CXXC-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALH6_LEIMU

TriTrypDb:

LmxM.08_29.2480

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALH6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALH6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	103	107	PF00656	0.547
CLV_C14_Caspase3-7	144	148	PF00656	0.685
CLV_C14_Caspase3-7	299	303	PF00656	0.620
CLV_C14_Caspase3-7	308	312	PF00656	0.578
CLV_C14_Caspase3-7	327	331	PF00656	0.538
CLV_C14_Caspase3-7	465	469	PF00656	0.516
CLV_C14_Caspase3-7	566	570	PF00656	0.552
CLV_NRD_NRD_1	204	206	PF00675	0.577
CLV_NRD_NRD_1	392	394	PF00675	0.680
CLV_NRD_NRD_1	509	511	PF00675	0.712
CLV_NRD_NRD_1	556	558	PF00675	0.541
CLV_NRD_NRD_1	567	569	PF00675	0.438
CLV_NRD_NRD_1	635	637	PF00675	0.626
CLV_NRD_NRD_1	645	647	PF00675	0.554
CLV_NRD_NRD_1	710	712	PF00675	0.636
CLV_NRD_NRD_1	721	723	PF00675	0.509
CLV_NRD_NRD_1	732	734	PF00675	0.490
CLV_NRD_NRD_1	762	764	PF00675	0.540
CLV_NRD_NRD_1	785	787	PF00675	0.638
CLV_NRD_NRD_1	839	841	PF00675	0.715
CLV_PCSK_FUR_1	390	394	PF00082	0.677
CLV_PCSK_FUR_1	565	569	PF00082	0.552
CLV_PCSK_FUR_1	730	734	PF00082	0.548
CLV_PCSK_FUR_1	760	764	PF00082	0.575
CLV_PCSK_KEX2_1	189	191	PF00082	0.568
CLV_PCSK_KEX2_1	204	206	PF00082	0.504
CLV_PCSK_KEX2_1	274	276	PF00082	0.556
CLV_PCSK_KEX2_1	383	385	PF00082	0.681
CLV_PCSK_KEX2_1	390	392	PF00082	0.624
CLV_PCSK_KEX2_1	442	444	PF00082	0.594
CLV_PCSK_KEX2_1	508	510	PF00082	0.712
CLV_PCSK_KEX2_1	532	534	PF00082	0.641
CLV_PCSK_KEX2_1	555	557	PF00082	0.542
CLV_PCSK_KEX2_1	567	569	PF00082	0.428
CLV_PCSK_KEX2_1	635	637	PF00082	0.626
CLV_PCSK_KEX2_1	645	647	PF00082	0.554
CLV_PCSK_KEX2_1	709	711	PF00082	0.637
CLV_PCSK_KEX2_1	721	723	PF00082	0.780
CLV_PCSK_KEX2_1	732	734	PF00082	0.537
CLV_PCSK_KEX2_1	762	764	PF00082	0.540
CLV_PCSK_KEX2_1	785	787	PF00082	0.638
CLV_PCSK_KEX2_1	839	841	PF00082	0.715
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.568
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.504
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.556
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.681
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.640
CLV_PCSK_PC1ET2_1	532	534	PF00082	0.641
CLV_PCSK_PC7_1	563	569	PF00082	0.546
CLV_PCSK_PC7_1	631	637	PF00082	0.569
CLV_PCSK_SKI1_1	374	378	PF00082	0.699
CLV_PCSK_SKI1_1	380	384	PF00082	0.670
CLV_PCSK_SKI1_1	395	399	PF00082	0.576
CLV_PCSK_SKI1_1	556	560	PF00082	0.541
CLV_PCSK_SKI1_1	578	582	PF00082	0.593
CLV_PCSK_SKI1_1	722	726	PF00082	0.648
DEG_APCC_DBOX_1	555	563	PF00400	0.540
DEG_COP1_1	338	348	PF00400	0.597
DEG_Nend_UBRbox_3	1	3	PF02207	0.644
DEG_SCF_TRCP1_1	468	473	PF00400	0.508
DOC_CKS1_1	74	79	PF01111	0.553
DOC_CYCLIN_RxL_1	554	561	PF00134	0.542
DOC_MAPK_gen_1	532	542	PF00069	0.568
DOC_MAPK_gen_1	555	562	PF00069	0.543
DOC_MAPK_MEF2A_6	555	562	PF00069	0.543
DOC_MAPK_MEF2A_6	665	674	PF00069	0.551
DOC_PP1_RVXF_1	576	583	PF00149	0.595
DOC_PP2B_LxvP_1	254	257	PF13499	0.718
DOC_PP2B_LxvP_1	343	346	PF13499	0.658
DOC_PP2B_LxvP_1	549	552	PF13499	0.506
DOC_PP2B_LxvP_1	678	681	PF13499	0.469
DOC_PP4_FxxP_1	624	627	PF00568	0.643
DOC_USP7_MATH_1	150	154	PF00917	0.691
DOC_USP7_MATH_1	265	269	PF00917	0.668
DOC_USP7_MATH_1	305	309	PF00917	0.730
DOC_USP7_MATH_1	31	35	PF00917	0.683
DOC_USP7_MATH_1	313	317	PF00917	0.649
DOC_USP7_MATH_1	344	348	PF00917	0.659
DOC_USP7_MATH_1	366	370	PF00917	0.670
DOC_USP7_MATH_1	397	401	PF00917	0.621
DOC_USP7_MATH_1	431	435	PF00917	0.666
DOC_USP7_MATH_1	482	486	PF00917	0.685
DOC_USP7_MATH_1	501	505	PF00917	0.517
DOC_USP7_MATH_1	616	620	PF00917	0.516
DOC_USP7_MATH_1	664	668	PF00917	0.650
DOC_USP7_MATH_1	720	724	PF00917	0.637
DOC_USP7_MATH_1	743	747	PF00917	0.658
DOC_USP7_MATH_1	831	835	PF00917	0.703
DOC_USP7_UBL2_3	374	378	PF12436	0.704
DOC_USP7_UBL2_3	532	536	PF12436	0.615
DOC_USP7_UBL2_3	665	669	PF12436	0.478
DOC_WW_Pin1_4	101	106	PF00397	0.668
DOC_WW_Pin1_4	153	158	PF00397	0.564
DOC_WW_Pin1_4	233	238	PF00397	0.723
DOC_WW_Pin1_4	261	266	PF00397	0.679
DOC_WW_Pin1_4	594	599	PF00397	0.820
DOC_WW_Pin1_4	604	609	PF00397	0.667
DOC_WW_Pin1_4	625	630	PF00397	0.684
DOC_WW_Pin1_4	635	640	PF00397	0.579
DOC_WW_Pin1_4	680	685	PF00397	0.611
DOC_WW_Pin1_4	715	720	PF00397	0.643
DOC_WW_Pin1_4	73	78	PF00397	0.552
DOC_WW_Pin1_4	731	736	PF00397	0.680
DOC_WW_Pin1_4	739	744	PF00397	0.642
DOC_WW_Pin1_4	780	785	PF00397	0.677
DOC_WW_Pin1_4	787	792	PF00397	0.652
DOC_WW_Pin1_4	89	94	PF00397	0.603
LIG_14-3-3_CanoR_1	190	199	PF00244	0.528
LIG_14-3-3_CanoR_1	266	271	PF00244	0.535
LIG_14-3-3_CanoR_1	296	304	PF00244	0.648
LIG_14-3-3_CanoR_1	3	9	PF00244	0.665
LIG_14-3-3_CanoR_1	421	430	PF00244	0.723
LIG_14-3-3_CanoR_1	508	513	PF00244	0.582
LIG_14-3-3_CanoR_1	54	61	PF00244	0.619
LIG_14-3-3_CanoR_1	721	725	PF00244	0.657
LIG_14-3-3_CanoR_1	733	739	PF00244	0.691
LIG_14-3-3_CanoR_1	762	769	PF00244	0.610
LIG_14-3-3_CanoR_1	816	825	PF00244	0.651
LIG_14-3-3_CanoR_1	828	837	PF00244	0.576
LIG_14-3-3_CanoR_1	839	848	PF00244	0.621
LIG_APCC_ABBA_1	162	167	PF00400	0.663
LIG_BIR_III_2	595	599	PF00653	0.646
LIG_BRCT_BRCA1_1	611	615	PF00533	0.662
LIG_deltaCOP1_diTrp_1	576	582	PF00928	0.712
LIG_eIF4E_1	554	560	PF01652	0.542
LIG_FHA_1	340	346	PF00498	0.666
LIG_FHA_1	536	542	PF00498	0.637
LIG_FHA_1	802	808	PF00498	0.649
LIG_FHA_2	101	107	PF00498	0.664
LIG_FHA_2	144	150	PF00498	0.557
LIG_FHA_2	325	331	PF00498	0.557
LIG_FHA_2	806	812	PF00498	0.519
LIG_FHA_2	833	839	PF00498	0.667
LIG_FHA_2	845	851	PF00498	0.611
LIG_GSK3_LRP6_1	101	107	PF00069	0.664
LIG_IBAR_NPY_1	588	590	PF08397	0.573
LIG_Integrin_RGD_1	799	801	PF01839	0.653
LIG_LIR_Apic_2	622	627	PF02991	0.645
LIG_LIR_Gen_1	338	348	PF02991	0.539
LIG_LIR_Gen_1	673	681	PF02991	0.449
LIG_LIR_Gen_1	723	731	PF02991	0.651
LIG_LIR_Nem_3	338	343	PF02991	0.539
LIG_LIR_Nem_3	576	580	PF02991	0.582
LIG_LIR_Nem_3	673	678	PF02991	0.484
LIG_LIR_Nem_3	723	728	PF02991	0.773
LIG_PDZ_Class_3	846	851	PF00595	0.567
LIG_SH2_CRK	340	344	PF00017	0.540
LIG_SH2_STAP1	476	480	PF00017	0.691
LIG_SH2_STAT5	679	682	PF00017	0.496
LIG_SH2_STAT5	707	710	PF00017	0.766
LIG_SH3_1	645	651	PF00018	0.663
LIG_SH3_3	151	157	PF00018	0.635
LIG_SH3_3	167	173	PF00018	0.659
LIG_SH3_3	287	293	PF00018	0.554
LIG_SH3_3	356	362	PF00018	0.682
LIG_SH3_3	449	455	PF00018	0.628
LIG_SH3_3	63	69	PF00018	0.672
LIG_SH3_3	645	651	PF00018	0.663
LIG_SH3_3	652	658	PF00018	0.556
LIG_SH3_3	678	684	PF00018	0.581
LIG_SH3_3	691	697	PF00018	0.576
LIG_SH3_3	745	751	PF00018	0.567
LIG_SH3_3	766	772	PF00018	0.543
LIG_SH3_3	99	105	PF00018	0.699
LIG_SH3_4	374	381	PF00018	0.723
LIG_TRAF2_1	223	226	PF00917	0.684
LIG_TRAF2_1	280	283	PF00917	0.695
LIG_TRAF2_1	39	42	PF00917	0.543
LIG_TRAF2_1	68	71	PF00917	0.557
LIG_UBA3_1	184	192	PF00899	0.485
LIG_UBA3_1	199	207	PF00899	0.584
LIG_WW_3	718	722	PF00397	0.629
