Epiglycanin_C domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALG2_LEIMU

TriTrypDb:

LmxM.08_29.2620

Length:

122

Annotations

LeishMANIAdb annotations

A short, single-pass TM protein of unclear topology and function.. A highly conserved protein family in parazitic kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9ALG2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALG2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.521
DOC_CKS1_1	19	24	PF01111	0.478
DOC_WW_Pin1_4	102	107	PF00397	0.696
DOC_WW_Pin1_4	12	17	PF00397	0.508
DOC_WW_Pin1_4	18	23	PF00397	0.399
DOC_WW_Pin1_4	34	39	PF00397	0.422
LIG_14-3-3_CterR_2	117	122	PF00244	0.756
LIG_BIR_II_1	1	5	PF00653	0.441
LIG_eIF4E_1	95	101	PF01652	0.619
LIG_FHA_1	19	25	PF00498	0.472
LIG_FHA_1	28	34	PF00498	0.434
LIG_FHA_1	46	52	PF00498	0.404
LIG_FHA_1	83	89	PF00498	0.692
LIG_SH2_CRK	97	101	PF00017	0.651
LIG_SH2_PTP2	19	22	PF00017	0.470
LIG_SH2_PTP2	69	72	PF00017	0.378
LIG_SH2_SRC	69	72	PF00017	0.378
LIG_SH2_STAT5	113	116	PF00017	0.717
LIG_SH2_STAT5	19	22	PF00017	0.470
LIG_SH2_STAT5	69	72	PF00017	0.355
LIG_SH3_3	103	109	PF00018	0.697
LIG_SUMO_SIM_anti_2	48	55	PF11976	0.386
LIG_SUMO_SIM_par_1	85	92	PF11976	0.655
MOD_CDK_SPxxK_3	18	25	PF00069	0.477
MOD_GlcNHglycan	54	57	PF01048	0.434
MOD_GSK3_1	27	34	PF00069	0.437
MOD_NEK2_1	100	105	PF00069	0.679
MOD_NEK2_1	47	52	PF00069	0.367
MOD_OFUCOSY	29	36	PF10250	0.573
MOD_Plk_4	108	114	PF00069	0.684
MOD_Plk_4	47	53	PF00069	0.283
MOD_ProDKin_1	102	108	PF00069	0.698
MOD_ProDKin_1	12	18	PF00069	0.500
MOD_ProDKin_1	34	40	PF00069	0.430
MOD_SUMO_rev_2	110	119	PF00179	0.689
TRG_ENDOCYTIC_2	69	72	PF00928	0.335
TRG_ENDOCYTIC_2	97	100	PF00928	0.630
TRG_Pf-PMV_PEXEL_1	117	122	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6I0	Leptomonas seymouri	67%	100%
A0A1X0P914	Trypanosomatidae	40%	100%
A0A3R7NJ38	Trypanosoma rangeli	47%	100%
A0A3S7X2V8	Leishmania donovani	98%	100%
A4HHR0	Leishmania braziliensis	84%	100%
A4I4T8	Leishmania infantum	98%	100%
C9ZKY3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	93%
E9AEC4	Leishmania major	93%	100%
V5DU61	Trypanosoma cruzi	39%	100%