Ribonuclease inhibitor-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania mexicana

UniProt:

E9ALE3_LEIMU

TriTrypDb:

LmxM.08_29.2810

Length:

739

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	16
GO:0042995	cell projection	2	16
GO:0043226	organelle	2	16
GO:0043227	membrane-bounded organelle	3	16
GO:0110165	cellular anatomical entity	1	17
GO:0120025	plasma membrane bounded cell projection	3	16
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

E9ALE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	623	627	PF00656	0.587
CLV_C14_Caspase3-7	651	655	PF00656	0.420
CLV_C14_Caspase3-7	706	710	PF00656	0.505
CLV_NRD_NRD_1	499	501	PF00675	0.256
CLV_NRD_NRD_1	595	597	PF00675	0.450
CLV_NRD_NRD_1	608	610	PF00675	0.355
CLV_NRD_NRD_1	675	677	PF00675	0.466
CLV_NRD_NRD_1	723	725	PF00675	0.542
CLV_NRD_NRD_1	733	735	PF00675	0.661
CLV_NRD_NRD_1	737	739	PF00675	0.712
CLV_PCSK_KEX2_1	199	201	PF00082	0.377
CLV_PCSK_KEX2_1	499	501	PF00082	0.265
CLV_PCSK_KEX2_1	583	585	PF00082	0.446
CLV_PCSK_KEX2_1	595	597	PF00082	0.497
CLV_PCSK_KEX2_1	608	610	PF00082	0.379
CLV_PCSK_KEX2_1	649	651	PF00082	0.498
CLV_PCSK_KEX2_1	675	677	PF00082	0.496
CLV_PCSK_KEX2_1	723	725	PF00082	0.614
CLV_PCSK_KEX2_1	733	735	PF00082	0.682
CLV_PCSK_PC1ET2_1	199	201	PF00082	0.377
CLV_PCSK_PC1ET2_1	583	585	PF00082	0.538
CLV_PCSK_PC1ET2_1	649	651	PF00082	0.543
CLV_PCSK_SKI1_1	224	228	PF00082	0.430
CLV_PCSK_SKI1_1	463	467	PF00082	0.348
CLV_PCSK_SKI1_1	551	555	PF00082	0.545
CLV_PCSK_SKI1_1	61	65	PF00082	0.486
CLV_PCSK_SKI1_1	676	680	PF00082	0.483
CLV_Separin_Metazoa	258	262	PF03568	0.354
CLV_Separin_Metazoa	592	596	PF03568	0.344
DEG_APCC_KENBOX_2	567	571	PF00400	0.403
DEG_Nend_UBRbox_2	1	3	PF02207	0.664
DEG_SCF_FBW7_2	248	254	PF00400	0.493
DOC_ANK_TNKS_1	75	82	PF00023	0.642
DOC_CKS1_1	248	253	PF01111	0.489
DOC_CYCLIN_RxL_1	221	231	PF00134	0.419
DOC_CYCLIN_RxL_1	494	507	PF00134	0.247
DOC_CYCLIN_yClb5_NLxxxL_5	493	502	PF00134	0.278
DOC_MAPK_gen_1	199	209	PF00069	0.365
DOC_MAPK_gen_1	446	455	PF00069	0.367
DOC_MAPK_gen_1	489	498	PF00069	0.415
DOC_MAPK_gen_1	723	729	PF00069	0.551
DOC_MAPK_HePTP_8	197	209	PF00069	0.278
DOC_MAPK_MEF2A_6	200	209	PF00069	0.296
DOC_PP2B_LxvP_1	553	556	PF13499	0.445
DOC_PP4_FxxP_1	151	154	PF00568	0.486
DOC_USP7_MATH_1	4	8	PF00917	0.727
DOC_USP7_UBL2_3	485	489	PF12436	0.382
DOC_WW_Pin1_4	247	252	PF00397	0.502
LIG_14-3-3_CanoR_1	172	179	PF00244	0.447
LIG_14-3-3_CanoR_1	200	205	PF00244	0.427
LIG_14-3-3_CanoR_1	268	276	PF00244	0.439
LIG_14-3-3_CanoR_1	296	304	PF00244	0.320
LIG_14-3-3_CanoR_1	31	37	PF00244	0.673
LIG_14-3-3_CanoR_1	320	326	PF00244	0.311
LIG_14-3-3_CanoR_1	516	522	PF00244	0.302
LIG_14-3-3_CanoR_1	54	63	PF00244	0.538
LIG_14-3-3_CanoR_1	633	639	PF00244	0.548
LIG_Actin_WH2_2	371	388	PF00022	0.406
LIG_APCC_ABBAyCdc20_2	202	208	PF00400	0.278
LIG_BIR_III_4	370	374	PF00653	0.420
LIG_BRCT_BRCA1_1	511	515	PF00533	0.363
LIG_BRCT_BRCA1_1	59	63	PF00533	0.688
LIG_Clathr_ClatBox_1	204	208	PF01394	0.415
LIG_CtBP_PxDLS_1	480	485	PF00389	0.427
LIG_DLG_GKlike_1	290	297	PF00625	0.397
LIG_FHA_1	110	116	PF00498	0.506
LIG_FHA_1	24	30	PF00498	0.515
LIG_FHA_1	382	388	PF00498	0.376
LIG_FHA_1	465	471	PF00498	0.383
LIG_FHA_1	550	556	PF00498	0.577
LIG_FHA_1	662	668	PF00498	0.532
LIG_FHA_1	69	75	PF00498	0.545
LIG_FHA_2	109	115	PF00498	0.542
LIG_FHA_2	320	326	PF00498	0.415
LIG_FHA_2	621	627	PF00498	0.543
LIG_FHA_2	649	655	PF00498	0.561
LIG_LIR_Gen_1	135	144	PF02991	0.388
LIG_LIR_Gen_1	174	181	PF02991	0.414
LIG_LIR_Gen_1	355	364	PF02991	0.322
LIG_LIR_Gen_1	525	536	PF02991	0.296
LIG_LIR_Gen_1	85	94	PF02991	0.465
LIG_LIR_Nem_3	135	141	PF02991	0.393
LIG_LIR_Nem_3	174	179	PF02991	0.418
LIG_LIR_Nem_3	355	359	PF02991	0.332
LIG_LIR_Nem_3	525	531	PF02991	0.284
LIG_LIR_Nem_3	85	91	PF02991	0.454
LIG_MYND_1	75	79	PF01753	0.694
LIG_NRBOX	255	261	PF00104	0.217
LIG_PTB_Apo_2	527	534	PF02174	0.199
LIG_PTB_Phospho_1	527	533	PF10480	0.199
LIG_SH2_STAP1	48	52	PF00017	0.598
LIG_SH2_STAP1	84	88	PF00017	0.487
LIG_SH2_STAT5	356	359	PF00017	0.377
LIG_SH2_STAT5	533	536	PF00017	0.481
LIG_SH2_STAT5	84	87	PF00017	0.496
LIG_SH3_3	6	12	PF00018	0.558
LIG_SUMO_SIM_par_1	177	182	PF11976	0.274
LIG_SUMO_SIM_par_1	231	236	PF11976	0.332
LIG_SUMO_SIM_par_1	374	379	PF11976	0.445
LIG_TYR_ITIM	354	359	PF00017	0.391
LIG_WRC_WIRS_1	88	93	PF05994	0.444
MOD_CK1_1	106	112	PF00069	0.538
MOD_CK1_1	171	177	PF00069	0.452
MOD_CK1_1	381	387	PF00069	0.346
MOD_CK1_1	40	46	PF00069	0.599
MOD_CK1_1	408	414	PF00069	0.366
MOD_CK1_1	415	421	PF00069	0.381
MOD_CK1_1	514	520	PF00069	0.249
MOD_CK1_1	549	555	PF00069	0.570
MOD_CK1_1	57	63	PF00069	0.678
MOD_CK1_1	622	628	PF00069	0.423
MOD_CK2_1	283	289	PF00069	0.330
MOD_CK2_1	311	317	PF00069	0.439
MOD_CK2_1	319	325	PF00069	0.388
MOD_CK2_1	639	645	PF00069	0.555
MOD_Cter_Amidation	731	734	PF01082	0.515
MOD_GlcNHglycan	142	145	PF01048	0.388
MOD_GlcNHglycan	161	164	PF01048	0.398
MOD_GlcNHglycan	180	184	PF01048	0.194
MOD_GlcNHglycan	285	288	PF01048	0.352
MOD_GlcNHglycan	313	316	PF01048	0.465
MOD_GlcNHglycan	366	370	PF01048	0.433
MOD_GlcNHglycan	378	381	PF01048	0.432
MOD_GlcNHglycan	387	390	PF01048	0.259
MOD_GSK3_1	374	381	PF00069	0.377
MOD_GSK3_1	40	47	PF00069	0.640
MOD_GSK3_1	408	415	PF00069	0.389
MOD_GSK3_1	464	471	PF00069	0.271
MOD_GSK3_1	637	644	PF00069	0.526
MOD_N-GLC_1	200	205	PF02516	0.250
MOD_N-GLC_1	228	233	PF02516	0.335
MOD_N-GLC_1	269	274	PF02516	0.344
MOD_N-GLC_1	290	295	PF02516	0.356
MOD_N-GLC_1	297	302	PF02516	0.297
MOD_N-GLC_1	405	410	PF02516	0.413
MOD_N-GLC_1	433	438	PF02516	0.270
MOD_N-GLC_1	468	473	PF02516	0.287
MOD_N-GLC_1	489	494	PF02516	0.287
MOD_N-GLC_1	517	522	PF02516	0.281
MOD_N-GLC_1	529	534	PF02516	0.272
MOD_N-GLC_1	549	554	PF02516	0.565
MOD_N-GLC_2	462	464	PF02516	0.415
MOD_NEK2_1	179	184	PF00069	0.254
MOD_NEK2_1	269	274	PF00069	0.313
MOD_NEK2_1	283	288	PF00069	0.383
MOD_NEK2_1	297	302	PF00069	0.232
MOD_NEK2_1	32	37	PF00069	0.603
MOD_NEK2_1	376	381	PF00069	0.359
MOD_NEK2_1	385	390	PF00069	0.395
MOD_NEK2_1	412	417	PF00069	0.393
MOD_NEK2_1	440	445	PF00069	0.269
MOD_NEK2_1	55	60	PF00069	0.622
MOD_NEK2_1	648	653	PF00069	0.460
MOD_NEK2_2	627	632	PF00069	0.413
MOD_PIKK_1	4	10	PF00454	0.693
MOD_PIKK_1	701	707	PF00454	0.539
MOD_PK_1	374	380	PF00069	0.224
MOD_PKA_2	171	177	PF00069	0.452
MOD_PKA_2	319	325	PF00069	0.322
MOD_PKA_2	385	391	PF00069	0.300
MOD_PKA_2	546	552	PF00069	0.458
MOD_PKA_2	632	638	PF00069	0.500
MOD_Plk_1	106	112	PF00069	0.406
MOD_Plk_1	200	206	PF00069	0.250
MOD_Plk_1	228	234	PF00069	0.332
MOD_Plk_1	405	411	PF00069	0.424
MOD_Plk_1	433	439	PF00069	0.262
MOD_Plk_1	489	495	PF00069	0.301
MOD_Plk_1	517	523	PF00069	0.250
MOD_Plk_1	529	535	PF00069	0.250
MOD_Plk_1	549	555	PF00069	0.450
MOD_Plk_4	174	180	PF00069	0.368
MOD_Plk_4	228	234	PF00069	0.365
MOD_Plk_4	32	38	PF00069	0.628
MOD_Plk_4	549	555	PF00069	0.591
MOD_Plk_4	627	633	PF00069	0.433
MOD_ProDKin_1	247	253	PF00069	0.497
MOD_SUMO_for_1	710	713	PF00179	0.633
MOD_SUMO_rev_2	642	648	PF00179	0.396
MOD_SUMO_rev_2	706	712	PF00179	0.608
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.420
TRG_DiLeu_BaLyEn_6	688	693	PF01217	0.538
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.659
TRG_ENDOCYTIC_2	176	179	PF00928	0.312
TRG_ENDOCYTIC_2	356	359	PF00928	0.351
TRG_ENDOCYTIC_2	528	531	PF00928	0.268
TRG_ER_diArg_1	498	500	PF00400	0.265
TRG_ER_diArg_1	594	596	PF00400	0.460
TRG_ER_diArg_1	607	609	PF00400	0.409
TRG_ER_diArg_1	674	676	PF00400	0.501
TRG_ER_diArg_1	722	724	PF00400	0.426
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	192	196	PF00026	0.318
TRG_Pf-PMV_PEXEL_1	224	228	PF00026	0.424
TRG_Pf-PMV_PEXEL_1	500	505	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	609	613	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	679	683	PF00026	0.512
TRG_Pf-PMV_PEXEL_1	76	80	PF00026	0.652

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I557	Leptomonas seymouri	71%	100%
A0A0S4IPG0	Bodo saltans	44%	98%
A0A0S4JDM4	Bodo saltans	23%	100%
A0A0S4JL02	Bodo saltans	24%	100%
A0A1X0P9A4	Trypanosomatidae	53%	100%
A0A3Q8IBH7	Leishmania donovani	23%	100%
A0A3Q8IEN3	Leishmania donovani	93%	100%
A0A422NEU0	Trypanosoma rangeli	51%	100%
A4HHT8	Leishmania braziliensis	81%	100%
A4I4Y7	Leishmania infantum	93%	100%
C9ZHZ2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	99%
C9ZKJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	97%
E9AEE3	Leishmania major	92%	100%
E9AGF7	Leishmania infantum	23%	100%
V5BC66	Trypanosoma cruzi	52%	100%