MOD_CDC14_SPxK_1	236	239	PF00782	0.616
MOD_CDC14_SPxK_1	628	631	PF00782	0.590
MOD_CDC14_SPxK_1	738	741	PF00782	0.697
MOD_CDC14_SPxK_1	742	745	PF00782	0.686
MOD_CDC14_SPxK_1	783	786	PF00782	0.640
MOD_CDC14_SPxK_1	790	793	PF00782	0.599
MOD_CDK_SPK_2	261	266	PF00069	0.600
MOD_CDK_SPK_2	635	640	PF00069	0.666
MOD_CDK_SPK_2	780	785	PF00069	0.639
MOD_CDK_SPxK_1	233	239	PF00069	0.621
MOD_CDK_SPxK_1	625	631	PF00069	0.595
MOD_CDK_SPxK_1	715	721	PF00069	0.644
MOD_CDK_SPxK_1	735	741	PF00069	0.698
MOD_CDK_SPxK_1	780	786	PF00069	0.641
MOD_CDK_SPxK_1	787	793	PF00069	0.597
MOD_CDK_SPxxK_3	715	722	PF00069	0.684
MOD_CK1_1	104	110	PF00069	0.557
MOD_CK1_1	153	159	PF00069	0.717
MOD_CK1_1	269	275	PF00069	0.703
MOD_CK1_1	324	330	PF00069	0.585
MOD_CK1_1	338	344	PF00069	0.648
MOD_CK1_1	400	406	PF00069	0.673
MOD_CK1_1	413	419	PF00069	0.617
MOD_CK1_1	422	428	PF00069	0.618
MOD_CK1_1	435	441	PF00069	0.720
MOD_CK1_1	445	451	PF00069	0.645
MOD_CK1_1	45	51	PF00069	0.619
MOD_CK1_1	478	484	PF00069	0.711
MOD_CK1_1	516	522	PF00069	0.658
MOD_CK1_1	528	534	PF00069	0.597
MOD_CK1_1	607	613	PF00069	0.712
MOD_CK1_1	619	625	PF00069	0.580
MOD_CK1_1	734	740	PF00069	0.699
MOD_CK1_1	817	823	PF00069	0.686
MOD_CK1_1	92	98	PF00069	0.557
MOD_CK2_1	143	149	PF00069	0.560
MOD_CK2_1	247	253	PF00069	0.582
MOD_CK2_1	413	419	PF00069	0.680
MOD_DYRK1A_RPxSP_1	604	608	PF00069	0.699
MOD_DYRK1A_RPxSP_1	682	686	PF00069	0.632
MOD_GlcNHglycan	112	115	PF01048	0.667
MOD_GlcNHglycan	128	131	PF01048	0.701
MOD_GlcNHglycan	178	181	PF01048	0.653
MOD_GlcNHglycan	218	221	PF01048	0.689
MOD_GlcNHglycan	268	271	PF01048	0.649
MOD_GlcNHglycan	299	302	PF01048	0.706
MOD_GlcNHglycan	307	310	PF01048	0.660
MOD_GlcNHglycan	368	371	PF01048	0.714
MOD_GlcNHglycan	37	40	PF01048	0.691
MOD_GlcNHglycan	399	402	PF01048	0.674
MOD_GlcNHglycan	405	408	PF01048	0.693
MOD_GlcNHglycan	418	424	PF01048	0.567
MOD_GlcNHglycan	462	465	PF01048	0.705
MOD_GlcNHglycan	468	471	PF01048	0.658
MOD_GlcNHglycan	480	483	PF01048	0.561
MOD_GlcNHglycan	503	506	PF01048	0.651
MOD_GlcNHglycan	515	518	PF01048	0.547
MOD_GlcNHglycan	522	525	PF01048	0.559
MOD_GlcNHglycan	528	531	PF01048	0.517
MOD_GlcNHglycan	619	622	PF01048	0.651
MOD_GlcNHglycan	745	748	PF01048	0.675
MOD_GlcNHglycan	764	767	PF01048	0.446
MOD_GSK3_1	100	107	PF00069	0.580
MOD_GSK3_1	116	123	PF00069	0.685
MOD_GSK3_1	243	250	PF00069	0.684
MOD_GSK3_1	261	268	PF00069	0.570
MOD_GSK3_1	269	276	PF00069	0.628
MOD_GSK3_1	31	38	PF00069	0.725
MOD_GSK3_1	313	320	PF00069	0.563
MOD_GSK3_1	335	342	PF00069	0.670
MOD_GSK3_1	406	413	PF00069	0.714
MOD_GSK3_1	431	438	PF00069	0.660
MOD_GSK3_1	454	461	PF00069	0.688
MOD_GSK3_1	462	469	PF00069	0.548
MOD_GSK3_1	470	477	PF00069	0.568
MOD_GSK3_1	478	485	PF00069	0.524
MOD_GSK3_1	486	493	PF00069	0.552
MOD_GSK3_1	508	515	PF00069	0.646
MOD_GSK3_1	516	523	PF00069	0.617
MOD_GSK3_1	531	538	PF00069	0.673
MOD_GSK3_1	594	601	PF00069	0.645
MOD_GSK3_1	705	712	PF00069	0.564
MOD_GSK3_1	731	738	PF00069	0.822
MOD_GSK3_1	739	746	PF00069	0.709
MOD_GSK3_1	801	808	PF00069	0.670
MOD_GSK3_1	810	817	PF00069	0.671
MOD_GSK3_1	827	834	PF00069	0.560
MOD_GSK3_1	89	96	PF00069	0.558
MOD_N-GLC_1	110	115	PF02516	0.544
MOD_N-GLC_1	296	301	PF02516	0.554
MOD_N-GLC_1	45	50	PF02516	0.673
MOD_N-GLC_1	787	792	PF02516	0.676
MOD_N-GLC_2	591	593	PF02516	0.617
MOD_NEK2_1	110	115	PF00069	0.672
MOD_NEK2_1	35	40	PF00069	0.591
MOD_NEK2_1	458	463	PF00069	0.518
MOD_NEK2_1	520	525	PF00069	0.527
MOD_NEK2_1	609	614	PF00069	0.666
MOD_NEK2_1	641	646	PF00069	0.662
MOD_NEK2_1	83	88	PF00069	0.556
MOD_NEK2_1	841	846	PF00069	0.654
MOD_NEK2_2	31	36	PF00069	0.551
MOD_NEK2_2	664	669	PF00069	0.531
MOD_NEK2_2	720	725	PF00069	0.615
MOD_OFUCOSY	188	194	PF10250	0.488
MOD_PIKK_1	137	143	PF00454	0.679
MOD_PIKK_1	171	177	PF00454	0.644
MOD_PIKK_1	321	327	PF00454	0.556
MOD_PIKK_1	346	352	PF00454	0.664
MOD_PIKK_1	658	664	PF00454	0.452
MOD_PIKK_1	839	845	PF00454	0.702
MOD_PK_1	198	204	PF00069	0.590
MOD_PK_1	252	258	PF00069	0.614
MOD_PK_1	508	514	PF00069	0.533
MOD_PK_1	536	542	PF00069	0.614
MOD_PKA_1	176	182	PF00069	0.672
MOD_PKA_1	391	397	PF00069	0.672
MOD_PKA_1	442	448	PF00069	0.539
MOD_PKA_1	508	514	PF00069	0.662
MOD_PKA_1	709	715	PF00069	0.583
MOD_PKA_1	762	768	PF00069	0.544
MOD_PKA_1	839	845	PF00069	0.707
MOD_PKA_2	2	8	PF00069	0.658
MOD_PKA_2	243	249	PF00069	0.672
MOD_PKA_2	265	271	PF00069	0.566
MOD_PKA_2	391	397	PF00069	0.672
MOD_PKA_2	442	448	PF00069	0.599
MOD_PKA_2	508	514	PF00069	0.708
MOD_PKA_2	53	59	PF00069	0.616
MOD_PKA_2	709	715	PF00069	0.583
MOD_PKA_2	720	726	PF00069	0.564
MOD_PKA_2	762	768	PF00069	0.560
MOD_PKA_2	778	784	PF00069	0.518
MOD_PKA_2	815	821	PF00069	0.648
MOD_PKA_2	827	833	PF00069	0.575
MOD_PKA_2	839	845	PF00069	0.614
MOD_PKB_1	294	302	PF00069	0.679
MOD_PKB_1	760	768	PF00069	0.583
MOD_Plk_1	252	258	PF00069	0.544
MOD_Plk_1	288	294	PF00069	0.683
MOD_Plk_1	578	584	PF00069	0.604
MOD_Plk_1	814	820	PF00069	0.579
MOD_Plk_1	821	827	PF00069	0.554
MOD_Plk_1	83	89	PF00069	0.687
MOD_Plk_2-3	247	253	PF00069	0.540
MOD_Plk_4	116	122	PF00069	0.662
MOD_Plk_4	536	542	PF00069	0.746
MOD_Plk_4	619	625	PF00069	0.524
MOD_ProDKin_1	101	107	PF00069	0.669
MOD_ProDKin_1	153	159	PF00069	0.563
MOD_ProDKin_1	233	239	PF00069	0.726
MOD_ProDKin_1	261	267	PF00069	0.678
MOD_ProDKin_1	594	600	PF00069	0.821
MOD_ProDKin_1	604	610	PF00069	0.671
MOD_ProDKin_1	625	631	PF00069	0.685
MOD_ProDKin_1	635	641	PF00069	0.578
MOD_ProDKin_1	680	686	PF00069	0.611
MOD_ProDKin_1	715	721	PF00069	0.644
MOD_ProDKin_1	73	79	PF00069	0.552
MOD_ProDKin_1	731	737	PF00069	0.684
MOD_ProDKin_1	739	745	PF00069	0.644
MOD_ProDKin_1	780	786	PF00069	0.679
MOD_ProDKin_1	787	793	PF00069	0.656
MOD_ProDKin_1	89	95	PF00069	0.605
TRG_DiLeu_BaEn_4	544	550	PF01217	0.488
TRG_DiLeu_BaLyEn_6	637	642	PF01217	0.661
TRG_ENDOCYTIC_2	340	343	PF00928	0.543
TRG_ER_diArg_1	293	296	PF00400	0.539
TRG_ER_diArg_1	389	392	PF00400	0.677
TRG_ER_diArg_1	507	510	PF00400	0.709
TRG_ER_diArg_1	554	557	PF00400	0.543
TRG_ER_diArg_1	562	565	PF00400	0.463
TRG_ER_diArg_1	634	636	PF00400	0.616
TRG_ER_diArg_1	709	711	PF00400	0.639
TRG_ER_diArg_1	720	722	PF00400	0.517
TRG_ER_diArg_1	729	732	PF00400	0.485
TRG_ER_diArg_1	760	763	PF00400	0.533
TRG_ER_diArg_1	784	786	PF00400	0.699
TRG_ER_diArg_1	792	795	PF00400	0.705
TRG_ER_diArg_1	839	841	PF00400	0.681
TRG_NLS_Bipartite_1	176	193	PF00514	0.644
TRG_NLS_MonoCore_2	203	208	PF00514	0.569
TRG_NLS_MonoExtC_3	204	209	PF00514	0.492
TRG_NLS_MonoExtN_4	204	209	PF00514	0.621
TRG_NLS_MonoExtN_4	380	387	PF00514	0.677
TRG_Pf-PMV_PEXEL_1	557	561	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	839	843	PF00026	0.604

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H7L9	Leishmania donovani	78%	100%
A4HHP7	Leishmania braziliensis	52%	100%
A4I4W2	Leishmania infantum	78%	100%
E9AEB0	Leishmania major	76%	97%