Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALC9_LEIMU

TriTrypDb:

LmxM.07.1100

Length:

305

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALC9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	157	161	PF00656	0.655
CLV_NRD_NRD_1	173	175	PF00675	0.664
CLV_NRD_NRD_1	183	185	PF00675	0.483
CLV_NRD_NRD_1	293	295	PF00675	0.501
CLV_NRD_NRD_1	297	299	PF00675	0.574
CLV_NRD_NRD_1	71	73	PF00675	0.550
CLV_PCSK_FUR_1	69	73	PF00082	0.546
CLV_PCSK_KEX2_1	173	175	PF00082	0.662
CLV_PCSK_KEX2_1	185	187	PF00082	0.463
CLV_PCSK_KEX2_1	266	268	PF00082	0.593
CLV_PCSK_KEX2_1	293	295	PF00082	0.520
CLV_PCSK_KEX2_1	297	299	PF00082	0.560
CLV_PCSK_KEX2_1	71	73	PF00082	0.558
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.668
CLV_PCSK_PC1ET2_1	266	268	PF00082	0.564
CLV_PCSK_PC7_1	293	299	PF00082	0.455
CLV_PCSK_SKI1_1	212	216	PF00082	0.701
CLV_PCSK_SKI1_1	293	297	PF00082	0.594
CLV_PCSK_SKI1_1	71	75	PF00082	0.544
CLV_PCSK_SKI1_1	94	98	PF00082	0.515
DEG_SPOP_SBC_1	9	13	PF00917	0.593
DOC_USP7_MATH_1	258	262	PF00917	0.395
DOC_USP7_MATH_1	44	48	PF00917	0.674
DOC_USP7_MATH_1	9	13	PF00917	0.723
DOC_WW_Pin1_4	176	181	PF00397	0.722
LIG_14-3-3_CanoR_1	257	263	PF00244	0.584
LIG_14-3-3_CanoR_1	71	79	PF00244	0.578
LIG_14-3-3_CanoR_1	94	104	PF00244	0.644
LIG_Actin_WH2_2	55	73	PF00022	0.615
LIG_BIR_III_4	200	204	PF00653	0.601
LIG_CaM_NSCaTE_8	235	242	PF13499	0.555
LIG_FHA_1	100	106	PF00498	0.627
LIG_FHA_1	177	183	PF00498	0.662
LIG_FHA_1	54	60	PF00498	0.676
LIG_GBD_Chelix_1	129	137	PF00786	0.637
LIG_LIR_Apic_2	147	151	PF02991	0.591
LIG_PTB_Apo_2	138	145	PF02174	0.504
LIG_SH2_CRK	148	152	PF00017	0.660
LIG_SH2_STAT5	106	109	PF00017	0.599
LIG_SH2_STAT5	145	148	PF00017	0.678
LIG_SH2_STAT5	262	265	PF00017	0.514
LIG_SH2_STAT5	277	280	PF00017	0.425
LIG_SUMO_SIM_par_1	55	60	PF11976	0.632
LIG_TRAF2_1	273	276	PF00917	0.622
LIG_WRC_WIRS_1	250	255	PF05994	0.405
MOD_CK1_1	12	18	PF00069	0.660
MOD_CK1_1	19	25	PF00069	0.619
MOD_CK1_1	217	223	PF00069	0.611
MOD_CK1_1	231	237	PF00069	0.417
MOD_CK1_1	53	59	PF00069	0.564
MOD_CK2_1	162	168	PF00069	0.672
MOD_CK2_1	8	14	PF00069	0.663
MOD_GlcNHglycan	126	129	PF01048	0.601
MOD_GlcNHglycan	204	207	PF01048	0.679
MOD_GlcNHglycan	21	24	PF01048	0.644
MOD_GlcNHglycan	216	219	PF01048	0.610
MOD_GlcNHglycan	221	224	PF01048	0.594
MOD_GlcNHglycan	41	44	PF01048	0.425
MOD_GlcNHglycan	48	51	PF01048	0.647
MOD_GSK3_1	120	127	PF00069	0.542
MOD_GSK3_1	18	25	PF00069	0.561
MOD_GSK3_1	213	220	PF00069	0.600
MOD_GSK3_1	249	256	PF00069	0.507
MOD_GSK3_1	46	53	PF00069	0.640
MOD_GSK3_1	8	15	PF00069	0.677
MOD_GSK3_1	95	102	PF00069	0.582
MOD_NEK2_1	144	149	PF00069	0.552
MOD_NEK2_1	17	22	PF00069	0.764
MOD_NEK2_1	214	219	PF00069	0.615
MOD_NEK2_1	221	226	PF00069	0.670
MOD_NEK2_1	239	244	PF00069	0.539
MOD_NEK2_1	253	258	PF00069	0.610
MOD_NEK2_1	39	44	PF00069	0.478
MOD_NEK2_1	90	95	PF00069	0.683
MOD_PIKK_1	72	78	PF00454	0.565
MOD_PKA_2	253	259	PF00069	0.678
MOD_Plk_1	13	19	PF00069	0.775
MOD_Plk_1	99	105	PF00069	0.564
MOD_Plk_2-3	246	252	PF00069	0.545
MOD_Plk_4	132	138	PF00069	0.591
MOD_ProDKin_1	176	182	PF00069	0.726
MOD_SUMO_rev_2	198	206	PF00179	0.612
MOD_SUMO_rev_2	261	268	PF00179	0.626
TRG_ER_diArg_1	172	174	PF00400	0.693
TRG_ER_diArg_1	183	186	PF00400	0.470
TRG_ER_diArg_1	292	294	PF00400	0.504
TRG_ER_diArg_1	296	298	PF00400	0.536
TRG_ER_diArg_1	69	72	PF00400	0.549
TRG_NLS_Bipartite_1	173	188	PF00514	0.743
TRG_NLS_MonoExtN_4	181	188	PF00514	0.744
TRG_Pf-PMV_PEXEL_1	174	178	PF00026	0.711
TRG_Pf-PMV_PEXEL_1	72	76	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3L7	Leptomonas seymouri	57%	100%
A0A1X0NPM5	Trypanosomatidae	29%	91%
A0A3R7LS50	Trypanosoma rangeli	34%	100%
A0A3S5H619	Leishmania donovani	87%	100%
A4H559	Leishmania braziliensis	73%	100%
A4HTD6	Leishmania infantum	87%	100%
C9ZUH8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4QIH6	Leishmania major	86%	100%
V5BYD2	Trypanosoma cruzi	34%	90%