FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9ALI4_LEIMU

TriTrypDb:

LmxM.08_29.2400

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALI4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALI4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004721	phosphoprotein phosphatase activity	3	2
GO:0016787	hydrolase activity	2	3
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0016791	phosphatase activity	5	3
GO:0042578	phosphoric ester hydrolase activity	4	3
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	57	61	PF00656	0.600
CLV_NRD_NRD_1	262	264	PF00675	0.572
CLV_NRD_NRD_1	34	36	PF00675	0.601
CLV_PCSK_KEX2_1	140	142	PF00082	0.336
CLV_PCSK_KEX2_1	262	264	PF00082	0.568
CLV_PCSK_KEX2_1	276	278	PF00082	0.451
CLV_PCSK_KEX2_1	86	88	PF00082	0.715
CLV_PCSK_PC1ET2_1	140	142	PF00082	0.336
CLV_PCSK_PC1ET2_1	276	278	PF00082	0.553
CLV_PCSK_PC1ET2_1	86	88	PF00082	0.713
CLV_PCSK_SKI1_1	134	138	PF00082	0.510
CLV_PCSK_SKI1_1	149	153	PF00082	0.420
CLV_PCSK_SKI1_1	211	215	PF00082	0.336
CLV_PCSK_SKI1_1	248	252	PF00082	0.462
CLV_PCSK_SKI1_1	262	266	PF00082	0.600
DEG_SPOP_SBC_1	78	82	PF00917	0.472
DOC_CYCLIN_RxL_1	245	255	PF00134	0.246
DOC_CYCLIN_yCln2_LP_2	108	111	PF00134	0.385
DOC_MAPK_gen_1	140	147	PF00069	0.478
DOC_MAPK_gen_1	149	159	PF00069	0.369
DOC_MAPK_gen_1	276	285	PF00069	0.404
DOC_MAPK_gen_1	70	78	PF00069	0.440
DOC_MAPK_MEF2A_6	119	126	PF00069	0.329
DOC_MAPK_MEF2A_6	287	295	PF00069	0.448
DOC_PP2B_LxvP_1	108	111	PF13499	0.385
DOC_PP4_FxxP_1	235	238	PF00568	0.407
DOC_PP4_FxxP_1	264	267	PF00568	0.546
DOC_USP7_MATH_1	226	230	PF00917	0.358
DOC_USP7_MATH_1	66	70	PF00917	0.646
DOC_USP7_MATH_1	79	83	PF00917	0.526
DOC_WW_Pin1_4	215	220	PF00397	0.405
DOC_WW_Pin1_4	263	268	PF00397	0.404
DOC_WW_Pin1_4	294	299	PF00397	0.463
DOC_WW_Pin1_4	39	44	PF00397	0.769
DOC_WW_Pin1_4	49	54	PF00397	0.425
LIG_14-3-3_CanoR_1	227	231	PF00244	0.371
LIG_14-3-3_CanoR_1	262	267	PF00244	0.475
LIG_14-3-3_CanoR_1	6	10	PF00244	0.616
LIG_14-3-3_CanoR_1	87	97	PF00244	0.514
LIG_BRCT_BRCA1_1	41	45	PF00533	0.573
LIG_FHA_1	101	107	PF00498	0.588
LIG_FHA_1	197	203	PF00498	0.266
LIG_FHA_1	216	222	PF00498	0.445
LIG_FHA_1	247	253	PF00498	0.403
LIG_FHA_1	73	79	PF00498	0.484
LIG_FHA_2	45	51	PF00498	0.469
LIG_FHA_2	55	61	PF00498	0.584
LIG_GBD_Chelix_1	122	130	PF00786	0.405
LIG_LIR_Apic_2	137	142	PF02991	0.435
LIG_LIR_Apic_2	234	238	PF02991	0.399
LIG_LIR_Gen_1	255	264	PF02991	0.482
LIG_LIR_Nem_3	255	260	PF02991	0.445
LIG_MAD2	211	219	PF02301	0.506
LIG_NRBOX	13	19	PF00104	0.530
LIG_PCNA_yPIPBox_3	6	18	PF02747	0.497
LIG_PDZ_Class_1	294	299	PF00595	0.408
LIG_Pex14_2	257	261	PF04695	0.336
LIG_SH2_CRK	139	143	PF00017	0.506
LIG_SH2_STAP1	132	136	PF00017	0.286
