Putative actin-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

actin-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9ALF0_LEIMU

TriTrypDb:

LmxM.08_29.2740

Length:

323

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0043226	organelle	2	14
GO:0110165	cellular anatomical entity	1	14
GO:0005869	dynactin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

E9ALF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALF0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.404
CLV_NRD_NRD_1	23	25	PF00675	0.657
CLV_NRD_NRD_1	34	36	PF00675	0.572
CLV_PCSK_KEX2_1	34	36	PF00082	0.523
CLV_PCSK_SKI1_1	277	281	PF00082	0.515
CLV_PCSK_SKI1_1	81	85	PF00082	0.231
DEG_COP1_1	180	188	PF00400	0.513
DEG_Nend_UBRbox_2	1	3	PF02207	0.412
DEG_SPOP_SBC_1	237	241	PF00917	0.492
DOC_MAPK_DCC_7	181	190	PF00069	0.504
DOC_MAPK_gen_1	21	31	PF00069	0.573
DOC_MAPK_HePTP_8	178	190	PF00069	0.492
DOC_MAPK_MEF2A_6	181	190	PF00069	0.504
DOC_MAPK_MEF2A_6	24	31	PF00069	0.579
DOC_MAPK_MEF2A_6	61	70	PF00069	0.546
DOC_PP2B_LxvP_1	188	191	PF13499	0.475
DOC_USP7_MATH_1	191	195	PF00917	0.557
DOC_USP7_UBL2_3	21	25	PF12436	0.549
LIG_14-3-3_CanoR_1	142	147	PF00244	0.511
LIG_14-3-3_CanoR_1	208	215	PF00244	0.535
LIG_14-3-3_CanoR_1	24	28	PF00244	0.630
LIG_14-3-3_CanoR_1	34	42	PF00244	0.588
LIG_APCC_ABBA_1	195	200	PF00400	0.488
LIG_BRCT_BRCA1_1	232	236	PF00533	0.537
LIG_FHA_1	111	117	PF00498	0.451
LIG_FHA_1	146	152	PF00498	0.457
LIG_FHA_1	165	171	PF00498	0.537
LIG_FHA_1	2	8	PF00498	0.334
LIG_FHA_1	208	214	PF00498	0.457
LIG_FHA_1	216	222	PF00498	0.409
LIG_FHA_1	238	244	PF00498	0.466
LIG_FHA_1	24	30	PF00498	0.522
LIG_FHA_1	261	267	PF00498	0.289
LIG_FHA_1	65	71	PF00498	0.445
LIG_FHA_2	187	193	PF00498	0.441
LIG_FHA_2	200	206	PF00498	0.431
LIG_FHA_2	41	47	PF00498	0.470
LIG_Integrin_RGD_1	160	162	PF01839	0.251
LIG_LIR_Gen_1	239	250	PF02991	0.397
LIG_LIR_Gen_1	87	97	PF02991	0.510
LIG_LIR_LC3C_4	113	118	PF02991	0.433
LIG_LIR_Nem_3	119	125	PF02991	0.413
LIG_LIR_Nem_3	13	19	PF02991	0.385
LIG_LIR_Nem_3	239	245	PF02991	0.347
LIG_LIR_Nem_3	304	309	PF02991	0.514
LIG_LIR_Nem_3	87	92	PF02991	0.503
LIG_NRBOX	154	160	PF00104	0.496
LIG_NRBOX	67	73	PF00104	0.543
LIG_SH2_CRK	122	126	PF00017	0.405
LIG_SH2_CRK	16	20	PF00017	0.448
LIG_SH2_STAP1	101	105	PF00017	0.537
LIG_SH2_STAT5	101	104	PF00017	0.517
LIG_SH2_STAT5	41	44	PF00017	0.458
LIG_SH2_STAT5	5	8	PF00017	0.460
LIG_SUMO_SIM_anti_2	26	31	PF11976	0.579
LIG_SUMO_SIM_anti_2	63	70	PF11976	0.489
LIG_SUMO_SIM_par_1	67	74	PF11976	0.500
LIG_TRAF2_1	62	65	PF00917	0.537
LIG_TYR_ITIM	120	125	PF00017	0.421
LIG_TYR_ITIM	14	19	PF00017	0.434
LIG_UBA3_1	289	297	PF00899	0.416
LIG_WRC_WIRS_1	72	77	PF05994	0.451
MOD_CK1_1	138	144	PF00069	0.504
MOD_CK1_1	145	151	PF00069	0.512
MOD_CK1_1	216	222	PF00069	0.512
MOD_CK1_1	249	255	PF00069	0.450
MOD_CK1_1	77	83	PF00069	0.504
MOD_CK2_1	174	180	PF00069	0.439
MOD_CK2_1	199	205	PF00069	0.543
MOD_CK2_1	301	307	PF00069	0.392
MOD_CK2_1	40	46	PF00069	0.474
MOD_CK2_1	84	90	PF00069	0.537
MOD_GlcNHglycan	103	106	PF01048	0.260
MOD_GlcNHglycan	112	116	PF01048	0.243
MOD_GlcNHglycan	210	213	PF01048	0.402
MOD_GlcNHglycan	251	254	PF01048	0.357
MOD_GlcNHglycan	284	287	PF01048	0.350
MOD_GlcNHglycan	56	59	PF01048	0.305
MOD_GSK3_1	131	138	PF00069	0.548
MOD_GSK3_1	141	148	PF00069	0.524
MOD_GSK3_1	170	177	PF00069	0.405
MOD_GSK3_1	213	220	PF00069	0.401
MOD_GSK3_1	256	263	PF00069	0.283
MOD_LATS_1	275	281	PF00433	0.531
MOD_NEK2_1	1	6	PF00069	0.359
MOD_NEK2_1	170	175	PF00069	0.377
MOD_NEK2_1	213	218	PF00069	0.483
MOD_NEK2_1	71	76	PF00069	0.501
MOD_NEK2_1	84	89	PF00069	0.530
MOD_NEK2_1	99	104	PF00069	0.436
MOD_NEK2_2	10	15	PF00069	0.355
MOD_NEK2_2	191	196	PF00069	0.567
MOD_PIKK_1	288	294	PF00454	0.391
MOD_PIKK_1	74	80	PF00454	0.550
MOD_PK_1	142	148	PF00069	0.546
MOD_PKA_2	141	147	PF00069	0.537
MOD_PKA_2	207	213	PF00069	0.401
MOD_PKA_2	23	29	PF00069	0.506
MOD_PKA_2	33	39	PF00069	0.399
MOD_Plk_1	1	7	PF00069	0.377
MOD_Plk_1	164	170	PF00069	0.606
MOD_Plk_1	186	192	PF00069	0.572
MOD_Plk_1	237	243	PF00069	0.460
MOD_Plk_1	64	70	PF00069	0.474
MOD_Plk_4	1	7	PF00069	0.405
MOD_Plk_4	174	180	PF00069	0.506
MOD_Plk_4	191	197	PF00069	0.546
MOD_Plk_4	238	244	PF00069	0.360
MOD_Plk_4	246	252	PF00069	0.377
MOD_Plk_4	64	70	PF00069	0.466
TRG_DiLeu_BaEn_1	112	117	PF01217	0.353
TRG_DiLeu_BaEn_1	154	159	PF01217	0.546
TRG_DiLeu_BaEn_1	180	185	PF01217	0.643
TRG_DiLeu_BaEn_1	64	69	PF01217	0.546
TRG_DiLeu_BaEn_3	64	70	PF01217	0.537
TRG_DiLeu_LyEn_5	154	159	PF01217	0.487
TRG_ENDOCYTIC_2	122	125	PF00928	0.438
TRG_ENDOCYTIC_2	16	19	PF00928	0.406
TRG_ENDOCYTIC_2	86	89	PF00928	0.553
TRG_NES_CRM1_1	292	305	PF08389	0.413
TRG_Pf-PMV_PEXEL_1	157	162	PF00026	0.225
TRG_Pf-PMV_PEXEL_1	226	230	PF00026	0.267

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y8	Leptomonas seymouri	77%	100%
A0A0S4KG45	Bodo saltans	27%	89%
A0A1X0NIU0	Trypanosomatidae	23%	82%
A0A1X0NRG7	Trypanosomatidae	26%	83%
A0A1X0P9A3	Trypanosomatidae	37%	99%
A0A3S5IR27	Trypanosoma rangeli	38%	95%
A0A3S7X2U7	Leishmania donovani	92%	100%
A4HHT1	Leishmania braziliensis	85%	100%
A4I4Z1	Leishmania infantum	93%	100%
C9ZKK7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	99%
Q4FXC8	Leishmania major	95%	100%
V5C0Q2	Trypanosoma cruzi	22%	83%
V5DTX0	Trypanosoma cruzi	37%	99%