SAM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 24

Species:

Leishmania mexicana

UniProt:

E9ALG1_LEIMU

TriTrypDb:

LmxM.08_29.2630

Length:

1236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005741	mitochondrial outer membrane	5	1
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1

Expansion

Sequence features

E9ALG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALG1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1076	1080	PF00656	0.630
CLV_C14_Caspase3-7	1141	1145	PF00656	0.605
CLV_C14_Caspase3-7	1147	1151	PF00656	0.602
CLV_C14_Caspase3-7	1185	1189	PF00656	0.744
CLV_C14_Caspase3-7	1221	1225	PF00656	0.596
CLV_NRD_NRD_1	127	129	PF00675	0.525
CLV_NRD_NRD_1	300	302	PF00675	0.369
CLV_NRD_NRD_1	35	37	PF00675	0.441
CLV_NRD_NRD_1	579	581	PF00675	0.410
CLV_NRD_NRD_1	643	645	PF00675	0.436
CLV_NRD_NRD_1	882	884	PF00675	0.405
CLV_NRD_NRD_1	919	921	PF00675	0.386
CLV_PCSK_KEX2_1	127	129	PF00082	0.527
CLV_PCSK_KEX2_1	282	284	PF00082	0.389
CLV_PCSK_KEX2_1	35	37	PF00082	0.439
CLV_PCSK_KEX2_1	364	366	PF00082	0.348
CLV_PCSK_KEX2_1	543	545	PF00082	0.489
CLV_PCSK_KEX2_1	643	645	PF00082	0.407
CLV_PCSK_KEX2_1	882	884	PF00082	0.446
CLV_PCSK_KEX2_1	919	921	PF00082	0.386
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.418
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.348
CLV_PCSK_PC1ET2_1	543	545	PF00082	0.489
CLV_PCSK_PC7_1	123	129	PF00082	0.518
CLV_PCSK_SKI1_1	282	286	PF00082	0.391
CLV_PCSK_SKI1_1	315	319	PF00082	0.408
CLV_PCSK_SKI1_1	336	340	PF00082	0.382
CLV_PCSK_SKI1_1	489	493	PF00082	0.450
CLV_PCSK_SKI1_1	496	500	PF00082	0.392
CLV_PCSK_SKI1_1	630	634	PF00082	0.517
CLV_PCSK_SKI1_1	643	647	PF00082	0.298
CLV_PCSK_SKI1_1	780	784	PF00082	0.353
CLV_PCSK_SKI1_1	840	844	PF00082	0.492
CLV_Separin_Metazoa	690	694	PF03568	0.658
DEG_APCC_DBOX_1	110	118	PF00400	0.600
DEG_APCC_DBOX_1	335	343	PF00400	0.589
DEG_APCC_DBOX_1	775	783	PF00400	0.612
DEG_APCC_DBOX_1	918	926	PF00400	0.576
DEG_Kelch_actinfilin_1	9	13	PF01344	0.172
DEG_MDM2_SWIB_1	148	155	PF02201	0.618
DEG_SCF_FBW7_1	134	140	PF00400	0.588
DEG_SPOP_SBC_1	188	192	PF00917	0.488
DOC_ANK_TNKS_1	73	80	PF00023	0.578
DOC_ANK_TNKS_1	881	888	PF00023	0.589
DOC_CKS1_1	134	139	PF01111	0.635
DOC_CYCLIN_RxL_1	1021	1032	PF00134	0.642
DOC_CYCLIN_RxL_1	1036	1046	PF00134	0.630
DOC_CYCLIN_RxL_1	774	787	PF00134	0.510
DOC_MAPK_gen_1	395	403	PF00069	0.487
DOC_MAPK_gen_1	580	587	PF00069	0.643
DOC_MAPK_MEF2A_6	496	503	PF00069	0.575
DOC_MAPK_MEF2A_6	580	587	PF00069	0.579
DOC_MAPK_MEF2A_6	693	702	PF00069	0.568
DOC_MAPK_MEF2A_6	919	926	PF00069	0.545
DOC_PP1_RVXF_1	956	962	PF00149	0.566
DOC_PP2B_LxvP_1	1085	1088	PF13499	0.662
DOC_PP2B_LxvP_1	139	142	PF13499	0.599
DOC_PP2B_LxvP_1	611	614	PF13499	0.587
DOC_PP2B_LxvP_1	635	638	PF13499	0.477
DOC_PP4_FxxP_1	295	298	PF00568	0.452
DOC_PP4_MxPP_1	1	4	PF00568	0.490
DOC_USP7_MATH_1	1029	1033	PF00917	0.583
DOC_USP7_MATH_1	1142	1146	PF00917	0.639
DOC_USP7_MATH_1	1204	1208	PF00917	0.660
DOC_USP7_MATH_1	213	217	PF00917	0.624
DOC_USP7_MATH_1	334	338	PF00917	0.525
DOC_USP7_MATH_1	358	362	PF00917	0.575
DOC_USP7_MATH_1	373	377	PF00917	0.575
DOC_USP7_MATH_1	709	713	PF00917	0.649
DOC_USP7_MATH_1	738	742	PF00917	0.582
DOC_USP7_MATH_1	801	805	PF00917	0.705
DOC_USP7_MATH_1	864	868	PF00917	0.646
DOC_USP7_MATH_1	895	899	PF00917	0.672
DOC_USP7_UBL2_3	582	586	PF12436	0.549
DOC_USP7_UBL2_3	992	996	PF12436	0.625
DOC_WW_Pin1_4	118	123	PF00397	0.706
DOC_WW_Pin1_4	130	135	PF00397	0.694
DOC_WW_Pin1_4	164	169	PF00397	0.637
DOC_WW_Pin1_4	256	261	PF00397	0.619
DOC_WW_Pin1_4	42	47	PF00397	0.664
DOC_WW_Pin1_4	479	484	PF00397	0.562
DOC_WW_Pin1_4	840	845	PF00397	0.650
LIG_14-3-3_CanoR_1	127	133	PF00244	0.789
LIG_14-3-3_CanoR_1	336	346	PF00244	0.635
LIG_14-3-3_CanoR_1	643	651	PF00244	0.569
LIG_14-3-3_CanoR_1	704	709	PF00244	0.542
LIG_14-3-3_CanoR_1	774	783	PF00244	0.589
LIG_14-3-3_CanoR_1	84	91	PF00244	0.592
LIG_14-3-3_CanoR_1	919	923	PF00244	0.532
LIG_14-3-3_CanoR_1	972	981	PF00244	0.567
LIG_Actin_WH2_2	270	288	PF00022	0.583
LIG_Actin_WH2_2	380	397	PF00022	0.600
LIG_Actin_WH2_2	967	984	PF00022	0.602
LIG_BRCT_BRCA1_1	447	451	PF00533	0.616
LIG_BRCT_BRCA1_1	628	632	PF00533	0.725
LIG_BRCT_BRCA1_1	647	651	PF00533	0.464
LIG_CORNRBOX	393	401	PF00104	0.531
LIG_FHA_1	134	140	PF00498	0.740
LIG_FHA_1	156	162	PF00498	0.671
LIG_FHA_1	177	183	PF00498	0.631
LIG_FHA_1	25	31	PF00498	0.348
LIG_FHA_1	462	468	PF00498	0.666
LIG_FHA_1	47	53	PF00498	0.606
LIG_FHA_1	493	499	PF00498	0.590
LIG_FHA_1	607	613	PF00498	0.621
LIG_FHA_1	634	640	PF00498	0.636
LIG_FHA_1	731	737	PF00498	0.599
LIG_FHA_1	910	916	PF00498	0.637
LIG_FHA_1	945	951	PF00498	0.592
LIG_FHA_1	966	972	PF00498	0.532
LIG_FHA_2	1035	1041	PF00498	0.583
LIG_FHA_2	1071	1077	PF00498	0.749
LIG_FHA_2	1122	1128	PF00498	0.632
LIG_FHA_2	1155	1161	PF00498	0.688
LIG_FHA_2	179	185	PF00498	0.696
LIG_FHA_2	188	194	PF00498	0.549
LIG_FHA_2	339	345	PF00498	0.566
LIG_FHA_2	436	442	PF00498	0.660
LIG_FHA_2	506	512	PF00498	0.660
LIG_FHA_2	535	541	PF00498	0.689
LIG_FHA_2	574	580	PF00498	0.731
LIG_FHA_2	684	690	PF00498	0.668
LIG_FHA_2	745	751	PF00498	0.632
LIG_FHA_2	810	816	PF00498	0.730
LIG_FHA_2	84	90	PF00498	0.619
LIG_FHA_2	934	940	PF00498	0.663
LIG_LIR_Gen_1	1020	1029	PF02991	0.621
LIG_LIR_Gen_1	184	193	PF02991	0.643
LIG_LIR_Gen_1	251	260	PF02991	0.525
LIG_LIR_Gen_1	269	278	PF02991	0.534
LIG_LIR_Gen_1	304	312	PF02991	0.490
LIG_LIR_Gen_1	561	572	PF02991	0.583
LIG_LIR_Gen_1	629	639	PF02991	0.568
LIG_LIR_Gen_1	648	657	PF02991	0.556
LIG_LIR_Gen_1	674	681	PF02991	0.618
LIG_LIR_Gen_1	731	738	PF02991	0.572
LIG_LIR_Nem_3	1017	1022	PF02991	0.633
LIG_LIR_Nem_3	149	155	PF02991	0.621
LIG_LIR_Nem_3	184	189	PF02991	0.638
LIG_LIR_Nem_3	251	256	PF02991	0.522
LIG_LIR_Nem_3	269	273	PF02991	0.547
LIG_LIR_Nem_3	27	31	PF02991	0.323
LIG_LIR_Nem_3	304	310	PF02991	0.590
LIG_LIR_Nem_3	561	567	PF02991	0.572
LIG_LIR_Nem_3	629	635	PF02991	0.581
LIG_LIR_Nem_3	648	654	PF02991	0.552
LIG_LIR_Nem_3	674	680	PF02991	0.617
LIG_MYND_3	769	773	PF01753	0.470
LIG_NRBOX	1113	1119	PF00104	0.694
LIG_PCNA_yPIPBox_3	485	496	PF02747	0.662
LIG_PCNA_yPIPBox_3	693	703	PF02747	0.571
LIG_PCNA_yPIPBox_3	996	1009	PF02747	0.594
LIG_PDZ_Class_1	1231	1236	PF00595	0.704
LIG_Pex14_2	148	152	PF04695	0.616
LIG_SH2_STAP1	1106	1110	PF00017	0.565
LIG_SH2_STAP1	1213	1217	PF00017	0.671
LIG_SH2_STAP1	1219	1223	PF00017	0.685
LIG_SH2_STAT3	556	559	PF00017	0.532
LIG_SH2_STAT5	1022	1025	PF00017	0.629
LIG_SH2_STAT5	178	181	PF00017	0.612
LIG_SH2_STAT5	556	559	PF00017	0.599
LIG_SH3_2	844	849	PF14604	0.596
LIG_SH3_3	1178	1184	PF00018	0.707
LIG_SH3_3	1203	1209	PF00018	0.636
LIG_SH3_3	131	137	PF00018	0.674
LIG_SH3_3	206	212	PF00018	0.675
LIG_SH3_3	339	345	PF00018	0.623
LIG_SH3_3	375	381	PF00018	0.581
LIG_SH3_3	425	431	PF00018	0.595
LIG_SH3_3	477	483	PF00018	0.602
LIG_SH3_3	841	847	PF00018	0.601
LIG_SUMO_SIM_anti_2	1040	1046	PF11976	0.605
LIG_SUMO_SIM_anti_2	113	119	PF11976	0.630
LIG_SUMO_SIM_anti_2	383	388	PF11976	0.594
LIG_SUMO_SIM_anti_2	938	945	PF11976	0.648
LIG_SUMO_SIM_par_1	113	119	PF11976	0.664
LIG_SUMO_SIM_par_1	432	438	PF11976	0.634
LIG_TRAF2_1	1046	1049	PF00917	0.669
LIG_TRAF2_1	1087	1090	PF00917	0.596
LIG_TRAF2_1	1100	1103	PF00917	0.640
LIG_TRAF2_1	238	241	PF00917	0.626
LIG_TRAF2_1	410	413	PF00917	0.623
LIG_TRAF2_1	576	579	PF00917	0.729
LIG_TRAF2_1	687	690	PF00917	0.599
LIG_TRAF2_1	712	715	PF00917	0.694
LIG_TRAF2_1	868	871	PF00917	0.639
LIG_UBA3_1	1041	1045	PF00899	0.490
LIG_WRC_WIRS_1	183	188	PF05994	0.520
MOD_CDK_SPK_2	118	123	PF00069	0.662
MOD_CDK_SPK_2	130	135	PF00069	0.665
MOD_CK1_1	1175	1181	PF00069	0.539
MOD_CK1_1	118	124	PF00069	0.716
MOD_CK1_1	1207	1213	PF00069	0.756
MOD_CK1_1	130	136	PF00069	0.669
MOD_CK1_1	164	170	PF00069	0.592
MOD_CK1_1	337	343	PF00069	0.449
MOD_CK1_1	675	681	PF00069	0.553
MOD_CK1_1	683	689	PF00069	0.516
MOD_CK1_1	707	713	PF00069	0.460
MOD_CK1_1	965	971	PF00069	0.495
MOD_CK2_1	1011	1017	PF00069	0.395
MOD_CK2_1	1034	1040	PF00069	0.555
MOD_CK2_1	1043	1049	PF00069	0.540
MOD_CK2_1	1070	1076	PF00069	0.619
MOD_CK2_1	1096	1102	PF00069	0.693
MOD_CK2_1	1154	1160	PF00069	0.602
MOD_CK2_1	140	146	PF00069	0.609
MOD_CK2_1	164	170	PF00069	0.580
MOD_CK2_1	178	184	PF00069	0.427
MOD_CK2_1	187	193	PF00069	0.517
MOD_CK2_1	318	324	PF00069	0.560
MOD_CK2_1	337	343	PF00069	0.520
MOD_CK2_1	401	407	PF00069	0.462
MOD_CK2_1	534	540	PF00069	0.612
MOD_CK2_1	573	579	PF00069	0.673
MOD_CK2_1	683	689	PF00069	0.602
MOD_CK2_1	709	715	PF00069	0.645
MOD_CK2_1	809	815	PF00069	0.726
MOD_CK2_1	933	939	PF00069	0.528
MOD_CK2_1	942	948	PF00069	0.429
MOD_CK2_1	992	998	PF00069	0.524
MOD_DYRK1A_RPxSP_1	840	844	PF00069	0.453
MOD_GlcNHglycan	1031	1034	PF01048	0.517
MOD_GlcNHglycan	1079	1082	PF01048	0.599
MOD_GlcNHglycan	1099	1102	PF01048	0.754
MOD_GlcNHglycan	1144	1147	PF01048	0.585
MOD_GlcNHglycan	118	121	PF01048	0.642
MOD_GlcNHglycan	1200	1203	PF01048	0.713
MOD_GlcNHglycan	1206	1209	PF01048	0.738
MOD_GlcNHglycan	1210	1213	PF01048	0.752
MOD_GlcNHglycan	1233	1236	PF01048	0.714
MOD_GlcNHglycan	142	145	PF01048	0.678
MOD_GlcNHglycan	163	166	PF01048	0.557
MOD_GlcNHglycan	295	298	PF01048	0.357
MOD_GlcNHglycan	320	323	PF01048	0.627
MOD_GlcNHglycan	455	458	PF01048	0.633
MOD_GlcNHglycan	711	714	PF01048	0.624
MOD_GlcNHglycan	739	743	PF01048	0.551
MOD_GlcNHglycan	796	800	PF01048	0.671
MOD_GlcNHglycan	802	806	PF01048	0.587
MOD_GlcNHglycan	866	869	PF01048	0.409
MOD_GlcNHglycan	897	900	PF01048	0.627
MOD_GlcNHglycan	952	955	PF01048	0.492
MOD_GlcNHglycan	983	986	PF01048	0.694
MOD_GSK3_1	1043	1050	PF00069	0.487
MOD_GSK3_1	1168	1175	PF00069	0.529
MOD_GSK3_1	1204	1211	PF00069	0.729
MOD_GSK3_1	1226	1233	PF00069	0.708
MOD_GSK3_1	123	130	PF00069	0.623
MOD_GSK3_1	133	140	PF00069	0.688
MOD_GSK3_1	178	185	PF00069	0.647
MOD_GSK3_1	334	341	PF00069	0.424
MOD_GSK3_1	40	47	PF00069	0.565
MOD_GSK3_1	534	541	PF00069	0.763
MOD_GSK3_1	617	624	PF00069	0.542
MOD_GSK3_1	633	640	PF00069	0.577
MOD_GSK3_1	671	678	PF00069	0.487
MOD_GSK3_1	938	945	PF00069	0.512
MOD_GSK3_1	950	957	PF00069	0.453
MOD_N-GLC_1	626	631	PF02516	0.554
MOD_N-GLC_1	64	69	PF02516	0.378
MOD_NEK2_1	1001	1006	PF00069	0.433
MOD_NEK2_1	1043	1048	PF00069	0.504
MOD_NEK2_1	116	121	PF00069	0.509
MOD_NEK2_1	155	160	PF00069	0.597
MOD_NEK2_1	182	187	PF00069	0.573
MOD_NEK2_1	318	323	PF00069	0.719
MOD_NEK2_1	389	394	PF00069	0.333
MOD_NEK2_1	462	467	PF00069	0.492
MOD_NEK2_1	492	497	PF00069	0.443
MOD_NEK2_1	633	638	PF00069	0.464
MOD_NEK2_1	673	678	PF00069	0.530
MOD_NEK2_1	823	828	PF00069	0.350
MOD_NEK2_1	83	88	PF00069	0.535
MOD_NEK2_1	918	923	PF00069	0.432
MOD_NEK2_1	981	986	PF00069	0.631
MOD_PIKK_1	1168	1174	PF00454	0.605
MOD_PIKK_1	534	540	PF00454	0.533
MOD_PIKK_1	543	549	PF00454	0.730
MOD_PIKK_1	774	780	PF00454	0.450
MOD_PIKK_1	809	815	PF00454	0.569
MOD_PKA_1	127	133	PF00069	0.679
MOD_PKA_1	543	549	PF00069	0.608
MOD_PKA_2	110	116	PF00069	0.399
MOD_PKA_2	127	133	PF00069	0.659
MOD_PKA_2	401	407	PF00069	0.438
MOD_PKA_2	543	549	PF00069	0.733
MOD_PKA_2	83	89	PF00069	0.487
MOD_PKA_2	918	924	PF00069	0.427
MOD_PKA_2	981	987	PF00069	0.653
MOD_PKB_1	1068	1076	PF00069	0.635
MOD_Plk_1	230	236	PF00069	0.624
MOD_Plk_1	64	70	PF00069	0.363
MOD_Plk_1	730	736	PF00069	0.532
MOD_Plk_1	738	744	PF00069	0.420
MOD_Plk_1	938	944	PF00069	0.524
MOD_Plk_2-3	1121	1127	PF00069	0.550
MOD_Plk_2-3	573	579	PF00069	0.686
MOD_Plk_4	1047	1053	PF00069	0.488
MOD_Plk_4	110	116	PF00069	0.526
MOD_Plk_4	178	184	PF00069	0.515
MOD_Plk_4	196	202	PF00069	0.415
MOD_Plk_4	389	395	PF00069	0.477
MOD_Plk_4	462	468	PF00069	0.476
MOD_Plk_4	603	609	PF00069	0.554
MOD_Plk_4	731	737	PF00069	0.526
MOD_Plk_4	78	84	PF00069	0.411
MOD_Plk_4	876	882	PF00069	0.439
MOD_Plk_4	938	944	PF00069	0.560
MOD_ProDKin_1	118	124	PF00069	0.650
MOD_ProDKin_1	130	136	PF00069	0.628
MOD_ProDKin_1	164	170	PF00069	0.546
MOD_ProDKin_1	256	262	PF00069	0.520
MOD_ProDKin_1	42	48	PF00069	0.583
MOD_ProDKin_1	479	485	PF00069	0.440
MOD_ProDKin_1	840	846	PF00069	0.567
MOD_SUMO_for_1	458	461	PF00179	0.496
MOD_SUMO_rev_2	1220	1229	PF00179	0.630
MOD_SUMO_rev_2	573	583	PF00179	0.531
TRG_DiLeu_BaEn_1	764	769	PF01217	0.462
TRG_DiLeu_BaLyEn_6	1021	1026	PF01217	0.450
TRG_DiLeu_BaLyEn_6	295	300	PF01217	0.491
TRG_ENDOCYTIC_2	1022	1025	PF00928	0.539
TRG_ER_diArg_1	312	315	PF00400	0.358
TRG_ER_diArg_1	587	590	PF00400	0.527
TRG_ER_diArg_1	642	644	PF00400	0.537
TRG_ER_diArg_1	881	883	PF00400	0.547
TRG_ER_diArg_1	918	920	PF00400	0.464
TRG_NES_CRM1_1	1127	1141	PF08389	0.488
TRG_NES_CRM1_1	385	399	PF08389	0.396
TRG_NES_CRM1_1	689	701	PF08389	0.325
TRG_Pf-PMV_PEXEL_1	1045	1049	PF00026	0.515
TRG_Pf-PMV_PEXEL_1	1056	1060	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	395	399	PF00026	0.506
TRG_Pf-PMV_PEXEL_1	644	649	PF00026	0.505
TRG_Pf-PMV_PEXEL_1	693	697	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	972	976	PF00026	0.476

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J6	Leptomonas seymouri	43%	99%
A0A1X0P9W2	Trypanosomatidae	24%	76%
A0A3Q8IBP4	Leishmania donovani	89%	100%
A0A3R7MCK0	Trypanosoma rangeli	24%	77%
A4HHR1	Leishmania braziliensis	66%	100%
A4I4T9	Leishmania infantum	89%	100%
E9AEC5	Leishmania major	88%	100%
V5C230	Trypanosoma cruzi	24%	78%