SP-RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MIZ/SP-RING zinc finger, putative

Species:

Leishmania mexicana

UniProt:

E9ALH2_LEIMU

TriTrypDb:

LmxM.08_29.2520

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALH2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0008270	zinc ion binding	6	7
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0046914	transition metal ion binding	5	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	150	154	PF00656	0.429
CLV_C14_Caspase3-7	325	329	PF00656	0.566
CLV_NRD_NRD_1	183	185	PF00675	0.396
CLV_NRD_NRD_1	20	22	PF00675	0.470
CLV_NRD_NRD_1	354	356	PF00675	0.628
CLV_NRD_NRD_1	39	41	PF00675	0.471
CLV_NRD_NRD_1	390	392	PF00675	0.608
CLV_NRD_NRD_1	95	97	PF00675	0.329
CLV_PCSK_FUR_1	183	187	PF00082	0.417
CLV_PCSK_FUR_1	352	356	PF00082	0.536
CLV_PCSK_KEX2_1	183	185	PF00082	0.396
CLV_PCSK_KEX2_1	20	22	PF00082	0.483
CLV_PCSK_KEX2_1	354	356	PF00082	0.586
CLV_PCSK_KEX2_1	389	391	PF00082	0.537
CLV_PCSK_KEX2_1	95	97	PF00082	0.347
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.423
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.563
CLV_PCSK_SKI1_1	346	350	PF00082	0.360
DEG_SPOP_SBC_1	154	158	PF00917	0.499
DEG_SPOP_SBC_1	321	325	PF00917	0.536
DOC_CKS1_1	137	142	PF01111	0.487
DOC_CKS1_1	216	221	PF01111	0.502
DOC_CKS1_1	237	242	PF01111	0.473
DOC_CKS1_1	371	376	PF01111	0.672
DOC_CYCLIN_yCln2_LP_2	216	222	PF00134	0.494
DOC_MAPK_gen_1	255	264	PF00069	0.458
DOC_MAPK_gen_1	388	394	PF00069	0.562
DOC_MAPK_MEF2A_6	255	264	PF00069	0.479
DOC_PP2B_LxvP_1	66	69	PF13499	0.527
DOC_PP4_FxxP_1	137	140	PF00568	0.491
DOC_USP7_MATH_1	289	293	PF00917	0.487
DOC_USP7_MATH_1	309	313	PF00917	0.256
DOC_USP7_MATH_1	320	324	PF00917	0.484
DOC_USP7_MATH_1	359	363	PF00917	0.753
DOC_USP7_MATH_1	372	376	PF00917	0.616
DOC_USP7_MATH_1	50	54	PF00917	0.403
DOC_USP7_MATH_1	78	82	PF00917	0.500
DOC_WW_Pin1_4	136	141	PF00397	0.410
DOC_WW_Pin1_4	160	165	PF00397	0.554
DOC_WW_Pin1_4	215	220	PF00397	0.622
DOC_WW_Pin1_4	236	241	PF00397	0.478
DOC_WW_Pin1_4	370	375	PF00397	0.700
DOC_WW_Pin1_4	68	73	PF00397	0.407
LIG_14-3-3_CanoR_1	102	106	PF00244	0.468
LIG_14-3-3_CanoR_1	20	28	PF00244	0.457
LIG_14-3-3_CanoR_1	346	351	PF00244	0.512
LIG_14-3-3_CanoR_1	354	364	PF00244	0.731
LIG_14-3-3_CanoR_1	40	46	PF00244	0.216
LIG_AP2alpha_2	221	223	PF02296	0.451
LIG_BIR_II_1	1	5	PF00653	0.668
LIG_BIR_III_2	328	332	PF00653	0.518
LIG_BRCT_BRCA1_1	52	56	PF00533	0.309
LIG_FHA_1	101	107	PF00498	0.432
LIG_FHA_1	118	124	PF00498	0.525
LIG_FHA_1	129	135	PF00498	0.489
LIG_FHA_1	137	143	PF00498	0.485
LIG_FHA_1	155	161	PF00498	0.615
LIG_FHA_1	204	210	PF00498	0.430
LIG_FHA_1	23	29	PF00498	0.511
LIG_FHA_1	233	239	PF00498	0.536
LIG_FHA_1	292	298	PF00498	0.556
LIG_FHA_1	302	308	PF00498	0.336
LIG_FHA_1	343	349	PF00498	0.537
LIG_FHA_1	40	46	PF00498	0.500
LIG_FHA_2	148	154	PF00498	0.472
LIG_FHA_2	216	222	PF00498	0.532
LIG_FHA_2	225	231	PF00498	0.662
LIG_LIR_Gen_1	104	113	PF02991	0.560
LIG_LIR_Gen_1	12	19	PF02991	0.323
LIG_LIR_Gen_1	278	287	PF02991	0.491
LIG_LIR_Gen_1	62	72	PF02991	0.565
LIG_LIR_Nem_3	104	110	PF02991	0.547
LIG_LIR_Nem_3	12	16	PF02991	0.353
LIG_LIR_Nem_3	278	282	PF02991	0.521
LIG_LIR_Nem_3	30	35	PF02991	0.545
LIG_LIR_Nem_3	62	68	PF02991	0.579
LIG_NRBOX	190	196	PF00104	0.490
LIG_SH2_CRK	13	17	PF00017	0.400
LIG_SH2_CRK	32	36	PF00017	0.255
LIG_SH2_NCK_1	107	111	PF00017	0.558
LIG_SH2_NCK_1	313	317	PF00017	0.486
LIG_SH2_SRC	105	108	PF00017	0.565
LIG_SH2_STAP1	313	317	PF00017	0.486
LIG_SH2_STAT3	190	193	PF00017	0.472
LIG_SH2_STAT5	105	108	PF00017	0.593
LIG_SH2_STAT5	190	193	PF00017	0.491
LIG_SH2_STAT5	65	68	PF00017	0.588
LIG_SH3_2	371	376	PF14604	0.721
LIG_SH3_3	216	222	PF00018	0.554
LIG_SH3_3	234	240	PF00018	0.504
LIG_SH3_3	281	287	PF00018	0.491
LIG_SH3_3	368	374	PF00018	0.790
LIG_SH3_3	66	72	PF00018	0.634
LIG_SUMO_SIM_anti_2	347	352	PF11976	0.424
LIG_SUMO_SIM_par_1	156	163	PF11976	0.348
LIG_SUMO_SIM_par_1	208	215	PF11976	0.416
LIG_TRAF2_1	358	361	PF00917	0.602
LIG_WRC_WIRS_1	267	272	PF05994	0.319
MOD_CDK_SPxK_1	236	242	PF00069	0.478
MOD_CDK_SPxK_1	370	376	PF00069	0.715
MOD_CK1_1	156	162	PF00069	0.593
MOD_CK1_1	228	234	PF00069	0.532
MOD_CK1_1	323	329	PF00069	0.683
MOD_CK1_1	70	76	PF00069	0.461
MOD_CK2_1	208	214	PF00069	0.417
MOD_CK2_1	224	230	PF00069	0.635
MOD_CK2_1	355	361	PF00069	0.738
MOD_Cter_Amidation	352	355	PF01082	0.528
MOD_GlcNHglycan	1	4	PF01048	0.615
MOD_GlcNHglycan	123	126	PF01048	0.540
MOD_GlcNHglycan	357	360	PF01048	0.663
MOD_GlcNHglycan	361	364	PF01048	0.707
MOD_GlcNHglycan	52	55	PF01048	0.348
MOD_GlcNHglycan	72	75	PF01048	0.523
MOD_GSK3_1	117	124	PF00069	0.591
MOD_GSK3_1	154	161	PF00069	0.590
MOD_GSK3_1	208	215	PF00069	0.439
MOD_GSK3_1	224	231	PF00069	0.549
MOD_GSK3_1	232	239	PF00069	0.462
MOD_GSK3_1	271	278	PF00069	0.404
MOD_GSK3_1	320	327	PF00069	0.599
MOD_GSK3_1	340	347	PF00069	0.491
MOD_GSK3_1	355	362	PF00069	0.584
MOD_GSK3_1	380	387	PF00069	0.690
MOD_GSK3_1	55	62	PF00069	0.624
MOD_N-GLC_1	212	217	PF02516	0.465
MOD_NEK2_1	101	106	PF00069	0.427
MOD_NEK2_1	155	160	PF00069	0.657
MOD_NEK2_1	212	217	PF00069	0.479
MOD_NEK2_2	117	122	PF00069	0.607
MOD_NEK2_2	291	296	PF00069	0.472
MOD_PIKK_1	203	209	PF00454	0.408
MOD_PIKK_1	243	249	PF00454	0.408
MOD_PIKK_1	271	277	PF00454	0.289
MOD_PIKK_1	289	295	PF00454	0.191
MOD_PIKK_1	78	84	PF00454	0.485
MOD_PKA_2	101	107	PF00069	0.546
MOD_PKA_2	22	28	PF00069	0.579
MOD_PKA_2	39	45	PF00069	0.320
MOD_Plk_1	212	218	PF00069	0.477
MOD_Plk_1	228	234	PF00069	0.613
MOD_Plk_1	359	365	PF00069	0.620
MOD_Plk_4	101	107	PF00069	0.414
MOD_Plk_4	266	272	PF00069	0.294
MOD_Plk_4	346	352	PF00069	0.368
MOD_Plk_4	84	90	PF00069	0.317
MOD_ProDKin_1	136	142	PF00069	0.403
MOD_ProDKin_1	160	166	PF00069	0.551
MOD_ProDKin_1	215	221	PF00069	0.620
MOD_ProDKin_1	236	242	PF00069	0.478
MOD_ProDKin_1	370	376	PF00069	0.704
MOD_ProDKin_1	68	74	PF00069	0.398
TRG_ENDOCYTIC_2	107	110	PF00928	0.545
TRG_ENDOCYTIC_2	13	16	PF00928	0.584
TRG_ENDOCYTIC_2	32	35	PF00928	0.357
TRG_ENDOCYTIC_2	65	68	PF00928	0.588
TRG_ER_diArg_1	183	186	PF00400	0.380
TRG_ER_diArg_1	19	21	PF00400	0.505
TRG_ER_diArg_1	351	354	PF00400	0.490
TRG_ER_diArg_1	390	392	PF00400	0.596
TRG_ER_diArg_1	95	97	PF00400	0.347
TRG_NLS_MonoCore_2	387	392	PF00514	0.627
TRG_NLS_MonoExtC_3	387	393	PF00514	0.623
TRG_NLS_MonoExtN_4	183	188	PF00514	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I530	Leptomonas seymouri	57%	99%
A0A1X0P9D0	Trypanosomatidae	24%	100%
A0A3R7LU18	Trypanosoma rangeli	28%	100%
A0A3S7X2U8	Leishmania donovani	89%	100%
A4HHQ1	Leishmania braziliensis	79%	100%
A4I4W6	Leishmania infantum	89%	100%
C9ZKZ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AEB4	Leishmania major	91%	100%
V5C220	Trypanosoma cruzi	29%	100%