PlsC domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

acyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9ALI3_LEIMU

TriTrypDb:

LmxM.08_29.2410

Length:

414

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 3, no: 7
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

E9ALI3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALI3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0008374	O-acyltransferase activity	5	11
GO:0016740	transferase activity	2	11
GO:0016746	acyltransferase activity	3	11
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	11
GO:0005488	binding	1	2
GO:0005509	calcium ion binding	5	2
GO:0043167	ion binding	2	2
GO:0043169	cation binding	3	2
GO:0046872	metal ion binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.450
CLV_NRD_NRD_1	238	240	PF00675	0.464
CLV_NRD_NRD_1	277	279	PF00675	0.538
CLV_NRD_NRD_1	371	373	PF00675	0.490
CLV_PCSK_KEX2_1	277	279	PF00082	0.500
CLV_PCSK_KEX2_1	371	373	PF00082	0.536
CLV_PCSK_SKI1_1	306	310	PF00082	0.434
CLV_PCSK_SKI1_1	402	406	PF00082	0.624
DEG_APCC_KENBOX_2	239	243	PF00400	0.311
DEG_SPOP_SBC_1	149	153	PF00917	0.147
DOC_CKS1_1	12	17	PF01111	0.582
DOC_CKS1_1	122	127	PF01111	0.470
DOC_MAPK_gen_1	239	245	PF00069	0.274
DOC_PP2B_LxvP_1	26	29	PF13499	0.601
DOC_PP2B_LxvP_1	282	285	PF13499	0.140
DOC_PP2B_LxvP_1	92	95	PF13499	0.601
DOC_USP7_MATH_1	150	154	PF00917	0.315
DOC_USP7_MATH_1	216	220	PF00917	0.347
DOC_USP7_MATH_1	264	268	PF00917	0.241
DOC_USP7_MATH_1	54	58	PF00917	0.414
DOC_WW_Pin1_4	11	16	PF00397	0.579
DOC_WW_Pin1_4	121	126	PF00397	0.482
LIG_14-3-3_CanoR_1	181	189	PF00244	0.435
LIG_14-3-3_CanoR_1	253	260	PF00244	0.282
LIG_14-3-3_CanoR_1	347	355	PF00244	0.240
LIG_14-3-3_CanoR_1	383	389	PF00244	0.352
LIG_14-3-3_CanoR_1	48	55	PF00244	0.460
LIG_14-3-3_CanoR_1	98	103	PF00244	0.552
LIG_APCC_ABBA_1	287	292	PF00400	0.218
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_BRCT_BRCA1_1	243	247	PF00533	0.278
LIG_BRCT_BRCA1_1	348	352	PF00533	0.291
LIG_BRCT_BRCA1_1	56	60	PF00533	0.348
LIG_CaM_NSCaTE_8	35	42	PF13499	0.341
LIG_Clathr_ClatBox_1	83	87	PF01394	0.237
LIG_deltaCOP1_diTrp_1	223	233	PF00928	0.341
LIG_eIF4E_1	355	361	PF01652	0.301
LIG_FHA_1	12	18	PF00498	0.600
LIG_FHA_1	149	155	PF00498	0.314
LIG_FHA_1	158	164	PF00498	0.255
LIG_FHA_1	181	187	PF00498	0.397
LIG_FHA_1	271	277	PF00498	0.287
LIG_FHA_1	80	86	PF00498	0.337
LIG_FHA_2	110	116	PF00498	0.509
LIG_FHA_2	122	128	PF00498	0.518
LIG_FHA_2	205	211	PF00498	0.441
LIG_FHA_2	264	270	PF00498	0.232
LIG_FHA_2	365	371	PF00498	0.300
LIG_LIR_Apic_2	121	125	PF02991	0.514
LIG_LIR_Gen_1	127	137	PF02991	0.473
LIG_LIR_Gen_1	183	193	PF02991	0.351
LIG_LIR_Gen_1	223	234	PF02991	0.400
LIG_LIR_Gen_1	23	33	PF02991	0.474
LIG_LIR_Gen_1	244	252	PF02991	0.140
LIG_LIR_Nem_3	127	132	PF02991	0.477
LIG_LIR_Nem_3	152	158	PF02991	0.319
LIG_LIR_Nem_3	183	188	PF02991	0.306
LIG_LIR_Nem_3	223	229	PF02991	0.366
LIG_LIR_Nem_3	23	28	PF02991	0.609
LIG_LIR_Nem_3	244	248	PF02991	0.278
LIG_LIR_Nem_3	349	355	PF02991	0.294
LIG_LIR_Nem_3	395	401	PF02991	0.270
LIG_LIR_Nem_3	403	408	PF02991	0.282
LIG_NRP_CendR_1	412	414	PF00754	0.562
LIG_PCNA_yPIPBox_3	375	389	PF02747	0.294
LIG_Pex14_1	174	178	PF04695	0.314
LIG_Pex14_1	68	72	PF04695	0.260
LIG_Pex14_2	144	148	PF04695	0.294
LIG_Pex14_2	155	159	PF04695	0.300
LIG_Pex14_2	327	331	PF04695	0.242
LIG_SH2_CRK	122	126	PF00017	0.526
LIG_SH2_NCK_1	122	126	PF00017	0.531
LIG_SH2_SRC	106	109	PF00017	0.555
LIG_SH2_SRC	355	358	PF00017	0.333
LIG_SH2_STAT3	197	200	PF00017	0.290
LIG_SH2_STAT5	16	19	PF00017	0.660
LIG_SH2_STAT5	166	169	PF00017	0.362
LIG_SH2_STAT5	228	231	PF00017	0.341
LIG_SH2_STAT5	25	28	PF00017	0.520
LIG_SH2_STAT5	36	39	PF00017	0.271
LIG_SH2_STAT5	72	75	PF00017	0.288
LIG_SH3_3	360	366	PF00018	0.301
LIG_SH3_3	9	15	PF00018	0.636
LIG_TRAF2_1	366	369	PF00917	0.343
LIG_TYR_ITIM	34	39	PF00017	0.290
LIG_TYR_ITIM	353	358	PF00017	0.333
LIG_WRC_WIRS_1	233	238	PF05994	0.218
MOD_CK1_1	180	186	PF00069	0.278
MOD_CK1_1	206	212	PF00069	0.466
MOD_CK1_1	235	241	PF00069	0.240
MOD_CK1_1	394	400	PF00069	0.275
MOD_CK2_1	115	121	PF00069	0.412
MOD_CK2_1	204	210	PF00069	0.474
MOD_CK2_1	235	241	PF00069	0.218
MOD_CK2_1	263	269	PF00069	0.302
MOD_CK2_1	364	370	PF00069	0.299
MOD_GlcNHglycan	139	142	PF01048	0.205
MOD_GlcNHglycan	39	42	PF01048	0.466
MOD_GSK3_1	121	128	PF00069	0.549
MOD_GSK3_1	180	187	PF00069	0.353
MOD_GSK3_1	50	57	PF00069	0.292
MOD_GSK3_1	7	14	PF00069	0.593
MOD_N-GLC_1	216	221	PF02516	0.275
MOD_N-GLC_1	241	246	PF02516	0.511
MOD_N-GLC_1	391	396	PF02516	0.490
MOD_NEK2_1	137	142	PF00069	0.260
MOD_NEK2_1	148	153	PF00069	0.266
MOD_NEK2_1	159	164	PF00069	0.256
MOD_NEK2_1	346	351	PF00069	0.302
MOD_NEK2_1	37	42	PF00069	0.295
MOD_NEK2_1	376	381	PF00069	0.398
MOD_NEK2_1	384	389	PF00069	0.232
MOD_NEK2_1	79	84	PF00069	0.275
MOD_NEK2_2	150	155	PF00069	0.356
MOD_PKA_2	180	186	PF00069	0.300
MOD_PKA_2	252	258	PF00069	0.311
MOD_PKA_2	346	352	PF00069	0.295
MOD_PKA_2	47	53	PF00069	0.295
MOD_Plk_1	216	222	PF00069	0.275
MOD_Plk_1	241	247	PF00069	0.322
MOD_Plk_1	394	400	PF00069	0.260
MOD_Plk_1	50	56	PF00069	0.302
MOD_Plk_1	7	13	PF00069	0.458
MOD_Plk_4	150	156	PF00069	0.277
MOD_Plk_4	232	238	PF00069	0.240
MOD_Plk_4	241	247	PF00069	0.311
MOD_Plk_4	254	260	PF00069	0.188
MOD_Plk_4	271	277	PF00069	0.274
MOD_Plk_4	384	390	PF00069	0.277
MOD_Plk_4	7	13	PF00069	0.643
MOD_Plk_4	79	85	PF00069	0.314
MOD_ProDKin_1	11	17	PF00069	0.582
MOD_ProDKin_1	121	127	PF00069	0.481
MOD_SUMO_rev_2	206	214	PF00179	0.428
MOD_SUMO_rev_2	368	376	PF00179	0.387
MOD_SUMO_rev_2	394	404	PF00179	0.364
TRG_DiLeu_BaEn_1	210	215	PF01217	0.431
TRG_DiLeu_BaEn_2	240	246	PF01217	0.140
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.298
TRG_ENDOCYTIC_2	129	132	PF00928	0.464
TRG_ENDOCYTIC_2	202	205	PF00928	0.494
TRG_ENDOCYTIC_2	25	28	PF00928	0.601
TRG_ENDOCYTIC_2	324	327	PF00928	0.263
TRG_ENDOCYTIC_2	355	358	PF00928	0.333
TRG_ENDOCYTIC_2	36	39	PF00928	0.271
TRG_ENDOCYTIC_2	4	7	PF00928	0.590
TRG_ER_diArg_1	276	278	PF00400	0.321

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3C8	Leptomonas seymouri	62%	99%
A0A0S4IPK1	Bodo saltans	44%	86%
A0A1X0P927	Trypanosomatidae	46%	88%
A0A3R7NZP9	Trypanosoma rangeli	50%	91%
A0A3S7X2X4	Leishmania donovani	90%	100%
A4HHP0	Leishmania braziliensis	80%	100%
A4I4V5	Leishmania infantum	90%	100%
C9ZL05	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	89%
E9AEA3	Leishmania major	89%	100%
Q8BYI6	Mus musculus	30%	76%
Q8S8S2	Arabidopsis thaliana	28%	77%