Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALI2_LEIMU

TriTrypDb:

LmxM.08_29.2420

Length:

658

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALI2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALI2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.561
CLV_C14_Caspase3-7	9	13	PF00656	0.782
CLV_NRD_NRD_1	108	110	PF00675	0.592
CLV_NRD_NRD_1	181	183	PF00675	0.482
CLV_NRD_NRD_1	217	219	PF00675	0.413
CLV_NRD_NRD_1	240	242	PF00675	0.519
CLV_NRD_NRD_1	270	272	PF00675	0.640
CLV_NRD_NRD_1	448	450	PF00675	0.480
CLV_NRD_NRD_1	451	453	PF00675	0.491
CLV_NRD_NRD_1	456	458	PF00675	0.486
CLV_NRD_NRD_1	499	501	PF00675	0.544
CLV_NRD_NRD_1	605	607	PF00675	0.698
CLV_NRD_NRD_1	622	624	PF00675	0.650
CLV_PCSK_FUR_1	179	183	PF00082	0.576
CLV_PCSK_FUR_1	268	272	PF00082	0.449
CLV_PCSK_FUR_1	449	453	PF00082	0.418
CLV_PCSK_KEX2_1	108	110	PF00082	0.640
CLV_PCSK_KEX2_1	181	183	PF00082	0.449
CLV_PCSK_KEX2_1	239	241	PF00082	0.464
CLV_PCSK_KEX2_1	270	272	PF00082	0.595
CLV_PCSK_KEX2_1	329	331	PF00082	0.599
CLV_PCSK_KEX2_1	447	449	PF00082	0.492
CLV_PCSK_KEX2_1	451	453	PF00082	0.495
CLV_PCSK_KEX2_1	499	501	PF00082	0.574
CLV_PCSK_KEX2_1	605	607	PF00082	0.642
CLV_PCSK_KEX2_1	622	624	PF00082	0.723
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.741
CLV_PCSK_PC7_1	447	453	PF00082	0.621
CLV_PCSK_SKI1_1	128	132	PF00082	0.612
CLV_PCSK_SKI1_1	210	214	PF00082	0.649
DEG_APCC_DBOX_1	220	228	PF00400	0.500
DEG_APCC_DBOX_1	406	414	PF00400	0.457
DEG_COP1_1	199	207	PF00400	0.521
DEG_COP1_1	222	232	PF00400	0.423
DEG_SPOP_SBC_1	541	545	PF00917	0.561
DEG_SPOP_SBC_1	614	618	PF00917	0.779
DOC_CKS1_1	307	312	PF01111	0.616
DOC_CYCLIN_yCln2_LP_2	307	313	PF00134	0.515
DOC_MAPK_gen_1	139	149	PF00069	0.453
DOC_MAPK_gen_1	84	94	PF00069	0.677
DOC_MAPK_MEF2A_6	87	94	PF00069	0.649
DOC_PP1_RVXF_1	291	298	PF00149	0.524
DOC_PP2B_LxvP_1	411	414	PF13499	0.459
DOC_USP7_MATH_1	163	167	PF00917	0.701
DOC_USP7_MATH_1	258	262	PF00917	0.654
DOC_USP7_MATH_1	345	349	PF00917	0.717
DOC_USP7_MATH_1	377	381	PF00917	0.618
DOC_USP7_MATH_1	401	405	PF00917	0.672
DOC_USP7_MATH_1	418	422	PF00917	0.549
DOC_USP7_MATH_1	42	46	PF00917	0.529
DOC_USP7_MATH_1	433	437	PF00917	0.585
DOC_USP7_MATH_1	476	480	PF00917	0.658
DOC_USP7_MATH_1	486	490	PF00917	0.683
DOC_USP7_MATH_1	540	544	PF00917	0.631
DOC_USP7_MATH_1	632	636	PF00917	0.696
DOC_USP7_UBL2_3	165	169	PF12436	0.632
DOC_WW_Pin1_4	10	15	PF00397	0.651
DOC_WW_Pin1_4	299	304	PF00397	0.575
DOC_WW_Pin1_4	306	311	PF00397	0.498
DOC_WW_Pin1_4	38	43	PF00397	0.767
