Disabled homolog 1-like

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALF5_LEIMU

TriTrypDb:

LmxM.08_29.2690

Length:

309

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALF5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	5	7	PF00675	0.617
CLV_PCSK_SKI1_1	23	27	PF00082	0.734
DEG_Nend_UBRbox_2	1	3	PF02207	0.671
DEG_SPOP_SBC_1	170	174	PF00917	0.615
DEG_SPOP_SBC_1	181	185	PF00917	0.510
DOC_PP2B_LxvP_1	51	54	PF13499	0.626
DOC_PP4_FxxP_1	79	82	PF00568	0.672
DOC_PP4_MxPP_1	97	100	PF00568	0.629
DOC_USP7_MATH_1	114	118	PF00917	0.651
DOC_USP7_MATH_1	159	163	PF00917	0.583
DOC_USP7_MATH_1	170	174	PF00917	0.602
DOC_USP7_MATH_1	181	185	PF00917	0.583
DOC_USP7_MATH_1	216	220	PF00917	0.666
DOC_USP7_MATH_1	286	290	PF00917	0.680
DOC_WW_Pin1_4	108	113	PF00397	0.775
DOC_WW_Pin1_4	12	17	PF00397	0.511
DOC_WW_Pin1_4	142	147	PF00397	0.574
DOC_WW_Pin1_4	165	170	PF00397	0.609
DOC_WW_Pin1_4	185	190	PF00397	0.626
DOC_WW_Pin1_4	218	223	PF00397	0.636
DOC_WW_Pin1_4	269	274	PF00397	0.625
DOC_WW_Pin1_4	42	47	PF00397	0.479
DOC_WW_Pin1_4	68	73	PF00397	0.456
DOC_WW_Pin1_4	86	91	PF00397	0.679
LIG_AP2alpha_2	240	242	PF02296	0.547
LIG_BIR_III_2	34	38	PF00653	0.583
LIG_BRCT_BRCA1_1	191	195	PF00533	0.671
LIG_BRCT_BRCA1_1	26	30	PF00533	0.503
LIG_CSL_BTD_1	92	95	PF09270	0.582
LIG_EVH1_1	79	83	PF00568	0.621
LIG_FHA_1	170	176	PF00498	0.549
LIG_FHA_1	186	192	PF00498	0.636
LIG_FHA_1	294	300	PF00498	0.592
LIG_FHA_2	219	225	PF00498	0.581
LIG_LIR_Gen_1	224	232	PF02991	0.582
LIG_LIR_Gen_1	251	261	PF02991	0.451
LIG_LIR_Nem_3	251	256	PF02991	0.447
LIG_LYPXL_yS_3	64	67	PF13949	0.564
LIG_SH2_CRK	133	137	PF00017	0.518
LIG_SH2_CRK	253	257	PF00017	0.451
LIG_SH2_NCK_1	253	257	PF00017	0.632
LIG_SH2_NCK_1	262	266	PF00017	0.556
LIG_SH2_STAP1	171	175	PF00017	0.646
LIG_SH2_STAP1	262	266	PF00017	0.467
LIG_SH2_STAT3	115	118	PF00017	0.634
LIG_SH2_STAT3	60	63	PF00017	0.532
LIG_SH2_STAT5	115	118	PF00017	0.646
LIG_SH2_STAT5	171	174	PF00017	0.692
LIG_SH2_STAT5	253	256	PF00017	0.540
LIG_SH3_1	235	241	PF00018	0.536
LIG_SH3_3	10	16	PF00018	0.572
LIG_SH3_3	172	178	PF00018	0.581
LIG_SH3_3	203	209	PF00018	0.689
LIG_SH3_3	212	218	PF00018	0.608
LIG_SH3_3	226	232	PF00018	0.765
LIG_SH3_3	235	241	PF00018	0.611
LIG_SH3_3	77	83	PF00018	0.654
LIG_SH3_3	95	101	PF00018	0.564
MOD_CDK_SPK_2	12	17	PF00069	0.511
MOD_CDK_SPK_2	269	274	PF00069	0.625
MOD_CK1_1	251	257	PF00069	0.449
MOD_CK1_1	294	300	PF00069	0.590
MOD_CK1_1	52	58	PF00069	0.445
MOD_CK2_1	181	187	PF00069	0.561
MOD_CK2_1	218	224	PF00069	0.582
MOD_GlcNHglycan	161	164	PF01048	0.640
MOD_GlcNHglycan	199	202	PF01048	0.588
MOD_GlcNHglycan	256	259	PF01048	0.589
MOD_GlcNHglycan	26	29	PF01048	0.629
MOD_GlcNHglycan	305	309	PF01048	0.554
MOD_GSK3_1	165	172	PF00069	0.612
MOD_GSK3_1	181	188	PF00069	0.695
MOD_GSK3_1	197	204	PF00069	0.637
MOD_GSK3_1	248	255	PF00069	0.615
MOD_GSK3_1	26	33	PF00069	0.734
MOD_N-GLC_1	106	111	PF02516	0.659
MOD_N-GLC_1	201	206	PF02516	0.581
MOD_N-GLC_1	277	282	PF02516	0.508
MOD_NEK2_1	139	144	PF00069	0.588
MOD_NEK2_1	150	155	PF00069	0.608
MOD_NEK2_1	196	201	PF00069	0.620
MOD_NEK2_1	277	282	PF00069	0.508
MOD_PIKK_1	114	120	PF00454	0.640
MOD_PIKK_1	248	254	PF00454	0.558
MOD_PIKK_1	286	292	PF00454	0.689
MOD_Plk_1	106	112	PF00069	0.659
MOD_Plk_1	223	229	PF00069	0.657
MOD_Plk_1	267	273	PF00069	0.615
MOD_Plk_1	277	283	PF00069	0.565
MOD_Plk_4	294	300	PF00069	0.509
MOD_ProDKin_1	108	114	PF00069	0.773
MOD_ProDKin_1	12	18	PF00069	0.510
MOD_ProDKin_1	142	148	PF00069	0.575
MOD_ProDKin_1	165	171	PF00069	0.611
MOD_ProDKin_1	185	191	PF00069	0.624
MOD_ProDKin_1	218	224	PF00069	0.635
MOD_ProDKin_1	269	275	PF00069	0.626
MOD_ProDKin_1	42	48	PF00069	0.478
MOD_ProDKin_1	68	74	PF00069	0.456
MOD_ProDKin_1	86	92	PF00069	0.681
MOD_SUMO_rev_2	2	8	PF00179	0.604
TRG_DiLeu_BaEn_2	42	48	PF01217	0.478
TRG_ENDOCYTIC_2	128	131	PF00928	0.516
TRG_ENDOCYTIC_2	253	256	PF00928	0.449
TRG_ENDOCYTIC_2	64	67	PF00928	0.569

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCA0	Leptomonas seymouri	46%	99%
A0A3S7X2X0	Leishmania donovani	87%	100%
A4HHS6	Leishmania braziliensis	67%	100%
A4I4X7	Leishmania infantum	87%	100%
E9AED1	Leishmania major	87%	100%