LeishMANIAdb
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Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ALD9_LEIMU
TriTrypDb:
LmxM.08_29.2850
Length:
125

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALD9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALD9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 48 52 PF00656 0.437
CLV_C14_Caspase3-7 85 89 PF00656 0.526
CLV_NRD_NRD_1 25 27 PF00675 0.545
CLV_NRD_NRD_1 37 39 PF00675 0.564
CLV_PCSK_KEX2_1 25 27 PF00082 0.545
CLV_PCSK_KEX2_1 36 38 PF00082 0.536
CLV_PCSK_SKI1_1 25 29 PF00082 0.546
CLV_PCSK_SKI1_1 6 10 PF00082 0.644
DEG_APCC_DBOX_1 25 33 PF00400 0.537
DEG_Nend_Nbox_1 1 3 PF02207 0.466
DOC_CYCLIN_RxL_1 22 33 PF00134 0.542
DOC_MAPK_gen_1 25 32 PF00069 0.517
DOC_MAPK_MEF2A_6 25 34 PF00069 0.518
DOC_USP7_MATH_1 7 11 PF00917 0.740
LIG_BRCT_BRCA1_1 20 24 PF00533 0.330
LIG_Clathr_ClatBox_1 27 31 PF01394 0.574
LIG_DCNL_PONY_1 1 4 PF03556 0.466
LIG_FHA_1 70 76 PF00498 0.649
LIG_FHA_1 77 83 PF00498 0.441
LIG_Integrin_RGD_1 62 64 PF01839 0.463
LIG_LIR_Gen_1 91 101 PF02991 0.593
LIG_LIR_Nem_3 21 27 PF02991 0.542
LIG_LIR_Nem_3 91 97 PF02991 0.594
LIG_PDZ_Class_3 120 125 PF00595 0.665
LIG_Pex14_2 100 104 PF04695 0.494
LIG_SH2_CRK 39 43 PF00017 0.564
LIG_SUMO_SIM_anti_2 31 36 PF11976 0.529
LIG_SUMO_SIM_par_1 26 31 PF11976 0.541
LIG_UBA3_1 1 9 PF00899 0.457
MOD_CK2_1 65 71 PF00069 0.699
MOD_CK2_1 7 13 PF00069 0.736
MOD_GlcNHglycan 21 24 PF01048 0.583
MOD_GlcNHglycan 57 60 PF01048 0.758
MOD_GlcNHglycan 67 70 PF01048 0.619
MOD_GSK3_1 14 21 PF00069 0.531
MOD_GSK3_1 65 72 PF00069 0.628
MOD_Plk_1 30 36 PF00069 0.430
MOD_Plk_1 70 76 PF00069 0.548
MOD_Plk_2-3 71 77 PF00069 0.623
MOD_Plk_4 30 36 PF00069 0.560
TRG_DiLeu_BaEn_4 77 83 PF01217 0.604
TRG_DiLeu_BaLyEn_6 23 28 PF01217 0.512
TRG_ENDOCYTIC_2 39 42 PF00928 0.543
TRG_ER_diArg_1 24 26 PF00400 0.509
TRG_ER_diArg_1 35 38 PF00400 0.507
TRG_Pf-PMV_PEXEL_1 14 18 PF00026 0.664
TRG_Pf-PMV_PEXEL_1 26 31 PF00026 0.392

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HY97 Leptomonas seymouri 55% 100%
A0A3Q8IFK4 Leishmania donovani 91% 100%
A0A3R7K9Q0 Trypanosoma rangeli 36% 100%
A4H3R4 Leishmania braziliensis 67% 100%
A4I4Y3 Leishmania infantum 91% 100%
C9ZKJ4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 43% 92%
E9AEE7 Leishmania major 86% 100%
V5C2C8 Trypanosoma cruzi 36% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS