Putative serine/threonine-protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine-protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9ALG7_LEIMU

TriTrypDb:

LmxM.08_29.2570

Length:

501

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALG7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALG7

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	17
GO:0006793	phosphorus metabolic process	3	17
GO:0006796	phosphate-containing compound metabolic process	4	17
GO:0006807	nitrogen compound metabolic process	2	17
GO:0008152	metabolic process	1	17
GO:0009987	cellular process	1	17
GO:0016310	phosphorylation	5	17
GO:0019538	protein metabolic process	3	17
GO:0036211	protein modification process	4	17
GO:0043170	macromolecule metabolic process	3	17
GO:0043412	macromolecule modification	4	17
GO:0044237	cellular metabolic process	2	17
GO:0044238	primary metabolic process	2	17
GO:0071704	organic substance metabolic process	2	17
GO:1901564	organonitrogen compound metabolic process	3	17

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	17
GO:0003824	catalytic activity	1	17
GO:0004672	protein kinase activity	3	17
GO:0004674	protein serine/threonine kinase activity	4	16
GO:0005488	binding	1	17
GO:0005524	ATP binding	5	17
GO:0016301	kinase activity	4	17
GO:0016740	transferase activity	2	17
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	17
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	17
GO:0017076	purine nucleotide binding	4	17
GO:0030554	adenyl nucleotide binding	5	17
GO:0032553	ribonucleotide binding	3	17
GO:0032555	purine ribonucleotide binding	4	17
GO:0032559	adenyl ribonucleotide binding	5	17
GO:0035639	purine ribonucleoside triphosphate binding	4	17
GO:0036094	small molecule binding	2	17
GO:0043167	ion binding	2	17
GO:0043168	anion binding	3	17
GO:0097159	organic cyclic compound binding	2	17
GO:0097367	carbohydrate derivative binding	2	17
GO:0140096	catalytic activity, acting on a protein	2	17
GO:1901265	nucleoside phosphate binding	3	17
GO:1901363	heterocyclic compound binding	2	17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	39	43	PF00656	0.284
CLV_C14_Caspase3-7	411	415	PF00656	0.529
CLV_C14_Caspase3-7	97	101	PF00656	0.323
CLV_NRD_NRD_1	61	63	PF00675	0.299
CLV_PCSK_KEX2_1	44	46	PF00082	0.284
CLV_PCSK_KEX2_1	61	63	PF00082	0.284
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.284
CLV_PCSK_SKI1_1	109	113	PF00082	0.305
CLV_PCSK_SKI1_1	147	151	PF00082	0.346
CLV_PCSK_SKI1_1	21	25	PF00082	0.333
CLV_PCSK_SKI1_1	226	230	PF00082	0.315
CLV_PCSK_SKI1_1	233	237	PF00082	0.310
CLV_PCSK_SKI1_1	310	314	PF00082	0.445
CLV_PCSK_SKI1_1	351	355	PF00082	0.578
CLV_PCSK_SKI1_1	432	436	PF00082	0.487
DOC_CYCLIN_yCln2_LP_2	219	225	PF00134	0.356
DOC_MAPK_gen_1	147	156	PF00069	0.346
DOC_USP7_MATH_1	10	14	PF00917	0.500
DOC_USP7_MATH_1	416	420	PF00917	0.596
DOC_USP7_MATH_1	485	489	PF00917	0.380
DOC_USP7_MATH_1	5	9	PF00917	0.562
DOC_USP7_MATH_1	50	54	PF00917	0.332
DOC_USP7_MATH_2	248	254	PF00917	0.430
DOC_USP7_UBL2_3	109	113	PF12436	0.267
DOC_USP7_UBL2_3	159	163	PF12436	0.359
DOC_USP7_UBL2_3	229	233	PF12436	0.301
DOC_USP7_UBL2_3	24	28	PF12436	0.349
DOC_USP7_UBL2_3	362	366	PF12436	0.770
DOC_USP7_UBL2_3	40	44	PF12436	0.249
DOC_WW_Pin1_4	183	188	PF00397	0.347
DOC_WW_Pin1_4	272	277	PF00397	0.342
DOC_WW_Pin1_4	312	317	PF00397	0.561
DOC_WW_Pin1_4	54	59	PF00397	0.396
LIG_14-3-3_CanoR_1	323	331	PF00244	0.666
LIG_14-3-3_CanoR_1	38	47	PF00244	0.370
LIG_BIR_II_1	1	5	PF00653	0.592
LIG_BRCT_BRCA1_1	12	16	PF00533	0.374
LIG_CtBP_PxDLS_1	248	252	PF00389	0.359
LIG_deltaCOP1_diTrp_1	205	213	PF00928	0.324
LIG_EH1_1	166	174	PF00400	0.273
LIG_FHA_1	149	155	PF00498	0.342
LIG_FHA_1	214	220	PF00498	0.418
LIG_FHA_1	244	250	PF00498	0.359
LIG_FHA_1	394	400	PF00498	0.420
LIG_FHA_1	423	429	PF00498	0.423
LIG_FHA_1	475	481	PF00498	0.359
LIG_FHA_2	225	231	PF00498	0.359
LIG_FHA_2	466	472	PF00498	0.566
LIG_FHA_2	55	61	PF00498	0.301
LIG_Integrin_isoDGR_2	430	432	PF01839	0.457
LIG_LIR_Apic_2	186	192	PF02991	0.346
LIG_LIR_Gen_1	90	99	PF02991	0.301
LIG_LIR_Nem_3	18	23	PF02991	0.291
LIG_LIR_Nem_3	239	243	PF02991	0.372
LIG_MAD2	234	242	PF02301	0.314
LIG_MAD2	69	77	PF02301	0.284
LIG_NRBOX	227	233	PF00104	0.320
LIG_NRBOX	475	481	PF00104	0.521
LIG_PCNA_yPIPBox_3	473	483	PF02747	0.415
LIG_SH2_CRK	20	24	PF00017	0.294
LIG_SH2_CRK	240	244	PF00017	0.301
LIG_SH2_NCK_1	240	244	PF00017	0.284
LIG_SH2_SRC	240	243	PF00017	0.284
LIG_SH2_SRC	98	101	PF00017	0.334
LIG_SH2_STAT3	385	388	PF00017	0.429
LIG_SH2_STAT5	138	141	PF00017	0.330
LIG_SH2_STAT5	189	192	PF00017	0.346
LIG_SH2_STAT5	263	266	PF00017	0.458
LIG_SH2_STAT5	277	280	PF00017	0.458
LIG_SH2_STAT5	385	388	PF00017	0.429
LIG_SH2_STAT5	46	49	PF00017	0.284
LIG_SH3_3	113	119	PF00018	0.291
LIG_SH3_3	325	331	PF00018	0.641
LIG_SH3_3	71	77	PF00018	0.291
LIG_TRAF2_1	358	361	PF00917	0.668
LIG_TYR_ITIM	212	217	PF00017	0.337
LIG_UBA3_1	341	349	PF00899	0.585
LIG_WRC_WIRS_1	282	287	PF05994	0.424
MOD_CDC14_SPxK_1	315	318	PF00782	0.542
MOD_CDK_SPK_2	54	59	PF00069	0.396
MOD_CDK_SPxK_1	312	318	PF00069	0.597
MOD_CDK_SPxxK_3	54	61	PF00069	0.396
MOD_CK1_1	465	471	PF00069	0.467
MOD_CK2_1	27	33	PF00069	0.325
MOD_CK2_1	281	287	PF00069	0.586
MOD_CK2_1	303	309	PF00069	0.514
MOD_CK2_1	331	337	PF00069	0.592
MOD_CK2_1	465	471	PF00069	0.470
MOD_CK2_1	54	60	PF00069	0.289
MOD_Cter_Amidation	42	45	PF01082	0.284
MOD_GlcNHglycan	360	365	PF01048	0.669
MOD_GlcNHglycan	418	421	PF01048	0.729
MOD_GlcNHglycan	460	463	PF01048	0.410
MOD_GlcNHglycan	464	467	PF01048	0.450
MOD_GSK3_1	179	186	PF00069	0.350
MOD_GSK3_1	250	257	PF00069	0.368
MOD_GSK3_1	277	284	PF00069	0.422
MOD_GSK3_1	360	367	PF00069	0.683
MOD_GSK3_1	430	437	PF00069	0.464
MOD_GSK3_1	458	465	PF00069	0.455
MOD_GSK3_1	485	492	PF00069	0.367
MOD_GSK3_1	50	57	PF00069	0.355
MOD_N-GLC_1	201	206	PF02516	0.284
MOD_NEK2_1	155	160	PF00069	0.345
MOD_NEK2_1	167	172	PF00069	0.301
MOD_NEK2_1	173	178	PF00069	0.303
MOD_NEK2_1	194	199	PF00069	0.359
MOD_NEK2_1	213	218	PF00069	0.517
MOD_NEK2_1	254	259	PF00069	0.359
MOD_NEK2_1	36	41	PF00069	0.303
MOD_NEK2_1	458	463	PF00069	0.467
MOD_PIKK_1	322	328	PF00454	0.519
MOD_PKA_1	303	309	PF00069	0.460
MOD_PKA_2	265	271	PF00069	0.346
MOD_PKA_2	322	328	PF00069	0.659
MOD_Plk_1	87	93	PF00069	0.424
MOD_Plk_4	168	174	PF00069	0.284
MOD_Plk_4	254	260	PF00069	0.359
MOD_Plk_4	87	93	PF00069	0.352
MOD_ProDKin_1	183	189	PF00069	0.347
MOD_ProDKin_1	272	278	PF00069	0.342
MOD_ProDKin_1	312	318	PF00069	0.569
MOD_ProDKin_1	54	60	PF00069	0.396
MOD_SUMO_for_1	317	320	PF00179	0.514
MOD_SUMO_rev_2	296	305	PF00179	0.472
MOD_SUMO_rev_2	6	16	PF00179	0.341
TRG_DiLeu_BaEn_1	475	480	PF01217	0.412
TRG_DiLeu_BaEn_1	87	92	PF01217	0.284
TRG_DiLeu_BaEn_4	6	12	PF01217	0.419
TRG_ENDOCYTIC_2	20	23	PF00928	0.294
TRG_ENDOCYTIC_2	214	217	PF00928	0.346
TRG_ENDOCYTIC_2	240	243	PF00928	0.323
TRG_NES_CRM1_1	446	457	PF08389	0.306
TRG_Pf-PMV_PEXEL_1	303	307	PF00026	0.594

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2D3	Leptomonas seymouri	30%	96%
A0A0N1HY86	Leptomonas seymouri	79%	96%
A0A0N1I9A0	Leptomonas seymouri	32%	77%
A0A0S4IKH2	Bodo saltans	68%	100%
A0A0S4JIJ6	Bodo saltans	30%	89%
A0A1X0NLY7	Trypanosomatidae	27%	74%
A0A1X0NUB2	Trypanosomatidae	31%	86%
A0A1X0P863	Trypanosomatidae	32%	100%
A0A1X0P9C4	Trypanosomatidae	74%	100%
A0A3Q8IAQ1	Leishmania donovani	38%	100%
A0A3Q8IB30	Leishmania donovani	31%	100%
A0A3Q8IB74	Leishmania donovani	28%	100%
A0A3Q8IC87	Leishmania donovani	28%	100%
A0A3Q8IH39	Leishmania donovani	25%	100%
A0A3Q8IHH8	Leishmania donovani	96%	100%
A0A3Q8IIG1	Leishmania donovani	29%	100%
A0A3Q8INQ4	Leishmania donovani	27%	100%
A0A3R7KDE9	Trypanosoma rangeli	31%	69%
A0A3R7RIN5	Trypanosoma rangeli	73%	100%
A0A3S5H5G0	Leishmania donovani	25%	100%
A0A3S7WTN9	Leishmania donovani	27%	100%
A0A3S7WWE7	Leishmania donovani	26%	100%
A0A3S7WYP4	Leishmania donovani	28%	100%
A0A3S7X2W3	Leishmania donovani	27%	100%
A0A3S7X5M4	Leishmania donovani	32%	76%
A0A3S7X7D5	Leishmania donovani	25%	100%
A0A3S7X7Y2	Leishmania donovani	27%	100%
A0A3S7X9S2	Leishmania donovani	31%	100%
A0A422N3U8	Trypanosoma rangeli	27%	69%
A0A422NH41	Trypanosoma rangeli	34%	87%
A4H459	Leishmania braziliensis	27%	100%
A4H9L8	Leishmania braziliensis	32%	100%
A4HAS1	Leishmania braziliensis	28%	100%
A4HBL4	Leishmania braziliensis	24%	100%
A4HCE6	Leishmania braziliensis	37%	100%
A4HDU3	Leishmania braziliensis	29%	100%
A4HED7	Leishmania braziliensis	27%	100%
A4HH03	Leishmania braziliensis	30%	100%
A4HHN1	Leishmania braziliensis	27%	100%
A4HHQ5	Leishmania braziliensis	86%	100%
A4HJW2	Leishmania braziliensis	42%	100%
A4HKG9	Leishmania braziliensis	33%	76%
A4HN71	Leishmania braziliensis	30%	100%
A4HSE2	Leishmania infantum	25%	100%
A4HUC8	Leishmania infantum	25%	100%
A4HWP5	Leishmania infantum	27%	100%
A4HXY2	Leishmania infantum	31%	100%
A4HZA2	Leishmania infantum	26%	100%
A4HZV1	Leishmania infantum	28%	100%
A4HZW8	Leishmania infantum	38%	100%
A4I140	Leishmania infantum	28%	100%
A4I1T4	Leishmania infantum	27%	100%
A4I435	Leishmania infantum	29%	100%
A4I4U6	Leishmania infantum	27%	100%
A4I4X0	Leishmania infantum	96%	100%
A4I7Z6	Leishmania infantum	32%	76%
A4I9H1	Leishmania infantum	25%	100%
A4I9Y5	Leishmania infantum	27%	100%
C9ZKE1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZWK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
D0AA64	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	87%
E9AEB9	Leishmania major	95%	100%
E9AFM1	Leishmania major	31%	100%
E9AGS0	Leishmania infantum	28%	100%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9ALJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AN28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AQF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9ARP5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9ARW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AUY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AVR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AVS7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9AX78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AXW8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B0C2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9B2V8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	76%
E9B4G9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9B4Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
F4JBP3	Arabidopsis thaliana	29%	70%
O13839	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	69%
P11837	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	34%	72%
P22209	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
P51955	Homo sapiens	36%	100%
Q10SC8	Oryza sativa subsp. japonica	27%	100%
Q15349	Homo sapiens	26%	68%
Q27687	Leishmania major	31%	100%
Q4Q2Z2	Leishmania major	27%	100%
Q4Q598	Leishmania major	34%	76%
Q4Q7W2	Leishmania major	29%	100%
Q4Q9K2	Leishmania major	27%	100%
Q4QA98	Leishmania major	27%	100%
Q4QBQ2	Leishmania major	38%	100%
Q4QBR6	Leishmania major	28%	100%
Q4QCK0	Leishmania major	24%	100%
Q4QDK3	Leishmania major	28%	100%
Q4QF23	Leishmania major	26%	100%
Q4QHJ8	Leishmania major	25%	100%
Q4QJJ0	Leishmania major	25%	100%
Q69Q47	Oryza sativa subsp. japonica	29%	100%
Q6PFQ0	Danio rerio	24%	68%
Q6X4A2	Oryza sativa subsp. japonica	27%	100%
Q75LR7	Oryza sativa subsp. japonica	31%	100%
Q8WNU8	Macaca fascicularis	32%	79%
Q9N3Z3	Caenorhabditis elegans	28%	100%
Q9SN43	Arabidopsis thaliana	27%	100%
Q9TXJ0	Caenorhabditis elegans	28%	100%
Q9WUT3	Mus musculus	25%	68%
Q9XIW0	Arabidopsis thaliana	28%	100%
Q9Y077	Leishmania major	27%	100%
V5BCH2	Trypanosoma cruzi	27%	100%
V5BQE9	Trypanosoma cruzi	29%	68%
V5C224	Trypanosoma cruzi	73%	100%