IU_nuc_hydro domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inosine-adenosine-guanosine-nucleosidehydrolase, putative

Species:

Leishmania mexicana

UniProt:

E9ALE4_LEIMU

TriTrypDb:

LmxM.08_29.2800

Length:

333

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005777	peroxisome	6	1
GO:0005829	cytosol	2	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALE4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALE4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:1901360	organic cyclic compound metabolic process	3	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:0006152	purine nucleoside catabolic process	6	1
GO:0006166	purine ribonucleoside salvage	5	1
GO:0009056	catabolic process	2	1
GO:0009058	biosynthetic process	2	1
GO:0009116	nucleoside metabolic process	4	1
GO:0009119	ribonucleoside metabolic process	5	1
GO:0009163	nucleoside biosynthetic process	5	1
GO:0009164	nucleoside catabolic process	5	1
GO:0018130	heterocycle biosynthetic process	4	1
GO:0019438	aromatic compound biosynthetic process	4	1
GO:0019439	aromatic compound catabolic process	4	1
GO:0034404	nucleobase-containing small molecule biosynthetic process	4	1
GO:0034654	nucleobase-containing compound biosynthetic process	4	1
GO:0034655	nucleobase-containing compound catabolic process	4	1
GO:0034656	nucleobase-containing small molecule catabolic process	4	1
GO:0042278	purine nucleoside metabolic process	5	1
GO:0042451	purine nucleoside biosynthetic process	6	1
GO:0042455	ribonucleoside biosynthetic process	6	1
GO:0043094	cellular metabolic compound salvage	3	1
GO:0043101	purine-containing compound salvage	4	1
GO:0043174	nucleoside salvage	4	1
GO:0044248	cellular catabolic process	3	1
GO:0044249	cellular biosynthetic process	3	1
GO:0044270	cellular nitrogen compound catabolic process	4	1
GO:0044271	cellular nitrogen compound biosynthetic process	4	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046128	purine ribonucleoside metabolic process	6	1
GO:0046129	purine ribonucleoside biosynthetic process	7	1
GO:0046700	heterocycle catabolic process	4	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0072521	purine-containing compound metabolic process	4	1
GO:0072522	purine-containing compound biosynthetic process	5	1
GO:0072523	purine-containing compound catabolic process	5	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901136	carbohydrate derivative catabolic process	4	1
GO:1901137	carbohydrate derivative biosynthetic process	4	1
GO:1901361	organic cyclic compound catabolic process	4	1
GO:1901362	organic cyclic compound biosynthetic process	4	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901566	organonitrogen compound biosynthetic process	4	1
GO:1901575	organic substance catabolic process	3	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901657	glycosyl compound metabolic process	4	1
GO:1901658	glycosyl compound catabolic process	5	1
GO:1901659	glycosyl compound biosynthetic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	12
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	4	12
GO:0008477	purine nucleosidase activity	5	6
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.452
CLV_NRD_NRD_1	179	181	PF00675	0.187
CLV_NRD_NRD_1	273	275	PF00675	0.236
CLV_NRD_NRD_1	298	300	PF00675	0.360
CLV_NRD_NRD_1	60	62	PF00675	0.244
CLV_PCSK_KEX2_1	179	181	PF00082	0.187
CLV_PCSK_KEX2_1	273	275	PF00082	0.236
CLV_PCSK_KEX2_1	298	300	PF00082	0.389
CLV_PCSK_SKI1_1	197	201	PF00082	0.260
CLV_PCSK_SKI1_1	207	211	PF00082	0.282
CLV_PCSK_SKI1_1	233	237	PF00082	0.300
CLV_PCSK_SKI1_1	61	65	PF00082	0.337
CLV_Separin_Metazoa	251	255	PF03568	0.400
DOC_ANK_TNKS_1	297	304	PF00023	0.539
DOC_CYCLIN_RxL_1	227	237	PF00134	0.500
DOC_MAPK_DCC_7	89	99	PF00069	0.480
DOC_PP1_RVXF_1	204	211	PF00149	0.477
DOC_PP4_FxxP_1	190	193	PF00568	0.554
DOC_USP7_MATH_1	219	223	PF00917	0.467
DOC_USP7_MATH_1	243	247	PF00917	0.583
DOC_USP7_MATH_1	70	74	PF00917	0.500
DOC_USP7_MATH_1	79	83	PF00917	0.523
DOC_USP7_UBL2_3	71	75	PF12436	0.519
DOC_WW_Pin1_4	126	131	PF00397	0.480
LIG_14-3-3_CanoR_1	179	187	PF00244	0.387
LIG_14-3-3_CanoR_1	85	91	PF00244	0.496
LIG_APCC_ABBAyCdc20_2	172	178	PF00400	0.500
LIG_deltaCOP1_diTrp_1	186	191	PF00928	0.456
LIG_deltaCOP1_diTrp_1	83	86	PF00928	0.523
LIG_EH_1	77	81	PF12763	0.480
LIG_FHA_1	132	138	PF00498	0.467
LIG_FHA_1	213	219	PF00498	0.456
LIG_FHA_1	304	310	PF00498	0.436
LIG_FHA_2	246	252	PF00498	0.467
LIG_FHA_2	313	319	PF00498	0.570
LIG_FHA_2	36	42	PF00498	0.467
LIG_LIR_Gen_1	184	195	PF02991	0.560
LIG_LIR_Gen_1	248	255	PF02991	0.538
LIG_LIR_Nem_3	184	190	PF02991	0.457
LIG_LIR_Nem_3	248	253	PF02991	0.538
LIG_LIR_Nem_3	318	324	PF02991	0.480
LIG_LIR_Nem_3	72	77	PF02991	0.480
LIG_NRBOX	19	25	PF00104	0.467
LIG_Pex14_2	80	84	PF04695	0.456
LIG_SH2_CRK	321	325	PF00017	0.415
LIG_SH2_STAP1	260	264	PF00017	0.501
LIG_SH2_STAT5	234	237	PF00017	0.480
LIG_SH2_STAT5	310	313	PF00017	0.523
LIG_SH3_3	134	140	PF00018	0.467
LIG_SH3_3	94	100	PF00018	0.547
LIG_SUMO_SIM_anti_2	282	288	PF11976	0.441
LIG_SUMO_SIM_par_1	4	9	PF11976	0.341
LIG_UBA3_1	54	62	PF00899	0.399
MOD_CDC14_SPxK_1	129	132	PF00782	0.494
MOD_CDK_SPxK_1	126	132	PF00069	0.494
MOD_CK1_1	211	217	PF00069	0.480
MOD_CK2_1	125	131	PF00069	0.500
MOD_CK2_1	245	251	PF00069	0.467
MOD_GlcNHglycan	182	186	PF01048	0.319
MOD_GlcNHglycan	241	244	PF01048	0.350
MOD_GlcNHglycan	326	329	PF01048	0.474
MOD_GlcNHglycan	50	53	PF01048	0.350
MOD_GSK3_1	131	138	PF00069	0.466
MOD_GSK3_1	208	215	PF00069	0.456
MOD_GSK3_1	239	246	PF00069	0.538
MOD_LATS_1	59	65	PF00433	0.494
MOD_NEK2_1	125	130	PF00069	0.603
MOD_NEK2_1	212	217	PF00069	0.464
MOD_NEK2_1	239	244	PF00069	0.473
MOD_NEK2_1	48	53	PF00069	0.466
MOD_NEK2_2	70	75	PF00069	0.480
MOD_OFUCOSY	136	143	PF10250	0.360
MOD_PIKK_1	234	240	PF00454	0.467
MOD_PKA_1	61	67	PF00069	0.387
MOD_PKA_2	178	184	PF00069	0.387
MOD_PKA_2	84	90	PF00069	0.496
MOD_Plk_2-3	279	285	PF00069	0.387
MOD_Plk_4	195	201	PF00069	0.560
MOD_ProDKin_1	126	132	PF00069	0.480
TRG_DiLeu_BaEn_1	112	117	PF01217	0.550
TRG_ENDOCYTIC_2	321	324	PF00928	0.381
TRG_ER_diArg_1	273	275	PF00400	0.436
TRG_Pf-PMV_PEXEL_1	273	277	PF00026	0.341

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDW1	Leptomonas seymouri	79%	100%
A0A0S4KHF3	Bodo saltans	49%	91%
A0A1X0P908	Trypanosomatidae	64%	100%
A0A3S7X2U5	Leishmania donovani	92%	100%
A0A422NEX0	Trypanosoma rangeli	61%	100%
A4HHT6	Leishmania braziliensis	87%	100%
A4I4Y9	Leishmania infantum	93%	100%
A8AJF8	Citrobacter koseri (strain ATCC BAA-895 / CDC 4225-83 / SGSC4696)	26%	100%
B4SYM0	Salmonella newport (strain SL254)	27%	100%
C9ZKK0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9AEE2	Leishmania major	93%	100%
Q10314	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q8LAC4	Arabidopsis thaliana	27%	100%
Q9P6J4	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
V5BSM6	Trypanosoma cruzi	62%	100%