LeishMANIAdb
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EF-hand domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
EF-hand domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania mexicana
UniProt:
E9ALD2_LEIMU
TriTrypDb:
LmxM.07.1130
Length:
576

Annotations

LeishMANIAdb annotations

Homologous to other Eukaryotic mitochondrial outer membrane GTPases.. The lone C-terminal TM segment has a high positive charge at both ends, characteristic of mitochondrial outer membrane anchored proteins.. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0016020 membrane 2 10
GO:0110165 cellular anatomical entity 1 10
GO:0005737 cytoplasm 2 1
GO:0005856 cytoskeleton 5 1
GO:0005886 plasma membrane 3 1
GO:0005938 cell cortex 3 1
GO:0031410 cytoplasmic vesicle 6 1
GO:0031982 vesicle 4 1
GO:0042995 cell projection 2 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0097708 intracellular vesicle 5 1

Expansion

Sequence features

E9ALD2
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALD2

Function

Biological processes
Term Name Level Count
GO:0006996 organelle organization 4 1
GO:0007010 cytoskeleton organization 5 1
GO:0007015 actin filament organization 5 1
GO:0007163 establishment or maintenance of cell polarity 2 1
GO:0008360 regulation of cell shape 6 1
GO:0009987 cellular process 1 1
GO:0016043 cellular component organization 3 1
GO:0022603 regulation of anatomical structure morphogenesis 4 1
GO:0022604 regulation of cell morphogenesis 5 1
GO:0030865 cortical cytoskeleton organization 6 1
GO:0032956 regulation of actin cytoskeleton organization 5 1
GO:0032970 regulation of actin filament-based process 4 1
GO:0033043 regulation of organelle organization 5 1
GO:0050789 regulation of biological process 2 1
GO:0050793 regulation of developmental process 3 1
GO:0050794 regulation of cellular process 3 1
GO:0051128 regulation of cellular component organization 4 1
GO:0051493 regulation of cytoskeleton organization 6 1
GO:0065007 biological regulation 1 1
GO:0071840 cellular component organization or biogenesis 2 1
GO:0097435 supramolecular fiber organization 4 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 1
GO:0003824 catalytic activity 1 1
GO:0003924 GTPase activity 7 1
GO:0005488 binding 1 4
GO:0005515 protein binding 2 1
GO:0005525 GTP binding 5 1
GO:0016462 pyrophosphatase activity 5 1
GO:0016787 hydrolase activity 2 1
GO:0016817 hydrolase activity, acting on acid anhydrides 3 1
GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 4 1
GO:0017076 purine nucleotide binding 4 1
GO:0017111 ribonucleoside triphosphate phosphatase activity 6 1
GO:0019001 guanyl nucleotide binding 5 1
GO:0019899 enzyme binding 3 1
GO:0019900 kinase binding 4 1
GO:0019901 protein kinase binding 5 1
GO:0032553 ribonucleotide binding 3 1
GO:0032555 purine ribonucleotide binding 4 1
GO:0032561 guanyl ribonucleotide binding 5 1
GO:0035639 purine ribonucleoside triphosphate binding 4 1
GO:0036094 small molecule binding 2 1
GO:0043167 ion binding 2 4
GO:0043168 anion binding 3 1
GO:0097159 organic cyclic compound binding 2 1
GO:0097367 carbohydrate derivative binding 2 1
GO:1901265 nucleoside phosphate binding 3 1
GO:1901363 heterocyclic compound binding 2 1
GO:0005509 calcium ion binding 5 3
GO:0043169 cation binding 3 3
GO:0046872 metal ion binding 4 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 440 444 PF00656 0.292
CLV_C14_Caspase3-7 457 461 PF00656 0.437
CLV_C14_Caspase3-7 472 476 PF00656 0.343
CLV_C14_Caspase3-7 93 97 PF00656 0.399
CLV_NRD_NRD_1 163 165 PF00675 0.582
CLV_NRD_NRD_1 309 311 PF00675 0.575
CLV_NRD_NRD_1 332 334 PF00675 0.572
CLV_NRD_NRD_1 361 363 PF00675 0.520
CLV_NRD_NRD_1 548 550 PF00675 0.450
CLV_PCSK_FUR_1 572 576 PF00082 0.455
CLV_PCSK_KEX2_1 265 267 PF00082 0.507
CLV_PCSK_KEX2_1 309 311 PF00082 0.538
CLV_PCSK_KEX2_1 332 334 PF00082 0.572
CLV_PCSK_KEX2_1 361 363 PF00082 0.520
CLV_PCSK_KEX2_1 51 53 PF00082 0.598
CLV_PCSK_KEX2_1 548 550 PF00082 0.450
CLV_PCSK_KEX2_1 572 574 PF00082 0.437
CLV_PCSK_PC1ET2_1 265 267 PF00082 0.573
CLV_PCSK_PC1ET2_1 51 53 PF00082 0.611
CLV_PCSK_SKI1_1 112 116 PF00082 0.565
CLV_PCSK_SKI1_1 137 141 PF00082 0.526
CLV_PCSK_SKI1_1 51 55 PF00082 0.601
CLV_PCSK_SKI1_1 548 552 PF00082 0.541
CLV_PCSK_SKI1_1 78 82 PF00082 0.565
DEG_MDM2_SWIB_1 181 189 PF02201 0.389
DEG_SCF_TRCP1_1 423 429 PF00400 0.209
DEG_SPOP_SBC_1 367 371 PF00917 0.314
DEG_SPOP_SBC_1 387 391 PF00917 0.312
DEG_SPOP_SBC_1 408 412 PF00917 0.317
DEG_SPOP_SBC_1 506 510 PF00917 0.421
DOC_MAPK_gen_1 110 118 PF00069 0.373
DOC_MAPK_gen_1 48 56 PF00069 0.390
DOC_MAPK_gen_1 545 555 PF00069 0.252
DOC_MAPK_MEF2A_6 110 118 PF00069 0.323
DOC_MAPK_MEF2A_6 290 298 PF00069 0.325
DOC_PP2B_LxvP_1 118 121 PF13499 0.312
DOC_PP2B_LxvP_1 155 158 PF13499 0.390
DOC_PP2B_LxvP_1 502 505 PF13499 0.324
DOC_PP2B_LxvP_1 81 84 PF13499 0.373
DOC_USP7_MATH_1 281 285 PF00917 0.347
DOC_USP7_MATH_1 456 460 PF00917 0.258
DOC_USP7_MATH_1 513 517 PF00917 0.429
DOC_USP7_MATH_1 527 531 PF00917 0.343
DOC_USP7_MATH_1 70 74 PF00917 0.387
DOC_WW_Pin1_4 130 135 PF00397 0.360
DOC_WW_Pin1_4 274 279 PF00397 0.298
DOC_WW_Pin1_4 65 70 PF00397 0.321
LIG_14-3-3_CanoR_1 244 250 PF00244 0.337
LIG_14-3-3_CanoR_1 30 38 PF00244 0.385
LIG_14-3-3_CanoR_1 361 365 PF00244 0.313
LIG_14-3-3_CanoR_1 388 393 PF00244 0.335
LIG_14-3-3_CanoR_1 548 553 PF00244 0.341
LIG_APCC_ABBA_1 201 206 PF00400 0.392
LIG_BIR_II_1 1 5 PF00653 0.397
LIG_BIR_III_2 475 479 PF00653 0.271
LIG_BIR_III_4 150 154 PF00653 0.378
LIG_BRCT_BRCA1_1 326 330 PF00533 0.302
LIG_BRCT_BRCA1_1 34 38 PF00533 0.408
LIG_BRCT_BRCA1_1 96 100 PF00533 0.337
LIG_CSL_BTD_1 502 505 PF09270 0.324
LIG_FHA_1 101 107 PF00498 0.372
LIG_FHA_1 113 119 PF00498 0.380
LIG_FHA_1 346 352 PF00498 0.298
LIG_FHA_1 368 374 PF00498 0.363
LIG_FHA_1 39 45 PF00498 0.366
LIG_FHA_1 427 433 PF00498 0.385
LIG_FHA_2 410 416 PF00498 0.383
LIG_FHA_2 438 444 PF00498 0.396
LIG_FHA_2 470 476 PF00498 0.320
LIG_FHA_2 506 512 PF00498 0.357
LIG_LIR_Gen_1 215 225 PF02991 0.390
LIG_LIR_Gen_1 286 296 PF02991 0.207
LIG_LIR_Gen_1 542 550 PF02991 0.479
LIG_LIR_Gen_1 551 560 PF02991 0.386
LIG_LIR_Nem_3 141 147 PF02991 0.377
LIG_LIR_Nem_3 215 220 PF02991 0.378
LIG_LIR_Nem_3 233 237 PF02991 0.200
LIG_LIR_Nem_3 286 291 PF02991 0.312
LIG_LIR_Nem_3 300 304 PF02991 0.271
LIG_LIR_Nem_3 542 546 PF02991 0.494
LIG_LIR_Nem_3 551 555 PF02991 0.344
LIG_MAD2 112 120 PF02301 0.388
LIG_MLH1_MIPbox_1 96 100 PF16413 0.337
LIG_NRBOX 4 10 PF00104 0.328
LIG_NRP_CendR_1 573 576 PF00754 0.466
LIG_Pex14_1 32 36 PF04695 0.323
LIG_Pex14_2 140 144 PF04695 0.326
LIG_Pex14_2 181 185 PF04695 0.387
LIG_Pex14_2 298 302 PF04695 0.284
LIG_REV1ctd_RIR_1 390 397 PF16727 0.384
LIG_SH2_CRK 304 308 PF00017 0.309
LIG_SH2_CRK 338 342 PF00017 0.417
LIG_SH2_NCK_1 526 530 PF00017 0.410
LIG_SH2_PTP2 543 546 PF00017 0.494
LIG_SH2_STAP1 316 320 PF00017 0.275
LIG_SH2_STAP1 448 452 PF00017 0.422
LIG_SH2_STAP1 75 79 PF00017 0.418
LIG_SH2_STAT5 249 252 PF00017 0.290
LIG_SH2_STAT5 328 331 PF00017 0.386
LIG_SH2_STAT5 386 389 PF00017 0.317
LIG_SH2_STAT5 543 546 PF00017 0.494
LIG_SH3_1 338 344 PF00018 0.245
LIG_SH3_3 275 281 PF00018 0.302
LIG_SH3_3 288 294 PF00018 0.314
LIG_SH3_3 338 344 PF00018 0.339
LIG_SH3_3 533 539 PF00018 0.380
LIG_SUMO_SIM_anti_2 429 434 PF11976 0.285
LIG_SUMO_SIM_anti_2 551 557 PF11976 0.426
LIG_SUMO_SIM_par_1 6 13 PF11976 0.364
LIG_SUMO_SIM_par_1 79 85 PF11976 0.325
LIG_TRAF2_1 105 108 PF00917 0.415
LIG_TRAF2_1 173 176 PF00917 0.450
LIG_TYR_ITIM 541 546 PF00017 0.496
LIG_UBA3_1 59 64 PF00899 0.239
MOD_CDK_SPxxK_3 130 137 PF00069 0.402
MOD_CDK_SPxxK_3 65 72 PF00069 0.384
MOD_CK1_1 379 385 PF00069 0.431
MOD_CK1_1 39 45 PF00069 0.354
MOD_CK1_1 410 416 PF00069 0.419
MOD_CK1_1 424 430 PF00069 0.375
MOD_CK1_1 73 79 PF00069 0.332
MOD_CK2_1 170 176 PF00069 0.432
MOD_CK2_1 368 374 PF00069 0.360
MOD_CK2_1 409 415 PF00069 0.353
MOD_CK2_1 448 454 PF00069 0.358
MOD_CK2_1 505 511 PF00069 0.346
MOD_CK2_1 517 523 PF00069 0.356
MOD_Cter_Amidation 359 362 PF01082 0.505
MOD_GlcNHglycan 168 171 PF01048 0.565
MOD_GlcNHglycan 172 175 PF01048 0.561
MOD_GlcNHglycan 370 373 PF01048 0.695
MOD_GlcNHglycan 412 415 PF01048 0.606
MOD_GlcNHglycan 423 426 PF01048 0.601
MOD_GlcNHglycan 443 447 PF01048 0.596
MOD_GlcNHglycan 96 99 PF01048 0.548
MOD_GSK3_1 166 173 PF00069 0.287
MOD_GSK3_1 21 28 PF00069 0.382
MOD_GSK3_1 216 223 PF00069 0.283
MOD_GSK3_1 245 252 PF00069 0.368
MOD_GSK3_1 32 39 PF00069 0.351
MOD_GSK3_1 376 383 PF00069 0.464
MOD_GSK3_1 388 395 PF00069 0.365
MOD_GSK3_1 403 410 PF00069 0.340
MOD_GSK3_1 513 520 PF00069 0.416
MOD_N-GLC_1 32 37 PF02516 0.616
MOD_N-GLC_1 70 75 PF02516 0.489
MOD_N-GLC_2 494 496 PF02516 0.398
MOD_NEK2_1 1 6 PF00069 0.415
MOD_NEK2_1 100 105 PF00069 0.377
MOD_NEK2_1 21 26 PF00069 0.195
MOD_NEK2_1 220 225 PF00069 0.302
MOD_NEK2_1 368 373 PF00069 0.370
MOD_NEK2_1 38 43 PF00069 0.259
MOD_NEK2_1 392 397 PF00069 0.399
MOD_NEK2_1 407 412 PF00069 0.376
MOD_NEK2_1 421 426 PF00069 0.398
MOD_NEK2_1 94 99 PF00069 0.382
MOD_NEK2_2 216 221 PF00069 0.362
MOD_NEK2_2 448 453 PF00069 0.411
MOD_PKA_1 548 554 PF00069 0.341
MOD_PKA_2 243 249 PF00069 0.305
MOD_PKA_2 360 366 PF00069 0.312
MOD_PKA_2 387 393 PF00069 0.337
MOD_PKA_2 548 554 PF00069 0.341
MOD_PKA_2 94 100 PF00069 0.336
MOD_Plk_1 32 38 PF00069 0.400
MOD_Plk_1 324 330 PF00069 0.338
MOD_Plk_1 70 76 PF00069 0.291
MOD_Plk_2-3 517 523 PF00069 0.423
MOD_Plk_4 230 236 PF00069 0.348
MOD_Plk_4 245 251 PF00069 0.211
MOD_Plk_4 382 388 PF00069 0.391
MOD_Plk_4 403 409 PF00069 0.359
MOD_Plk_4 448 454 PF00069 0.406
MOD_Plk_4 539 545 PF00069 0.504
MOD_Plk_4 548 554 PF00069 0.298
MOD_Plk_4 563 569 PF00069 0.426
MOD_ProDKin_1 130 136 PF00069 0.355
MOD_ProDKin_1 274 280 PF00069 0.296
MOD_ProDKin_1 65 71 PF00069 0.325
MOD_SUMO_rev_2 107 111 PF00179 0.413
TRG_DiLeu_BaEn_1 403 408 PF01217 0.393
TRG_DiLeu_BaEn_2 462 468 PF01217 0.365
TRG_DiLeu_BaLyEn_6 49 54 PF01217 0.328
TRG_ENDOCYTIC_2 304 307 PF00928 0.284
TRG_ENDOCYTIC_2 543 546 PF00928 0.478
TRG_ER_diArg_1 308 310 PF00400 0.376
TRG_ER_diArg_1 547 549 PF00400 0.369
TRG_ER_diArg_1 571 574 PF00400 0.633

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PCT6 Leptomonas seymouri 70% 100%
A0A1X0NPJ9 Trypanosomatidae 46% 100%
A0A3R7KVN9 Trypanosoma rangeli 48% 100%
A0A3S5H622 Leishmania donovani 93% 100%
A4H562 Leishmania braziliensis 86% 100%
A4HTD9 Leishmania infantum 93% 100%
C9ZUH2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
Q2UM43 Aspergillus oryzae (strain ATCC 42149 / RIB 40) 23% 91%
Q4QIH3 Leishmania major 93% 100%
Q4WN24 Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) 23% 91%
Q5B5L3 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 23% 91%
Q8RXF8 Arabidopsis thaliana 21% 89%
V5BTM0 Trypanosoma cruzi 47% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS