Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ALI1_LEIMU

TriTrypDb:

LmxM.08_29.2430

Length:

790

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALI1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALI1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.700
CLV_C14_Caspase3-7	249	253	PF00656	0.668
CLV_C14_Caspase3-7	262	266	PF00656	0.583
CLV_C14_Caspase3-7	510	514	PF00656	0.632
CLV_C14_Caspase3-7	56	60	PF00656	0.558
CLV_C14_Caspase3-7	76	80	PF00656	0.570
CLV_NRD_NRD_1	112	114	PF00675	0.651
CLV_NRD_NRD_1	281	283	PF00675	0.603
CLV_NRD_NRD_1	311	313	PF00675	0.618
CLV_NRD_NRD_1	412	414	PF00675	0.494
CLV_NRD_NRD_1	503	505	PF00675	0.614
CLV_NRD_NRD_1	543	545	PF00675	0.631
CLV_NRD_NRD_1	639	641	PF00675	0.523
CLV_NRD_NRD_1	730	732	PF00675	0.663
CLV_NRD_NRD_1	735	737	PF00675	0.612
CLV_PCSK_FUR_1	501	505	PF00082	0.588
CLV_PCSK_KEX2_1	112	114	PF00082	0.651
CLV_PCSK_KEX2_1	281	283	PF00082	0.603
CLV_PCSK_KEX2_1	311	313	PF00082	0.618
CLV_PCSK_KEX2_1	362	364	PF00082	0.581
CLV_PCSK_KEX2_1	412	414	PF00082	0.494
CLV_PCSK_KEX2_1	503	505	PF00082	0.614
CLV_PCSK_KEX2_1	542	544	PF00082	0.628
CLV_PCSK_KEX2_1	590	592	PF00082	0.681
CLV_PCSK_KEX2_1	614	616	PF00082	0.561
CLV_PCSK_KEX2_1	639	641	PF00082	0.687
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.581
CLV_PCSK_PC1ET2_1	590	592	PF00082	0.681
CLV_PCSK_PC1ET2_1	614	616	PF00082	0.572
CLV_PCSK_PC1ET2_1	639	641	PF00082	0.687
CLV_PCSK_PC7_1	358	364	PF00082	0.488
CLV_PCSK_SKI1_1	194	198	PF00082	0.578
CLV_PCSK_SKI1_1	523	527	PF00082	0.698
CLV_PCSK_SKI1_1	731	735	PF00082	0.659
CLV_Separin_Metazoa	744	748	PF03568	0.563
DEG_SCF_FBW7_1	484	491	PF00400	0.517
DEG_SCF_FBW7_1	719	725	PF00400	0.606
DEG_SIAH_1	348	356	PF03145	0.572
DEG_SPOP_SBC_1	568	572	PF00917	0.518
DEG_SPOP_SBC_1	673	677	PF00917	0.486
DOC_CDC14_PxL_1	589	597	PF14671	0.545
DOC_CKS1_1	127	132	PF01111	0.594
DOC_CKS1_1	471	476	PF01111	0.513
DOC_CKS1_1	485	490	PF01111	0.540
DOC_CKS1_1	573	578	PF01111	0.626
DOC_CKS1_1	719	724	PF01111	0.608
DOC_CYCLIN_RxL_1	163	174	PF00134	0.600
DOC_CYCLIN_yCln2_LP_2	573	579	PF00134	0.570
DOC_MAPK_DCC_7	591	601	PF00069	0.499
DOC_MAPK_MEF2A_6	350	359	PF00069	0.502
DOC_MAPK_RevD_3	755	769	PF00069	0.533
DOC_PP1_RVXF_1	164	171	PF00149	0.604
DOC_PP2B_LxvP_1	239	242	PF13499	0.510
DOC_PP2B_LxvP_1	291	294	PF13499	0.657
DOC_PP2B_LxvP_1	383	386	PF13499	0.647
DOC_PP2B_LxvP_1	46	49	PF13499	0.625
DOC_USP7_MATH_1	15	19	PF00917	0.603
DOC_USP7_MATH_1	205	209	PF00917	0.658
DOC_USP7_MATH_1	299	303	PF00917	0.572
DOC_USP7_MATH_1	399	403	PF00917	0.577
DOC_USP7_MATH_1	405	409	PF00917	0.573
DOC_USP7_MATH_1	419	423	PF00917	0.472
DOC_USP7_MATH_1	447	451	PF00917	0.543
DOC_USP7_MATH_1	488	492	PF00917	0.733
DOC_USP7_MATH_1	652	656	PF00917	0.587
DOC_USP7_MATH_1	673	677	PF00917	0.606
DOC_USP7_MATH_1	706	710	PF00917	0.653
DOC_USP7_MATH_1	95	99	PF00917	0.655
DOC_USP7_UBL2_3	183	187	PF12436	0.533
DOC_USP7_UBL2_3	562	566	PF12436	0.639
DOC_USP7_UBL2_3	728	732	PF12436	0.618
DOC_USP7_UBL2_3	776	780	PF12436	0.600
DOC_WW_Pin1_4	120	125	PF00397	0.652
DOC_WW_Pin1_4	126	131	PF00397	0.607
DOC_WW_Pin1_4	178	183	PF00397	0.566
DOC_WW_Pin1_4	185	190	PF00397	0.590
DOC_WW_Pin1_4	22	27	PF00397	0.473
DOC_WW_Pin1_4	265	270	PF00397	0.669
DOC_WW_Pin1_4	369	374	PF00397	0.682
DOC_WW_Pin1_4	470	475	PF00397	0.514
DOC_WW_Pin1_4	484	489	PF00397	0.543
DOC_WW_Pin1_4	526	531	PF00397	0.655
DOC_WW_Pin1_4	554	559	PF00397	0.690
DOC_WW_Pin1_4	572	577	PF00397	0.510
DOC_WW_Pin1_4	59	64	PF00397	0.576
DOC_WW_Pin1_4	614	619	PF00397	0.584
DOC_WW_Pin1_4	623	628	PF00397	0.624
DOC_WW_Pin1_4	645	650	PF00397	0.596
DOC_WW_Pin1_4	689	694	PF00397	0.648
DOC_WW_Pin1_4	718	723	PF00397	0.735
DOC_WW_Pin1_4	780	785	PF00397	0.601
LIG_14-3-3_CanoR_1	112	118	PF00244	0.625
LIG_14-3-3_CanoR_1	128	138	PF00244	0.630
LIG_14-3-3_CanoR_1	281	291	PF00244	0.551
LIG_14-3-3_CanoR_1	311	319	PF00244	0.639
LIG_14-3-3_CanoR_1	334	338	PF00244	0.600
LIG_14-3-3_CanoR_1	341	349	PF00244	0.663
LIG_14-3-3_CanoR_1	413	423	PF00244	0.576
LIG_14-3-3_CanoR_1	542	551	PF00244	0.618
LIG_14-3-3_CanoR_1	731	738	PF00244	0.624
LIG_14-3-3_CanoR_1	86	94	PF00244	0.644
LIG_Actin_WH2_2	734	749	PF00022	0.467
LIG_BRCT_BRCA1_1	284	288	PF00533	0.581
LIG_BRCT_BRCA1_1	61	65	PF00533	0.504
LIG_BRCT_BRCA1_1	676	680	PF00533	0.493
LIG_EVH1_1	383	387	PF00568	0.524
LIG_FHA_1	133	139	PF00498	0.659
LIG_FHA_1	366	372	PF00498	0.600
LIG_FHA_1	41	47	PF00498	0.569
LIG_FHA_1	471	477	PF00498	0.522
LIG_FHA_1	555	561	PF00498	0.671
LIG_FHA_1	568	574	PF00498	0.598
LIG_FHA_1	611	617	PF00498	0.625
LIG_FHA_2	169	175	PF00498	0.576
LIG_FHA_2	298	304	PF00498	0.518
LIG_FHA_2	54	60	PF00498	0.765
LIG_FHA_2	569	575	PF00498	0.684
LIG_FHA_2	64	70	PF00498	0.623
LIG_FHA_2	74	80	PF00498	0.611
LIG_Integrin_isoDGR_2	395	397	PF01839	0.584
LIG_LIR_Apic_2	502	508	PF02991	0.664
LIG_LIR_Apic_2	715	720	PF02991	0.521
LIG_LIR_Gen_1	24	34	PF02991	0.483
LIG_LIR_Gen_1	285	294	PF02991	0.577
LIG_LIR_Gen_1	317	325	PF02991	0.601
LIG_LIR_Gen_1	400	410	PF02991	0.600
LIG_LIR_Nem_3	161	167	PF02991	0.597
LIG_LIR_Nem_3	24	30	PF02991	0.479
LIG_LIR_Nem_3	285	291	PF02991	0.581
LIG_LIR_Nem_3	317	322	PF02991	0.617
LIG_LIR_Nem_3	400	406	PF02991	0.603
LIG_LIR_Nem_3	79	85	PF02991	0.629
LIG_MLH1_MIPbox_1	61	65	PF16413	0.504
LIG_MYND_1	593	597	PF01753	0.532
LIG_SH2_CRK	164	168	PF00017	0.579
LIG_SH2_CRK	319	323	PF00017	0.609
LIG_SH2_CRK	440	444	PF00017	0.603
LIG_SH2_CRK	717	721	PF00017	0.530
LIG_SH2_GRB2like	319	322	PF00017	0.495
LIG_SH2_NCK_1	440	444	PF00017	0.559
LIG_SH2_NCK_1	717	721	PF00017	0.533
LIG_SH2_PTP2	505	508	PF00017	0.661
LIG_SH2_SRC	319	322	PF00017	0.495
LIG_SH2_SRC	505	508	PF00017	0.661
LIG_SH2_STAP1	236	240	PF00017	0.510
LIG_SH2_STAP1	319	323	PF00017	0.609
LIG_SH2_STAP1	455	459	PF00017	0.488
LIG_SH2_STAT5	331	334	PF00017	0.576
LIG_SH2_STAT5	440	443	PF00017	0.580
LIG_SH2_STAT5	505	508	PF00017	0.597
LIG_SH2_STAT5	54	57	PF00017	0.496
LIG_SH3_1	440	446	PF00018	0.555
LIG_SH3_1	590	596	PF00018	0.565
LIG_SH3_1	667	673	PF00018	0.506
LIG_SH3_1	717	723	PF00018	0.530
LIG_SH3_3	121	127	PF00018	0.594
LIG_SH3_3	153	159	PF00018	0.611
LIG_SH3_3	291	297	PF00018	0.607
LIG_SH3_3	346	352	PF00018	0.661
LIG_SH3_3	381	387	PF00018	0.673
LIG_SH3_3	433	439	PF00018	0.528
LIG_SH3_3	440	446	PF00018	0.539
LIG_SH3_3	463	469	PF00018	0.644
LIG_SH3_3	503	509	PF00018	0.614
LIG_SH3_3	524	530	PF00018	0.638
LIG_SH3_3	545	551	PF00018	0.616
LIG_SH3_3	590	596	PF00018	0.561
LIG_SH3_3	600	606	PF00018	0.583
LIG_SH3_3	626	632	PF00018	0.598
LIG_SH3_3	654	660	PF00018	0.597
LIG_SH3_3	667	673	PF00018	0.526
LIG_SH3_3	716	722	PF00018	0.580
LIG_SUMO_SIM_anti_2	460	466	PF11976	0.495
LIG_SUMO_SIM_par_1	496	502	PF11976	0.590
LIG_SUMO_SIM_par_1	631	636	PF11976	0.632
LIG_SxIP_EBH_1	542	553	PF03271	0.520
LIG_TRAF2_1	171	174	PF00917	0.568
LIG_TRAF2_1	508	511	PF00917	0.602
LIG_TRAF2_1	68	71	PF00917	0.630
LIG_UBA3_1	287	296	PF00899	0.549
LIG_WRC_WIRS_1	406	411	PF05994	0.488
LIG_WW_2	593	596	PF00397	0.490
MOD_CDK_SPK_2	178	183	PF00069	0.545
MOD_CDK_SPK_2	780	785	PF00069	0.601
MOD_CDK_SPxK_1	484	490	PF00069	0.563
MOD_CDK_SPxxK_3	185	192	PF00069	0.587
MOD_CDK_SPxxK_3	780	787	PF00069	0.546
MOD_CK1_1	114	120	PF00069	0.684
MOD_CK1_1	188	194	PF00069	0.618
MOD_CK1_1	258	264	PF00069	0.621
MOD_CK1_1	271	277	PF00069	0.583
MOD_CK1_1	374	380	PF00069	0.715
MOD_CK1_1	408	414	PF00069	0.557
MOD_CK1_1	422	428	PF00069	0.549
MOD_CK1_1	491	497	PF00069	0.550
MOD_CK1_1	572	578	PF00069	0.552
MOD_CK1_1	674	680	PF00069	0.668
MOD_CK1_1	73	79	PF00069	0.738
MOD_CK1_1	783	789	PF00069	0.543
MOD_CK1_1	88	94	PF00069	0.596
MOD_CK2_1	168	174	PF00069	0.588
MOD_CK2_1	210	216	PF00069	0.640
MOD_CK2_1	297	303	PF00069	0.551
MOD_CK2_1	424	430	PF00069	0.472
MOD_CK2_1	568	574	PF00069	0.653
MOD_CK2_1	63	69	PF00069	0.649
MOD_CK2_1	652	658	PF00069	0.641
MOD_GlcNHglycan	114	117	PF01048	0.634
MOD_GlcNHglycan	228	231	PF01048	0.429
MOD_GlcNHglycan	248	251	PF01048	0.573
MOD_GlcNHglycan	399	402	PF01048	0.625
MOD_GlcNHglycan	424	427	PF01048	0.695
MOD_GlcNHglycan	667	670	PF01048	0.605
MOD_GlcNHglycan	708	711	PF01048	0.654
MOD_GlcNHglycan	97	100	PF01048	0.701
MOD_GSK3_1	104	111	PF00069	0.573
MOD_GSK3_1	112	119	PF00069	0.666
MOD_GSK3_1	129	136	PF00069	0.591
MOD_GSK3_1	196	203	PF00069	0.719
MOD_GSK3_1	210	217	PF00069	0.734
MOD_GSK3_1	255	262	PF00069	0.626
MOD_GSK3_1	268	275	PF00069	0.563
MOD_GSK3_1	295	302	PF00069	0.537
MOD_GSK3_1	365	372	PF00069	0.630
MOD_GSK3_1	374	381	PF00069	0.669
MOD_GSK3_1	408	415	PF00069	0.635
MOD_GSK3_1	417	424	PF00069	0.611
MOD_GSK3_1	426	433	PF00069	0.644
MOD_GSK3_1	484	491	PF00069	0.665
MOD_GSK3_1	5	12	PF00069	0.527
MOD_GSK3_1	53	60	PF00069	0.616
MOD_GSK3_1	542	549	PF00069	0.639
MOD_GSK3_1	568	575	PF00069	0.750
MOD_GSK3_1	610	617	PF00069	0.581
MOD_GSK3_1	672	679	PF00069	0.574
MOD_GSK3_1	718	725	PF00069	0.631
MOD_GSK3_1	85	92	PF00069	0.810
MOD_GSK3_1	95	102	PF00069	0.701
MOD_N-GLC_1	168	173	PF02516	0.650
MOD_N-GLC_1	701	706	PF02516	0.614
MOD_N-GLC_1	73	78	PF02516	0.670
MOD_N-GLC_1	95	100	PF02516	0.612
MOD_NEK2_1	246	251	PF00069	0.497
MOD_NEK2_1	257	262	PF00069	0.546
MOD_NEK2_1	272	277	PF00069	0.813
MOD_NEK2_1	378	383	PF00069	0.561
MOD_NEK2_1	5	10	PF00069	0.553
MOD_NEK2_1	635	640	PF00069	0.791
MOD_NEK2_1	85	90	PF00069	0.629
MOD_NEK2_2	283	288	PF00069	0.548
MOD_NEK2_2	775	780	PF00069	0.496
MOD_OFUCOSY	421	428	PF10250	0.541
MOD_PIKK_1	196	202	PF00454	0.645
MOD_PIKK_1	205	211	PF00454	0.613
MOD_PIKK_1	255	261	PF00454	0.572
MOD_PIKK_1	323	329	PF00454	0.565
MOD_PIKK_1	333	339	PF00454	0.485
MOD_PIKK_1	441	447	PF00454	0.674
MOD_PIKK_1	731	737	PF00454	0.495
MOD_PIKK_1	89	95	PF00454	0.690
MOD_PIKK_1	9	15	PF00454	0.514
MOD_PK_1	737	743	PF00069	0.534
MOD_PKA_1	112	118	PF00069	0.654
MOD_PKA_1	281	287	PF00069	0.673
MOD_PKA_1	295	301	PF00069	0.512
MOD_PKA_1	412	418	PF00069	0.495
MOD_PKA_1	542	548	PF00069	0.620
MOD_PKA_1	731	737	PF00069	0.659
MOD_PKA_2	108	114	PF00069	0.606
MOD_PKA_2	281	287	PF00069	0.613
MOD_PKA_2	333	339	PF00069	0.524
MOD_PKA_2	412	418	PF00069	0.495
MOD_PKA_2	542	548	PF00069	0.620
MOD_PKA_2	85	91	PF00069	0.636
MOD_PKB_1	192	200	PF00069	0.541
MOD_PKB_1	312	320	PF00069	0.621
MOD_Plk_1	455	461	PF00069	0.490
MOD_Plk_1	568	574	PF00069	0.563
MOD_Plk_1	701	707	PF00069	0.552
MOD_Plk_2-3	569	575	PF00069	0.520
MOD_Plk_4	15	21	PF00069	0.610
MOD_Plk_4	152	158	PF00069	0.778
MOD_Plk_4	283	289	PF00069	0.550
MOD_Plk_4	314	320	PF00069	0.625
MOD_Plk_4	405	411	PF00069	0.490
MOD_Plk_4	99	105	PF00069	0.585
MOD_ProDKin_1	120	126	PF00069	0.651
MOD_ProDKin_1	178	184	PF00069	0.572
MOD_ProDKin_1	185	191	PF00069	0.593
MOD_ProDKin_1	22	28	PF00069	0.473
MOD_ProDKin_1	265	271	PF00069	0.669
MOD_ProDKin_1	369	375	PF00069	0.681
MOD_ProDKin_1	470	476	PF00069	0.514
MOD_ProDKin_1	484	490	PF00069	0.542
MOD_ProDKin_1	526	532	PF00069	0.655
MOD_ProDKin_1	554	560	PF00069	0.691
MOD_ProDKin_1	572	578	PF00069	0.514
MOD_ProDKin_1	59	65	PF00069	0.580
MOD_ProDKin_1	614	620	PF00069	0.581
MOD_ProDKin_1	623	629	PF00069	0.624
MOD_ProDKin_1	645	651	PF00069	0.598
MOD_ProDKin_1	689	695	PF00069	0.652
MOD_ProDKin_1	718	724	PF00069	0.739
MOD_ProDKin_1	780	786	PF00069	0.544
MOD_SUMO_for_1	525	528	PF00179	0.696
MOD_SUMO_for_1	741	744	PF00179	0.565
MOD_SUMO_rev_2	725	730	PF00179	0.602
TRG_DiLeu_BaEn_4	303	309	PF01217	0.621
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.644
TRG_ENDOCYTIC_2	164	167	PF00928	0.578
TRG_ENDOCYTIC_2	236	239	PF00928	0.550
TRG_ENDOCYTIC_2	319	322	PF00928	0.615
TRG_ER_diArg_1	192	195	PF00400	0.576
TRG_ER_diArg_1	280	282	PF00400	0.612
TRG_ER_diArg_1	311	314	PF00400	0.621
TRG_ER_diArg_1	412	414	PF00400	0.609
TRG_ER_diArg_1	500	503	PF00400	0.598
TRG_ER_diArg_1	541	544	PF00400	0.629
TRG_NLS_MonoExtC_3	638	643	PF00514	0.513
TRG_Pf-PMV_PEXEL_1	731	735	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0L3	Leptomonas seymouri	34%	91%
A0A3S7X2R9	Leishmania donovani	75%	100%
A4HHP2	Leishmania braziliensis	52%	98%
A4I4V7	Leishmania infantum	78%	100%
E9AEA5	Leishmania major	74%	97%