Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

serine/threonine protein kinase, putative

Species:

Leishmania mexicana

UniProt:

E9ALF2_LEIMU

TriTrypDb:

LmxM.08_29.2720

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9ALF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALF2

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0004672	protein kinase activity	3	11
GO:0005488	binding	1	11
GO:0005524	ATP binding	5	11
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0030554	adenyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032559	adenyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11
GO:0004674	protein serine/threonine kinase activity	4	4
GO:0004713	protein tyrosine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	308	312	PF00656	0.544
CLV_NRD_NRD_1	162	164	PF00675	0.355
CLV_NRD_NRD_1	204	206	PF00675	0.385
CLV_NRD_NRD_1	291	293	PF00675	0.490
CLV_NRD_NRD_1	298	300	PF00675	0.464
CLV_PCSK_KEX2_1	162	164	PF00082	0.362
CLV_PCSK_KEX2_1	204	206	PF00082	0.355
CLV_PCSK_KEX2_1	291	293	PF00082	0.534
CLV_PCSK_KEX2_1	298	300	PF00082	0.500
CLV_PCSK_KEX2_1	68	70	PF00082	0.346
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.351
CLV_PCSK_SKI1_1	106	110	PF00082	0.366
CLV_PCSK_SKI1_1	291	295	PF00082	0.554
DOC_PP2B_LxvP_1	122	125	PF13499	0.457
DOC_USP7_MATH_1	18	22	PF00917	0.676
DOC_USP7_MATH_1	243	247	PF00917	0.336
DOC_USP7_MATH_1	86	90	PF00917	0.424
DOC_WW_Pin1_4	205	210	PF00397	0.369
DOC_WW_Pin1_4	251	256	PF00397	0.366
DOC_WW_Pin1_4	317	322	PF00397	0.637
LIG_14-3-3_CanoR_1	17	27	PF00244	0.631
LIG_BIR_II_1	1	5	PF00653	0.717
LIG_BRCT_BRCA1_1	253	257	PF00533	0.424
LIG_deltaCOP1_diTrp_1	100	109	PF00928	0.355
LIG_eIF4E_1	206	212	PF01652	0.424
LIG_FHA_1	105	111	PF00498	0.200
LIG_FHA_1	130	136	PF00498	0.457
LIG_FHA_2	235	241	PF00498	0.426
LIG_FHA_2	280	286	PF00498	0.533
LIG_LIR_Apic_2	203	209	PF02991	0.312
LIG_LIR_Gen_1	107	115	PF02991	0.271
LIG_LIR_Gen_1	254	265	PF02991	0.424
LIG_LIR_Gen_1	56	64	PF02991	0.360
LIG_LIR_Nem_3	107	112	PF02991	0.271
LIG_LIR_Nem_3	192	197	PF02991	0.424
LIG_LIR_Nem_3	254	260	PF02991	0.357
LIG_LIR_Nem_3	44	50	PF02991	0.316
LIG_LIR_Nem_3	56	60	PF02991	0.304
LIG_SH2_STAT5	98	101	PF00017	0.346
LIG_SH3_3	215	221	PF00018	0.388
LIG_SH3_3	315	321	PF00018	0.409
LIG_Sin3_3	257	264	PF02671	0.457
MOD_CK1_1	129	135	PF00069	0.447
MOD_CK1_1	2	8	PF00069	0.657
MOD_CK1_1	271	277	PF00069	0.165
MOD_CK1_1	30	36	PF00069	0.558
MOD_CK1_1	43	49	PF00069	0.363
MOD_CK2_1	234	240	PF00069	0.381
MOD_CK2_1	279	285	PF00069	0.486
MOD_GlcNHglycan	273	276	PF01048	0.424
MOD_GlcNHglycan	4	7	PF01048	0.705
MOD_GSK3_1	18	25	PF00069	0.582
MOD_GSK3_1	30	37	PF00069	0.299
MOD_GSK3_1	316	323	PF00069	0.686
MOD_N-GLC_1	243	248	PF02516	0.384
MOD_NEK2_1	135	140	PF00069	0.338
MOD_NEK2_1	19	24	PF00069	0.627
MOD_NEK2_1	234	239	PF00069	0.269
MOD_NEK2_1	260	265	PF00069	0.424
MOD_NEK2_2	243	248	PF00069	0.165
MOD_PIKK_1	19	25	PF00454	0.671
MOD_PKA_2	271	277	PF00069	0.385
MOD_PKA_2	30	36	PF00069	0.583
MOD_Plk_1	104	110	PF00069	0.192
MOD_Plk_1	243	249	PF00069	0.252
MOD_Plk_4	126	132	PF00069	0.434
MOD_Plk_4	166	172	PF00069	0.405
MOD_Plk_4	260	266	PF00069	0.445
MOD_ProDKin_1	205	211	PF00069	0.369
MOD_ProDKin_1	251	257	PF00069	0.366
MOD_ProDKin_1	317	323	PF00069	0.645
MOD_SUMO_for_1	155	158	PF00179	0.355
MOD_SUMO_rev_2	149	157	PF00179	0.409
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.557
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.452
TRG_ER_diArg_1	161	163	PF00400	0.407
TRG_ER_diArg_1	204	206	PF00400	0.385
TRG_ER_diArg_1	291	293	PF00400	0.521
TRG_ER_diArg_1	298	300	PF00400	0.510
TRG_Pf-PMV_PEXEL_1	163	168	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.578
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.580

