START domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

START domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ALF1_LEIMU

TriTrypDb:

LmxM.08_29.2730

Length:

366

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALF1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	20
GO:0008289	lipid binding	2	20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	274	278	PF00656	0.537
CLV_NRD_NRD_1	24	26	PF00675	0.421
CLV_PCSK_SKI1_1	15	19	PF00082	0.316
CLV_PCSK_SKI1_1	162	166	PF00082	0.270
CLV_PCSK_SKI1_1	207	211	PF00082	0.361
CLV_PCSK_SKI1_1	334	338	PF00082	0.456
CLV_PCSK_SKI1_1	68	72	PF00082	0.353
DEG_APCC_DBOX_1	14	22	PF00400	0.386
DEG_Nend_UBRbox_2	1	3	PF02207	0.570
DEG_SIAH_1	302	310	PF03145	0.445
DOC_CKS1_1	236	241	PF01111	0.301
DOC_CYCLIN_RxL_1	23	36	PF00134	0.321
DOC_MAPK_gen_1	12	21	PF00069	0.426
DOC_MAPK_gen_1	25	32	PF00069	0.363
DOC_PP4_FxxP_1	117	120	PF00568	0.256
DOC_USP7_MATH_1	189	193	PF00917	0.218
DOC_USP7_MATH_1	268	272	PF00917	0.661
DOC_USP7_MATH_1	295	299	PF00917	0.497
DOC_USP7_UBL2_3	48	52	PF12436	0.215
DOC_WW_Pin1_4	235	240	PF00397	0.378
DOC_WW_Pin1_4	242	247	PF00397	0.385
DOC_WW_Pin1_4	297	302	PF00397	0.542
LIG_14-3-3_CanoR_1	311	318	PF00244	0.616
LIG_14-3-3_CanoR_1	360	365	PF00244	0.456
LIG_14-3-3_CanoR_1	88	92	PF00244	0.334
LIG_Actin_WH2_2	325	340	PF00022	0.523
LIG_Clathr_ClatBox_1	46	50	PF01394	0.134
LIG_EH1_1	309	317	PF00400	0.441
LIG_eIF4E_1	310	316	PF01652	0.581
LIG_FHA_1	177	183	PF00498	0.355
LIG_FHA_1	311	317	PF00498	0.509
LIG_FHA_1	91	97	PF00498	0.312
LIG_FHA_2	134	140	PF00498	0.243
LIG_FHA_2	342	348	PF00498	0.469
LIG_FHA_2	360	366	PF00498	0.505
LIG_HCF-1_HBM_1	231	234	PF13415	0.349
LIG_LIR_Apic_2	166	172	PF02991	0.330
LIG_LIR_Apic_2	242	246	PF02991	0.331
LIG_LIR_Gen_1	125	133	PF02991	0.288
LIG_LIR_Gen_1	139	148	PF02991	0.291
LIG_LIR_Gen_1	97	104	PF02991	0.335
LIG_LIR_Nem_3	109	115	PF02991	0.224
LIG_LIR_Nem_3	131	135	PF02991	0.294
LIG_LIR_Nem_3	139	143	PF02991	0.293
LIG_LIR_Nem_3	217	223	PF02991	0.394
LIG_LIR_Nem_3	97	102	PF02991	0.337
LIG_MYND_1	246	250	PF01753	0.468
LIG_PDZ_Class_2	361	366	PF00595	0.600
LIG_Pex14_1	243	247	PF04695	0.362
LIG_Pex14_1	38	42	PF04695	0.241
LIG_PTB_Apo_2	120	127	PF02174	0.259
LIG_PTB_Apo_2	134	141	PF02174	0.241
LIG_PTB_Phospho_1	134	140	PF10480	0.386
LIG_SH2_CRK	321	325	PF00017	0.400
LIG_SH2_CRK	79	83	PF00017	0.260
LIG_SH2_CRK	99	103	PF00017	0.120
LIG_SH2_NCK_1	99	103	PF00017	0.244
LIG_SH2_PTP2	169	172	PF00017	0.330
LIG_SH2_SRC	247	250	PF00017	0.473
LIG_SH2_STAP1	113	117	PF00017	0.256
LIG_SH2_STAP1	216	220	PF00017	0.453
LIG_SH2_STAP1	42	46	PF00017	0.346
LIG_SH2_STAT5	140	143	PF00017	0.373
LIG_SH2_STAT5	16	19	PF00017	0.396
LIG_SH2_STAT5	169	172	PF00017	0.239
LIG_SH2_STAT5	183	186	PF00017	0.335
LIG_SH2_STAT5	223	226	PF00017	0.381
LIG_SH2_STAT5	247	250	PF00017	0.459
LIG_SH2_STAT5	348	351	PF00017	0.396
LIG_SH2_STAT5	8	11	PF00017	0.442
LIG_SH3_2	150	155	PF14604	0.335
LIG_SH3_2	306	311	PF14604	0.587
LIG_SH3_3	112	118	PF00018	0.368
LIG_SH3_3	147	153	PF00018	0.341
LIG_SH3_3	300	306	PF00018	0.562
LIG_TRAF2_1	282	285	PF00917	0.538
LIG_TYR_ITIM	110	115	PF00017	0.368
LIG_TYR_ITIM	77	82	PF00017	0.335
LIG_UBA3_1	18	26	PF00899	0.290
LIG_UBA3_1	349	353	PF00899	0.498
MOD_CK1_1	163	169	PF00069	0.274
MOD_CK1_1	279	285	PF00069	0.587
MOD_CK1_1	33	39	PF00069	0.340
MOD_CK2_1	128	134	PF00069	0.241
MOD_CK2_1	268	274	PF00069	0.577
MOD_CK2_1	279	285	PF00069	0.749
MOD_CK2_1	341	347	PF00069	0.512
MOD_GlcNHglycan	165	168	PF01048	0.216
MOD_GlcNHglycan	173	176	PF01048	0.283
MOD_GlcNHglycan	270	273	PF01048	0.670
MOD_GlcNHglycan	277	281	PF01048	0.722
MOD_GlcNHglycan	293	296	PF01048	0.510
MOD_GlcNHglycan	297	300	PF01048	0.519
MOD_GSK3_1	189	196	PF00069	0.236
MOD_GSK3_1	291	298	PF00069	0.498
MOD_GSK3_1	30	37	PF00069	0.293
MOD_N-GLC_1	143	148	PF02516	0.260
MOD_NEK2_1	133	138	PF00069	0.242
MOD_NEK2_1	200	205	PF00069	0.256
MOD_NEK2_1	290	295	PF00069	0.635
MOD_PIKK_1	176	182	PF00454	0.319
MOD_PK_1	160	166	PF00069	0.241
MOD_PKA_2	310	316	PF00069	0.626
MOD_PKA_2	33	39	PF00069	0.168
MOD_PKA_2	359	365	PF00069	0.446
MOD_PKA_2	64	70	PF00069	0.369
MOD_PKA_2	87	93	PF00069	0.313
MOD_Plk_1	332	338	PF00069	0.443
MOD_Plk_1	34	40	PF00069	0.248
MOD_Plk_4	193	199	PF00069	0.307
MOD_Plk_4	42	48	PF00069	0.284
MOD_ProDKin_1	235	241	PF00069	0.370
MOD_ProDKin_1	242	248	PF00069	0.383
MOD_ProDKin_1	297	303	PF00069	0.540
MOD_SUMO_for_1	47	50	PF00179	0.392
MOD_SUMO_rev_2	279	288	PF00179	0.502
MOD_SUMO_rev_2	44	54	PF00179	0.392
TRG_ENDOCYTIC_2	112	115	PF00928	0.243
TRG_ENDOCYTIC_2	140	143	PF00928	0.353
TRG_ENDOCYTIC_2	16	19	PF00928	0.320
TRG_ENDOCYTIC_2	321	324	PF00928	0.391
TRG_ENDOCYTIC_2	79	82	PF00928	0.268
TRG_ENDOCYTIC_2	99	102	PF00928	0.120
TRG_ER_diArg_1	159	162	PF00400	0.275
TRG_NLS_MonoExtN_4	22	29	PF00514	0.225
TRG_Pf-PMV_PEXEL_1	171	176	PF00026	0.134
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.339
TRG_Pf-PMV_PEXEL_1	322	326	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6J9	Leptomonas seymouri	75%	99%
A0A0S4KH88	Bodo saltans	47%	93%
A0A1X0P910	Trypanosomatidae	49%	97%
A0A3Q8IBA5	Leishmania donovani	34%	100%
A0A3Q8IJ21	Leishmania donovani	92%	100%
A0A3R7KCX0	Trypanosoma rangeli	48%	100%
A0A422MZR8	Trypanosoma rangeli	35%	100%
A4H6L4	Leishmania braziliensis	35%	100%
A4HHT0	Leishmania braziliensis	82%	100%
A4HUZ7	Leishmania infantum	34%	89%
A4I4Z0	Leishmania infantum	92%	100%
C9ZKK9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	99%
D0A7F2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AED5	Leishmania major	91%	100%
E9ANN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
Q4QGZ1	Leishmania major	35%	100%
Q9Y365	Homo sapiens	32%	100%
V5BC62	Trypanosoma cruzi	51%	100%
V5DT41	Trypanosoma cruzi	36%	100%