 89 PF00498 0.339
LIG_FHA_2 84 90 PF00498 0.258
LIG_LIR_Apic_2 48 52 PF02991 0.360
LIG_LIR_Gen_1 151 161 PF02991 0.343
LIG_LIR_LC3C_4 8 11 PF02991 0.361
LIG_LIR_Nem_3 120 126 PF02991 0.391
LIG_LIR_Nem_3 151 156 PF02991 0.283
LIG_LRP6_Inhibitor_1 187 193 PF00058 0.243
LIG_LYPXL_yS_3 185 188 PF13949 0.243
LIG_PCNA_yPIPBox_3 21 29 PF02747 0.305
LIG_SH2_CRK 189 193 PF00017 0.243
LIG_SH2_STAT3 126 129 PF00017 0.243
LIG_SH2_STAT5 159 162 PF00017 0.288
LIG_SH3_3 180 186 PF00018 0.243
LIG_SH3_3 8 14 PF00018 0.447
LIG_SUMO_SIM_anti_2 132 138 PF11976 0.254
LIG_SUMO_SIM_anti_2 8 13 PF11976 0.369
LIG_TYR_ITIM 187 192 PF00017 0.243
MOD_CK2_1 143 149 PF00069 0.411
MOD_GlcNHglycan 100 103 PF01048 0.188
MOD_LATS_1 70 76 PF00433 0.339
MOD_PKA_2 83 89 PF00069 0.243
MOD_Plk_1 118 124 PF00069 0.243
MOD_Plk_4 118 124 PF00069 0.264
MOD_Plk_4 5 11 PF00069 0.556
MOD_ProDKin_1 48 54 PF00069 0.243
MOD_SUMO_rev_2 132 141 PF00179 0.418
TRG_DiLeu_BaLyEn_6 183 188 PF01217 0.267
TRG_ENDOCYTIC_2 185 188 PF00928 0.243
TRG_ENDOCYTIC_2 189 192 PF00928 0.243
TRG_Pf-PMV_PEXEL_1 61 65 PF00026 0.144

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PB42 Leptomonas seymouri 82% 100%
A0A1X0P9Z6 Trypanosomatidae 65% 100%
A0A3R7LIB4 Trypanosoma rangeli 65% 100%
A0A3S7X2Q6 Leishmania donovani 95% 100%
A4HHN4 Leishmania braziliensis 88% 100%
A4I4U9 Leishmania infantum 95% 100%
C9ZLJ7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 65% 100%
E9AE97 Leishmania major 94% 100%
O74826 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 37% 95%
P41735 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 33% 88%
P48376 Caenorhabditis elegans 38% 100%
P97478 Mus musculus 35% 95%
Q2RNK3 Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1) 35% 97%
Q2TBW2 Bos taurus 35% 95%
Q54VB3 Dictyostelium discoideum 36% 95%
Q63619 Rattus norvegicus 36% 100%
Q99807 Homo sapiens 35% 95%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS