SAM_MT_RSMB_NOP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NOL1/NOP2/sun family, putative

Species:

Leishmania mexicana

UniProt:

E9ALH0_LEIMU

TriTrypDb:

LmxM.08_29.2540

Length:

634

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALH0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALH0

Function

Biological processes
Term	Name	Level	Count
GO:0001510	RNA methylation	4	12
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009451	RNA modification	5	12
GO:0009987	cellular process	1	12
GO:0016070	RNA metabolic process	5	12
GO:0032259	methylation	2	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0043414	macromolecule methylation	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0008168	methyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016741	transferase activity, transferring one-carbon groups	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	212	216	PF00656	0.480
CLV_C14_Caspase3-7	415	419	PF00656	0.588
CLV_C14_Caspase3-7	615	619	PF00656	0.652
CLV_C14_Caspase3-7	73	77	PF00656	0.458
CLV_NRD_NRD_1	111	113	PF00675	0.549
CLV_NRD_NRD_1	243	245	PF00675	0.224
CLV_NRD_NRD_1	357	359	PF00675	0.272
CLV_NRD_NRD_1	382	384	PF00675	0.256
CLV_NRD_NRD_1	6	8	PF00675	0.585
CLV_PCSK_FUR_1	380	384	PF00082	0.274
CLV_PCSK_KEX2_1	111	113	PF00082	0.407
CLV_PCSK_KEX2_1	12	14	PF00082	0.581
CLV_PCSK_KEX2_1	357	359	PF00082	0.302
CLV_PCSK_KEX2_1	382	384	PF00082	0.238
CLV_PCSK_KEX2_1	90	92	PF00082	0.393
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.407
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.578
CLV_PCSK_PC1ET2_1	90	92	PF00082	0.448
CLV_PCSK_PC7_1	107	113	PF00082	0.396
CLV_PCSK_SKI1_1	267	271	PF00082	0.198
CLV_PCSK_SKI1_1	335	339	PF00082	0.256
CLV_PCSK_SKI1_1	382	386	PF00082	0.256
CLV_PCSK_SKI1_1	400	404	PF00082	0.238
CLV_PCSK_SKI1_1	595	599	PF00082	0.476
DEG_APCC_DBOX_1	217	225	PF00400	0.468
DEG_APCC_DBOX_1	266	274	PF00400	0.439
DEG_SPOP_SBC_1	558	562	PF00917	0.449
DOC_CYCLIN_RxL_1	434	446	PF00134	0.431
DOC_MAPK_MEF2A_6	164	173	PF00069	0.437
DOC_MAPK_MEF2A_6	595	602	PF00069	0.433
DOC_MAPK_NFAT4_5	595	603	PF00069	0.484
DOC_PP1_RVXF_1	498	504	PF00149	0.314
DOC_PP1_RVXF_1	97	104	PF00149	0.464
DOC_PP2B_LxvP_1	441	444	PF13499	0.308
DOC_PP2B_LxvP_1	598	601	PF13499	0.456
DOC_PP4_MxPP_1	140	143	PF00568	0.304
DOC_USP7_MATH_1	296	300	PF00917	0.441
DOC_USP7_MATH_1	50	54	PF00917	0.408
DOC_USP7_MATH_1	573	577	PF00917	0.473
DOC_USP7_UBL2_3	8	12	PF12436	0.634
DOC_WW_Pin1_4	312	317	PF00397	0.472
DOC_WW_Pin1_4	321	326	PF00397	0.420
DOC_WW_Pin1_4	521	526	PF00397	0.403
DOC_WW_Pin1_4	532	537	PF00397	0.448
LIG_14-3-3_CanoR_1	271	281	PF00244	0.551
LIG_14-3-3_CanoR_1	357	361	PF00244	0.483
LIG_14-3-3_CanoR_1	400	409	PF00244	0.275
LIG_14-3-3_CanoR_1	434	438	PF00244	0.485
LIG_14-3-3_CanoR_1	502	511	PF00244	0.310
LIG_Actin_WH2_2	228	246	PF00022	0.413
LIG_Actin_WH2_2	482	497	PF00022	0.401
LIG_BIR_II_1	1	5	PF00653	0.644
LIG_BIR_III_4	418	422	PF00653	0.535
LIG_BRCT_BRCA1_1	486	490	PF00533	0.335
LIG_BRCT_BRCA1_1	61	65	PF00533	0.371
LIG_BRCT_BRCA1_1	83	87	PF00533	0.433
LIG_Clathr_ClatBox_1	145	149	PF01394	0.418
LIG_deltaCOP1_diTrp_1	248	253	PF00928	0.413
LIG_deltaCOP1_diTrp_1	47	51	PF00928	0.343
LIG_FHA_1	163	169	PF00498	0.413
LIG_FHA_1	284	290	PF00498	0.424
LIG_FHA_1	306	312	PF00498	0.458
LIG_FHA_1	313	319	PF00498	0.409
LIG_FHA_1	332	338	PF00498	0.424
LIG_FHA_1	368	374	PF00498	0.497
LIG_FHA_1	379	385	PF00498	0.354
LIG_FHA_1	503	509	PF00498	0.480
LIG_FHA_1	522	528	PF00498	0.382
LIG_FHA_1	544	550	PF00498	0.577
LIG_FHA_1	78	84	PF00498	0.474
LIG_FHA_2	131	137	PF00498	0.312
LIG_FHA_2	210	216	PF00498	0.432
LIG_FHA_2	30	36	PF00498	0.392
LIG_FHA_2	331	337	PF00498	0.452
LIG_Integrin_RGD_1	107	109	PF01839	0.459
LIG_LIR_Gen_1	226	236	PF02991	0.440
LIG_LIR_Gen_1	308	317	PF02991	0.469
LIG_LIR_Gen_1	446	454	PF02991	0.421
LIG_LIR_Gen_1	458	467	PF02991	0.427
LIG_LIR_Gen_1	46	55	PF02991	0.338
LIG_LIR_Gen_1	487	496	PF02991	0.399
LIG_LIR_Gen_1	538	544	PF02991	0.245
LIG_LIR_Nem_3	217	222	PF02991	0.426
LIG_LIR_Nem_3	226	231	PF02991	0.450
LIG_LIR_Nem_3	32	37	PF02991	0.398
LIG_LIR_Nem_3	446	452	PF02991	0.447
LIG_LIR_Nem_3	458	464	PF02991	0.457
LIG_LIR_Nem_3	46	51	PF02991	0.306
LIG_LIR_Nem_3	487	493	PF02991	0.366
LIG_LIR_Nem_3	538	542	PF02991	0.291
LIG_MAD2	153	161	PF02301	0.424
LIG_NRBOX	168	174	PF00104	0.479
LIG_PTB_Apo_2	28	35	PF02174	0.350
LIG_SH2_CRK	461	465	PF00017	0.423
LIG_SH2_GRB2like	496	499	PF00017	0.372
LIG_SH2_NCK_1	625	629	PF00017	0.443
LIG_SH2_SRC	344	347	PF00017	0.503
LIG_SH2_SRC	362	365	PF00017	0.547
LIG_SH2_SRC	625	628	PF00017	0.446
LIG_SH2_STAP1	449	453	PF00017	0.429
LIG_SH2_STAT5	131	134	PF00017	0.332
LIG_SH2_STAT5	465	468	PF00017	0.308
LIG_SH2_STAT5	570	573	PF00017	0.308
LIG_SH3_1	90	96	PF00018	0.343
LIG_SH3_3	217	223	PF00018	0.422
LIG_SH3_3	422	428	PF00018	0.460
LIG_SH3_3	510	516	PF00018	0.324
LIG_SH3_3	562	568	PF00018	0.516
LIG_SH3_3	90	96	PF00018	0.390
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.435
LIG_SUMO_SIM_par_1	519	524	PF11976	0.374
LIG_TRAF2_1	133	136	PF00917	0.321
LIG_TRAF2_1	605	608	PF00917	0.725
LIG_TRFH_1	219	223	PF08558	0.413
LIG_UBA3_1	269	277	PF00899	0.456
MOD_CK1_1	163	169	PF00069	0.437
MOD_CK1_1	275	281	PF00069	0.456
MOD_CK1_1	285	291	PF00069	0.376
MOD_CK1_1	543	549	PF00069	0.576
MOD_CK2_1	130	136	PF00069	0.314
MOD_CK2_1	29	35	PF00069	0.501
MOD_CK2_1	43	49	PF00069	0.310
MOD_CK2_1	602	608	PF00069	0.640
MOD_CMANNOS	250	253	PF00535	0.213
MOD_Cter_Amidation	10	13	PF01082	0.498
MOD_GlcNHglycan	123	126	PF01048	0.384
MOD_GlcNHglycan	237	240	PF01048	0.213
MOD_GlcNHglycan	277	280	PF01048	0.285
MOD_GlcNHglycan	298	301	PF01048	0.333
MOD_GlcNHglycan	414	417	PF01048	0.654
MOD_GlcNHglycan	541	545	PF01048	0.501
MOD_GlcNHglycan	604	607	PF01048	0.382
MOD_GSK3_1	130	137	PF00069	0.344
MOD_GSK3_1	235	242	PF00069	0.413
MOD_GSK3_1	25	32	PF00069	0.367
MOD_GSK3_1	321	328	PF00069	0.455
MOD_GSK3_1	331	338	PF00069	0.409
MOD_GSK3_1	352	359	PF00069	0.468
MOD_GSK3_1	410	417	PF00069	0.439
MOD_GSK3_1	466	473	PF00069	0.440
MOD_GSK3_1	50	57	PF00069	0.393
MOD_GSK3_1	519	526	PF00069	0.444
MOD_GSK3_1	543	550	PF00069	0.405
MOD_GSK3_1	553	560	PF00069	0.446
MOD_GSK3_1	77	84	PF00069	0.374
MOD_NEK2_1	103	108	PF00069	0.446
MOD_NEK2_1	209	214	PF00069	0.453
MOD_NEK2_1	261	266	PF00069	0.424
MOD_NEK2_1	29	34	PF00069	0.361
MOD_NEK2_1	302	307	PF00069	0.490
MOD_NEK2_1	337	342	PF00069	0.399
MOD_NEK2_1	433	438	PF00069	0.471
MOD_NEK2_1	519	524	PF00069	0.403
MOD_NEK2_1	557	562	PF00069	0.364
MOD_NEK2_2	239	244	PF00069	0.413
MOD_NEK2_2	272	277	PF00069	0.514
MOD_PIKK_1	163	169	PF00454	0.413
MOD_PIKK_1	261	267	PF00454	0.424
MOD_PIKK_1	385	391	PF00454	0.437
MOD_PIKK_1	472	478	PF00454	0.452
MOD_PIKK_1	77	83	PF00454	0.499
MOD_PK_1	427	433	PF00069	0.253
MOD_PKA_2	243	249	PF00069	0.413
MOD_PKA_2	356	362	PF00069	0.482
MOD_PKA_2	433	439	PF00069	0.446
MOD_PKB_1	410	418	PF00069	0.604
MOD_Plk_1	214	220	PF00069	0.438
MOD_Plk_4	136	142	PF00069	0.295
MOD_Plk_4	362	368	PF00069	0.413
MOD_Plk_4	489	495	PF00069	0.418
MOD_Plk_4	523	529	PF00069	0.350
MOD_Plk_4	553	559	PF00069	0.373
MOD_ProDKin_1	312	318	PF00069	0.472
MOD_ProDKin_1	321	327	PF00069	0.420
MOD_ProDKin_1	521	527	PF00069	0.400
MOD_ProDKin_1	532	538	PF00069	0.442
MOD_SUMO_rev_2	345	350	PF00179	0.520
MOD_SUMO_rev_2	414	422	PF00179	0.679
MOD_SUMO_rev_2	84	92	PF00179	0.465
TRG_DiLeu_BaEn_2	46	52	PF01217	0.384
TRG_DiLeu_BaLyEn_6	140	145	PF01217	0.433
TRG_DiLeu_BaLyEn_6	217	222	PF01217	0.424
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.476
TRG_ENDOCYTIC_2	449	452	PF00928	0.436
TRG_ENDOCYTIC_2	461	464	PF00928	0.435
TRG_ENDOCYTIC_2	539	542	PF00928	0.485
TRG_ER_diArg_1	380	383	PF00400	0.462
TRG_ER_diArg_1	409	412	PF00400	0.388
TRG_NLS_MonoCore_2	110	115	PF00514	0.491
TRG_NLS_MonoExtC_3	11	17	PF00514	0.614
TRG_NLS_MonoExtN_4	111	116	PF00514	0.487
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.226

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y2	Leptomonas seymouri	72%	99%
A0A0S4IKI3	Bodo saltans	51%	94%
A0A1X0P924	Trypanosomatidae	54%	92%
A0A3Q8IJ07	Leishmania donovani	93%	100%
A0A3S5IQZ3	Trypanosoma rangeli	57%	100%
C9ZKZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	97%
D0A5C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	79%
E9AEB6	Leishmania major	93%	100%
E9AHJ5	Leishmania infantum	93%	100%
E9AIT8	Leishmania braziliensis	87%	100%
O13935	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	28%	93%
P38205	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	93%
Q08J23	Homo sapiens	37%	83%
Q1HFZ0	Mus musculus	37%	84%
Q28E61	Xenopus tropicalis	31%	79%
Q9HGQ2	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	92%
Q9W4M9	Drosophila melanogaster	35%	85%
V5BSK4	Trypanosoma cruzi	54%	100%