Rhomboid domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9ALE5_LEIMU

TriTrypDb:

LmxM.08_29.2790

Length:

192

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

E9ALE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALE5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	129	131	PF00675	0.463
CLV_NRD_NRD_1	161	163	PF00675	0.659
CLV_NRD_NRD_1	22	24	PF00675	0.485
CLV_NRD_NRD_1	7	9	PF00675	0.442
CLV_PCSK_KEX2_1	161	163	PF00082	0.689
CLV_PCSK_KEX2_1	22	24	PF00082	0.485
CLV_PCSK_SKI1_1	162	166	PF00082	0.690
CLV_PCSK_SKI1_1	8	12	PF00082	0.440
DEG_APCC_DBOX_1	7	15	PF00400	0.699
DEG_SCF_FBW7_1	164	169	PF00400	0.515
DOC_CYCLIN_RxL_1	5	16	PF00134	0.671
DOC_MAPK_gen_1	130	138	PF00069	0.499
DOC_PP1_RVXF_1	6	13	PF00149	0.691
DOC_USP7_MATH_1	166	170	PF00917	0.485
DOC_USP7_UBL2_3	70	74	PF12436	0.716
DOC_WW_Pin1_4	162	167	PF00397	0.484
LIG_14-3-3_CterR_2	189	192	PF00244	0.498
LIG_BIR_II_1	1	5	PF00653	0.669
LIG_BRCT_BRCA1_1	1	5	PF00533	0.741
LIG_BRCT_BRCA1_1	105	109	PF00533	0.338
LIG_Clathr_ClatBox_1	11	15	PF01394	0.716
LIG_deltaCOP1_diTrp_1	75	82	PF00928	0.482
LIG_FHA_1	138	144	PF00498	0.438
LIG_FHA_1	152	158	PF00498	0.486
LIG_FHA_1	66	72	PF00498	0.736
LIG_LIR_Gen_1	167	178	PF02991	0.466
LIG_LIR_Nem_3	167	173	PF02991	0.459
LIG_LIR_Nem_3	182	188	PF02991	0.442
LIG_MLH1_MIPbox_1	105	109	PF16413	0.338
LIG_NRBOX	6	12	PF00104	0.666
LIG_Pex14_1	78	82	PF04695	0.335
LIG_SH2_CRK	170	174	PF00017	0.452
LIG_SH2_CRK	188	192	PF00017	0.455
LIG_SH2_CRK	31	35	PF00017	0.684
LIG_SH2_CRK	89	93	PF00017	0.354
LIG_SH2_GRB2like	88	91	PF00017	0.354
LIG_SH2_SRC	145	148	PF00017	0.479
LIG_SH2_STAT3	176	179	PF00017	0.478
LIG_SH2_STAT5	135	138	PF00017	0.190
LIG_SH2_STAT5	176	179	PF00017	0.463
LIG_SH3_3	37	43	PF00018	0.693
LIG_SUMO_SIM_anti_2	37	42	PF11976	0.730
LIG_TYR_ITIM	133	138	PF00017	0.190
LIG_TYR_ITIM	186	191	PF00017	0.464
LIG_TYR_ITIM	87	92	PF00017	0.447
LIG_WRC_WIRS_1	60	65	PF05994	0.727
MOD_CDK_SPxK_1	162	168	PF00069	0.514
MOD_CK1_1	62	68	PF00069	0.727
MOD_GlcNHglycan	1	4	PF01048	0.491
MOD_GlcNHglycan	105	108	PF01048	0.313
MOD_GlcNHglycan	125	128	PF01048	0.499
MOD_GlcNHglycan	49	52	PF01048	0.457
MOD_GSK3_1	151	158	PF00069	0.479
MOD_GSK3_1	162	169	PF00069	0.500
MOD_GSK3_1	58	65	PF00069	0.719
MOD_NEK2_1	1	6	PF00069	0.650
MOD_NEK2_1	123	128	PF00069	0.669
MOD_NEK2_1	34	39	PF00069	0.654
MOD_NEK2_1	59	64	PF00069	0.662
MOD_NEK2_2	88	93	PF00069	0.428
MOD_Plk_1	166	172	PF00069	0.498
MOD_ProDKin_1	162	168	PF00069	0.485
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.683
TRG_ENDOCYTIC_2	135	138	PF00928	0.190
TRG_ENDOCYTIC_2	170	173	PF00928	0.452
TRG_ENDOCYTIC_2	188	191	PF00928	0.456
TRG_ENDOCYTIC_2	31	34	PF00928	0.664
TRG_ENDOCYTIC_2	89	92	PF00928	0.354
TRG_ER_diArg_1	160	162	PF00400	0.496
TRG_Pf-PMV_PEXEL_1	8	13	PF00026	0.473

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZV8	Leptomonas seymouri	81%	100%
A0A0S4KHT2	Bodo saltans	41%	94%
A0A1X0P8Y9	Trypanosomatidae	64%	99%
A0A3Q8IHI8	Leishmania donovani	95%	100%
A4HHT7	Leishmania braziliensis	85%	100%
A4I4Y8	Leishmania infantum	95%	100%
C9ZKK1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	98%
E9AEE1	Leishmania major	93%	100%
V5BXI8	Trypanosoma cruzi	60%	99%