Phosphodiesterase

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Phosphodiesterase

Gene product:

3'5'-cyclic nucleotide phosphodiesterase, putative

Species:

Leishmania mexicana

UniProt:

E9ALI0_LEIMU

TriTrypDb:

LmxM.08_29.2440

Length:

714

Annotations

LeishMANIAdb annotations

Phosphodiesterase, with probable N-terminal lipidation signal. Not embedded in membrane, like its homologs.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	1
GO:0020016	ciliary pocket	2	1

Expansion

Sequence features

E9ALI0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALI0

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	15
GO:0009987	cellular process	1	15
GO:0050789	regulation of biological process	2	15
GO:0050794	regulation of cellular process	3	15
GO:0065007	biological regulation	1	15

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	15
GO:0004112	cyclic-nucleotide phosphodiesterase activity	6	15
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity	7	15
GO:0005488	binding	1	15
GO:0008081	phosphoric diester hydrolase activity	5	15
GO:0016787	hydrolase activity	2	15
GO:0016788	hydrolase activity, acting on ester bonds	3	15
GO:0042578	phosphoric ester hydrolase activity	4	15
GO:0043167	ion binding	2	15
GO:0043169	cation binding	3	15
GO:0046872	metal ion binding	4	15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.531
CLV_NRD_NRD_1	185	187	PF00675	0.524
CLV_NRD_NRD_1	305	307	PF00675	0.542
CLV_NRD_NRD_1	380	382	PF00675	0.562
CLV_NRD_NRD_1	447	449	PF00675	0.500
CLV_NRD_NRD_1	646	648	PF00675	0.352
CLV_NRD_NRD_1	707	709	PF00675	0.579
CLV_PCSK_KEX2_1	305	307	PF00082	0.547
CLV_PCSK_KEX2_1	447	449	PF00082	0.500
CLV_PCSK_KEX2_1	707	709	PF00082	0.565
CLV_PCSK_PC7_1	301	307	PF00082	0.644
CLV_PCSK_SKI1_1	108	112	PF00082	0.542
CLV_PCSK_SKI1_1	221	225	PF00082	0.504
CLV_PCSK_SKI1_1	357	361	PF00082	0.402
CLV_PCSK_SKI1_1	447	451	PF00082	0.381
CLV_PCSK_SKI1_1	531	535	PF00082	0.314
CLV_PCSK_SKI1_1	583	587	PF00082	0.348
CLV_PCSK_SKI1_1	606	610	PF00082	0.381
CLV_PCSK_SKI1_1	93	97	PF00082	0.538
CLV_Separin_Metazoa	544	548	PF03568	0.401
DEG_APCC_DBOX_1	446	454	PF00400	0.452
DOC_CYCLIN_RxL_1	644	654	PF00134	0.439
DOC_CYCLIN_yClb5_NLxxxL_5	301	307	PF00134	0.453
DOC_MAPK_gen_1	174	182	PF00069	0.284
DOC_MAPK_gen_1	447	453	PF00069	0.495
DOC_MAPK_gen_1	601	609	PF00069	0.401
DOC_MAPK_gen_1	647	653	PF00069	0.447
DOC_MAPK_MEF2A_6	174	182	PF00069	0.502
DOC_MAPK_MEF2A_6	601	609	PF00069	0.317
DOC_PP4_FxxP_1	118	121	PF00568	0.517
DOC_PP4_FxxP_1	205	208	PF00568	0.554
