Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALG0_LEIMU

TriTrypDb:

LmxM.08_29.2640

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALG0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALG0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	24	26	PF00675	0.408
CLV_NRD_NRD_1	422	424	PF00675	0.370
CLV_NRD_NRD_1	86	88	PF00675	0.271
CLV_PCSK_KEX2_1	422	424	PF00082	0.372
CLV_PCSK_SKI1_1	175	179	PF00082	0.399
CLV_PCSK_SKI1_1	260	264	PF00082	0.282
CLV_PCSK_SKI1_1	318	322	PF00082	0.296
CLV_PCSK_SKI1_1	400	404	PF00082	0.331
CLV_Separin_Metazoa	84	88	PF03568	0.241
DEG_APCC_DBOX_1	86	94	PF00400	0.222
DEG_SCF_SKP2-CKS1_1	212	219	PF00560	0.385
DOC_CYCLIN_RxL_1	420	429	PF00134	0.354
DOC_MAPK_DCC_7	87	95	PF00069	0.293
DOC_MAPK_gen_1	334	343	PF00069	0.375
DOC_MAPK_gen_1	347	354	PF00069	0.509
DOC_MAPK_gen_1	87	95	PF00069	0.308
DOC_MAPK_MEF2A_6	129	137	PF00069	0.263
DOC_MAPK_MEF2A_6	292	299	PF00069	0.368
DOC_MAPK_MEF2A_6	347	354	PF00069	0.357
DOC_MAPK_MEF2A_6	87	95	PF00069	0.400
DOC_PP1_RVXF_1	421	428	PF00149	0.461
DOC_PP2B_LxvP_1	197	200	PF13499	0.348
DOC_USP7_MATH_1	147	151	PF00917	0.509
DOC_USP7_MATH_1	202	206	PF00917	0.328
DOC_USP7_MATH_1	374	378	PF00917	0.502
DOC_WW_Pin1_4	213	218	PF00397	0.498
DOC_WW_Pin1_4	42	47	PF00397	0.387
LIG_14-3-3_CanoR_1	230	235	PF00244	0.543
LIG_14-3-3_CanoR_1	260	268	PF00244	0.306
LIG_14-3-3_CanoR_1	336	343	PF00244	0.523
LIG_14-3-3_CanoR_1	391	399	PF00244	0.433
LIG_14-3-3_CanoR_1	75	83	PF00244	0.470
LIG_Actin_WH2_2	383	399	PF00022	0.505
LIG_BIR_II_1	1	5	PF00653	0.535
LIG_CaM_IQ_9	222	238	PF13499	0.372
LIG_DLG_GKlike_1	230	238	PF00625	0.326
LIG_FAT_LD_1	48	56	PF03623	0.439
LIG_FHA_1	219	225	PF00498	0.446
LIG_FHA_1	270	276	PF00498	0.402
LIG_FHA_1	319	325	PF00498	0.297
LIG_FHA_1	336	342	PF00498	0.490
LIG_FHA_1	346	352	PF00498	0.403
LIG_FHA_1	378	384	PF00498	0.474
LIG_FHA_1	401	407	PF00498	0.430
LIG_FHA_1	64	70	PF00498	0.498
LIG_FHA_2	230	236	PF00498	0.391
LIG_FHA_2	427	433	PF00498	0.353
LIG_FHA_2	79	85	PF00498	0.412
LIG_GBD_Chelix_1	203	211	PF00786	0.323
LIG_LIR_Gen_1	239	248	PF02991	0.366
LIG_LIR_Gen_1	296	303	PF02991	0.445
LIG_LIR_Gen_1	359	368	PF02991	0.514
LIG_LIR_Nem_3	183	189	PF02991	0.467
LIG_LIR_Nem_3	239	244	PF02991	0.393
LIG_LIR_Nem_3	296	302	PF02991	0.357
LIG_LIR_Nem_3	359	363	PF02991	0.463
LIG_PDZ_Class_2	436	441	PF00595	0.546
LIG_Pex14_1	431	435	PF04695	0.326
LIG_Pex14_2	427	431	PF04695	0.429
LIG_SH2_CRK	43	47	PF00017	0.379
LIG_SH2_GRB2like	368	371	PF00017	0.472
LIG_SH2_NCK_1	368	372	PF00017	0.478
LIG_SH2_STAP1	73	77	PF00017	0.505
LIG_SH2_STAT3	223	226	PF00017	0.365
LIG_SH2_STAT5	11	14	PF00017	0.529
LIG_SH2_STAT5	223	226	PF00017	0.365
LIG_SH2_STAT5	356	359	PF00017	0.437
LIG_SH2_STAT5	368	371	PF00017	0.552
LIG_SH2_STAT5	420	423	PF00017	0.409
LIG_SH2_STAT5	426	429	PF00017	0.330
LIG_SH3_3	55	61	PF00018	0.439
LIG_SUMO_SIM_anti_2	245	253	PF11976	0.451
LIG_SUMO_SIM_anti_2	272	277	PF11976	0.340
LIG_SUMO_SIM_anti_2	348	355	PF11976	0.334
LIG_SUMO_SIM_par_1	110	116	PF11976	0.487
LIG_SUMO_SIM_par_1	348	355	PF11976	0.353
LIG_SUMO_SIM_par_1	405	411	PF11976	0.384
LIG_SUMO_SIM_par_1	91	97	PF11976	0.398
LIG_TRAF2_1	61	64	PF00917	0.552
LIG_TRAF2_1	77	80	PF00917	0.295
LIG_Vh1_VBS_1	375	393	PF01044	0.390
LIG_WRC_WIRS_1	203	208	PF05994	0.373
MOD_CDK_SPxK_1	213	219	PF00069	0.385
MOD_CK1_1	169	175	PF00069	0.377
MOD_CK1_1	210	216	PF00069	0.531
MOD_CK1_1	325	331	PF00069	0.496
MOD_CK1_1	377	383	PF00069	0.322
MOD_CK1_1	78	84	PF00069	0.503
MOD_CK2_1	229	235	PF00069	0.383
MOD_CK2_1	339	345	PF00069	0.545
MOD_CK2_1	426	432	PF00069	0.356
MOD_CK2_1	78	84	PF00069	0.491
MOD_GlcNHglycan	145	148	PF01048	0.596
MOD_GlcNHglycan	171	174	PF01048	0.455
MOD_GlcNHglycan	304	308	PF01048	0.530
MOD_GlcNHglycan	324	327	PF01048	0.217
MOD_GlcNHglycan	75	78	PF01048	0.394
MOD_GSK3_1	139	146	PF00069	0.482
MOD_GSK3_1	165	172	PF00069	0.415
MOD_GSK3_1	318	325	PF00069	0.336
MOD_GSK3_1	335	342	PF00069	0.427
MOD_GSK3_1	377	384	PF00069	0.242
MOD_N-GLC_1	169	174	PF02516	0.458
MOD_N-GLC_1	277	282	PF02516	0.412
MOD_N-GLC_1	369	374	PF02516	0.470
MOD_NEK2_1	113	118	PF00069	0.339
MOD_NEK2_1	143	148	PF00069	0.417
MOD_NEK2_1	165	170	PF00069	0.453
MOD_NEK2_1	224	229	PF00069	0.514
MOD_NEK2_1	302	307	PF00069	0.484
MOD_NEK2_1	363	368	PF00069	0.478
MOD_NEK2_1	51	56	PF00069	0.466
MOD_NEK2_1	94	99	PF00069	0.383
MOD_PIKK_1	260	266	PF00454	0.538
MOD_PIKK_1	325	331	PF00454	0.336
MOD_PIKK_1	363	369	PF00454	0.441
MOD_PIKK_1	75	81	PF00454	0.382
MOD_PKA_2	229	235	PF00069	0.379
MOD_PKA_2	335	341	PF00069	0.551
MOD_PKA_2	5	11	PF00069	0.648
MOD_Plk_1	189	195	PF00069	0.318
MOD_Plk_1	277	283	PF00069	0.435
MOD_Plk_2-3	339	345	PF00069	0.271
MOD_Plk_4	189	195	PF00069	0.428
MOD_Plk_4	202	208	PF00069	0.466
MOD_Plk_4	219	225	PF00069	0.374
MOD_ProDKin_1	213	219	PF00069	0.499
MOD_ProDKin_1	42	48	PF00069	0.370
MOD_SUMO_rev_2	394	399	PF00179	0.431
MOD_SUMO_rev_2	57	66	PF00179	0.515
MOD_SUMO_rev_2	76	83	PF00179	0.283
TRG_DiLeu_BaEn_1	359	364	PF01217	0.382
TRG_DiLeu_BaLyEn_6	89	94	PF01217	0.448
TRG_ER_diArg_1	31	34	PF00400	0.500
TRG_ER_diArg_1	347	350	PF00400	0.480
TRG_ER_diArg_1	421	423	PF00400	0.370
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.282
TRG_Pf-PMV_PEXEL_1	292	296	PF00026	0.210

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y5	Leptomonas seymouri	50%	96%
A0A0S4IKI5	Bodo saltans	29%	97%
A0A1X0P918	Trypanosomatidae	36%	95%
A0A3Q8IFJ3	Leishmania donovani	91%	100%
A0A3R7K871	Trypanosoma rangeli	38%	100%
A4HHR2	Leishmania braziliensis	78%	100%
A4I4X2	Leishmania infantum	91%	100%
C9ZKY1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AEC6	Leishmania major	90%	100%
V5BSL0	Trypanosoma cruzi	38%	100%