RAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALF4_LEIMU

TriTrypDb:

LmxM.08_29.2700

Length:

992

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

E9ALF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALF4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.653
CLV_MEL_PAP_1	687	693	PF00089	0.393
CLV_NRD_NRD_1	102	104	PF00675	0.369
CLV_NRD_NRD_1	16	18	PF00675	0.385
CLV_NRD_NRD_1	325	327	PF00675	0.442
CLV_NRD_NRD_1	7	9	PF00675	0.479
CLV_NRD_NRD_1	739	741	PF00675	0.441
CLV_PCSK_KEX2_1	102	104	PF00082	0.369
CLV_PCSK_KEX2_1	16	18	PF00082	0.385
CLV_PCSK_KEX2_1	199	201	PF00082	0.469
CLV_PCSK_KEX2_1	209	211	PF00082	0.433
CLV_PCSK_KEX2_1	325	327	PF00082	0.413
CLV_PCSK_KEX2_1	519	521	PF00082	0.359
CLV_PCSK_KEX2_1	7	9	PF00082	0.479
CLV_PCSK_KEX2_1	739	741	PF00082	0.449
CLV_PCSK_KEX2_1	755	757	PF00082	0.454
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.440
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.394
CLV_PCSK_PC1ET2_1	519	521	PF00082	0.359
CLV_PCSK_PC1ET2_1	755	757	PF00082	0.423
CLV_PCSK_SKI1_1	106	110	PF00082	0.401
CLV_PCSK_SKI1_1	236	240	PF00082	0.435
CLV_PCSK_SKI1_1	275	279	PF00082	0.408
CLV_PCSK_SKI1_1	298	302	PF00082	0.421
CLV_PCSK_SKI1_1	496	500	PF00082	0.486
CLV_PCSK_SKI1_1	513	517	PF00082	0.315
CLV_PCSK_SKI1_1	526	530	PF00082	0.330
CLV_PCSK_SKI1_1	545	549	PF00082	0.303
CLV_PCSK_SKI1_1	557	561	PF00082	0.413
CLV_PCSK_SKI1_1	574	578	PF00082	0.280
CLV_PCSK_SKI1_1	7	11	PF00082	0.479
CLV_PCSK_SKI1_1	720	724	PF00082	0.393
CLV_PCSK_SKI1_1	920	924	PF00082	0.454
CLV_PCSK_SKI1_1	975	979	PF00082	0.476
CLV_Separin_Metazoa	380	384	PF03568	0.605
DEG_APCC_DBOX_1	235	243	PF00400	0.650
DEG_APCC_DBOX_1	573	581	PF00400	0.633
DEG_APCC_DBOX_1	672	680	PF00400	0.630
DEG_APCC_DBOX_1	79	87	PF00400	0.568
DEG_MDM2_SWIB_1	183	191	PF02201	0.606
DEG_Nend_Nbox_1	1	3	PF02207	0.766
DOC_ANK_TNKS_1	772	779	PF00023	0.690
DOC_CYCLIN_RxL_1	272	282	PF00134	0.644
DOC_CYCLIN_yCln2_LP_2	271	274	PF00134	0.641
DOC_CYCLIN_yCln2_LP_2	848	854	PF00134	0.522
DOC_MAPK_gen_1	102	111	PF00069	0.576
DOC_MAPK_gen_1	16	24	PF00069	0.598
DOC_MAPK_gen_1	243	252	PF00069	0.624
DOC_MAPK_gen_1	5	14	PF00069	0.673
DOC_MAPK_gen_1	519	527	PF00069	0.546
DOC_MAPK_gen_1	862	871	PF00069	0.345
DOC_MAPK_gen_1	917	926	PF00069	0.612
DOC_MAPK_MEF2A_6	520	529	PF00069	0.640
DOC_MAPK_MEF2A_6	862	871	PF00069	0.318
DOC_PP2B_LxvP_1	271	274	PF13499	0.565
DOC_PP2B_LxvP_1	762	765	PF13499	0.631
DOC_PP2B_LxvP_1	769	772	PF13499	0.626
DOC_PP4_FxxP_1	648	651	PF00568	0.672
DOC_USP7_MATH_1	110	114	PF00917	0.601
DOC_USP7_MATH_1	155	159	PF00917	0.600
DOC_USP7_MATH_1	176	180	PF00917	0.593
DOC_USP7_MATH_1	205	209	PF00917	0.636
DOC_USP7_MATH_1	261	265	PF00917	0.615
DOC_USP7_MATH_1	40	44	PF00917	0.771
DOC_USP7_MATH_1	537	541	PF00917	0.650
DOC_USP7_MATH_1	582	586	PF00917	0.634
DOC_USP7_MATH_1	748	752	PF00917	0.616
DOC_USP7_MATH_1	818	822	PF00917	0.586
DOC_USP7_MATH_1	852	856	PF00917	0.397
DOC_USP7_MATH_1	918	922	PF00917	0.659
DOC_USP7_MATH_1	95	99	PF00917	0.623
DOC_USP7_MATH_2	765	771	PF00917	0.667
DOC_USP7_UBL2_3	117	121	PF12436	0.450
DOC_WW_Pin1_4	230	235	PF00397	0.656
DOC_WW_Pin1_4	90	95	PF00397	0.619
LIG_14-3-3_CanoR_1	11	15	PF00244	0.652
LIG_14-3-3_CanoR_1	141	150	PF00244	0.598
LIG_14-3-3_CanoR_1	16	25	PF00244	0.686
LIG_14-3-3_CanoR_1	167	172	PF00244	0.548
LIG_14-3-3_CanoR_1	27	37	PF00244	0.766
LIG_14-3-3_CanoR_1	275	281	PF00244	0.569
LIG_14-3-3_CanoR_1	318	323	PF00244	0.583
LIG_14-3-3_CanoR_1	436	444	PF00244	0.463
LIG_14-3-3_CanoR_1	545	551	PF00244	0.598
LIG_14-3-3_CanoR_1	566	576	PF00244	0.651
LIG_14-3-3_CanoR_1	62	71	PF00244	0.568
LIG_14-3-3_CanoR_1	673	679	PF00244	0.612
LIG_14-3-3_CanoR_1	690	695	PF00244	0.533
LIG_14-3-3_CanoR_1	720	729	PF00244	0.482
LIG_14-3-3_CanoR_1	739	744	PF00244	0.646
LIG_14-3-3_CanoR_1	756	765	PF00244	0.626
LIG_14-3-3_CanoR_1	783	788	PF00244	0.506
LIG_14-3-3_CanoR_1	917	923	PF00244	0.609
LIG_14-3-3_CanoR_1	96	105	PF00244	0.588
LIG_APCC_ABBA_1	129	134	PF00400	0.628
LIG_BRCT_BRCA1_1	17	21	PF00533	0.667
LIG_BRCT_BRCA1_1	584	588	PF00533	0.510
LIG_BRCT_BRCA1_1	813	817	PF00533	0.616
LIG_BRCT_BRCA1_1	843	847	PF00533	0.444
LIG_Clathr_ClatBox_1	130	134	PF01394	0.423
LIG_deltaCOP1_diTrp_1	406	415	PF00928	0.590
LIG_EH1_1	375	383	PF00400	0.582
LIG_EH1_1	900	908	PF00400	0.602
LIG_EVH1_2	717	721	PF00568	0.630
LIG_FHA_1	360	366	PF00498	0.516
LIG_FHA_1	432	438	PF00498	0.589
LIG_FHA_1	458	464	PF00498	0.605
LIG_FHA_1	570	576	PF00498	0.579
LIG_FHA_1	777	783	PF00498	0.594
LIG_FHA_1	788	794	PF00498	0.550
LIG_FHA_2	280	286	PF00498	0.644
LIG_FHA_2	352	358	PF00498	0.655
LIG_FHA_2	611	617	PF00498	0.616
LIG_FHA_2	82	88	PF00498	0.623
LIG_GBD_Chelix_1	465	473	PF00786	0.383
LIG_GBD_Chelix_1	542	550	PF00786	0.413
LIG_Integrin_isoDGR_2	911	913	PF01839	0.239
LIG_LIR_Apic_2	646	651	PF02991	0.667
LIG_LIR_Apic_2	65	71	PF02991	0.597
LIG_LIR_Gen_1	18	28	PF02991	0.676
LIG_LIR_Gen_1	184	195	PF02991	0.648
LIG_LIR_Gen_1	703	711	PF02991	0.504
LIG_LIR_Gen_1	942	951	PF02991	0.579
LIG_LIR_Nem_3	18	24	PF02991	0.663
LIG_LIR_Nem_3	184	190	PF02991	0.664
LIG_LIR_Nem_3	424	430	PF02991	0.601
LIG_LIR_Nem_3	623	628	PF02991	0.603
LIG_LIR_Nem_3	703	707	PF02991	0.506
LIG_LIR_Nem_3	844	850	PF02991	0.485
LIG_LIR_Nem_3	855	861	PF02991	0.440
LIG_LIR_Nem_3	883	889	PF02991	0.477
LIG_LIR_Nem_3	929	934	PF02991	0.599
LIG_LIR_Nem_3	942	947	PF02991	0.403
LIG_NRBOX	292	298	PF00104	0.662
LIG_NRBOX	511	517	PF00104	0.601
LIG_NRBOX	682	688	PF00104	0.656
LIG_Pex14_2	183	187	PF04695	0.676
LIG_Pex14_2	662	666	PF04695	0.621
LIG_Rb_pABgroove_1	248	256	PF01858	0.654
LIG_REV1ctd_RIR_1	883	892	PF16727	0.558
LIG_RPA_C_Fungi	735	747	PF08784	0.541
LIG_SH2_CRK	809	813	PF00017	0.453
LIG_SH2_GRB2like	766	769	PF00017	0.528
LIG_SH2_NCK_1	454	458	PF00017	0.613
LIG_SH2_PTP2	68	71	PF00017	0.582
LIG_SH2_PTP2	877	880	PF00017	0.485
LIG_SH2_SRC	68	71	PF00017	0.582
LIG_SH2_STAP1	704	708	PF00017	0.468
LIG_SH2_STAP1	859	863	PF00017	0.536
LIG_SH2_STAP1	889	893	PF00017	0.502
LIG_SH2_STAT5	114	117	PF00017	0.512
LIG_SH2_STAT5	375	378	PF00017	0.370
LIG_SH2_STAT5	430	433	PF00017	0.514
LIG_SH2_STAT5	68	71	PF00017	0.582
LIG_SH2_STAT5	727	730	PF00017	0.394
LIG_SH2_STAT5	833	836	PF00017	0.335
LIG_SH2_STAT5	877	880	PF00017	0.446
LIG_SH3_1	325	331	PF00018	0.542
LIG_SH3_3	325	331	PF00018	0.557
LIG_SH3_3	34	40	PF00018	0.739
LIG_SH3_3	426	432	PF00018	0.536
LIG_SH3_3	636	642	PF00018	0.568
LIG_SH3_3	870	876	PF00018	0.357
LIG_SH3_3	930	936	PF00018	0.582
LIG_SUMO_SIM_anti_2	267	273	PF11976	0.566
LIG_SUMO_SIM_anti_2	484	490	PF11976	0.445
LIG_SUMO_SIM_par_1	167	173	PF11976	0.510
LIG_SxIP_EBH_1	343	356	PF03271	0.363
LIG_TRAF2_1	377	380	PF00917	0.512
LIG_TRFH_1	847	851	PF08558	0.401
LIG_TYR_ITIM	702	707	PF00017	0.528
LIG_TYR_ITIM	764	769	PF00017	0.541
LIG_WW_3	272	276	PF00397	0.526
LIG_WW_3	493	497	PF00397	0.511
MOD_CDC14_SPxK_1	93	96	PF00782	0.516
MOD_CDK_SPxK_1	230	236	PF00069	0.411
MOD_CDK_SPxK_1	90	96	PF00069	0.521
MOD_CK1_1	170	176	PF00069	0.518
MOD_CK1_1	265	271	PF00069	0.530
MOD_CK1_1	386	392	PF00069	0.528
MOD_CK1_1	43	49	PF00069	0.660
MOD_CK1_1	570	576	PF00069	0.555
MOD_CK1_1	677	683	PF00069	0.528
MOD_CK1_1	734	740	PF00069	0.557
MOD_CK1_1	751	757	PF00069	0.594
MOD_CK1_1	800	806	PF00069	0.536
MOD_CK1_1	840	846	PF00069	0.376
MOD_CK2_1	155	161	PF00069	0.537
MOD_CK2_1	191	197	PF00069	0.544
MOD_CK2_1	261	267	PF00069	0.428
MOD_CK2_1	279	285	PF00069	0.548
MOD_CK2_1	351	357	PF00069	0.576
MOD_CK2_1	610	616	PF00069	0.513
MOD_CK2_1	81	87	PF00069	0.476
MOD_GlcNHglycan	18	21	PF01048	0.678
MOD_GlcNHglycan	183	186	PF01048	0.531
MOD_GlcNHglycan	230	233	PF01048	0.443
MOD_GlcNHglycan	331	334	PF01048	0.544
MOD_GlcNHglycan	369	372	PF01048	0.455
MOD_GlcNHglycan	385	388	PF01048	0.400
MOD_GlcNHglycan	475	478	PF01048	0.479
MOD_GlcNHglycan	539	542	PF01048	0.516
MOD_GlcNHglycan	552	555	PF01048	0.432
MOD_GlcNHglycan	584	587	PF01048	0.440
MOD_GlcNHglycan	648	651	PF01048	0.436
MOD_GlcNHglycan	750	753	PF01048	0.517
MOD_GlcNHglycan	758	761	PF01048	0.508
MOD_GlcNHglycan	769	772	PF01048	0.263
MOD_GlcNHglycan	785	788	PF01048	0.521
MOD_GlcNHglycan	800	803	PF01048	0.530
MOD_GlcNHglycan	813	816	PF01048	0.411
MOD_GlcNHglycan	818	821	PF01048	0.270
MOD_GlcNHglycan	843	846	PF01048	0.338
MOD_GlcNHglycan	852	855	PF01048	0.477
MOD_GlcNHglycan	894	897	PF01048	0.568
MOD_GlcNHglycan	980	983	PF01048	0.608
MOD_GSK3_1	141	148	PF00069	0.525
MOD_GSK3_1	261	268	PF00069	0.463
MOD_GSK3_1	279	286	PF00069	0.530
MOD_GSK3_1	314	321	PF00069	0.449
MOD_GSK3_1	457	464	PF00069	0.543
MOD_GSK3_1	537	544	PF00069	0.519
MOD_GSK3_1	546	553	PF00069	0.532
MOD_GSK3_1	674	681	PF00069	0.508
MOD_GSK3_1	731	738	PF00069	0.430
MOD_GSK3_1	778	785	PF00069	0.558
MOD_GSK3_1	837	844	PF00069	0.373
MOD_GSK3_1	850	857	PF00069	0.352
MOD_N-GLC_1	407	412	PF02516	0.502
MOD_N-GLC_1	461	466	PF02516	0.474
MOD_N-GLC_1	767	772	PF02516	0.563
MOD_NEK2_1	1	6	PF00069	0.582
MOD_NEK2_1	10	15	PF00069	0.507
MOD_NEK2_1	313	318	PF00069	0.406
MOD_NEK2_1	344	349	PF00069	0.458
MOD_NEK2_1	359	364	PF00069	0.465
MOD_NEK2_1	381	386	PF00069	0.535
MOD_NEK2_1	407	412	PF00069	0.435
MOD_NEK2_1	413	418	PF00069	0.422
MOD_NEK2_1	473	478	PF00069	0.452
MOD_NEK2_1	503	508	PF00069	0.498
MOD_NEK2_1	546	551	PF00069	0.564
MOD_NEK2_1	589	594	PF00069	0.436
MOD_NEK2_1	610	615	PF00069	0.505
MOD_NEK2_1	678	683	PF00069	0.483
MOD_NEK2_1	710	715	PF00069	0.483
MOD_NEK2_1	723	728	PF00069	0.446
MOD_NEK2_1	816	821	PF00069	0.431
MOD_NEK2_1	880	885	PF00069	0.394
MOD_NEK2_1	89	94	PF00069	0.443
MOD_NEK2_1	949	954	PF00069	0.510
MOD_NEK2_2	508	513	PF00069	0.389
MOD_NEK2_2	778	783	PF00069	0.586
MOD_NEK2_2	918	923	PF00069	0.585
MOD_PIKK_1	141	147	PF00454	0.493
MOD_PK_1	167	173	PF00069	0.425
MOD_PK_1	318	324	PF00069	0.236
MOD_PK_1	690	696	PF00069	0.391
MOD_PK_1	739	745	PF00069	0.513
MOD_PKA_1	16	22	PF00069	0.500
MOD_PKA_1	739	745	PF00069	0.550
MOD_PKA_2	10	16	PF00069	0.589
MOD_PKA_2	28	34	PF00069	0.636
MOD_PKA_2	399	405	PF00069	0.522
MOD_PKA_2	617	623	PF00069	0.525
MOD_PKA_2	689	695	PF00069	0.387
MOD_PKA_2	739	745	PF00069	0.533
MOD_PKA_2	782	788	PF00069	0.575
MOD_PKA_2	79	85	PF00069	0.440
MOD_PKA_2	95	101	PF00069	0.390
MOD_Plk_1	359	365	PF00069	0.315
MOD_Plk_1	461	467	PF00069	0.497
MOD_Plk_1	570	576	PF00069	0.560
MOD_Plk_1	620	626	PF00069	0.564
MOD_Plk_1	658	664	PF00069	0.502
MOD_Plk_1	973	979	PF00069	0.609
MOD_Plk_2-3	289	295	PF00069	0.541
MOD_Plk_4	110	116	PF00069	0.454
MOD_Plk_4	125	131	PF00069	0.342
MOD_Plk_4	318	324	PF00069	0.480
MOD_Plk_4	345	351	PF00069	0.476
MOD_Plk_4	620	626	PF00069	0.481
MOD_Plk_4	643	649	PF00069	0.506
MOD_Plk_4	658	664	PF00069	0.367
MOD_Plk_4	674	680	PF00069	0.431
MOD_Plk_4	690	696	PF00069	0.547
MOD_Plk_4	723	729	PF00069	0.486
MOD_Plk_4	739	745	PF00069	0.509
MOD_Plk_4	854	860	PF00069	0.550
MOD_Plk_4	881	887	PF00069	0.380
MOD_ProDKin_1	230	236	PF00069	0.576
MOD_ProDKin_1	90	96	PF00069	0.521
MOD_SUMO_rev_2	113	123	PF00179	0.277
MOD_SUMO_rev_2	193	201	PF00179	0.574
TRG_DiLeu_BaEn_1	267	272	PF01217	0.298
TRG_DiLeu_BaEn_1	433	438	PF01217	0.479
TRG_DiLeu_BaEn_1	484	489	PF01217	0.500
TRG_DiLeu_BaEn_1	703	708	PF01217	0.405
TRG_DiLeu_BaEn_1	902	907	PF01217	0.486
TRG_DiLeu_BaLyEn_6	164	169	PF01217	0.520
TRG_DiLeu_BaLyEn_6	292	297	PF01217	0.578
TRG_DiLeu_BaLyEn_6	542	547	PF01217	0.559
TRG_DiLeu_BaLyEn_6	876	881	PF01217	0.369
TRG_DiLeu_LyEn_5	433	438	PF01217	0.479
TRG_ENDOCYTIC_2	310	313	PF00928	0.425
TRG_ENDOCYTIC_2	375	378	PF00928	0.474
TRG_ENDOCYTIC_2	704	707	PF00928	0.385
TRG_ENDOCYTIC_2	766	769	PF00928	0.505
TRG_ENDOCYTIC_2	877	880	PF00928	0.477
TRG_ENDOCYTIC_2	944	947	PF00928	0.505
TRG_ER_diArg_1	102	104	PF00400	0.492
TRG_ER_diArg_1	324	326	PF00400	0.533
TRG_ER_diArg_1	7	9	PF00400	0.488
TRG_ER_diArg_1	739	741	PF00400	0.583
TRG_ER_FFAT_2	726	738	PF00635	0.447
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.483
TRG_Pf-PMV_PEXEL_1	436	440	PF00026	0.368
TRG_Pf-PMV_PEXEL_1	513	517	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	566	571	PF00026	0.357
TRG_Pf-PMV_PEXEL_1	612	616	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	626	630	PF00026	0.328
TRG_Pf-PMV_PEXEL_1	920	925	PF00026	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY92	Leptomonas seymouri	48%	98%
A0A1X0P9B3	Trypanosomatidae	24%	99%
A0A3S7X2T5	Leishmania donovani	91%	100%
A0A422NEU9	Trypanosoma rangeli	26%	99%
A4HHS7	Leishmania braziliensis	78%	100%
A4I4X8	Leishmania infantum	91%	100%
C9ZKL2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	97%
E9AED2	Leishmania major	89%	100%