DOC_WW_Pin1_4	394	399	PF00397	0.654
DOC_WW_Pin1_4	554	559	PF00397	0.533
LIG_14-3-3_CanoR_1	175	179	PF00244	0.462
LIG_14-3-3_CanoR_1	190	198	PF00244	0.427
LIG_14-3-3_CanoR_1	340	345	PF00244	0.665
LIG_14-3-3_CanoR_1	412	418	PF00244	0.698
LIG_14-3-3_CanoR_1	575	582	PF00244	0.529
LIG_14-3-3_CanoR_1	91	101	PF00244	0.495
LIG_BRCT_BRCA1_1	334	338	PF00533	0.699
LIG_deltaCOP1_diTrp_1	294	304	PF00928	0.595
LIG_FHA_2	365	371	PF00498	0.549
LIG_LIR_Apic_2	166	171	PF02991	0.744
LIG_LIR_Apic_2	382	387	PF02991	0.597
LIG_LIR_Nem_3	302	307	PF02991	0.499
LIG_LIR_Nem_3	546	552	PF02991	0.662
LIG_Pex14_2	15	19	PF04695	0.532
LIG_SH2_PTP2	384	387	PF00017	0.659
LIG_SH2_SRC	384	387	PF00017	0.676
LIG_SH2_STAP1	284	288	PF00017	0.518
LIG_SH2_STAP1	57	61	PF00017	0.504
LIG_SH2_STAT5	384	387	PF00017	0.676
LIG_SH2_STAT5	564	567	PF00017	0.477
LIG_SH3_3	146	152	PF00018	0.582
LIG_SH3_3	224	230	PF00018	0.394
LIG_SH3_3	300	306	PF00018	0.583
LIG_SH3_3	311	317	PF00018	0.661
LIG_SH3_3	98	104	PF00018	0.670
LIG_SUMO_SIM_anti_2	145	151	PF11976	0.483
LIG_SUMO_SIM_par_1	585	591	PF11976	0.407
LIG_TRAF2_1	130	133	PF00917	0.589
MOD_CDC14_SPxK_1	41	44	PF00782	0.576
MOD_CDK_SPxK_1	38	44	PF00069	0.768
MOD_CK1_1	35	41	PF00069	0.636
MOD_CK1_1	380	386	PF00069	0.639
MOD_CK1_1	394	400	PF00069	0.674
MOD_CK1_1	421	427	PF00069	0.542
MOD_CK1_1	428	434	PF00069	0.494
MOD_CK1_1	479	485	PF00069	0.745
MOD_CK1_1	543	549	PF00069	0.524
MOD_CK1_1	596	602	PF00069	0.641
MOD_CK1_1	626	632	PF00069	0.739
MOD_CK1_1	645	651	PF00069	0.751
MOD_CK2_1	18	24	PF00069	0.758
MOD_CK2_1	190	196	PF00069	0.528
MOD_CK2_1	364	370	PF00069	0.472
MOD_Cter_Amidation	620	623	PF01082	0.674
MOD_GlcNHglycan	105	108	PF01048	0.667
MOD_GlcNHglycan	157	160	PF01048	0.518
MOD_GlcNHglycan	20	23	PF01048	0.793
MOD_GlcNHglycan	210	213	PF01048	0.596
MOD_GlcNHglycan	342	345	PF01048	0.682
MOD_GlcNHglycan	356	359	PF01048	0.531
MOD_GlcNHglycan	375	378	PF01048	0.639
MOD_GlcNHglycan	392	396	PF01048	0.703
MOD_GlcNHglycan	420	423	PF01048	0.630
MOD_GlcNHglycan	427	430	PF01048	0.522
MOD_GlcNHglycan	44	47	PF01048	0.677
MOD_GlcNHglycan	486	489	PF01048	0.710
MOD_GlcNHglycan	494	497	PF01048	0.624
MOD_GlcNHglycan	598	601	PF01048	0.713
MOD_GlcNHglycan	634	637	PF01048	0.687
MOD_GlcNHglycan	653	656	PF01048	0.706
MOD_GlcNHglycan	94	97	PF01048	0.575
MOD_GSK3_1	14	21	PF00069	0.587
MOD_GSK3_1	32	39	PF00069	0.624
MOD_GSK3_1	328	335	PF00069	0.724
MOD_GSK3_1	336	343	PF00069	0.703
MOD_GSK3_1	345	352	PF00069	0.515
MOD_GSK3_1	373	380	PF00069	0.602
MOD_GSK3_1	42	49	PF00069	0.682
MOD_GSK3_1	421	428	PF00069	0.641
MOD_GSK3_1	434	441	PF00069	0.487
MOD_GSK3_1	536	543	PF00069	0.584
MOD_GSK3_1	6	13	PF00069	0.617
MOD_GSK3_1	622	629	PF00069	0.732
MOD_GSK3_1	634	641	PF00069	0.555
MOD_NEK2_1	332	337	PF00069	0.669
MOD_NEK2_1	36	41	PF00069	0.789
MOD_NEK2_1	427	432	PF00069	0.497
MOD_NEK2_1	547	552	PF00069	0.676
MOD_PIKK_1	401	407	PF00454	0.708
MOD_PIKK_1	575	581	PF00454	0.364
MOD_PIKK_1	6	12	PF00454	0.555
MOD_PK_1	623	629	PF00069	0.472
MOD_PK_1	638	644	PF00069	0.466
MOD_PKA_1	622	628	PF00069	0.515
MOD_PKA_2	174	180	PF00069	0.523
MOD_PKA_2	189	195	PF00069	0.390
MOD_PKA_2	345	351	PF00069	0.645
MOD_PKA_2	373	379	PF00069	0.583
MOD_PKA_2	622	628	PF00069	0.666
MOD_Plk_1	32	38	PF00069	0.629
MOD_Plk_1	466	472	PF00069	0.567
MOD_Plk_1	525	531	PF00069	0.532
MOD_Plk_1	638	644	PF00069	0.466
MOD_Plk_2-3	386	392	PF00069	0.543
MOD_Plk_4	380	386	PF00069	0.675
MOD_Plk_4	434	440	PF00069	0.653
MOD_Plk_4	547	553	PF00069	0.519
MOD_Plk_4	615	621	PF00069	0.748
MOD_ProDKin_1	10	16	PF00069	0.653
MOD_ProDKin_1	299	305	PF00069	0.580
MOD_ProDKin_1	306	312	PF00069	0.494
MOD_ProDKin_1	38	44	PF00069	0.766
MOD_ProDKin_1	394	400	PF00069	0.653
MOD_ProDKin_1	554	560	PF00069	0.528
MOD_SUMO_rev_2	127	135	PF00179	0.600
TRG_DiLeu_BaLyEn_6	117	122	PF01217	0.508
TRG_DiLeu_BaLyEn_6	286	291	PF01217	0.442
TRG_ENDOCYTIC_2	57	60	PF00928	0.564
TRG_ER_diArg_1	108	110	PF00400	0.642
TRG_ER_diArg_1	178	181	PF00400	0.527
TRG_ER_diArg_1	239	241	PF00400	0.518
TRG_ER_diArg_1	268	271	PF00400	0.599
TRG_ER_diArg_1	447	449	PF00400	0.530
TRG_ER_diArg_1	451	453	PF00400	0.558
TRG_ER_diArg_1	574	577	PF00400	0.540
TRG_ER_diArg_1	622	624	PF00400	0.595
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.499
TRG_Pf-PMV_PEXEL_1	240	244	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	289	294	PF00026	0.430

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2Y8	Leptomonas seymouri	62%	97%
A0A0S4IQ31	Bodo saltans	31%	100%
A0A0S4JIT3	Bodo saltans	27%	100%
A0A0S4JQK5	Bodo saltans	26%	100%
A0A0S4JTQ5	Bodo saltans	25%	87%
A0A1X0P950	Trypanosomatidae	34%	96%
A0A3Q8IRK3	Leishmania donovani	87%	96%
A0A3R7MS13	Trypanosoma rangeli	34%	99%
A0A3S5H6B0	Leishmania donovani	26%	100%
A0A422N6D6	Trypanosoma rangeli	25%	100%
A4HHP1	Leishmania braziliensis	74%	100%
A4HTT0	Leishmania infantum	25%	100%
A4I4V6	Leishmania infantum	87%	78%
E9AEA4	Leishmania major	82%	97%
E9AML3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q4QI23	Leishmania major	25%	100%
V5BC37	Trypanosoma cruzi	36%	99%