Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9ALH5_LEIMU

TriTrypDb:

LmxM.08_29.2490

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALH5

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	14
GO:0006793	phosphorus metabolic process	3	14
GO:0006796	phosphate-containing compound metabolic process	4	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009987	cellular process	1	14
GO:0016310	phosphorylation	5	14
GO:0019538	protein metabolic process	3	14
GO:0036211	protein modification process	4	14
GO:0043170	macromolecule metabolic process	3	14
GO:0043412	macromolecule modification	4	14
GO:0044237	cellular metabolic process	2	14
GO:0044238	primary metabolic process	2	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003824	catalytic activity	1	14
GO:0004672	protein kinase activity	3	14
GO:0005488	binding	1	14
GO:0005524	ATP binding	5	14
GO:0016301	kinase activity	4	14
GO:0016740	transferase activity	2	14
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	14
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	14
GO:0017076	purine nucleotide binding	4	14
GO:0030554	adenyl nucleotide binding	5	14
GO:0032553	ribonucleotide binding	3	14
GO:0032555	purine ribonucleotide binding	4	14
GO:0032559	adenyl ribonucleotide binding	5	14
GO:0035639	purine ribonucleoside triphosphate binding	4	14
GO:0036094	small molecule binding	2	14
GO:0043167	ion binding	2	14
GO:0043168	anion binding	3	14
GO:0097159	organic cyclic compound binding	2	14
GO:0097367	carbohydrate derivative binding	2	14
GO:0140096	catalytic activity, acting on a protein	2	14
GO:1901265	nucleoside phosphate binding	3	14
GO:1901363	heterocyclic compound binding	2	14
GO:0004674	protein serine/threonine kinase activity	4	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	162	164	PF00675	0.431
CLV_NRD_NRD_1	257	259	PF00675	0.325
CLV_NRD_NRD_1	326	328	PF00675	0.320
CLV_NRD_NRD_1	39	41	PF00675	0.501
CLV_PCSK_KEX2_1	325	327	PF00082	0.323
CLV_PCSK_KEX2_1	391	393	PF00082	0.359
CLV_PCSK_KEX2_1	399	401	PF00082	0.280
CLV_PCSK_PC1ET2_1	325	327	PF00082	0.405
CLV_PCSK_PC1ET2_1	391	393	PF00082	0.444
CLV_PCSK_PC1ET2_1	399	401	PF00082	0.394
CLV_PCSK_SKI1_1	163	167	PF00082	0.505
CLV_PCSK_SKI1_1	259	263	PF00082	0.416
CLV_PCSK_SKI1_1	290	294	PF00082	0.344
CLV_PCSK_SKI1_1	396	400	PF00082	0.204
DOC_CKS1_1	11	16	PF01111	0.253
DOC_CYCLIN_RxL_1	158	169	PF00134	0.536
DOC_MAPK_gen_1	256	266	PF00069	0.398
DOC_MAPK_gen_1	290	300	PF00069	0.353
DOC_MAPK_gen_1	40	47	PF00069	0.374
DOC_MAPK_gen_1	60	70	PF00069	0.276
DOC_MAPK_MEF2A_6	233	242	PF00069	0.322
DOC_MAPK_MEF2A_6	265	273	PF00069	0.275
DOC_MAPK_MEF2A_6	315	323	PF00069	0.160
DOC_MAPK_MEF2A_6	40	47	PF00069	0.417
DOC_MAPK_MEF2A_6	63	72	PF00069	0.283
DOC_PP2B_LxvP_1	128	131	PF13499	0.559
DOC_USP7_MATH_1	131	135	PF00917	0.647
DOC_USP7_MATH_1	156	160	PF00917	0.610
DOC_USP7_MATH_1	87	91	PF00917	0.260
DOC_WW_Pin1_4	10	15	PF00397	0.248
DOC_WW_Pin1_4	327	332	PF00397	0.275
DOC_WW_Pin1_4	383	388	PF00397	0.319
DOC_WW_Pin1_4	47	52	PF00397	0.420
LIG_14-3-3_CanoR_1	216	221	PF00244	0.171
LIG_14-3-3_CanoR_1	258	266	PF00244	0.405
LIG_14-3-3_CanoR_1	3	9	PF00244	0.464
LIG_14-3-3_CanoR_1	40	44	PF00244	0.372
LIG_14-3-3_CanoR_1	403	413	PF00244	0.390
LIG_14-3-3_CanoR_1	63	68	PF00244	0.591
LIG_APCC_ABBAyCdc20_2	193	199	PF00400	0.429
LIG_BIR_II_1	1	5	PF00653	0.533
LIG_BRCT_BRCA1_1	406	410	PF00533	0.405
LIG_Clathr_ClatBox_1	308	312	PF01394	0.275
LIG_FHA_1	314	320	PF00498	0.394
LIG_FHA_2	11	17	PF00498	0.256
LIG_FHA_2	201	207	PF00498	0.387
LIG_FHA_2	345	351	PF00498	0.339
LIG_FHA_2	361	367	PF00498	0.273
LIG_FHA_2	403	409	PF00498	0.462
LIG_FHA_2	48	54	PF00498	0.424
LIG_FXI_DFP_1	364	368	PF00024	0.324
LIG_GBD_Chelix_1	269	277	PF00786	0.353
LIG_LIR_Apic_2	332	338	PF02991	0.324
LIG_LIR_Gen_1	407	418	PF02991	0.405
LIG_LIR_Gen_1	66	73	PF02991	0.420
LIG_LIR_Nem_3	159	165	PF02991	0.445
LIG_LIR_Nem_3	366	370	PF02991	0.286
LIG_LIR_Nem_3	407	413	PF02991	0.410
LIG_LIR_Nem_3	66	70	PF02991	0.465
LIG_SH2_CRK	162	166	PF00017	0.454
LIG_SH2_PTP2	67	70	PF00017	0.301
LIG_SH2_SRC	226	229	PF00017	0.324
LIG_SH2_SRC	67	70	PF00017	0.301
LIG_SH2_STAP1	333	337	PF00017	0.405
LIG_SH2_STAP1	406	410	PF00017	0.294
LIG_SH2_STAT3	433	436	PF00017	0.313
LIG_SH2_STAT5	183	186	PF00017	0.210
LIG_SH2_STAT5	226	229	PF00017	0.316
LIG_SH2_STAT5	279	282	PF00017	0.275
LIG_SH2_STAT5	404	407	PF00017	0.324
LIG_SH2_STAT5	67	70	PF00017	0.331
LIG_SH3_3	137	143	PF00018	0.707
LIG_SH3_3	237	243	PF00018	0.324
LIG_SH3_3	362	368	PF00018	0.405
LIG_SH3_3	416	422	PF00018	0.340
LIG_SH3_3	8	14	PF00018	0.329
LIG_SUMO_SIM_anti_2	188	194	PF11976	0.405
LIG_SUMO_SIM_anti_2	295	301	PF11976	0.275
LIG_SUMO_SIM_anti_2	303	310	PF11976	0.275
LIG_SUMO_SIM_anti_2	320	325	PF11976	0.281
LIG_SUMO_SIM_par_1	188	194	PF11976	0.405
LIG_SUMO_SIM_par_1	315	320	PF11976	0.226
LIG_SUMO_SIM_par_1	376	381	PF11976	0.160
LIG_TYR_ITIM	224	229	PF00017	0.275
LIG_TYR_ITIM	65	70	PF00017	0.449
LIG_UBA3_1	377	384	PF00899	0.160
LIG_WW_1	51	54	PF00397	0.445
MOD_CK1_1	383	389	PF00069	0.272
MOD_CK1_1	88	94	PF00069	0.524
MOD_CK2_1	200	206	PF00069	0.324
MOD_CK2_1	402	408	PF00069	0.420
MOD_CK2_1	87	93	PF00069	0.463
MOD_GlcNHglycan	373	376	PF01048	0.367
MOD_GlcNHglycan	380	383	PF01048	0.336
MOD_GlcNHglycan	387	390	PF01048	0.319
MOD_GlcNHglycan	427	430	PF01048	0.329
MOD_GlcNHglycan	87	90	PF01048	0.433
MOD_GSK3_1	313	320	PF00069	0.317
MOD_GSK3_1	340	347	PF00069	0.283
MOD_GSK3_1	59	66	PF00069	0.463
MOD_GSK3_1	81	88	PF00069	0.437
MOD_N-GLC_1	197	202	PF02516	0.417
MOD_N-GLC_2	19	21	PF02516	0.399
MOD_NEK2_1	227	232	PF00069	0.425
MOD_NEK2_1	340	345	PF00069	0.275
MOD_NEK2_1	378	383	PF00069	0.335
MOD_NEK2_1	97	102	PF00069	0.570
MOD_PIKK_1	105	111	PF00454	0.579
MOD_PK_1	265	271	PF00069	0.275
MOD_PKA_2	39	45	PF00069	0.375
MOD_PKA_2	402	408	PF00069	0.281
MOD_PKA_2	424	430	PF00069	0.304
MOD_PKA_2	59	65	PF00069	0.425
MOD_PKB_1	214	222	PF00069	0.234
MOD_Plk_1	200	206	PF00069	0.379
MOD_Plk_1	227	233	PF00069	0.324
MOD_Plk_1	317	323	PF00069	0.172
MOD_Plk_4	265	271	PF00069	0.286
MOD_Plk_4	319	325	PF00069	0.374
MOD_ProDKin_1	10	16	PF00069	0.253
MOD_ProDKin_1	327	333	PF00069	0.275
MOD_ProDKin_1	383	389	PF00069	0.319
MOD_ProDKin_1	47	53	PF00069	0.434
MOD_SUMO_for_1	292	295	PF00179	0.378
MOD_SUMO_rev_2	246	253	PF00179	0.407
MOD_SUMO_rev_2	341	349	PF00179	0.425
TRG_DiLeu_BaEn_1	295	300	PF01217	0.298
TRG_DiLeu_BaEn_1	303	308	PF01217	0.248
TRG_DiLeu_BaEn_1	409	414	PF01217	0.321
TRG_ENDOCYTIC_2	162	165	PF00928	0.434
TRG_ENDOCYTIC_2	226	229	PF00928	0.294
TRG_ENDOCYTIC_2	67	70	PF00928	0.490
TRG_NES_CRM1_1	409	421	PF08389	0.390

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HT76	Leptomonas seymouri	73%	100%
A0A0N1HTF0	Leptomonas seymouri	24%	71%
A0A0N1IM47	Leptomonas seymouri	27%	100%
A0A0S4IXR9	Bodo saltans	27%	97%
A0A0S4IZ14	Bodo saltans	24%	75%
A0A0S4JWD5	Bodo saltans	28%	100%
A0A0S4KN74	Bodo saltans	27%	100%
A0A1X0PA19	Trypanosomatidae	46%	90%
A0A3Q8IAQ1	Leishmania donovani	26%	100%
A0A3Q8IDY1	Leishmania donovani	95%	100%
A0A3R7K1T4	Trypanosoma rangeli	47%	89%
A0A3R7M848	Trypanosoma rangeli	28%	96%
A0A3S7X2W9	Leishmania donovani	25%	100%
A0A3S7X7D5	Leishmania donovani	28%	100%
A0A422P3P9	Trypanosoma rangeli	27%	90%
A4HCE6	Leishmania braziliensis	25%	100%
A4HHP8	Leishmania braziliensis	81%	100%
A4HHS9	Leishmania braziliensis	25%	100%
A4HZW8	Leishmania infantum	26%	100%
A4I4W3	Leishmania infantum	95%	100%
A4I4Y0	Leishmania infantum	25%	100%
A4I9H1	Leishmania infantum	28%	100%
C9ZKZ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	95%
C9ZW20	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	77%
E9AEB1	Leishmania major	92%	100%
E9AJJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	83%
E9ALF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AVS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9B4G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
F4IS56	Arabidopsis thaliana	23%	94%
Q2V419	Arabidopsis thaliana	26%	100%
Q3SYZ2	Bos taurus	27%	100%
Q4QBQ2	Leishmania major	27%	100%
Q66H84	Rattus norvegicus	28%	100%
Q7YRC6	Bos taurus	26%	100%
Q8LF80	Arabidopsis thaliana	26%	100%
Q9NI63	Drosophila melanogaster	27%	84%
V5BPJ0	Trypanosoma cruzi	26%	91%
V5BSK0	Trypanosoma cruzi	49%	90%