DOC_PP4_FxxP_1	507	510	PF00568	0.364
DOC_SPAK_OSR1_1	225	229	PF12202	0.479
DOC_SPAK_OSR1_1	448	452	PF12202	0.496
DOC_USP7_MATH_1	287	291	PF00917	0.606
DOC_USP7_MATH_1	452	456	PF00917	0.476
DOC_USP7_MATH_2	348	354	PF00917	0.533
DOC_USP7_UBL2_3	633	637	PF12436	0.437
DOC_WW_Pin1_4	11	16	PF00397	0.730
DOC_WW_Pin1_4	214	219	PF00397	0.610
DOC_WW_Pin1_4	335	340	PF00397	0.715
DOC_WW_Pin1_4	360	365	PF00397	0.525
DOC_WW_Pin1_4	58	63	PF00397	0.729
DOC_WW_Pin1_4	651	656	PF00397	0.314
DOC_WW_Pin1_4	66	71	PF00397	0.744
LIG_14-3-3_CanoR_1	141	148	PF00244	0.489
LIG_14-3-3_CanoR_1	591	598	PF00244	0.434
LIG_14-3-3_CanoR_1	606	612	PF00244	0.381
LIG_APCC_ABBA_1	115	120	PF00400	0.515
LIG_APCC_ABBA_1	653	658	PF00400	0.364
LIG_BRCT_BRCA1_1	635	639	PF00533	0.349
LIG_CSL_BTD_1	336	339	PF09270	0.717
LIG_CtBP_PxDLS_1	208	212	PF00389	0.567
LIG_FHA_1	112	118	PF00498	0.434
LIG_FHA_1	133	139	PF00498	0.543
LIG_FHA_1	168	174	PF00498	0.475
LIG_FHA_1	230	236	PF00498	0.521
LIG_FHA_1	267	273	PF00498	0.624
LIG_FHA_1	31	37	PF00498	0.769
LIG_FHA_1	408	414	PF00498	0.470
LIG_FHA_1	423	429	PF00498	0.370
LIG_FHA_1	540	546	PF00498	0.452
LIG_FHA_1	691	697	PF00498	0.474
LIG_FHA_1	72	78	PF00498	0.763
LIG_FHA_1	8	14	PF00498	0.763
LIG_FHA_2	142	148	PF00498	0.459
LIG_FHA_2	183	189	PF00498	0.481
LIG_FHA_2	268	274	PF00498	0.627
LIG_FHA_2	554	560	PF00498	0.377
LIG_FHA_2	566	572	PF00498	0.275
LIG_IBAR_NPY_1	460	462	PF08397	0.389
LIG_IRF3_LxIS_1	649	654	PF10401	0.426
LIG_LIR_Apic_2	202	208	PF02991	0.568
LIG_LIR_Apic_2	506	510	PF02991	0.314
LIG_LIR_Gen_1	188	199	PF02991	0.510
LIG_LIR_Gen_1	395	403	PF02991	0.400
LIG_LIR_Gen_1	407	416	PF02991	0.353
LIG_LIR_Gen_1	425	435	PF02991	0.336
LIG_LIR_Gen_1	542	551	PF02991	0.368
LIG_LIR_Nem_3	160	164	PF02991	0.410
LIG_LIR_Nem_3	188	194	PF02991	0.479
LIG_LIR_Nem_3	200	206	PF02991	0.466
LIG_LIR_Nem_3	395	400	PF02991	0.390
LIG_LIR_Nem_3	407	411	PF02991	0.367
LIG_LIR_Nem_3	425	430	PF02991	0.355
LIG_LIR_Nem_3	493	499	PF02991	0.424
LIG_LIR_Nem_3	542	546	PF02991	0.403
LIG_LIR_Nem_3	672	676	PF02991	0.327
LIG_LIR_Nem_3	97	101	PF02991	0.560
LIG_LYPXL_yS_3	203	206	PF13949	0.494
LIG_MYND_1	58	62	PF01753	0.492
LIG_Pex14_1	161	165	PF04695	0.382
LIG_PTB_Apo_2	545	552	PF02174	0.381
LIG_PTB_Apo_2	699	706	PF02174	0.525
LIG_PTB_Phospho_1	545	551	PF10480	0.424
LIG_PTB_Phospho_1	699	705	PF10480	0.525
LIG_Rb_pABgroove_1	318	326	PF01858	0.667
LIG_REV1ctd_RIR_1	162	170	PF16727	0.401
LIG_SH2_CRK	408	412	PF00017	0.416
LIG_SH2_CRK	98	102	PF00017	0.551
LIG_SH2_GRB2like	438	441	PF00017	0.498
LIG_SH2_GRB2like	462	465	PF00017	0.325
LIG_SH2_NCK_1	237	241	PF00017	0.680
LIG_SH2_NCK_1	408	412	PF00017	0.429
LIG_SH2_SRC	324	327	PF00017	0.622
LIG_SH2_STAP1	139	143	PF00017	0.488
LIG_SH2_STAP1	628	632	PF00017	0.401
LIG_SH2_STAT3	676	679	PF00017	0.424
LIG_SH2_STAT5	143	146	PF00017	0.595
LIG_SH2_STAT5	271	274	PF00017	0.620
LIG_SH2_STAT5	427	430	PF00017	0.383
LIG_SH2_STAT5	438	441	PF00017	0.432
LIG_SH2_STAT5	477	480	PF00017	0.306
LIG_SH2_STAT5	523	526	PF00017	0.336
LIG_SH2_STAT5	640	643	PF00017	0.401
LIG_SH2_STAT5	676	679	PF00017	0.314
LIG_SH2_STAT5	94	97	PF00017	0.466
LIG_SH3_3	12	18	PF00018	0.708
LIG_SH3_3	358	364	PF00018	0.425
LIG_SUMO_SIM_par_1	32	39	PF11976	0.576
LIG_SUMO_SIM_par_1	449	455	PF11976	0.488
LIG_TRAF2_1	144	147	PF00917	0.588
LIG_TRAF2_1	309	312	PF00917	0.588
LIG_TRAF2_1	343	346	PF00917	0.605
LIG_TRAF2_1	491	494	PF00917	0.381
LIG_TRFH_1	360	364	PF08558	0.446
LIG_TYR_ITIM	436	441	PF00017	0.462
LIG_TYR_ITSM	423	430	PF00017	0.392
LIG_WRC_WIRS_1	351	356	PF05994	0.430
LIG_WRC_WIRS_1	691	696	PF05994	0.388
MOD_CDK_SPxxK_3	214	221	PF00069	0.548
MOD_CDK_SPxxK_3	360	367	PF00069	0.534
MOD_CK1_1	134	140	PF00069	0.523
MOD_CK1_1	167	173	PF00069	0.383
MOD_CK1_1	213	219	PF00069	0.535
MOD_CK1_1	241	247	PF00069	0.593
MOD_CK1_1	3	9	PF00069	0.729
MOD_CK1_1	369	375	PF00069	0.506
MOD_CK1_1	593	599	PF00069	0.452
MOD_CK1_1	71	77	PF00069	0.741
MOD_CK2_1	126	132	PF00069	0.404
MOD_CK2_1	141	147	PF00069	0.481
MOD_CK2_1	17	23	PF00069	0.776
MOD_CK2_1	242	248	PF00069	0.682
MOD_CK2_1	488	494	PF00069	0.368
MOD_CK2_1	529	535	PF00069	0.314
MOD_CK2_1	565	571	PF00069	0.349
MOD_CK2_1	597	603	PF00069	0.370
MOD_GlcNHglycan	2	5	PF01048	0.770
MOD_GlcNHglycan	243	247	PF01048	0.605
MOD_GlcNHglycan	284	288	PF01048	0.650
MOD_GlcNHglycan	370	374	PF01048	0.494
MOD_GlcNHglycan	38	41	PF01048	0.686
MOD_GlcNHglycan	454	457	PF01048	0.452
MOD_GlcNHglycan	685	688	PF01048	0.436
MOD_GlcNHglycan	81	84	PF01048	0.721
MOD_GSK3_1	122	129	PF00069	0.464
MOD_GSK3_1	178	185	PF00069	0.468
MOD_GSK3_1	189	196	PF00069	0.412
MOD_GSK3_1	210	217	PF00069	0.538
MOD_GSK3_1	238	245	PF00069	0.611
MOD_GSK3_1	262	269	PF00069	0.599
MOD_GSK3_1	283	290	PF00069	0.578
MOD_GSK3_1	3	10	PF00069	0.753
MOD_GSK3_1	30	37	PF00069	0.638
MOD_GSK3_1	328	335	PF00069	0.680
MOD_GSK3_1	593	600	PF00069	0.401
MOD_GSK3_1	64	71	PF00069	0.733
MOD_N-GLC_1	633	638	PF02516	0.396
MOD_N-GLC_1	649	654	PF02516	0.325
MOD_N-GLC_2	697	699	PF02516	0.510
MOD_NEK2_1	111	116	PF00069	0.506
MOD_NEK2_1	126	131	PF00069	0.259
