Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALG3_LEIMU

TriTrypDb:

LmxM.08_29.2610

Length:

720

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALG3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.472
CLV_NRD_NRD_1	267	269	PF00675	0.410
CLV_NRD_NRD_1	399	401	PF00675	0.559
CLV_NRD_NRD_1	655	657	PF00675	0.446
CLV_NRD_NRD_1	680	682	PF00675	0.439
CLV_PCSK_KEX2_1	267	269	PF00082	0.410
CLV_PCSK_KEX2_1	28	30	PF00082	0.523
CLV_PCSK_KEX2_1	399	401	PF00082	0.595
CLV_PCSK_KEX2_1	655	657	PF00082	0.446
CLV_PCSK_KEX2_1	680	682	PF00082	0.439
CLV_PCSK_PC1ET2_1	28	30	PF00082	0.523
CLV_PCSK_SKI1_1	314	318	PF00082	0.481
CLV_PCSK_SKI1_1	325	329	PF00082	0.527
CLV_PCSK_SKI1_1	355	359	PF00082	0.536
CLV_PCSK_SKI1_1	361	365	PF00082	0.481
CLV_PCSK_SKI1_1	536	540	PF00082	0.473
CLV_PCSK_SKI1_1	710	714	PF00082	0.454
DEG_APCC_DBOX_1	535	543	PF00400	0.493
DEG_APCC_DBOX_1	654	662	PF00400	0.487
DEG_APCC_DBOX_1	692	700	PF00400	0.478
DEG_SPOP_SBC_1	278	282	PF00917	0.459
DEG_SPOP_SBC_1	97	101	PF00917	0.551
DOC_CYCLIN_RxL_1	533	541	PF00134	0.549
DOC_CYCLIN_RxL_1	653	663	PF00134	0.349
DOC_MAPK_gen_1	233	241	PF00069	0.438
DOC_MAPK_gen_1	352	360	PF00069	0.566
DOC_MAPK_gen_1	680	688	PF00069	0.331
DOC_MAPK_MEF2A_6	235	243	PF00069	0.549
DOC_PP1_RVXF_1	654	661	PF00149	0.352
DOC_PP4_FxxP_1	183	186	PF00568	0.447
DOC_PP4_FxxP_1	4	7	PF00568	0.580
DOC_USP7_MATH_1	111	115	PF00917	0.586
DOC_USP7_MATH_1	205	209	PF00917	0.502
DOC_USP7_MATH_1	213	217	PF00917	0.489
DOC_USP7_MATH_1	278	282	PF00917	0.537
DOC_USP7_MATH_1	365	369	PF00917	0.679
DOC_USP7_MATH_1	382	386	PF00917	0.518
DOC_USP7_MATH_1	580	584	PF00917	0.545
DOC_USP7_MATH_2	176	182	PF00917	0.586
DOC_WW_Pin1_4	159	164	PF00397	0.514
DOC_WW_Pin1_4	182	187	PF00397	0.544
DOC_WW_Pin1_4	274	279	PF00397	0.674
DOC_WW_Pin1_4	377	382	PF00397	0.536
DOC_WW_Pin1_4	547	552	PF00397	0.460
DOC_WW_Pin1_4	91	96	PF00397	0.621
LIG_14-3-3_CanoR_1	128	136	PF00244	0.535
LIG_14-3-3_CanoR_1	240	244	PF00244	0.593
LIG_14-3-3_CanoR_1	262	269	PF00244	0.492
LIG_14-3-3_CanoR_1	314	319	PF00244	0.438
LIG_14-3-3_CanoR_1	504	509	PF00244	0.493
LIG_14-3-3_CanoR_1	680	688	PF00244	0.420
LIG_14-3-3_CanoR_1	70	74	PF00244	0.536
LIG_Actin_WH2_2	225	242	PF00022	0.500
LIG_Actin_WH2_2	346	363	PF00022	0.506
LIG_Actin_WH2_2	397	414	PF00022	0.507
LIG_Actin_WH2_2	56	72	PF00022	0.589
LIG_BIR_II_1	1	5	PF00653	0.582
LIG_BRCT_BRCA1_1	453	457	PF00533	0.479
LIG_BRCT_BRCA1_2	453	459	PF00533	0.477
LIG_CSL_BTD_1	174	177	PF09270	0.583
LIG_FHA_1	160	166	PF00498	0.476
LIG_FHA_1	240	246	PF00498	0.541
LIG_FHA_1	315	321	PF00498	0.513
LIG_FHA_1	538	544	PF00498	0.480
LIG_FHA_1	548	554	PF00498	0.481
LIG_FHA_1	580	586	PF00498	0.594
LIG_FHA_1	591	597	PF00498	0.493
LIG_FHA_1	64	70	PF00498	0.535
LIG_FHA_1	97	103	PF00498	0.587
LIG_FHA_2	387	393	PF00498	0.473
LIG_FHA_2	39	45	PF00498	0.537
LIG_FHA_2	421	427	PF00498	0.520
LIG_FHA_2	453	459	PF00498	0.477
LIG_FHA_2	53	59	PF00498	0.557
LIG_FHA_2	547	553	PF00498	0.493
LIG_FHA_2	672	678	PF00498	0.502
LIG_FHA_2	680	686	PF00498	0.413
LIG_Integrin_isoDGR_2	305	307	PF01839	0.571
LIG_Integrin_RGD_1	49	51	PF01839	0.498
LIG_LIR_Apic_2	181	186	PF02991	0.455
LIG_LIR_Apic_2	2	7	PF02991	0.578
LIG_LIR_Apic_2	563	567	PF02991	0.562
LIG_LIR_Gen_1	22	31	PF02991	0.589
LIG_LIR_Gen_1	32	38	PF02991	0.482
LIG_LIR_Gen_1	530	539	PF02991	0.509
LIG_LIR_Gen_1	556	564	PF02991	0.537
LIG_LIR_Gen_1	74	85	PF02991	0.531
LIG_LIR_Nem_3	22	27	PF02991	0.606
LIG_LIR_Nem_3	30	36	PF02991	0.485
LIG_LIR_Nem_3	530	535	PF02991	0.553
LIG_LIR_Nem_3	556	560	PF02991	0.534
LIG_MLH1_MIPbox_1	453	457	PF16413	0.479
LIG_NRBOX	435	441	PF00104	0.491
LIG_NRBOX	538	544	PF00104	0.497
LIG_PCNA_yPIPBox_3	299	312	PF02747	0.493
LIG_Rb_LxCxE_1	264	285	PF01857	0.523
LIG_SH2_PTP2	336	339	PF00017	0.504
LIG_SH2_STAP1	342	346	PF00017	0.455
LIG_SH2_STAT3	224	227	PF00017	0.533
LIG_SH2_STAT5	336	339	PF00017	0.504
LIG_SH2_STAT5	359	362	PF00017	0.483
LIG_SH2_STAT5	456	459	PF00017	0.486
LIG_SH2_STAT5	564	567	PF00017	0.449
LIG_SH3_1	564	570	PF00018	0.615
LIG_SH3_3	11	17	PF00018	0.588
LIG_SH3_3	149	155	PF00018	0.489
LIG_SH3_3	313	319	PF00018	0.436
LIG_SH3_3	485	491	PF00018	0.548
LIG_SH3_3	564	570	PF00018	0.615
LIG_SH3_3	633	639	PF00018	0.458
LIG_SUMO_SIM_par_1	241	247	PF11976	0.450
LIG_TRAF2_1	208	211	PF00917	0.510
LIG_TRAF2_1	247	250	PF00917	0.451
LIG_TRAF2_1	682	685	PF00917	0.483
LIG_TRAF2_1	9	12	PF00917	0.646
LIG_TYR_ITIM	334	339	PF00017	0.501
LIG_UBA3_1	513	520	PF00899	0.378
LIG_WRC_WIRS_1	180	185	PF05994	0.464
LIG_WRC_WIRS_1	431	436	PF05994	0.500
LIG_WW_1	16	19	PF00397	0.599
MOD_CDK_SPxxK_3	159	166	PF00069	0.481
MOD_CK1_1	100	106	PF00069	0.638
MOD_CK1_1	114	120	PF00069	0.435
MOD_CK1_1	146	152	PF00069	0.567
MOD_CK1_1	182	188	PF00069	0.541
MOD_CK1_1	228	234	PF00069	0.456
MOD_CK1_1	274	280	PF00069	0.615
MOD_CK1_1	282	288	PF00069	0.484
MOD_CK1_1	385	391	PF00069	0.749
MOD_CK1_1	546	552	PF00069	0.529
MOD_CK1_1	576	582	PF00069	0.598
MOD_CK1_1	93	99	PF00069	0.626
MOD_CK2_1	205	211	PF00069	0.506
MOD_CK2_1	244	250	PF00069	0.450
MOD_CK2_1	365	371	PF00069	0.690
MOD_CK2_1	38	44	PF00069	0.531
MOD_CK2_1	386	392	PF00069	0.487
MOD_CK2_1	452	458	PF00069	0.480
MOD_CK2_1	52	58	PF00069	0.560
MOD_CK2_1	671	677	PF00069	0.393
MOD_CK2_1	679	685	PF00069	0.413
MOD_GlcNHglycan	104	107	PF01048	0.539
MOD_GlcNHglycan	113	116	PF01048	0.572
MOD_GlcNHglycan	133	136	PF01048	0.395
MOD_GlcNHglycan	146	149	PF01048	0.570
MOD_GlcNHglycan	215	218	PF01048	0.516
MOD_GlcNHglycan	273	276	PF01048	0.652
MOD_GlcNHglycan	330	333	PF01048	0.509
MOD_GlcNHglycan	366	370	PF01048	0.705
MOD_GlcNHglycan	412	415	PF01048	0.685
MOD_GlcNHglycan	417	420	PF01048	0.573
MOD_GlcNHglycan	460	463	PF01048	0.477
MOD_GlcNHglycan	556	560	PF01048	0.650
MOD_GlcNHglycan	570	573	PF01048	0.503
MOD_GlcNHglycan	575	578	PF01048	0.455
MOD_GlcNHglycan	666	671	PF01048	0.366
MOD_GSK3_1	127	134	PF00069	0.538
MOD_GSK3_1	178	185	PF00069	0.642
MOD_GSK3_1	274	281	PF00069	0.555
MOD_GSK3_1	382	389	PF00069	0.701
MOD_GSK3_1	420	427	PF00069	0.551
MOD_GSK3_1	518	525	PF00069	0.528
MOD_GSK3_1	542	549	PF00069	0.447
MOD_GSK3_1	576	583	PF00069	0.555
MOD_GSK3_1	590	597	PF00069	0.449
MOD_GSK3_1	662	669	PF00069	0.495
MOD_GSK3_1	69	76	PF00069	0.686
MOD_GSK3_1	712	719	PF00069	0.359
MOD_GSK3_1	93	100	PF00069	0.633
MOD_N-GLC_1	424	429	PF02516	0.526
MOD_N-GLC_2	444	446	PF02516	0.529
MOD_NEK2_1	102	107	PF00069	0.514
MOD_NEK2_1	144	149	PF00069	0.616
MOD_NEK2_1	328	333	PF00069	0.450
MOD_NEK2_1	37	42	PF00069	0.528
MOD_NEK2_1	452	457	PF00069	0.478
MOD_NEK2_1	503	508	PF00069	0.479
MOD_NEK2_1	542	547	PF00069	0.500
MOD_NEK2_1	63	68	PF00069	0.559
MOD_NEK2_1	671	676	PF00069	0.515
MOD_NEK2_1	713	718	PF00069	0.438
MOD_NEK2_1	73	78	PF00069	0.516
MOD_PIKK_1	114	120	PF00454	0.543
MOD_PIKK_1	127	133	PF00454	0.451
MOD_PIKK_1	244	250	PF00454	0.518
MOD_PIKK_1	314	320	PF00454	0.578
MOD_PIKK_1	527	533	PF00454	0.511
MOD_PIKK_1	580	586	PF00454	0.596
MOD_PK_1	504	510	PF00069	0.491
MOD_PKA_1	399	405	PF00069	0.555
MOD_PKA_1	680	686	PF00069	0.440
MOD_PKA_2	127	133	PF00069	0.539
MOD_PKA_2	239	245	PF00069	0.503
MOD_PKA_2	261	267	PF00069	0.486
MOD_PKA_2	38	44	PF00069	0.531
MOD_PKA_2	399	405	PF00069	0.574
MOD_PKA_2	503	509	PF00069	0.378
MOD_PKA_2	63	69	PF00069	0.422
MOD_PKA_2	679	685	PF00069	0.441
MOD_Plk_1	424	430	PF00069	0.525
MOD_Plk_1	478	484	PF00069	0.526
MOD_Plk_1	518	524	PF00069	0.525
MOD_Plk_1	555	561	PF00069	0.531
MOD_Plk_1	598	604	PF00069	0.410
MOD_Plk_1	666	672	PF00069	0.591
MOD_Plk_1	73	79	PF00069	0.585
MOD_Plk_1	97	103	PF00069	0.565
MOD_Plk_2-3	478	484	PF00069	0.522
MOD_Plk_4	104	110	PF00069	0.525
MOD_Plk_4	427	433	PF00069	0.691
MOD_Plk_4	452	458	PF00069	0.480
MOD_Plk_4	518	524	PF00069	0.487
MOD_Plk_4	591	597	PF00069	0.413
MOD_Plk_4	73	79	PF00069	0.585
MOD_ProDKin_1	159	165	PF00069	0.510
MOD_ProDKin_1	182	188	PF00069	0.538
MOD_ProDKin_1	274	280	PF00069	0.675
MOD_ProDKin_1	377	383	PF00069	0.538
MOD_ProDKin_1	547	553	PF00069	0.459
MOD_ProDKin_1	91	97	PF00069	0.620
MOD_SUMO_for_1	27	30	PF00179	0.589
MOD_SUMO_rev_2	563	570	PF00179	0.664
MOD_SUMO_rev_2	599	609	PF00179	0.483
TRG_DiLeu_BaEn_1	556	561	PF01217	0.493
TRG_DiLeu_BaEn_4	303	309	PF01217	0.573
TRG_DiLeu_BaEn_4	348	354	PF01217	0.565
TRG_DiLeu_BaLyEn_6	435	440	PF01217	0.542
TRG_DiLeu_BaLyEn_6	636	641	PF01217	0.462
TRG_ENDOCYTIC_2	24	27	PF00928	0.608
TRG_ENDOCYTIC_2	336	339	PF00928	0.504
TRG_ER_diArg_1	267	269	PF00400	0.410
TRG_ER_diArg_1	399	401	PF00400	0.572
TRG_ER_diArg_1	654	656	PF00400	0.441
TRG_Pf-PMV_PEXEL_1	299	303	PF00026	0.549
TRG_Pf-PMV_PEXEL_1	344	348	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	484	489	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	536	541	PF00026	0.553

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I841	Leptomonas seymouri	43%	97%
A0A3S7X2Z5	Leishmania donovani	86%	100%
A4HHQ9	Leishmania braziliensis	73%	99%
A4I4T7	Leishmania infantum	85%	100%
E9AEC3	Leishmania major	86%	100%