LIG_SH2_STAP1	167	171	PF00017	0.453
LIG_SH2_STAT3	243	246	PF00017	0.336
LIG_SH2_STAT5	183	186	PF00017	0.476
LIG_SH3_3	108	114	PF00018	0.466
LIG_SH3_3	234	240	PF00018	0.336
LIG_SH3_3	292	298	PF00018	0.460
LIG_SH3_3	40	46	PF00018	0.572
LIG_SH3_3	65	71	PF00018	0.635
LIG_SH3_3	73	79	PF00018	0.700
LIG_SH3_3	95	101	PF00018	0.538
LIG_SUMO_SIM_anti_2	105	110	PF11976	0.558
LIG_SUMO_SIM_anti_2	210	216	PF11976	0.415
LIG_SUMO_SIM_anti_2	249	255	PF11976	0.336
LIG_SUMO_SIM_par_1	119	125	PF11976	0.352
LIG_SUMO_SIM_par_1	210	216	PF11976	0.407
LIG_SUMO_SIM_par_1	249	255	PF11976	0.246
LIG_SUMO_SIM_par_1	74	82	PF11976	0.572
LIG_SxIP_EBH_1	102	113	PF03271	0.488
LIG_UBA3_1	147	154	PF00899	0.336
LIG_WW_3	110	114	PF00397	0.442
MOD_CK1_1	30	36	PF00069	0.608
MOD_CK1_1	81	87	PF00069	0.755
MOD_CK1_1	90	96	PF00069	0.735
MOD_CK2_1	44	50	PF00069	0.557
MOD_Cter_Amidation	33	36	PF01082	0.602
MOD_GlcNHglycan	192	195	PF01048	0.363
MOD_GlcNHglycan	32	35	PF01048	0.667
MOD_GlcNHglycan	54	57	PF01048	0.728
MOD_GSK3_1	126	133	PF00069	0.403
MOD_GSK3_1	272	279	PF00069	0.437
MOD_GSK3_1	45	52	PF00069	0.607
MOD_GSK3_1	74	81	PF00069	0.530
MOD_GSK3_1	88	95	PF00069	0.741
MOD_GSK3_1	96	103	PF00069	0.701
MOD_NEK2_1	102	107	PF00069	0.530
MOD_NEK2_1	126	131	PF00069	0.346
MOD_NEK2_1	147	152	PF00069	0.395
MOD_PKA_1	262	268	PF00069	0.384
MOD_PKA_1	276	282	PF00069	0.310
MOD_PKA_2	226	232	PF00069	0.371
MOD_PKA_2	262	268	PF00069	0.465
MOD_PKA_2	276	282	PF00069	0.521
MOD_PKA_2	5	11	PF00069	0.694
MOD_Plk_1	126	132	PF00069	0.371
MOD_Plk_1	134	140	PF00069	0.371
MOD_Plk_1	246	252	PF00069	0.405
MOD_Plk_4	104	110	PF00069	0.474
MOD_Plk_4	126	132	PF00069	0.355
MOD_Plk_4	134	140	PF00069	0.362
MOD_Plk_4	217	223	PF00069	0.420
MOD_Plk_4	226	232	PF00069	0.280
MOD_Plk_4	246	252	PF00069	0.384
MOD_ProDKin_1	215	221	PF00069	0.405
MOD_ProDKin_1	263	269	PF00069	0.397
MOD_ProDKin_1	39	45	PF00069	0.768
MOD_ProDKin_1	49	55	PF00069	0.432
TRG_DiLeu_BaEn_1	247	252	PF01217	0.282
TRG_DiLeu_BaEn_2	285	291	PF01217	0.380
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.403
TRG_ER_diArg_1	261	263	PF00400	0.573
TRG_Pf-PMV_PEXEL_1	211	216	PF00026	0.478

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3R7LAC9	Trypanosoma rangeli	41%	83%
A0A3S7X2Q4	Leishmania donovani	89%	75%
A0A3S7X8P8	Leishmania donovani	44%	100%
A0A422P410	Trypanosoma rangeli	34%	83%
A4HHN9	Leishmania braziliensis	82%	100%
A4HM58	Leishmania braziliensis	44%	100%
A4I4V4	Leishmania infantum	89%	75%
A4IAS0	Leishmania infantum	44%	100%
C9ZKA3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	71%
E9AEA2	Leishmania major	90%	100%
E9AEJ6	Leishmania major	43%	100%
E9B5Q7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	44%	100%