MOD_NEK2_1	164	169	PF00069	0.386
MOD_NEK2_1	178	183	PF00069	0.404
MOD_NEK2_1	332	337	PF00069	0.668
MOD_NEK2_1	422	427	PF00069	0.311
MOD_NEK2_1	607	612	PF00069	0.321
MOD_NEK2_1	649	654	PF00069	0.401
MOD_NEK2_2	189	194	PF00069	0.554
MOD_NEK2_2	523	528	PF00069	0.325
MOD_NMyristoyl	1	7	PF02799	0.675
MOD_PIKK_1	469	475	PF00454	0.381
MOD_PKA_1	707	713	PF00069	0.584
MOD_PKA_2	111	117	PF00069	0.352
MOD_PKA_2	238	244	PF00069	0.525
MOD_PKA_2	565	571	PF00069	0.326
MOD_PKA_2	590	596	PF00069	0.419
MOD_PKA_2	707	713	PF00069	0.577
MOD_Plk_1	187	193	PF00069	0.399
MOD_Plk_1	256	262	PF00069	0.573
MOD_Plk_1	283	289	PF00069	0.574
MOD_Plk_1	469	475	PF00069	0.336
MOD_Plk_1	529	535	PF00069	0.317
MOD_Plk_1	649	655	PF00069	0.424
MOD_Plk_4	111	117	PF00069	0.461
MOD_Plk_4	122	128	PF00069	0.449
MOD_Plk_4	134	140	PF00069	0.419
MOD_Plk_4	267	273	PF00069	0.577
MOD_Plk_4	332	338	PF00069	0.678
MOD_Plk_4	523	529	PF00069	0.322
MOD_Plk_4	565	571	PF00069	0.325
MOD_Plk_4	669	675	PF00069	0.377
MOD_ProDKin_1	11	17	PF00069	0.722
MOD_ProDKin_1	214	220	PF00069	0.611
MOD_ProDKin_1	335	341	PF00069	0.707
MOD_ProDKin_1	360	366	PF00069	0.522
MOD_ProDKin_1	58	64	PF00069	0.730
MOD_ProDKin_1	651	657	PF00069	0.314
MOD_ProDKin_1	66	72	PF00069	0.742
MOD_SUMO_rev_2	363	369	PF00179	0.277
MOD_SUMO_rev_2	644	649	PF00179	0.452
TRG_DiLeu_BaEn_1	560	565	PF01217	0.466
TRG_DiLeu_BaLyEn_6	84	89	PF01217	0.480
TRG_ENDOCYTIC_2	203	206	PF00928	0.530
TRG_ENDOCYTIC_2	408	411	PF00928	0.362
TRG_ENDOCYTIC_2	427	430	PF00928	0.318
TRG_ENDOCYTIC_2	438	441	PF00928	0.361
TRG_ENDOCYTIC_2	476	479	PF00928	0.326
TRG_ENDOCYTIC_2	551	554	PF00928	0.341
TRG_ENDOCYTIC_2	98	101	PF00928	0.549
TRG_ER_diArg_1	305	307	PF00400	0.576
TRG_ER_diArg_1	446	448	PF00400	0.498
TRG_ER_diArg_1	706	708	PF00400	0.559
TRG_NES_CRM1_1	350	365	PF08389	0.469
TRG_Pf-PMV_PEXEL_1	280	284	PF00026	0.573
TRG_Pf-PMV_PEXEL_1	531	535	PF00026	0.336
TRG_Pf-PMV_PEXEL_1	562	567	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	87	92	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1Y4	Leptomonas seymouri	72%	100%
A0A0S4IPG9	Bodo saltans	44%	96%
A0A0S4IRJ2	Bodo saltans	46%	100%
A0A1X0P701	Trypanosomatidae	31%	100%
A0A1X0P936	Trypanosomatidae	54%	100%
A0A3R7KV25	Trypanosoma rangeli	53%	100%
A0A3S7X2R6	Leishmania donovani	92%	99%
A4HHP3	Leishmania braziliensis	81%	100%
A4I4V8	Leishmania infantum	92%	99%
C9ZL03	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AEA6	Leishmania major	91%	100%
V5BNN7	Trypanosoma cruzi	32%	100%
V5DTU5	Trypanosoma cruzi	53%	100%