LeishMANIAdb
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Doublecortin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Doublecortin domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ALG5_LEIMU
TriTrypDb:
LmxM.08_29.2590
Length:
693

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 5
NetGPI no yes: 0, no: 5
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALG5
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALG5

Function

Biological processes
Term Name Level Count
GO:0007165 signal transduction 2 6
GO:0009987 cellular process 1 6
GO:0035556 intracellular signal transduction 3 6
GO:0050789 regulation of biological process 2 6
GO:0050794 regulation of cellular process 3 6
GO:0065007 biological regulation 1 6
Could not find GO molecular_function term for this entry.

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 341 345 PF00656 0.708
CLV_C14_Caspase3-7 412 416 PF00656 0.606
CLV_C14_Caspase3-7 657 661 PF00656 0.507
CLV_MEL_PAP_1 68 74 PF00089 0.447
CLV_NRD_NRD_1 195 197 PF00675 0.681
CLV_NRD_NRD_1 262 264 PF00675 0.660
CLV_NRD_NRD_1 409 411 PF00675 0.712
CLV_NRD_NRD_1 457 459 PF00675 0.495
CLV_NRD_NRD_1 48 50 PF00675 0.358
CLV_NRD_NRD_1 565 567 PF00675 0.724
CLV_NRD_NRD_1 6 8 PF00675 0.593
CLV_PCSK_KEX2_1 195 197 PF00082 0.681
CLV_PCSK_KEX2_1 227 229 PF00082 0.724
CLV_PCSK_KEX2_1 408 410 PF00082 0.719
CLV_PCSK_KEX2_1 582 584 PF00082 0.702
CLV_PCSK_KEX2_1 6 8 PF00082 0.604
CLV_PCSK_PC1ET2_1 227 229 PF00082 0.724
CLV_PCSK_PC1ET2_1 582 584 PF00082 0.702
CLV_PCSK_SKI1_1 107 111 PF00082 0.509
CLV_PCSK_SKI1_1 128 132 PF00082 0.444
CLV_PCSK_SKI1_1 161 165 PF00082 0.657
CLV_PCSK_SKI1_1 170 174 PF00082 0.561
CLV_PCSK_SKI1_1 471 475 PF00082 0.564
CLV_PCSK_SKI1_1 611 615 PF00082 0.509
CLV_PCSK_SKI1_1 656 660 PF00082 0.589
CLV_Separin_Metazoa 280 284 PF03568 0.667
CLV_Separin_Metazoa 436 440 PF03568 0.530
DEG_ODPH_VHL_1 584 597 PF01847 0.548
DEG_SCF_FBW7_1 351 358 PF00400 0.702
DEG_SPOP_SBC_1 546 550 PF00917 0.693
DEG_SPOP_SBC_1 551 555 PF00917 0.649
DOC_CYCLIN_yCln2_LP_2 172 175 PF00134 0.624
DOC_CYCLIN_yCln2_LP_2 310 316 PF00134 0.659
DOC_CYCLIN_yCln2_LP_2 434 440 PF00134 0.513
DOC_MAPK_gen_1 195 201 PF00069 0.492
DOC_MAPK_gen_1 636 645 PF00069 0.521
DOC_MAPK_HePTP_8 633 645 PF00069 0.513
DOC_MAPK_MEF2A_6 115 122 PF00069 0.478
DOC_MAPK_MEF2A_6 636 645 PF00069 0.560
DOC_MAPK_RevD_3 36 50 PF00069 0.390
DOC_PP1_RVXF_1 126 132 PF00149 0.456
DOC_PP1_RVXF_1 418 424 PF00149 0.494
DOC_PP1_RVXF_1 456 463 PF00149 0.485
DOC_PP1_RVXF_1 629 636 PF00149 0.514
DOC_PP2B_LxvP_1 172 175 PF13499 0.671
DOC_PP2B_LxvP_1 190 193 PF13499 0.585
DOC_PP2B_LxvP_1 519 522 PF13499 0.589
DOC_PP4_FxxP_1 209 212 PF00568 0.625
DOC_PP4_FxxP_1 239 242 PF00568 0.698
DOC_PP4_FxxP_1 672 675 PF00568 0.506
DOC_SPAK_OSR1_1 671 675 PF12202 0.516
DOC_USP7_MATH_1 146 150 PF00917 0.701
DOC_USP7_MATH_1 234 238 PF00917 0.772
DOC_USP7_MATH_1 245 249 PF00917 0.725
DOC_USP7_MATH_1 306 310 PF00917 0.596
DOC_USP7_MATH_1 355 359 PF00917 0.624
DOC_USP7_MATH_1 371 375 PF00917 0.601
DOC_USP7_MATH_1 392 396 PF00917 0.494
DOC_USP7_MATH_1 414 418 PF00917 0.571
DOC_USP7_MATH_1 515 519 PF00917 0.626
DOC_USP7_MATH_1 536 540 PF00917 0.690
DOC_USP7_MATH_1 545 549 PF00917 0.684
DOC_USP7_MATH_1 556 560 PF00917 0.635
DOC_USP7_MATH_1 572 576 PF00917 0.572
DOC_USP7_MATH_1 578 582 PF00917 0.547
DOC_USP7_MATH_1 70 74 PF00917 0.446
DOC_USP7_UBL2_3 683 687 PF12436 0.437
DOC_WW_Pin1_4 322 327 PF00397 0.721
DOC_WW_Pin1_4 345 350 PF00397 0.685
DOC_WW_Pin1_4 351 356 PF00397 0.696
DOC_WW_Pin1_4 388 393 PF00397 0.677
DOC_WW_Pin1_4 525 530 PF00397 0.768
DOC_WW_Pin1_4 584 589 PF00397 0.681
LIG_14-3-3_CanoR_1 107 113 PF00244 0.542
LIG_14-3-3_CanoR_1 161 167 PF00244 0.622
LIG_14-3-3_CanoR_1 235 240 PF00244 0.663
LIG_14-3-3_CanoR_1 287 294 PF00244 0.549
LIG_14-3-3_CanoR_1 439 443 PF00244 0.511
LIG_14-3-3_CanoR_1 466 473 PF00244 0.599
LIG_14-3-3_CanoR_1 491 500 PF00244 0.423
LIG_14-3-3_CanoR_1 516 522 PF00244 0.580
LIG_14-3-3_CanoR_1 58 62 PF00244 0.493
LIG_14-3-3_CanoR_1 611 616 PF00244 0.602
LIG_14-3-3_CanoR_1 71 75 PF00244 0.371
LIG_BIR_II_1 1 5 PF00653 0.739
LIG_BIR_III_2 514 518 PF00653 0.551
LIG_BIR_III_4 646 650 PF00653 0.488
LIG_BRCT_BRCA1_1 641 645 PF00533 0.424
LIG_FHA_1 158 164 PF00498 0.707
LIG_FHA_1 265 271 PF00498 0.707
LIG_FHA_1 346 352 PF00498 0.535
LIG_FHA_1 455 461 PF00498 0.551
LIG_FHA_1 526 532 PF00498 0.567
LIG_FHA_1 575 581 PF00498 0.719
LIG_FHA_1 610 616 PF00498 0.509
LIG_FHA_1 628 634 PF00498 0.479
LIG_FHA_1 648 654 PF00498 0.435
LIG_FHA_2 215 221 PF00498 0.712
LIG_FHA_2 339 345 PF00498 0.678
LIG_LIR_Apic_2 237 242 PF02991 0.692
LIG_LIR_Apic_2 670 675 PF02991 0.517
LIG_LIR_Gen_1 447 456 PF02991 0.471
LIG_LIR_Gen_1 506 517 PF02991 0.638
LIG_LIR_Nem_3 447 453 PF02991 0.476
LIG_LIR_Nem_3 506 512 PF02991 0.597
LIG_LIR_Nem_3 607 613 PF02991 0.532
LIG_LIR_Nem_3 618 622 PF02991 0.314
LIG_MYND_1 308 312 PF01753 0.599
LIG_MYND_1 349 353 PF01753 0.709
LIG_NRBOX 654 660 PF00104 0.507
LIG_PALB2_WD40_1 419 427 PF16756 0.289
LIG_PCNA_yPIPBox_3 95 109 PF02747 0.446
LIG_PTAP_UEV_1 175 180 PF05743 0.484
LIG_PTB_Apo_2 599 606 PF02174 0.483
LIG_PTB_Phospho_1 599 605 PF10480 0.479
LIG_Rb_pABgroove_1 639 647 PF01858 0.485
LIG_RPA_C_Fungi 217 229 PF08784 0.617
LIG_SH2_CRK 610 614 PF00017 0.508
LIG_SH2_CRK 619 623 PF00017 0.332
LIG_SH2_GRB2like 600 603 PF00017 0.482
LIG_SH2_SRC 600 603 PF00017 0.482
LIG_SH2_STAP1 605 609 PF00017 0.534
LIG_SH2_STAT5 98 101 PF00017 0.423
LIG_SH3_1 279 285 PF00018 0.668
LIG_SH3_2 282 287 PF14604 0.674
LIG_SH3_2 561 566 PF14604 0.656
LIG_SH3_3 173 179 PF00018 0.649
LIG_SH3_3 194 200 PF00018 0.663
LIG_SH3_3 208 214 PF00018 0.598
LIG_SH3_3 239 245 PF00018 0.710
LIG_SH3_3 279 285 PF00018 0.706
LIG_SH3_3 558 564 PF00018 0.691
LIG_SUMO_SIM_par_1 650 657 PF11976 0.499
LIG_ULM_U2AF65_1 458 463 PF00076 0.500
LIG_WRC_WIRS_1 109 114 PF05994 0.544
LIG_WW_3 280 284 PF00397 0.667
MOD_CDK_SPK_2 525 530 PF00069 0.530
MOD_CDK_SPxxK_3 345 352 PF00069 0.535
MOD_CDK_SPxxK_3 525 532 PF00069 0.670
MOD_CK1_1 138 144 PF00069 0.634
MOD_CK1_1 165 171 PF00069 0.805
MOD_CK1_1 289 295 PF00069 0.629
MOD_CK1_1 325 331 PF00069 0.712
MOD_CK1_1 345 351 PF00069 0.657
MOD_CK1_1 550 556 PF00069 0.780
MOD_CK1_1 576 582 PF00069 0.574
MOD_CK1_1 587 593 PF00069 0.573
MOD_CK2_1 214 220 PF00069 0.700
MOD_CK2_1 36 42 PF00069 0.534
MOD_CK2_1 645 651 PF00069 0.491
MOD_Cter_Amidation 637 640 PF01082 0.546
MOD_GlcNHglycan 148 151 PF01048 0.716
MOD_GlcNHglycan 167 170 PF01048 0.692
MOD_GlcNHglycan 176 179 PF01048 0.608
MOD_GlcNHglycan 201 204 PF01048 0.657
MOD_GlcNHglycan 289 292 PF01048 0.622
MOD_GlcNHglycan 299 302 PF01048 0.580
MOD_GlcNHglycan 373 376 PF01048 0.670
MOD_GlcNHglycan 411 414 PF01048 0.717
MOD_GlcNHglycan 415 419 PF01048 0.618
MOD_GlcNHglycan 549 552 PF01048 0.654
MOD_GlcNHglycan 558 561 PF01048 0.687
MOD_GlcNHglycan 646 650 PF01048 0.488
MOD_GlcNHglycan 666 669 PF01048 0.256
MOD_GSK3_1 141 148 PF00069 0.592
MOD_GSK3_1 195 202 PF00069 0.721
MOD_GSK3_1 338 345 PF00069 0.809
MOD_GSK3_1 351 358 PF00069 0.568
MOD_GSK3_1 388 395 PF00069 0.571
MOD_GSK3_1 404 411 PF00069 0.593
MOD_GSK3_1 467 474 PF00069 0.510
MOD_GSK3_1 546 553 PF00069 0.738
MOD_GSK3_1 572 579 PF00069 0.651
MOD_GSK3_1 611 618 PF00069 0.539
MOD_N-GLC_1 392 397 PF02516 0.561
MOD_N-GLC_1 432 437 PF02516 0.475
MOD_NEK2_1 467 472 PF00069 0.578
MOD_NEK2_1 492 497 PF00069 0.471
MOD_NEK2_1 645 650 PF00069 0.516
MOD_NEK2_2 70 75 PF00069 0.443
MOD_PIKK_1 135 141 PF00454 0.566
MOD_PIKK_1 245 251 PF00454 0.691
MOD_PK_1 195 201 PF00069 0.492
MOD_PKA_1 195 201 PF00069 0.680
MOD_PKA_1 264 270 PF00069 0.647
MOD_PKA_1 408 414 PF00069 0.686
MOD_PKA_1 639 645 PF00069 0.485
MOD_PKA_2 17 23 PF00069 0.528
MOD_PKA_2 195 201 PF00069 0.680
MOD_PKA_2 221 227 PF00069 0.687
MOD_PKA_2 234 240 PF00069 0.600
MOD_PKA_2 286 292 PF00069 0.581
MOD_PKA_2 408 414 PF00069 0.689
MOD_PKA_2 438 444 PF00069 0.504
MOD_PKA_2 465 471 PF00069 0.521
MOD_PKA_2 515 521 PF00069 0.663
MOD_PKA_2 57 63 PF00069 0.502
MOD_PKA_2 615 621 PF00069 0.490
MOD_PKA_2 70 76 PF00069 0.406
MOD_Plk_1 36 42 PF00069 0.482
MOD_Plk_1 64 70 PF00069 0.456
MOD_Plk_4 306 312 PF00069 0.678
MOD_Plk_4 445 451 PF00069 0.502
MOD_Plk_4 624 630 PF00069 0.525
MOD_Plk_4 639 645 PF00069 0.331
MOD_ProDKin_1 322 328 PF00069 0.720
MOD_ProDKin_1 345 351 PF00069 0.684
MOD_ProDKin_1 388 394 PF00069 0.680
MOD_ProDKin_1 525 531 PF00069 0.769
MOD_ProDKin_1 584 590 PF00069 0.680
MOD_SUMO_for_1 277 280 PF00179 0.681
MOD_SUMO_rev_2 475 483 PF00179 0.513
TRG_DiLeu_BaEn_1 654 659 PF01217 0.441
TRG_ENDOCYTIC_2 610 613 PF00928 0.509
TRG_ENDOCYTIC_2 619 622 PF00928 0.329
TRG_ER_diArg_1 195 197 PF00400 0.681
TRG_ER_diArg_1 408 410 PF00400 0.672
TRG_ER_diArg_1 529 532 PF00400 0.534
TRG_NLS_MonoExtC_3 457 463 PF00514 0.492
TRG_Pf-PMV_PEXEL_1 12 16 PF00026 0.569
TRG_Pf-PMV_PEXEL_1 397 401 PF00026 0.528
TRG_Pf-PMV_PEXEL_1 458 463 PF00026 0.567
TRG_Pf-PMV_PEXEL_1 656 660 PF00026 0.476
TRG_PTS2 1 14 PF00400 0.599

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IRL3 Leishmania donovani 88% 100%
A4HHQ7 Leishmania braziliensis 66% 100%
A4I4T5 Leishmania infantum 88% 100%
E9AEC1 Leishmania major 87% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS