LeishMANIAdb
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FYVE-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
FYVE-type domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ALF6_LEIMU
TriTrypDb:
LmxM.08_29.2680
Length:
1083

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9ALF6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALF6

Function

Biological processes
Term Name Level Count
GO:0007165 signal transduction 2 7
GO:0009987 cellular process 1 7
GO:0050789 regulation of biological process 2 7
GO:0050794 regulation of cellular process 3 7
GO:0065007 biological regulation 1 7
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 7
GO:0004112 cyclic-nucleotide phosphodiesterase activity 6 7
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity 7 7
GO:0005488 binding 1 7
GO:0008081 phosphoric diester hydrolase activity 5 7
GO:0016787 hydrolase activity 2 7
GO:0016788 hydrolase activity, acting on ester bonds 3 7
GO:0042578 phosphoric ester hydrolase activity 4 7
GO:0043167 ion binding 2 7
GO:0043169 cation binding 3 7
GO:0046872 metal ion binding 4 7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 130 134 PF00656 0.649
CLV_MEL_PAP_1 570 576 PF00089 0.467
CLV_NRD_NRD_1 1006 1008 PF00675 0.627
CLV_NRD_NRD_1 186 188 PF00675 0.682
CLV_NRD_NRD_1 69 71 PF00675 0.443
CLV_NRD_NRD_1 893 895 PF00675 0.689
CLV_NRD_NRD_1 970 972 PF00675 0.613
CLV_PCSK_KEX2_1 1005 1007 PF00082 0.630
CLV_PCSK_KEX2_1 186 188 PF00082 0.682
CLV_PCSK_KEX2_1 193 195 PF00082 0.595
CLV_PCSK_KEX2_1 26 28 PF00082 0.411
CLV_PCSK_KEX2_1 352 354 PF00082 0.437
CLV_PCSK_KEX2_1 642 644 PF00082 0.411
CLV_PCSK_KEX2_1 970 972 PF00082 0.655
CLV_PCSK_PC1ET2_1 193 195 PF00082 0.470
CLV_PCSK_PC1ET2_1 26 28 PF00082 0.411
CLV_PCSK_PC1ET2_1 352 354 PF00082 0.437
CLV_PCSK_PC1ET2_1 642 644 PF00082 0.411
CLV_PCSK_SKI1_1 1007 1011 PF00082 0.621
CLV_PCSK_SKI1_1 1065 1069 PF00082 0.527
CLV_PCSK_SKI1_1 152 156 PF00082 0.561
CLV_PCSK_SKI1_1 26 30 PF00082 0.436
CLV_PCSK_SKI1_1 263 267 PF00082 0.577
CLV_PCSK_SKI1_1 378 382 PF00082 0.581
CLV_PCSK_SKI1_1 412 416 PF00082 0.429
CLV_PCSK_SKI1_1 487 491 PF00082 0.574
CLV_PCSK_SKI1_1 643 647 PF00082 0.229
CLV_PCSK_SKI1_1 868 872 PF00082 0.791
CLV_PCSK_SKI1_1 908 912 PF00082 0.613
CLV_PCSK_SKI1_1 919 923 PF00082 0.611
CLV_PCSK_SKI1_1 956 960 PF00082 0.585
CLV_Separin_Metazoa 418 422 PF03568 0.593
CLV_Separin_Metazoa 546 550 PF03568 0.309
CLV_Separin_Metazoa 953 957 PF03568 0.602
DEG_APCC_DBOX_1 454 462 PF00400 0.560
DEG_APCC_DBOX_1 486 494 PF00400 0.577
DEG_APCC_KENBOX_2 33 37 PF00400 0.411
DEG_SPOP_SBC_1 99 103 PF00917 0.650
DOC_CKS1_1 693 698 PF01111 0.513
DOC_CYCLIN_RxL_1 794 805 PF00134 0.436
DOC_MAPK_gen_1 436 443 PF00069 0.378
DOC_MAPK_HePTP_8 570 582 PF00069 0.550
DOC_MAPK_MEF2A_6 487 494 PF00069 0.626
DOC_MAPK_MEF2A_6 573 582 PF00069 0.549
DOC_MAPK_MEF2A_6 754 762 PF00069 0.513
DOC_PP1_RVXF_1 214 220 PF00149 0.460
DOC_PP1_RVXF_1 641 648 PF00149 0.411
DOC_PP4_FxxP_1 822 825 PF00568 0.411
DOC_PP4_FxxP_1 861 864 PF00568 0.542
DOC_USP7_MATH_1 163 167 PF00917 0.566
DOC_USP7_MATH_1 22 26 PF00917 0.319
DOC_USP7_MATH_1 363 367 PF00917 0.563
DOC_USP7_MATH_1 502 506 PF00917 0.791
DOC_USP7_MATH_1 657 661 PF00917 0.459
DOC_USP7_MATH_1 803 807 PF00917 0.513
DOC_USP7_MATH_1 878 882 PF00917 0.625
DOC_USP7_MATH_1 945 949 PF00917 0.555
DOC_WW_Pin1_4 692 697 PF00397 0.513
DOC_WW_Pin1_4 799 804 PF00397 0.513
DOC_WW_Pin1_4 836 841 PF00397 0.353
LIG_14-3-3_CanoR_1 27 31 PF00244 0.411
LIG_14-3-3_CanoR_1 588 592 PF00244 0.578
LIG_14-3-3_CanoR_1 728 733 PF00244 0.513
LIG_14-3-3_CanoR_1 807 812 PF00244 0.513
LIG_14-3-3_CanoR_1 842 848 PF00244 0.506
LIG_14-3-3_CanoR_1 991 999 PF00244 0.727
LIG_APCC_ABBA_1 582 587 PF00400 0.583
LIG_BIR_II_1 1 5 PF00653 0.580
LIG_BRCT_BRCA1_1 24 28 PF00533 0.319
LIG_BRCT_BRCA1_1 659 663 PF00533 0.513
LIG_BRCT_BRCA1_2 659 665 PF00533 0.436
LIG_CaM_NSCaTE_8 482 489 PF13499 0.681
LIG_deltaCOP1_diTrp_1 552 556 PF00928 0.490
LIG_DLG_GKlike_1 807 815 PF00625 0.513
LIG_FHA_1 1075 1081 PF00498 0.701
LIG_FHA_1 264 270 PF00498 0.671
LIG_FHA_1 343 349 PF00498 0.473
LIG_FHA_1 381 387 PF00498 0.382
LIG_FHA_1 693 699 PF00498 0.513
LIG_FHA_1 706 712 PF00498 0.382
LIG_FHA_1 819 825 PF00498 0.222
LIG_FHA_1 909 915 PF00498 0.619
LIG_FHA_1 944 950 PF00498 0.766
LIG_FHA_1 977 983 PF00498 0.674
LIG_FHA_2 404 410 PF00498 0.578
LIG_FHA_2 469 475 PF00498 0.586
LIG_FHA_2 525 531 PF00498 0.658
LIG_FHA_2 556 562 PF00498 0.476
LIG_FHA_2 636 642 PF00498 0.411
LIG_GBD_Chelix_1 988 996 PF00786 0.727
LIG_LIR_Apic_2 521 526 PF02991 0.607
LIG_LIR_Apic_2 734 739 PF02991 0.513
LIG_LIR_Apic_2 820 825 PF02991 0.411
LIG_LIR_Apic_2 858 864 PF02991 0.654
LIG_LIR_Gen_1 133 141 PF02991 0.424
LIG_LIR_Gen_1 218 226 PF02991 0.587
LIG_LIR_Gen_1 25 32 PF02991 0.461
LIG_LIR_Gen_1 555 562 PF02991 0.529
LIG_LIR_Gen_1 688 698 PF02991 0.355
LIG_LIR_Gen_1 712 721 PF02991 0.272
LIG_LIR_Nem_3 133 138 PF02991 0.433
LIG_LIR_Nem_3 218 222 PF02991 0.550
LIG_LIR_Nem_3 25 31 PF02991 0.461
LIG_LIR_Nem_3 531 537 PF02991 0.659
LIG_LIR_Nem_3 555 559 PF02991 0.586
LIG_LIR_Nem_3 669 675 PF02991 0.411
LIG_LIR_Nem_3 688 693 PF02991 0.411
LIG_LIR_Nem_3 712 716 PF02991 0.420
LIG_LYPXL_yS_3 534 537 PF13949 0.592
LIG_OCRL_FandH_1 724 736 PF00620 0.513
LIG_PALB2_WD40_1 478 486 PF16756 0.385
LIG_Pex14_1 479 483 PF04695 0.382
LIG_Pex14_2 818 822 PF04695 0.411
LIG_PTAP_UEV_1 56 61 PF05743 0.436
LIG_REV1ctd_RIR_1 28 37 PF16727 0.411
LIG_SH2_CRK 675 679 PF00017 0.521
LIG_SH2_GRB2like 610 613 PF00017 0.411
LIG_SH2_SRC 472 475 PF00017 0.655
LIG_SH2_STAP1 283 287 PF00017 0.663
LIG_SH2_STAP1 746 750 PF00017 0.513
LIG_SH2_STAT3 329 332 PF00017 0.564
LIG_SH2_STAT5 1037 1040 PF00017 0.734
LIG_SH2_STAT5 672 675 PF00017 0.358
LIG_SH2_STAT5 851 854 PF00017 0.602
LIG_SH3_1 797 803 PF00018 0.513
LIG_SH3_2 57 62 PF14604 0.436
LIG_SH3_3 1043 1049 PF00018 0.675
LIG_SH3_3 2 8 PF00018 0.496
LIG_SH3_3 54 60 PF00018 0.394
LIG_SH3_3 797 803 PF00018 0.411
LIG_SUMO_SIM_anti_2 133 140 PF11976 0.592
LIG_SUMO_SIM_anti_2 354 360 PF11976 0.358
LIG_TRAF2_1 113 116 PF00917 0.659
LIG_TRAF2_1 240 243 PF00917 0.702
LIG_TRAF2_1 471 474 PF00917 0.663
LIG_TRAF2_1 854 857 PF00917 0.639
LIG_TRAF2_1 981 984 PF00917 0.627
LIG_TYR_ITIM 532 537 PF00017 0.655
LIG_TYR_ITIM 673 678 PF00017 0.358
LIG_UBA3_1 633 642 PF00899 0.411
LIG_WRC_WIRS_1 819 824 PF05994 0.308
MOD_CDC14_SPxK_1 839 842 PF00782 0.513
MOD_CDK_SPxK_1 836 842 PF00069 0.513
MOD_CK1_1 109 115 PF00069 0.662
MOD_CK1_1 156 162 PF00069 0.520
MOD_CK1_1 47 53 PF00069 0.410
MOD_CK1_1 505 511 PF00069 0.748
MOD_CK1_1 802 808 PF00069 0.513
MOD_CK1_1 943 949 PF00069 0.683
MOD_CK1_1 990 996 PF00069 0.627
MOD_CK2_1 1068 1074 PF00069 0.707
MOD_CK2_1 109 115 PF00069 0.741
MOD_CK2_1 186 192 PF00069 0.577
MOD_CK2_1 194 200 PF00069 0.448
MOD_CK2_1 237 243 PF00069 0.615
MOD_CK2_1 268 274 PF00069 0.624
MOD_CK2_1 403 409 PF00069 0.578
MOD_CK2_1 468 474 PF00069 0.549
MOD_CK2_1 524 530 PF00069 0.666
MOD_CK2_1 555 561 PF00069 0.484
MOD_CK2_1 635 641 PF00069 0.411
MOD_CK2_1 728 734 PF00069 0.513
MOD_CK2_1 75 81 PF00069 0.573
MOD_CK2_1 878 884 PF00069 0.801
MOD_CK2_1 945 951 PF00069 0.651
MOD_CK2_1 978 984 PF00069 0.628
MOD_CMANNOS 479 482 PF00535 0.673
MOD_Cter_Amidation 184 187 PF01082 0.589
MOD_GlcNHglycan 1070 1073 PF01048 0.600
MOD_GlcNHglycan 1077 1080 PF01048 0.590
MOD_GlcNHglycan 111 114 PF01048 0.658
MOD_GlcNHglycan 155 158 PF01048 0.571
MOD_GlcNHglycan 16 19 PF01048 0.411
MOD_GlcNHglycan 165 168 PF01048 0.690
MOD_GlcNHglycan 196 199 PF01048 0.557
MOD_GlcNHglycan 365 368 PF01048 0.636
MOD_GlcNHglycan 49 52 PF01048 0.411
MOD_GlcNHglycan 504 507 PF01048 0.821
MOD_GlcNHglycan 807 810 PF01048 0.416
MOD_GlcNHglycan 943 946 PF01048 0.493
MOD_GSK3_1 159 166 PF00069 0.550
MOD_GSK3_1 218 225 PF00069 0.377
MOD_GSK3_1 22 29 PF00069 0.424
MOD_GSK3_1 242 249 PF00069 0.536
MOD_GSK3_1 251 258 PF00069 0.525
MOD_GSK3_1 293 300 PF00069 0.701
MOD_GSK3_1 395 402 PF00069 0.624
MOD_GSK3_1 43 50 PF00069 0.411
MOD_GSK3_1 501 508 PF00069 0.781
MOD_GSK3_1 664 671 PF00069 0.346
MOD_GSK3_1 799 806 PF00069 0.513
MOD_GSK3_1 868 875 PF00069 0.801
MOD_GSK3_1 930 937 PF00069 0.664
MOD_GSK3_1 940 947 PF00069 0.582
MOD_GSK3_1 974 981 PF00069 0.524
MOD_N-GLC_1 131 136 PF02516 0.574
MOD_N-GLC_1 513 518 PF02516 0.554
MOD_NEK2_1 100 105 PF00069 0.468
MOD_NEK2_1 153 158 PF00069 0.742
MOD_NEK2_1 222 227 PF00069 0.399
MOD_NEK2_1 251 256 PF00069 0.654
MOD_NEK2_1 362 367 PF00069 0.640
MOD_NEK2_1 43 48 PF00069 0.411
MOD_NEK2_1 465 470 PF00069 0.666
MOD_NEK2_1 513 518 PF00069 0.527
MOD_NEK2_1 597 602 PF00069 0.543
MOD_NEK2_1 668 673 PF00069 0.341
MOD_NEK2_1 698 703 PF00069 0.369
MOD_NEK2_1 818 823 PF00069 0.222
MOD_NEK2_1 855 860 PF00069 0.569
MOD_PIKK_1 403 409 PF00454 0.655
MOD_PIKK_1 75 81 PF00454 0.651
MOD_PIKK_1 934 940 PF00454 0.621
MOD_PKA_1 186 192 PF00069 0.467
MOD_PKA_1 26 32 PF00069 0.411
MOD_PKA_2 186 192 PF00069 0.583
MOD_PKA_2 26 32 PF00069 0.411
MOD_PKA_2 587 593 PF00069 0.576
MOD_PKA_2 75 81 PF00069 0.567
MOD_PKA_2 812 818 PF00069 0.222
MOD_PKA_2 984 990 PF00069 0.715
MOD_PKB_1 906 914 PF00069 0.598
MOD_Plk_1 131 137 PF00069 0.602
MOD_Plk_1 222 228 PF00069 0.483
MOD_Plk_1 293 299 PF00069 0.704
MOD_Plk_1 668 674 PF00069 0.405
MOD_Plk_1 900 906 PF00069 0.591
MOD_Plk_2-3 131 137 PF00069 0.644
MOD_Plk_2-3 218 224 PF00069 0.592
MOD_Plk_2-3 555 561 PF00069 0.586
MOD_Plk_2-3 742 748 PF00069 0.411
MOD_Plk_4 131 137 PF00069 0.620
MOD_Plk_4 268 274 PF00069 0.455
MOD_Plk_4 396 402 PF00069 0.368
MOD_Plk_4 524 530 PF00069 0.666
MOD_Plk_4 668 674 PF00069 0.329
MOD_Plk_4 721 727 PF00069 0.362
MOD_Plk_4 728 734 PF00069 0.367
MOD_Plk_4 756 762 PF00069 0.378
MOD_Plk_4 812 818 PF00069 0.222
MOD_Plk_4 930 936 PF00069 0.440
MOD_ProDKin_1 692 698 PF00069 0.513
MOD_ProDKin_1 799 805 PF00069 0.513
MOD_ProDKin_1 836 842 PF00069 0.353
MOD_SUMO_for_1 1067 1070 PF00179 0.716
MOD_SUMO_for_1 177 180 PF00179 0.656
MOD_SUMO_for_1 215 218 PF00179 0.670
MOD_SUMO_for_1 226 229 PF00179 0.481
MOD_SUMO_for_1 323 326 PF00179 0.374
MOD_SUMO_for_1 392 395 PF00179 0.676
MOD_SUMO_rev_2 103 112 PF00179 0.749
MOD_SUMO_rev_2 737 745 PF00179 0.492
TRG_DiLeu_BaEn_1 435 440 PF01217 0.664
TRG_DiLeu_BaEn_1 567 572 PF01217 0.605
TRG_DiLeu_BaEn_1 712 717 PF01217 0.513
TRG_DiLeu_BaEn_3 130 136 PF01217 0.432
TRG_DiLeu_BaEn_4 242 248 PF01217 0.598
TRG_ENDOCYTIC_2 534 537 PF00928 0.670
TRG_ENDOCYTIC_2 624 627 PF00928 0.411
TRG_ENDOCYTIC_2 675 678 PF00928 0.521
TRG_ER_diArg_1 1005 1007 PF00400 0.651
TRG_ER_diArg_1 186 188 PF00400 0.682
TRG_ER_diArg_1 970 972 PF00400 0.655
TRG_Pf-PMV_PEXEL_1 126 130 PF00026 0.688
TRG_Pf-PMV_PEXEL_1 186 190 PF00026 0.758
TRG_Pf-PMV_PEXEL_1 738 742 PF00026 0.411
TRG_Pf-PMV_PEXEL_1 919 923 PF00026 0.635

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I536 Leptomonas seymouri 41% 90%
A0A3S7X2S6 Leishmania donovani 88% 100%
A4HHS5 Leishmania braziliensis 72% 100%
A4I4X6 Leishmania infantum 87% 100%
E9AED0 Leishmania major 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS