Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4586), putative

Species:

Leishmania mexicana

UniProt:

E9ALG8_LEIMU

TriTrypDb:

LmxM.08_29.2560

Length:

424

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	13
GO:0005815	microtubule organizing center	2	13
GO:0110165	cellular anatomical entity	1	13
GO:0016020	membrane	2	1

Expansion

Sequence features

E9ALG8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALG8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	113	117	PF00656	0.540
CLV_C14_Caspase3-7	22	26	PF00656	0.446
CLV_NRD_NRD_1	226	228	PF00675	0.207
CLV_NRD_NRD_1	281	283	PF00675	0.330
CLV_NRD_NRD_1	332	334	PF00675	0.239
CLV_NRD_NRD_1	384	386	PF00675	0.267
CLV_NRD_NRD_1	421	423	PF00675	0.465
CLV_PCSK_FUR_1	279	283	PF00082	0.264
CLV_PCSK_KEX2_1	167	169	PF00082	0.262
CLV_PCSK_KEX2_1	225	227	PF00082	0.241
CLV_PCSK_KEX2_1	281	283	PF00082	0.274
CLV_PCSK_KEX2_1	332	334	PF00082	0.258
CLV_PCSK_KEX2_1	336	338	PF00082	0.254
CLV_PCSK_KEX2_1	400	402	PF00082	0.309
CLV_PCSK_KEX2_1	421	423	PF00082	0.483
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.200
CLV_PCSK_PC1ET2_1	225	227	PF00082	0.251
CLV_PCSK_PC1ET2_1	332	334	PF00082	0.258
CLV_PCSK_PC1ET2_1	336	338	PF00082	0.254
CLV_PCSK_PC1ET2_1	400	402	PF00082	0.366
CLV_PCSK_SKI1_1	125	129	PF00082	0.267
CLV_PCSK_SKI1_1	145	149	PF00082	0.232
CLV_PCSK_SKI1_1	167	171	PF00082	0.318
CLV_PCSK_SKI1_1	333	337	PF00082	0.313
DEG_Nend_Nbox_1	1	3	PF02207	0.406
DEG_SPOP_SBC_1	58	62	PF00917	0.423
DOC_CYCLIN_yCln2_LP_2	293	299	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	65	71	PF00134	0.439
DOC_MAPK_MEF2A_6	291	299	PF00069	0.360
DOC_PP2B_LxvP_1	293	296	PF13499	0.491
DOC_PP2B_LxvP_1	297	300	PF13499	0.514
DOC_PP4_FxxP_1	94	97	PF00568	0.448
DOC_USP7_MATH_1	117	121	PF00917	0.442
DOC_USP7_MATH_1	192	196	PF00917	0.514
DOC_USP7_MATH_1	21	25	PF00917	0.444
DOC_USP7_MATH_1	300	304	PF00917	0.495
DOC_USP7_MATH_1	325	329	PF00917	0.442
DOC_USP7_MATH_1	355	359	PF00917	0.420
DOC_USP7_MATH_1	5	9	PF00917	0.516
DOC_USP7_MATH_1	53	57	PF00917	0.414
DOC_USP7_MATH_1	58	62	PF00917	0.417
DOC_USP7_MATH_1	71	75	PF00917	0.416
DOC_USP7_UBL2_3	174	178	PF12436	0.415
DOC_USP7_UBL2_3	221	225	PF12436	0.431
DOC_USP7_UBL2_3	332	336	PF12436	0.425
DOC_USP7_UBL2_3	386	390	PF12436	0.454
DOC_WW_Pin1_4	242	247	PF00397	0.431
DOC_WW_Pin1_4	67	72	PF00397	0.435
LIG_14-3-3_CanoR_1	406	411	PF00244	0.495
LIG_APCC_ABBA_1	370	375	PF00400	0.442
LIG_BIR_III_2	116	120	PF00653	0.565
LIG_BRCT_BRCA1_1	33	37	PF00533	0.419
LIG_BRCT_BRCA1_1	55	59	PF00533	0.429
LIG_BRCT_BRCA1_1	71	75	PF00533	0.438
LIG_deltaCOP1_diTrp_1	403	410	PF00928	0.487
LIG_EH_1	364	368	PF12763	0.442
LIG_eIF4E_1	252	258	PF01652	0.519
LIG_FHA_1	18	24	PF00498	0.530
LIG_FHA_1	411	417	PF00498	0.482
LIG_FHA_2	318	324	PF00498	0.529
LIG_LIR_Apic_2	251	255	PF02991	0.424
LIG_LIR_Apic_2	320	325	PF02991	0.360
LIG_LIR_Gen_1	144	151	PF02991	0.417
LIG_LIR_Gen_1	34	44	PF02991	0.606
LIG_LIR_Nem_3	144	150	PF02991	0.417
LIG_LIR_Nem_3	185	191	PF02991	0.531
LIG_LIR_Nem_3	200	205	PF02991	0.520
LIG_LIR_Nem_3	251	257	PF02991	0.445
LIG_LIR_Nem_3	316	322	PF02991	0.530
LIG_LIR_Nem_3	34	40	PF02991	0.453
LIG_LIR_Nem_3	88	93	PF02991	0.434
LIG_LYPXL_yS_3	254	257	PF13949	0.507
LIG_MYND_1	46	50	PF01753	0.382
LIG_Pex14_1	268	272	PF04695	0.507
LIG_Pex14_2	143	147	PF04695	0.481
LIG_Pex14_2	367	371	PF04695	0.419
LIG_PTB_Apo_2	204	211	PF02174	0.464
LIG_PTB_Apo_2	258	265	PF02174	0.426
LIG_PTB_Phospho_1	204	210	PF10480	0.507
LIG_PTB_Phospho_1	258	264	PF10480	0.426
LIG_SH2_CRK	252	256	PF00017	0.434
LIG_SH2_CRK	90	94	PF00017	0.447
LIG_SH2_NCK_1	272	276	PF00017	0.427
LIG_SH2_NCK_1	322	326	PF00017	0.484
LIG_SH2_SRC	163	166	PF00017	0.510
LIG_SH2_STAP1	264	268	PF00017	0.459
LIG_SH2_STAT5	122	125	PF00017	0.424
LIG_SH2_STAT5	142	145	PF00017	0.469
LIG_SH2_STAT5	306	309	PF00017	0.466
LIG_SH2_STAT5	319	322	PF00017	0.512
LIG_SH2_STAT5	99	102	PF00017	0.534
LIG_SH3_3	401	407	PF00018	0.444
LIG_SH3_3	41	47	PF00018	0.513
LIG_SH3_3	65	71	PF00018	0.438
LIG_TRAF2_2	135	140	PF00917	0.442
LIG_WW_2	46	49	PF00397	0.393
MOD_CDC14_SPxK_1	245	248	PF00782	0.382
MOD_CDK_SPxK_1	242	248	PF00069	0.382
MOD_CDK_SPxxK_3	242	249	PF00069	0.431
MOD_CK1_1	195	201	PF00069	0.406
MOD_CK1_1	260	266	PF00069	0.423
MOD_CK1_1	31	37	PF00069	0.401
MOD_CK1_1	414	420	PF00069	0.522
MOD_CK1_1	61	67	PF00069	0.425
MOD_CK2_1	179	185	PF00069	0.535
MOD_CK2_1	187	193	PF00069	0.515
MOD_CK2_1	317	323	PF00069	0.548
MOD_CK2_1	71	77	PF00069	0.439
MOD_Cter_Amidation	165	168	PF01082	0.160
MOD_GlcNHglycan	197	200	PF01048	0.185
MOD_GlcNHglycan	315	318	PF01048	0.253
MOD_GlcNHglycan	327	330	PF01048	0.235
MOD_GlcNHglycan	353	356	PF01048	0.260
MOD_GlcNHglycan	357	360	PF01048	0.242
MOD_GSK3_1	1	8	PF00069	0.488
MOD_GSK3_1	146	153	PF00069	0.481
MOD_GSK3_1	17	24	PF00069	0.473
MOD_GSK3_1	170	177	PF00069	0.568
MOD_GSK3_1	193	200	PF00069	0.465
MOD_GSK3_1	31	38	PF00069	0.400
MOD_GSK3_1	313	320	PF00069	0.532
MOD_GSK3_1	351	358	PF00069	0.481
MOD_GSK3_1	406	413	PF00069	0.444
MOD_GSK3_1	53	60	PF00069	0.430
MOD_GSK3_1	63	70	PF00069	0.434
MOD_GSK3_1	71	78	PF00069	0.424
MOD_N-GLC_1	125	130	PF02516	0.307
MOD_N-GLC_1	355	360	PF02516	0.307
MOD_N-GLC_1	82	87	PF02516	0.413
MOD_NEK2_1	1	6	PF00069	0.454
MOD_NEK2_1	186	191	PF00069	0.535
MOD_NEK2_1	257	262	PF00069	0.524
MOD_NEK2_1	351	356	PF00069	0.456
MOD_NEK2_1	410	415	PF00069	0.525
MOD_NEK2_1	59	64	PF00069	0.609
MOD_NEK2_1	75	80	PF00069	0.708
MOD_NEK2_1	9	14	PF00069	0.433
MOD_PIKK_1	11	17	PF00454	0.433
MOD_PIKK_1	374	380	PF00454	0.549
MOD_PKA_1	167	173	PF00069	0.421
MOD_PKA_1	248	254	PF00069	0.435
MOD_PKA_2	167	173	PF00069	0.393
MOD_Plk_1	125	131	PF00069	0.511
MOD_Plk_1	85	91	PF00069	0.279
MOD_Plk_4	197	203	PF00069	0.515
MOD_Plk_4	302	308	PF00069	0.565
MOD_Plk_4	341	347	PF00069	0.495
MOD_Plk_4	411	417	PF00069	0.442
MOD_Plk_4	71	77	PF00069	0.559
MOD_Plk_4	85	91	PF00069	0.277
MOD_ProDKin_1	242	248	PF00069	0.431
MOD_ProDKin_1	67	73	PF00069	0.438
MOD_SUMO_for_1	335	338	PF00179	0.442
MOD_SUMO_rev_2	101	109	PF00179	0.420
MOD_SUMO_rev_2	110	117	PF00179	0.436
MOD_SUMO_rev_2	140	148	PF00179	0.378
MOD_SUMO_rev_2	162	169	PF00179	0.432
MOD_SUMO_rev_2	215	222	PF00179	0.491
TRG_DiLeu_BaEn_4	234	240	PF01217	0.442
TRG_DiLeu_BaEn_4	393	399	PF01217	0.360
TRG_DiLeu_BaLyEn_6	47	52	PF01217	0.392
TRG_ENDOCYTIC_2	202	205	PF00928	0.529
TRG_ENDOCYTIC_2	210	213	PF00928	0.450
TRG_ENDOCYTIC_2	254	257	PF00928	0.493
TRG_ENDOCYTIC_2	90	93	PF00928	0.459
TRG_ER_diArg_1	279	282	PF00400	0.420
TRG_ER_diArg_1	420	422	PF00400	0.462
TRG_NLS_MonoCore_2	222	227	PF00514	0.445
TRG_NLS_MonoExtC_3	222	227	PF00514	0.398
TRG_NLS_MonoExtC_3	331	336	PF00514	0.430
TRG_NLS_MonoExtN_4	221	227	PF00514	0.428
TRG_NLS_MonoExtN_4	332	337	PF00514	0.439
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.160

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6K0	Leptomonas seymouri	67%	100%
A0A0S4IPI4	Bodo saltans	38%	100%
A0A1X0P929	Trypanosomatidae	49%	100%
A0A3R7NAQ1	Trypanosoma rangeli	46%	100%
A0A3S7X2W5	Leishmania donovani	95%	100%
A4HGN9	Leishmania braziliensis	31%	100%
A4HHQ4	Leishmania braziliensis	80%	99%
A4I4W9	Leishmania infantum	95%	100%
C9ZKZ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AEB8	Leishmania major	94%	100%
V5DTV3	Trypanosoma cruzi	47%	100%