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2X9	Leptomonas seymouri	26%	99%
A0A0N0P3N5	Leptomonas seymouri	24%	75%
A0A0N0P7D2	Leptomonas seymouri	26%	100%
A0A0N0P953	Leptomonas seymouri	25%	67%
A0A0N1HT76	Leptomonas seymouri	25%	72%
A0A0N1I6T8	Leptomonas seymouri	26%	100%
A0A0N1IHY4	Leptomonas seymouri	24%	79%
A0A0N1PC01	Leptomonas seymouri	69%	98%
A0A0N1PD05	Leptomonas seymouri	25%	72%
A0A0N1PDW7	Leptomonas seymouri	27%	82%
A0A0S4IHW4	Bodo saltans	22%	72%
A0A0S4IVQ6	Bodo saltans	25%	69%
A0A0S4IX86	Bodo saltans	26%	75%
A0A0S4J3Y5	Bodo saltans	27%	75%
A0A0S4J4B3	Bodo saltans	24%	72%
A0A0S4JCG2	Bodo saltans	27%	72%
A0A0S4JF22	Bodo saltans	25%	90%
A0A0S4JHA7	Bodo saltans	29%	70%
A0A0S4JU73	Bodo saltans	27%	68%
A0A0S4JUJ2	Bodo saltans	28%	100%
A0A0S4JVD7	Bodo saltans	26%	74%
A0A0S4JXW9	Bodo saltans	29%	81%
A0A0S4KEA4	Bodo saltans	33%	80%
A0A0S4KHS0	Bodo saltans	24%	82%
A0A0S4KN74	Bodo saltans	28%	99%
A0A1X0NIA0	Trypanosomatidae	28%	75%
A0A1X0NLC8	Trypanosomatidae	27%	68%
A0A1X0NM44	Trypanosomatidae	25%	94%
A0A1X0NQ63	Trypanosomatidae	25%	100%
A0A1X0NRZ9	Trypanosomatidae	25%	88%
A0A1X0NTR6	Trypanosomatidae	25%	92%
A0A1X0NW24	Trypanosomatidae	24%	92%
A0A1X0P020	Trypanosomatidae	27%	83%
A0A1X0P1A2	Trypanosomatidae	24%	70%
A0A1X0P3X8	Trypanosomatidae	26%	99%
A0A1X0P527	Trypanosomatidae	27%	73%
A0A1X0P549	Trypanosomatidae	27%	68%
A0A1X0P6E7	Trypanosomatidae	25%	82%
A0A1X0P919	Trypanosomatidae	26%	87%
A0A1X0P963	Trypanosomatidae	25%	67%
A0A1X0P9V2	Trypanosomatidae	46%	89%
A0A3Q8IBT5	Leishmania donovani	26%	100%
A0A3Q8IC87	Leishmania donovani	26%	87%
A0A3Q8IDY1	Leishmania donovani	25%	72%
A0A3Q8IEH3	Leishmania donovani	28%	100%
A0A3Q8IFW0	Leishmania donovani	24%	75%
A0A3Q8IPR6	Leishmania donovani	26%	99%
A0A3R7K5P9	Trypanosoma rangeli	25%	86%
A0A3R7KRP1	Trypanosoma rangeli	27%	68%
A0A3R7M5C7	Trypanosoma rangeli	25%	100%
A0A3R7MHW5	Trypanosoma rangeli	26%	81%
A0A3R7NKI8	Trypanosoma rangeli	23%	100%
A0A3S5H606	Leishmania donovani	25%	100%
A0A3S5H789	Leishmania donovani	24%	84%
A0A3S7WP41	Leishmania donovani	27%	100%
A0A3S7X2W9	Leishmania donovani	93%	100%
A0A3S7X6T8	Leishmania donovani	24%	72%
A0A3S7X7Y2	Leishmania donovani	25%	84%
A0A422NCX4	Trypanosoma rangeli	24%	82%
A0A422NEU6	Trypanosoma rangeli	46%	95%
A0A422NUF0	Trypanosoma rangeli	25%	81%
A2XFC8	Oryza sativa subsp. indica	28%	88%
A4H4A1	Leishmania braziliensis	27%	100%
A4HAS1	Leishmania braziliensis	24%	84%
A4HCD7	Leishmania braziliensis	25%	76%
A4HCE6	Leishmania braziliensis	25%	90%
A4HDU3	Leishmania braziliensis	24%	92%
A4HFI2	Leishmania braziliensis	25%	98%
A4HG92	Leishmania braziliensis	28%	100%
A4HHP8	Leishmania braziliensis	23%	72%
A4HHS9	Leishmania braziliensis	82%	100%
A4HJW2	Leishmania braziliensis	24%	75%
A4HLR0	Leishmania braziliensis	25%	72%
A4HSH7	Leishmania infantum	28%	100%
A4HTB4	Leishmania infantum	25%	100%
A4HYX6	Leishmania infantum	24%	84%
A4HZV1	Leishmania infantum	26%	87%
A4I3C6	Leishmania infantum	28%	100%
A4I4W3	Leishmania infantum	25%	72%
A4I4Y0	Leishmania infantum	93%	100%
A4I7C4	Leishmania infantum	24%	75%
A4I960	Leishmania infantum	23%	72%
A4I9Y5	Leishmania infantum	25%	84%
A4K2M3	Papio anubis	26%	66%
A4K2P5	Colobus guereza	26%	66%
A4K2Q5	Otolemur garnettii	26%	66%
A4K2S1	Lemur catta	26%	66%
A4K2T0	Macaca mulatta	26%	66%
A4K2W5	Aotus nancymaae	26%	66%
A4K2Y1	Chlorocebus aethiops	26%	66%
A9RWC9	Physcomitrium patens	25%	92%
A9S9Q8	Physcomitrium patens	25%	85%
B0LT89	Rattus norvegicus	24%	75%
C9ZKZ8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	68%
C9ZL78	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	77%
C9ZN29	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	67%
C9ZSI7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
C9ZUK8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
C9ZWI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	75%
D0A3L9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	92%
D0A8X3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	88%
D0N4E2	Phytophthora infestans (strain T30-4)	26%	81%
E9AD33	Leishmania major	26%	99%
E9AEB1	Leishmania major	25%	72%
E9AED4	Leishmania major	91%	100%
E9AHC6	Leishmania infantum	27%	99%
E9AKG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9ALA7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9ALH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	72%
E9ARW9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	79%
E9AVR5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	87%
E9AYV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	99%
E9AZL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9B2B7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	75%
E9B436	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	72%
E9B4Z4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	84%
O00506	Homo sapiens	25%	76%
O14047	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
O14305	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	69%
O14328	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	68%
O14733	Homo sapiens	31%	77%
O14965	Homo sapiens	24%	80%
O35942	Mus musculus	26%	73%
O59790	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	91%
O94768	Homo sapiens	26%	87%
P10506	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	25%	95%
P22517	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	72%
P23573	Drosophila melanogaster	23%	100%
P24100	Arabidopsis thaliana	27%	100%
P27466	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	72%
P38991	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	88%
P51955	Homo sapiens	27%	73%
P97377	Mus musculus	26%	93%
Q00771	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	27%	78%
Q09170	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	70%
Q10N20	Oryza sativa subsp. japonica	28%	88%
Q11179	Caenorhabditis elegans	26%	69%
Q13043	Homo sapiens	26%	66%
Q20085	Caenorhabditis elegans	23%	69%
Q21307	Caenorhabditis elegans	29%	93%
Q24324	Drosophila melanogaster	28%	82%
Q38772	Antirrhinum majus	27%	100%
Q3SWY6	Bos taurus	26%	76%
Q40531	Nicotiana tabacum	26%	87%
Q4KSH7	Rattus norvegicus	31%	77%
Q4Q2Z2	Leishmania major	24%	84%
Q4Q3Y9	Leishmania major	23%	72%
Q4Q5T9	Leishmania major	23%	75%
Q4QA98	Leishmania major	25%	92%
Q4QBR6	Leishmania major	26%	87%
Q4QIJ7	Leishmania major	25%	100%
Q4QJE7	Leishmania major	28%	100%
Q4V7Q6	Xenopus laevis	25%	69%
Q54E34	Dictyostelium discoideum	29%	92%
Q5E9L6	Bos taurus	26%	66%
Q5HZ38	Arabidopsis thaliana	24%	79%
Q5QN75	Oryza sativa subsp. japonica	24%	91%
Q5ZJK4	Gallus gallus	25%	66%
Q6AXJ9	Danio rerio	31%	92%
Q6C3J2	Yarrowia lipolytica (strain CLIB 122 / E 150)	24%	87%
Q6DE87	Xenopus laevis	27%	68%
Q6P3Q4	Xenopus tropicalis	26%	67%
Q6PA14	Xenopus laevis	26%	67%
Q755C4	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	27%	88%
Q8BG48	Mus musculus	24%	87%
Q8GVC7	Phytophthora infestans	26%	81%
Q8MYQ1	Caenorhabditis elegans	27%	73%
Q8RWC9	Arabidopsis thaliana	27%	73%
Q8SW92	Encephalitozoon cuniculi (strain GB-M1)	24%	100%
Q91XS8	Rattus norvegicus	25%	87%
Q925K9	Mus musculus	27%	100%
Q93V58	Arabidopsis thaliana	25%	82%
Q93VK0	Arabidopsis thaliana	26%	100%
Q99JT2	Mus musculus	24%	78%
Q99KH8	Mus musculus	24%	75%
Q9BXA6	Homo sapiens	28%	100%
Q9JI11	Mus musculus	26%	66%
Q9JJX8	Mus musculus	23%	78%
Q9LQQ9	Arabidopsis thaliana	26%	89%
Q9LT35	Arabidopsis thaliana	29%	78%
Q9N2N1	Leishmania major	28%	100%
Q9NY57	Homo sapiens	23%	78%
Q9P1W9	Homo sapiens	28%	100%
Q9P289	Homo sapiens	24%	78%
Q9Y6E0	Homo sapiens	24%	73%
Q9Z2W1	Mus musculus	25%	76%
V5B8E0	Trypanosoma cruzi	30%	92%
V5BC61	Trypanosoma cruzi	27%	100%
V5BG98	Trypanosoma cruzi	27%	100%
V5BJT8	Trypanosoma cruzi	27%	98%
V5BNV8	Trypanosoma cruzi	24%	100%
V5BQF4	Trypanosoma cruzi	25%	87%
V5BSM0	Trypanosoma cruzi	47%	77%
V5BWC2	Trypanosoma cruzi	26%	100%
V5DMJ4	Trypanosoma cruzi	25%	95%
V5DTI8	Trypanosoma cruzi	25%	82%