Beta_helix domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Right handed beta helix region, putative

Species:

Leishmania mexicana

UniProt:

E9ALF3_LEIMU

TriTrypDb:

LmxM.08_29.2710

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALF3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.347
CLV_NRD_NRD_1	93	95	PF00675	0.406
DOC_MAPK_gen_1	200	206	PF00069	0.365
DOC_USP7_MATH_1	57	61	PF00917	0.646
LIG_APCC_ABBA_1	179	184	PF00400	0.449
LIG_FHA_1	117	123	PF00498	0.435
LIG_FHA_1	176	182	PF00498	0.463
LIG_FHA_1	262	268	PF00498	0.517
LIG_FHA_1	29	35	PF00498	0.424
LIG_FHA_1	3	9	PF00498	0.452
LIG_FHA_1	40	46	PF00498	0.461
LIG_FHA_1	71	77	PF00498	0.392
LIG_FHA_2	146	152	PF00498	0.423
LIG_LIR_Nem_3	143	147	PF02991	0.449
LIG_LIR_Nem_3	176	182	PF02991	0.328
LIG_LIR_Nem_3	218	224	PF02991	0.475
LIG_LRP6_Inhibitor_1	169	175	PF00058	0.340
LIG_REV1ctd_RIR_1	225	235	PF16727	0.475
LIG_SH2_STAP1	183	187	PF00017	0.449
LIG_SH2_STAT5	138	141	PF00017	0.344
LIG_SH2_STAT5	205	208	PF00017	0.344
LIG_SH3_3	4	10	PF00018	0.556
LIG_SH3_3	40	46	PF00018	0.524
LIG_SUMO_SIM_par_1	30	35	PF11976	0.417
LIG_SUMO_SIM_par_1	72	77	PF11976	0.480
MOD_CK1_1	238	244	PF00069	0.464
MOD_CK1_1	60	66	PF00069	0.679
MOD_CK2_1	140	146	PF00069	0.363
MOD_GlcNHglycan	187	190	PF01048	0.437
MOD_GlcNHglycan	237	240	PF01048	0.432
MOD_GlcNHglycan	261	264	PF01048	0.473
MOD_GlcNHglycan	34	37	PF01048	0.487
MOD_GlcNHglycan	76	79	PF01048	0.465
MOD_GSK3_1	238	245	PF00069	0.382
MOD_GSK3_1	28	35	PF00069	0.541
MOD_GSK3_1	66	73	PF00069	0.512
MOD_GSK3_1	74	81	PF00069	0.471
MOD_N-GLC_1	47	52	PF02516	0.553
MOD_N-GLC_1	78	83	PF02516	0.409
MOD_NEK2_1	140	145	PF00069	0.475
MOD_NEK2_1	227	232	PF00069	0.413
MOD_NEK2_1	242	247	PF00069	0.243
MOD_NEK2_1	39	44	PF00069	0.526
MOD_NEK2_1	47	52	PF00069	0.502
MOD_NEK2_2	118	123	PF00069	0.363
MOD_PIKK_1	145	151	PF00454	0.398
MOD_PKA_1	185	191	PF00069	0.398
MOD_PKA_2	259	265	PF00069	0.268
MOD_PKB_1	173	181	PF00069	0.437
MOD_Plk_1	175	181	PF00069	0.399
MOD_Plk_1	215	221	PF00069	0.398
MOD_Plk_1	39	45	PF00069	0.437
MOD_Plk_1	47	53	PF00069	0.387
MOD_Plk_1	78	84	PF00069	0.413
MOD_Plk_2-3	192	198	PF00069	0.330
MOD_Plk_4	2	8	PF00069	0.601
MOD_Plk_4	269	275	PF00069	0.519
MOD_Plk_4	28	34	PF00069	0.483
MOD_Plk_4	66	72	PF00069	0.515
TRG_DiLeu_BaEn_4	40	46	PF01217	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL58	Leptomonas seymouri	55%	99%
A0A0S4KFM6	Bodo saltans	38%	100%
A0A1X0P907	Trypanosomatidae	48%	100%
A0A3Q8IDZ0	Leishmania donovani	94%	100%
A0A422NEU4	Trypanosoma rangeli	47%	100%
A4HHS8	Leishmania braziliensis	82%	100%
A4I4X9	Leishmania infantum	93%	100%
C9ZKL1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AED3	Leishmania major	94%	100%
V5C239	Trypanosoma cruzi	48%	100%