SAM domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 24

Species:

Leishmania mexicana

UniProt:

E9ALG1_LEIMU

TriTrypDb:

LmxM.08_29.2630

Length:

1236

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Show entries

Cellular components
Term	Name	Level	Count
GO:0005741	mitochondrial outer membrane	5	1
GO:0016020	membrane	2	5
GO:0019867	outer membrane	3	1
GO:0031090	organelle membrane	3	1
GO:0031966	mitochondrial membrane	4	1
GO:0031968	organelle outer membrane	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	5

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Expansion

Sequence features

E9ALG1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALG1

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1076	1080	PF00656	0.630
CLV_C14_Caspase3-7	1141	1145	PF00656	0.605
CLV_C14_Caspase3-7	1147	1151	PF00656	0.602
CLV_C14_Caspase3-7	1185	1189	PF00656	0.744
CLV_C14_Caspase3-7	1221	1225	PF00656	0.596
CLV_NRD_NRD_1	127	129	PF00675	0.525
CLV_NRD_NRD_1	300	302	PF00675	0.369
CLV_NRD_NRD_1	35	37	PF00675	0.441
CLV_NRD_NRD_1	579	581	PF00675	0.410
CLV_NRD_NRD_1	643	645	PF00675	0.436

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J6	Leptomonas seymouri	43%	99%
A0A1X0P9W2	Trypanosomatidae	24%	76%
A0A3Q8IBP4	Leishmania donovani	89%	100%
A0A3R7MCK0	Trypanosoma rangeli	24%	77%
A4HHR1	Leishmania braziliensis	66%	100%
A4I4T9	Leishmania infantum	89%	100%
E9AEC5	Leishmania major	88%	100%
V5C230	Trypanosoma cruzi	24%	78%

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