LeishMANIAdb
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TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TPR_REGION domain-containing protein
Gene product:
RNA polymerase-associated protein CTR9, putative
Species:
Leishmania mexicana
UniProt:
E9ALG9_LEIMU
TriTrypDb:
LmxM.08_29.2550
Length:
873

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0043226 organelle 2 11
GO:0043227 membrane-bounded organelle 3 11
GO:0043229 intracellular organelle 3 11
GO:0043231 intracellular membrane-bounded organelle 4 11
GO:0110165 cellular anatomical entity 1 12
GO:0005654 nucleoplasm 2 1
GO:0008023 transcription elongation factor complex 3 1
GO:0016593 Cdc73/Paf1 complex 4 1
GO:0032991 protein-containing complex 1 1
GO:0140513 nuclear protein-containing complex 2 1

Expansion

Sequence features

E9ALG9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALG9

Function

Biological processes
Term Name Level Count
GO:0006355 regulation of DNA-templated transcription 6 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008152 metabolic process 1 12
GO:0009889 regulation of biosynthetic process 4 12
GO:0010468 regulation of gene expression 5 12
GO:0010556 regulation of macromolecule biosynthetic process 5 12
GO:0016570 histone modification 5 12
GO:0019219 regulation of nucleobase-containing compound metabolic process 5 12
GO:0019222 regulation of metabolic process 3 12
GO:0019538 protein metabolic process 3 12
GO:0031323 regulation of cellular metabolic process 4 12
GO:0031326 regulation of cellular biosynthetic process 5 12
GO:0036211 protein modification process 4 12
GO:0043170 macromolecule metabolic process 3 12
GO:0043412 macromolecule modification 4 12
GO:0044238 primary metabolic process 2 12
GO:0050789 regulation of biological process 2 12
GO:0050794 regulation of cellular process 3 12
GO:0051171 regulation of nitrogen compound metabolic process 4 12
GO:0051252 regulation of RNA metabolic process 5 12
GO:0060255 regulation of macromolecule metabolic process 4 12
GO:0065007 biological regulation 1 12
GO:0071704 organic substance metabolic process 2 12
GO:0080090 regulation of primary metabolic process 4 12
GO:1901564 organonitrogen compound metabolic process 3 12
GO:1903506 regulation of nucleic acid-templated transcription 7 12
GO:2001141 regulation of RNA biosynthetic process 6 12
GO:0031056 regulation of histone modification 7 1
GO:0031060 regulation of histone methylation 5 1
GO:0031399 regulation of protein modification process 6 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0051569 regulation of histone H3-K4 methylation 6 1
Molecular functions
Term Name Level Count
GO:0000993 RNA polymerase II complex binding 5 1
GO:0001098 basal transcription machinery binding 3 1
GO:0001099 basal RNA polymerase II transcription machinery binding 4 1
GO:0005488 binding 1 1
GO:0005515 protein binding 2 1
GO:0019899 enzyme binding 3 1
GO:0043175 RNA polymerase core enzyme binding 5 1
GO:0070063 RNA polymerase binding 4 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 623 627 PF00656 0.509
CLV_C14_Caspase3-7 654 658 PF00656 0.509
CLV_C14_Caspase3-7 847 851 PF00656 0.618
CLV_NRD_NRD_1 100 102 PF00675 0.518
CLV_NRD_NRD_1 170 172 PF00675 0.484
CLV_NRD_NRD_1 383 385 PF00675 0.431
CLV_NRD_NRD_1 599 601 PF00675 0.456
CLV_NRD_NRD_1 788 790 PF00675 0.557
CLV_NRD_NRD_1 800 802 PF00675 0.599
CLV_NRD_NRD_1 815 817 PF00675 0.545
CLV_PCSK_FUR_1 747 751 PF00082 0.430
CLV_PCSK_KEX2_1 170 172 PF00082 0.433
CLV_PCSK_KEX2_1 383 385 PF00082 0.362
CLV_PCSK_KEX2_1 454 456 PF00082 0.445
CLV_PCSK_KEX2_1 533 535 PF00082 0.446
CLV_PCSK_KEX2_1 599 601 PF00082 0.456
CLV_PCSK_KEX2_1 749 751 PF00082 0.461
CLV_PCSK_KEX2_1 788 790 PF00082 0.502
CLV_PCSK_KEX2_1 800 802 PF00082 0.534
CLV_PCSK_KEX2_1 99 101 PF00082 0.456
CLV_PCSK_PC1ET2_1 454 456 PF00082 0.445
CLV_PCSK_PC1ET2_1 533 535 PF00082 0.304
CLV_PCSK_PC1ET2_1 749 751 PF00082 0.508
CLV_PCSK_SKI1_1 170 174 PF00082 0.466
CLV_PCSK_SKI1_1 246 250 PF00082 0.438
CLV_PCSK_SKI1_1 270 274 PF00082 0.322
CLV_PCSK_SKI1_1 330 334 PF00082 0.284
CLV_PCSK_SKI1_1 394 398 PF00082 0.520
CLV_PCSK_SKI1_1 526 530 PF00082 0.482
CLV_PCSK_SKI1_1 575 579 PF00082 0.428
CLV_PCSK_SKI1_1 583 587 PF00082 0.483
CLV_PCSK_SKI1_1 711 715 PF00082 0.591
CLV_PCSK_SKI1_1 788 792 PF00082 0.571
CLV_Separin_Metazoa 74 78 PF03568 0.474
DEG_APCC_DBOX_1 245 253 PF00400 0.386
DEG_APCC_DBOX_1 50 58 PF00400 0.431
DEG_SCF_FBW7_1 614 619 PF00400 0.481
DEG_SPOP_SBC_1 548 552 PF00917 0.276
DOC_CYCLIN_RxL_1 390 401 PF00134 0.523
DOC_MAPK_gen_1 459 467 PF00069 0.367
DOC_MAPK_MEF2A_6 147 156 PF00069 0.464
DOC_MAPK_MEF2A_6 459 467 PF00069 0.352
DOC_MAPK_MEF2A_6 831 839 PF00069 0.544
DOC_PP1_RVXF_1 478 484 PF00149 0.497
DOC_PP2B_LxvP_1 396 399 PF13499 0.541
DOC_PP4_FxxP_1 474 477 PF00568 0.319
DOC_USP7_MATH_1 34 38 PF00917 0.460
DOC_USP7_MATH_1 372 376 PF00917 0.410
DOC_USP7_MATH_1 537 541 PF00917 0.326
DOC_USP7_MATH_1 547 551 PF00917 0.329
DOC_USP7_MATH_1 79 83 PF00917 0.456
DOC_WW_Pin1_4 145 150 PF00397 0.458
DOC_WW_Pin1_4 254 259 PF00397 0.452
DOC_WW_Pin1_4 612 617 PF00397 0.467
LIG_14-3-3_CanoR_1 237 243 PF00244 0.381
LIG_14-3-3_CanoR_1 244 249 PF00244 0.377
LIG_14-3-3_CanoR_1 253 261 PF00244 0.309
LIG_14-3-3_CanoR_1 351 357 PF00244 0.402
LIG_14-3-3_CanoR_1 51 55 PF00244 0.489
LIG_14-3-3_CanoR_1 534 544 PF00244 0.353
LIG_14-3-3_CanoR_1 652 660 PF00244 0.483
LIG_14-3-3_CanoR_1 711 721 PF00244 0.400
LIG_14-3-3_CanoR_1 761 767 PF00244 0.495
LIG_Actin_WH2_2 226 241 PF00022 0.489
LIG_Actin_WH2_2 37 53 PF00022 0.499
LIG_Actin_WH2_2 694 710 PF00022 0.482
LIG_APCC_ABBA_1 177 182 PF00400 0.456
LIG_APCC_ABBA_1 191 196 PF00400 0.243
LIG_CtBP_PxDLS_1 258 262 PF00389 0.427
LIG_deltaCOP1_diTrp_1 784 791 PF00928 0.543
LIG_EH1_1 38 46 PF00400 0.468
LIG_eIF4E_1 446 452 PF01652 0.397
LIG_FHA_1 146 152 PF00498 0.534
LIG_FHA_1 216 222 PF00498 0.375
LIG_FHA_1 355 361 PF00498 0.397
LIG_FHA_1 5 11 PF00498 0.630
LIG_FHA_1 620 626 PF00498 0.518
LIG_FHA_1 65 71 PF00498 0.548
LIG_FHA_1 677 683 PF00498 0.426
LIG_FHA_1 693 699 PF00498 0.386
LIG_FHA_1 708 714 PF00498 0.520
LIG_FHA_1 730 736 PF00498 0.523
LIG_FHA_1 853 859 PF00498 0.783
LIG_FHA_2 102 108 PF00498 0.508
LIG_FHA_2 433 439 PF00498 0.489
LIG_FHA_2 766 772 PF00498 0.413
LIG_FHA_2 845 851 PF00498 0.629
LIG_GBD_Chelix_1 191 199 PF00786 0.433
LIG_Integrin_RGD_1 600 602 PF01839 0.453
LIG_Integrin_RGD_1 92 94 PF01839 0.459
LIG_LIR_Apic_2 472 477 PF02991 0.465
LIG_LIR_Gen_1 644 650 PF02991 0.509
LIG_LIR_Gen_1 822 832 PF02991 0.571
LIG_LIR_Nem_3 130 136 PF02991 0.333
LIG_LIR_Nem_3 184 190 PF02991 0.462
LIG_LIR_Nem_3 438 444 PF02991 0.428
LIG_LIR_Nem_3 560 566 PF02991 0.468
LIG_LIR_Nem_3 784 790 PF02991 0.474
LIG_LIR_Nem_3 822 827 PF02991 0.531
LIG_NRBOX 244 250 PF00104 0.503
LIG_NRBOX 447 453 PF00104 0.339
LIG_NRBOX 497 503 PF00104 0.396
LIG_PCNA_PIPBox_1 512 521 PF02747 0.483
LIG_PCNA_yPIPBox_3 512 526 PF02747 0.498
LIG_PCNA_yPIPBox_3 694 708 PF02747 0.473
LIG_Pex14_1 787 791 PF04695 0.491
LIG_Rb_LxCxE_1 268 286 PF01857 0.413
LIG_SH2_CRK 302 306 PF00017 0.328
LIG_SH2_PTP2 194 197 PF00017 0.401
LIG_SH2_PTP2 441 444 PF00017 0.326
LIG_SH2_PTP2 464 467 PF00017 0.339
LIG_SH2_SRC 670 673 PF00017 0.331
LIG_SH2_SRC 83 86 PF00017 0.336
LIG_SH2_STAP1 129 133 PF00017 0.469
LIG_SH2_STAP1 138 142 PF00017 0.503
LIG_SH2_STAP1 302 306 PF00017 0.284
LIG_SH2_STAP1 352 356 PF00017 0.381
LIG_SH2_STAP1 660 664 PF00017 0.367
LIG_SH2_STAP1 670 674 PF00017 0.301
LIG_SH2_STAT3 251 254 PF00017 0.505
LIG_SH2_STAT5 124 127 PF00017 0.464
LIG_SH2_STAT5 136 139 PF00017 0.402
LIG_SH2_STAT5 194 197 PF00017 0.426
LIG_SH2_STAT5 229 232 PF00017 0.336
LIG_SH2_STAT5 251 254 PF00017 0.505
LIG_SH2_STAT5 441 444 PF00017 0.326
LIG_SH2_STAT5 464 467 PF00017 0.314
LIG_SH2_STAT5 645 648 PF00017 0.432
LIG_SH2_STAT5 662 665 PF00017 0.318
LIG_SH2_STAT5 751 754 PF00017 0.389
LIG_SH2_STAT5 758 761 PF00017 0.338
LIG_SH2_STAT5 83 86 PF00017 0.336
LIG_SH3_2 72 77 PF14604 0.571
LIG_SH3_3 69 75 PF00018 0.578
LIG_SH3_3 855 861 PF00018 0.685
LIG_SUMO_SIM_anti_2 672 679 PF11976 0.453
LIG_TRAF2_1 257 260 PF00917 0.446
LIG_TRAF2_1 796 799 PF00917 0.430
LIG_TYR_ITIM 300 305 PF00017 0.328
LIG_TYR_ITIM 439 444 PF00017 0.333
MOD_CK1_1 145 151 PF00069 0.405
MOD_CK1_1 569 575 PF00069 0.454
MOD_CK1_1 612 618 PF00069 0.590
MOD_CK1_1 9 15 PF00069 0.517
MOD_CK2_1 101 107 PF00069 0.428
MOD_CK2_1 124 130 PF00069 0.403
MOD_CK2_1 254 260 PF00069 0.413
MOD_CK2_1 521 527 PF00069 0.509
MOD_CK2_1 607 613 PF00069 0.508
MOD_CK2_1 765 771 PF00069 0.568
MOD_CK2_1 79 85 PF00069 0.414
MOD_CMANNOS 497 500 PF00535 0.471
MOD_GlcNHglycan 20 23 PF01048 0.496
MOD_GlcNHglycan 404 407 PF01048 0.546
MOD_GlcNHglycan 411 414 PF01048 0.487
MOD_GlcNHglycan 523 526 PF01048 0.470
MOD_GlcNHglycan 568 571 PF01048 0.361
MOD_GlcNHglycan 755 758 PF01048 0.500
MOD_GSK3_1 350 357 PF00069 0.380
MOD_GSK3_1 372 379 PF00069 0.458
MOD_GSK3_1 398 405 PF00069 0.508
MOD_GSK3_1 4 11 PF00069 0.543
MOD_GSK3_1 57 64 PF00069 0.505
MOD_GSK3_1 612 619 PF00069 0.612
MOD_GSK3_1 707 714 PF00069 0.521
MOD_N-GLC_1 216 221 PF02516 0.429
MOD_N-GLC_1 322 327 PF02516 0.413
MOD_N-GLC_1 535 540 PF02516 0.527
MOD_NEK2_1 238 243 PF00069 0.472
MOD_NEK2_1 350 355 PF00069 0.380
MOD_NEK2_1 356 361 PF00069 0.365
MOD_NEK2_1 430 435 PF00069 0.511
MOD_NEK2_1 50 55 PF00069 0.427
MOD_NEK2_1 507 512 PF00069 0.470
MOD_NEK2_1 520 525 PF00069 0.416
MOD_NEK2_1 566 571 PF00069 0.441
MOD_NEK2_1 607 612 PF00069 0.519
MOD_NEK2_1 61 66 PF00069 0.438
MOD_NEK2_1 676 681 PF00069 0.489
MOD_NEK2_1 707 712 PF00069 0.475
MOD_NEK2_1 734 739 PF00069 0.374
MOD_NEK2_1 827 832 PF00069 0.528
MOD_NEK2_1 844 849 PF00069 0.414
MOD_NEK2_1 852 857 PF00069 0.646
MOD_NEK2_2 136 141 PF00069 0.486
MOD_PIKK_1 124 130 PF00454 0.486
MOD_PIKK_1 537 543 PF00454 0.332
MOD_PIKK_1 558 564 PF00454 0.460
MOD_PKA_2 252 258 PF00069 0.467
MOD_PKA_2 344 350 PF00069 0.486
MOD_PKA_2 50 56 PF00069 0.384
MOD_PKA_2 651 657 PF00069 0.463
MOD_PKA_2 762 768 PF00069 0.456
MOD_PKA_2 827 833 PF00069 0.547
MOD_PKB_1 99 107 PF00069 0.435
MOD_Plk_1 129 135 PF00069 0.472
MOD_Plk_1 216 222 PF00069 0.424
MOD_Plk_1 322 328 PF00069 0.413
MOD_Plk_1 437 443 PF00069 0.403
MOD_Plk_1 61 67 PF00069 0.434
MOD_Plk_4 216 222 PF00069 0.412
MOD_Plk_4 314 320 PF00069 0.337
MOD_Plk_4 437 443 PF00069 0.403
MOD_Plk_4 717 723 PF00069 0.555
MOD_Plk_4 765 771 PF00069 0.533
MOD_Plk_4 79 85 PF00069 0.441
MOD_ProDKin_1 145 151 PF00069 0.456
MOD_ProDKin_1 254 260 PF00069 0.447
MOD_ProDKin_1 612 618 PF00069 0.468
MOD_SUMO_for_1 35 38 PF00179 0.471
MOD_SUMO_rev_2 809 819 PF00179 0.652
TRG_DiLeu_BaEn_1 259 264 PF01217 0.488
TRG_DiLeu_BaEn_1 268 273 PF01217 0.338
TRG_DiLeu_BaEn_1 672 677 PF01217 0.487
TRG_DiLeu_BaEn_1 687 692 PF01217 0.531
TRG_DiLeu_BaLyEn_6 267 272 PF01217 0.361
TRG_DiLeu_BaLyEn_6 280 285 PF01217 0.252
TRG_DiLeu_BaLyEn_6 301 306 PF01217 0.362
TRG_DiLeu_BaLyEn_6 440 445 PF01217 0.420
TRG_ENDOCYTIC_2 194 197 PF00928 0.477
TRG_ENDOCYTIC_2 302 305 PF00928 0.303
TRG_ENDOCYTIC_2 441 444 PF00928 0.319
TRG_ENDOCYTIC_2 464 467 PF00928 0.323
TRG_ENDOCYTIC_2 478 481 PF00928 0.311
TRG_ENDOCYTIC_2 742 745 PF00928 0.474
TRG_ENDOCYTIC_2 824 827 PF00928 0.563
TRG_ER_diArg_1 170 172 PF00400 0.484
TRG_ER_diArg_1 383 385 PF00400 0.317
TRG_ER_diArg_1 787 789 PF00400 0.605
TRG_ER_diArg_1 99 101 PF00400 0.456
TRG_NES_CRM1_1 183 196 PF08389 0.299
TRG_NES_CRM1_1 493 508 PF08389 0.358
TRG_Pf-PMV_PEXEL_1 14 18 PF00026 0.499
TRG_Pf-PMV_PEXEL_1 170 174 PF00026 0.475
TRG_Pf-PMV_PEXEL_1 198 202 PF00026 0.424
TRG_Pf-PMV_PEXEL_1 231 235 PF00026 0.468
TRG_Pf-PMV_PEXEL_1 816 820 PF00026 0.530

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PEV8 Leptomonas seymouri 75% 100%
A0A0S4IRK7 Bodo saltans 28% 99%
A0A1X0P9X2 Trypanosomatidae 42% 96%
A0A3Q8IEI0 Leishmania donovani 96% 100%
A0A3R7MIY5 Trypanosoma rangeli 41% 95%
A4HHQ3 Leishmania braziliensis 90% 100%
A4I4W8 Leishmania infantum 96% 100%
C9ZKZ1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 38% 97%
E9AEB7 Leishmania major 96% 100%
V5BC46 Trypanosoma cruzi 41% 96%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS