NIT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALD0_LEIMU

TriTrypDb:

LmxM.07.1110

Length:

362

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

E9ALD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALD0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	302	306	PF00656	0.575
CLV_NRD_NRD_1	229	231	PF00675	0.556
CLV_NRD_NRD_1	251	253	PF00675	0.554
CLV_NRD_NRD_1	260	262	PF00675	0.496
CLV_NRD_NRD_1	27	29	PF00675	0.493
CLV_NRD_NRD_1	292	294	PF00675	0.653
CLV_NRD_NRD_1	302	304	PF00675	0.586
CLV_NRD_NRD_1	32	34	PF00675	0.463
CLV_PCSK_FUR_1	25	29	PF00082	0.471
CLV_PCSK_KEX2_1	251	253	PF00082	0.546
CLV_PCSK_KEX2_1	260	262	PF00082	0.468
CLV_PCSK_KEX2_1	27	29	PF00082	0.493
CLV_PCSK_KEX2_1	292	294	PF00082	0.674
CLV_PCSK_KEX2_1	32	34	PF00082	0.463
CLV_PCSK_PC7_1	28	34	PF00082	0.498
CLV_PCSK_SKI1_1	273	277	PF00082	0.538
CLV_PCSK_SKI1_1	284	288	PF00082	0.536
CLV_PCSK_SKI1_1	42	46	PF00082	0.591
DEG_APCC_DBOX_1	251	259	PF00400	0.496
DOC_CYCLIN_yClb5_NLxxxL_5	133	141	PF00134	0.524
DOC_CYCLIN_yCln2_LP_2	174	180	PF00134	0.569
DOC_MAPK_gen_1	292	298	PF00069	0.745
DOC_MAPK_gen_1	318	326	PF00069	0.481
DOC_MAPK_MEF2A_6	133	141	PF00069	0.522
DOC_PP2B_LxvP_1	174	177	PF13499	0.548
DOC_USP7_MATH_1	180	184	PF00917	0.563
DOC_USP7_MATH_1	186	190	PF00917	0.490
DOC_USP7_MATH_1	343	347	PF00917	0.493
DOC_WW_Pin1_4	218	223	PF00397	0.621
DOC_WW_Pin1_4	297	302	PF00397	0.541
LIG_14-3-3_CanoR_1	115	124	PF00244	0.528
LIG_14-3-3_CanoR_1	151	157	PF00244	0.499
LIG_14-3-3_CanoR_1	264	272	PF00244	0.441
LIG_14-3-3_CanoR_1	284	291	PF00244	0.332
LIG_14-3-3_CanoR_1	292	298	PF00244	0.639
LIG_BRCT_BRCA1_1	188	192	PF00533	0.413
LIG_BRCT_BRCA1_1	345	349	PF00533	0.361
LIG_deltaCOP1_diTrp_1	325	334	PF00928	0.457
LIG_FHA_1	169	175	PF00498	0.579
LIG_FHA_1	219	225	PF00498	0.670
LIG_FHA_1	277	283	PF00498	0.537
LIG_FHA_1	292	298	PF00498	0.667
LIG_FHA_1	330	336	PF00498	0.500
LIG_FHA_1	72	78	PF00498	0.482
LIG_FHA_2	234	240	PF00498	0.615
LIG_FHA_2	266	272	PF00498	0.446
LIG_FHA_2	355	361	PF00498	0.467
LIG_FHA_2	47	53	PF00498	0.579
LIG_LIR_Gen_1	38	47	PF02991	0.488
LIG_LIR_Nem_3	24	29	PF02991	0.435
LIG_LIR_Nem_3	332	337	PF02991	0.414
LIG_LIR_Nem_3	346	351	PF02991	0.418
LIG_LIR_Nem_3	38	43	PF02991	0.494
LIG_LIR_Nem_3	8	12	PF02991	0.675
LIG_MLH1_MIPbox_1	345	349	PF16413	0.361
LIG_PCNA_yPIPBox_3	85	97	PF02747	0.455
LIG_SH2_CRK	40	44	PF00017	0.537
LIG_SH2_CRK	86	90	PF00017	0.543
LIG_SH2_NCK_1	86	90	PF00017	0.573
LIG_SH2_STAP1	210	214	PF00017	0.633
LIG_SH2_STAP1	278	282	PF00017	0.555
LIG_SH2_STAP1	40	44	PF00017	0.464
LIG_SH2_STAT5	278	281	PF00017	0.430
LIG_SH2_STAT5	348	351	PF00017	0.496
LIG_SH2_STAT5	40	43	PF00017	0.532
LIG_SH2_STAT5	96	99	PF00017	0.446
LIG_SH3_3	174	180	PF00018	0.556
LIG_SUMO_SIM_anti_2	73	79	PF11976	0.566
LIG_TRAF2_1	213	216	PF00917	0.627
LIG_WRC_WIRS_1	47	52	PF05994	0.578
LIG_WRC_WIRS_1	6	11	PF05994	0.608
MOD_CDC14_SPxK_1	300	303	PF00782	0.485
MOD_CDK_SPxK_1	297	303	PF00069	0.536
MOD_CDK_SPxxK_3	297	304	PF00069	0.507
MOD_CK1_1	299	305	PF00069	0.617
MOD_CK1_1	330	336	PF00069	0.541
MOD_CK2_1	354	360	PF00069	0.345
MOD_CK2_1	46	52	PF00069	0.527
MOD_GlcNHglycan	188	191	PF01048	0.488
MOD_GlcNHglycan	308	311	PF01048	0.404
MOD_GlcNHglycan	329	332	PF01048	0.456
MOD_GSK3_1	165	172	PF00069	0.432
MOD_GSK3_1	186	193	PF00069	0.483
MOD_GSK3_1	233	240	PF00069	0.683
MOD_GSK3_1	38	45	PF00069	0.469
MOD_LATS_1	113	119	PF00433	0.583
MOD_N-GLC_1	218	223	PF02516	0.683
MOD_NEK2_1	165	170	PF00069	0.542
MOD_NEK2_1	21	26	PF00069	0.484
MOD_NEK2_1	225	230	PF00069	0.685
MOD_NEK2_1	296	301	PF00069	0.656
MOD_NEK2_1	351	356	PF00069	0.419
MOD_PKA_2	291	297	PF00069	0.658
MOD_PKA_2	327	333	PF00069	0.410
MOD_PKA_2	53	59	PF00069	0.599
MOD_Plk_2-3	46	52	PF00069	0.497
MOD_Plk_4	169	175	PF00069	0.459
MOD_Plk_4	330	336	PF00069	0.490
MOD_Plk_4	343	349	PF00069	0.507
MOD_ProDKin_1	218	224	PF00069	0.621
MOD_ProDKin_1	297	303	PF00069	0.536
MOD_SUMO_rev_2	314	320	PF00179	0.550
MOD_SUMO_rev_2	65	71	PF00179	0.585
TRG_DiLeu_BaEn_1	39	44	PF01217	0.608
TRG_DiLeu_BaEn_3	119	125	PF01217	0.555
TRG_ENDOCYTIC_2	114	117	PF00928	0.487
TRG_ENDOCYTIC_2	347	350	PF00928	0.422
TRG_ENDOCYTIC_2	40	43	PF00928	0.485
TRG_ENDOCYTIC_2	86	89	PF00928	0.558
TRG_ER_diArg_1	259	261	PF00400	0.594
TRG_ER_diArg_1	26	28	PF00400	0.497
TRG_ER_diArg_1	291	293	PF00400	0.621
TRG_ER_diArg_1	31	33	PF00400	0.469
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.611
TRG_Pf-PMV_PEXEL_1	264	269	PF00026	0.487

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0I2	Leptomonas seymouri	69%	99%
A0A1X0NRB2	Trypanosomatidae	42%	100%
A0A3R7MAC7	Trypanosoma rangeli	46%	100%
A0A3S7WQ18	Leishmania donovani	93%	100%
A4H560	Leishmania braziliensis	84%	100%
A4HTD7	Leishmania infantum	93%	100%
C9ZUH5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
Q4QIH5	Leishmania major	91%	100%
V5B8H7	Trypanosoma cruzi	45%	100%