Tc-38 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALE0_LEIMU

TriTrypDb:

LmxM.08_29.2840

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALE0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.326
CLV_NRD_NRD_1	129	131	PF00675	0.529
CLV_NRD_NRD_1	225	227	PF00675	0.362
CLV_NRD_NRD_1	86	88	PF00675	0.548
CLV_PCSK_KEX2_1	225	227	PF00082	0.382
CLV_PCSK_KEX2_1	86	88	PF00082	0.593
CLV_PCSK_SKI1_1	150	154	PF00082	0.499
CLV_PCSK_SKI1_1	225	229	PF00082	0.329
CLV_PCSK_SKI1_1	36	40	PF00082	0.641
DEG_APCC_DBOX_1	149	157	PF00400	0.306
DOC_CYCLIN_yCln2_LP_2	276	282	PF00134	0.351
DOC_MAPK_MEF2A_6	93	102	PF00069	0.485
DOC_PP1_RVXF_1	233	239	PF00149	0.272
DOC_USP7_MATH_1	300	304	PF00917	0.512
DOC_USP7_MATH_1	63	67	PF00917	0.534
DOC_USP7_MATH_1	71	75	PF00917	0.472
DOC_WW_Pin1_4	133	138	PF00397	0.405
DOC_WW_Pin1_4	162	167	PF00397	0.298
DOC_WW_Pin1_4	215	220	PF00397	0.482
LIG_14-3-3_CanoR_1	130	135	PF00244	0.479
LIG_14-3-3_CanoR_1	284	294	PF00244	0.188
LIG_APCC_ABBA_1	98	103	PF00400	0.615
LIG_BIR_II_1	1	5	PF00653	0.646
LIG_BIR_III_4	274	278	PF00653	0.421
LIG_FHA_1	156	162	PF00498	0.506
LIG_FHA_1	287	293	PF00498	0.440
LIG_FHA_2	114	120	PF00498	0.400
LIG_FHA_2	250	256	PF00498	0.289
LIG_FHA_2	304	310	PF00498	0.420
LIG_LIR_Apic_2	133	137	PF02991	0.419
LIG_LIR_Apic_2	170	175	PF02991	0.546
LIG_LIR_Gen_1	103	108	PF02991	0.271
LIG_LIR_Gen_1	188	199	PF02991	0.529
LIG_LIR_Gen_1	212	220	PF02991	0.447
LIG_LIR_Gen_1	243	253	PF02991	0.366
LIG_LIR_Gen_1	271	281	PF02991	0.376
LIG_LIR_Nem_3	103	107	PF02991	0.438
LIG_LIR_Nem_3	188	194	PF02991	0.525
LIG_LIR_Nem_3	212	216	PF02991	0.424
LIG_LIR_Nem_3	243	249	PF02991	0.312
LIG_LIR_Nem_3	271	276	PF02991	0.324
LIG_PCNA_PIPBox_1	142	151	PF02747	0.471
LIG_PDZ_Class_3	306	311	PF00595	0.459
LIG_Pex14_2	213	217	PF04695	0.448
LIG_PTB_Apo_2	255	262	PF02174	0.188
LIG_PTB_Apo_2	275	282	PF02174	0.410
LIG_SH2_CRK	134	138	PF00017	0.449
LIG_SH2_CRK	191	195	PF00017	0.416
LIG_SH2_GRB2like	172	175	PF00017	0.526
LIG_SH2_GRB2like	191	194	PF00017	0.461
LIG_SH2_GRB2like	256	259	PF00017	0.188
LIG_SH2_NCK_1	134	138	PF00017	0.393
LIG_SH2_NCK_1	172	176	PF00017	0.531
LIG_SH2_SRC	172	175	PF00017	0.526
LIG_SH2_STAP1	295	299	PF00017	0.439
LIG_SH2_STAT5	134	137	PF00017	0.430
LIG_SH3_3	57	63	PF00018	0.591
LIG_SUMO_SIM_anti_2	204	209	PF11976	0.445
MOD_CK1_1	133	139	PF00069	0.531
MOD_CK1_1	182	188	PF00069	0.508
MOD_CK1_1	303	309	PF00069	0.621
MOD_CK1_1	92	98	PF00069	0.389
MOD_CK2_1	113	119	PF00069	0.408
MOD_CK2_1	303	309	PF00069	0.513
MOD_CK2_1	71	77	PF00069	0.477
MOD_Cter_Amidation	84	87	PF01082	0.637
MOD_GlcNHglycan	110	113	PF01048	0.436
MOD_GlcNHglycan	242	245	PF01048	0.366
MOD_GlcNHglycan	40	43	PF01048	0.592
MOD_GlcNHglycan	94	97	PF01048	0.394
MOD_GSK3_1	102	109	PF00069	0.453
MOD_GSK3_1	126	133	PF00069	0.548
MOD_GSK3_1	245	252	PF00069	0.306
MOD_GSK3_1	303	310	PF00069	0.548
MOD_N-GLC_1	300	305	PF02516	0.462
MOD_NEK2_1	1	6	PF00069	0.688
MOD_NEK2_1	108	113	PF00069	0.455
MOD_NEK2_1	138	143	PF00069	0.429
MOD_NEK2_1	245	250	PF00069	0.188
MOD_NEK2_1	286	291	PF00069	0.379
MOD_NEK2_1	38	43	PF00069	0.561
MOD_NEK2_1	69	74	PF00069	0.529
MOD_NEK2_2	300	305	PF00069	0.384
MOD_PIKK_1	138	144	PF00454	0.387
MOD_PIKK_1	46	52	PF00454	0.525
MOD_PKA_1	130	136	PF00069	0.455
MOD_PKA_2	123	129	PF00069	0.468
MOD_PKA_2	69	75	PF00069	0.567
MOD_PKA_2	92	98	PF00069	0.447
MOD_PKB_1	87	95	PF00069	0.573
MOD_Plk_1	203	209	PF00069	0.473
MOD_Plk_1	300	306	PF00069	0.468
MOD_Plk_1	31	37	PF00069	0.473
MOD_Plk_4	203	209	PF00069	0.484
MOD_Plk_4	245	251	PF00069	0.328
MOD_Plk_4	300	306	PF00069	0.523
MOD_ProDKin_1	133	139	PF00069	0.402
MOD_ProDKin_1	162	168	PF00069	0.289
MOD_ProDKin_1	215	221	PF00069	0.477
MOD_SUMO_rev_2	22	31	PF00179	0.331
MOD_SUMO_rev_2	92	100	PF00179	0.406
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.468
TRG_ENDOCYTIC_2	191	194	PF00928	0.464
TRG_ER_diArg_1	235	238	PF00400	0.349
TRG_ER_diArg_1	86	89	PF00400	0.574
TRG_Pf-PMV_PEXEL_1	23	27	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Z2	Leptomonas seymouri	45%	100%
A0A1X0P8Z8	Trypanosomatidae	27%	91%
A0A3Q8IBQ4	Leishmania donovani	79%	99%
A4H3R5	Leishmania braziliensis	61%	100%
A4I4Y4	Leishmania infantum	79%	99%
C9ZKJ5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	93%
E9AEE6	Leishmania major	80%	100%
V5BSV9	Trypanosoma cruzi	36%	100%