Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALC7_LEIMU

TriTrypDb:

LmxM.07.1080

Length:

838

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALC7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	214	220	PF00089	0.539
CLV_NRD_NRD_1	367	369	PF00675	0.613
CLV_NRD_NRD_1	378	380	PF00675	0.619
CLV_NRD_NRD_1	381	383	PF00675	0.631
CLV_NRD_NRD_1	474	476	PF00675	0.703
CLV_NRD_NRD_1	511	513	PF00675	0.525
CLV_NRD_NRD_1	531	533	PF00675	0.358
CLV_NRD_NRD_1	608	610	PF00675	0.585
CLV_NRD_NRD_1	755	757	PF00675	0.527
CLV_NRD_NRD_1	796	798	PF00675	0.724
CLV_PCSK_KEX2_1	241	243	PF00082	0.510
CLV_PCSK_KEX2_1	367	369	PF00082	0.609
CLV_PCSK_KEX2_1	474	476	PF00082	0.703
CLV_PCSK_KEX2_1	530	532	PF00082	0.564
CLV_PCSK_KEX2_1	755	757	PF00082	0.508
CLV_PCSK_KEX2_1	767	769	PF00082	0.417
CLV_PCSK_PC1ET2_1	241	243	PF00082	0.510
CLV_PCSK_PC1ET2_1	767	769	PF00082	0.458
CLV_PCSK_SKI1_1	346	350	PF00082	0.652
CLV_PCSK_SKI1_1	360	364	PF00082	0.441
CLV_PCSK_SKI1_1	388	392	PF00082	0.529
CLV_PCSK_SKI1_1	394	398	PF00082	0.461
CLV_PCSK_SKI1_1	755	759	PF00082	0.528
DEG_APCC_DBOX_1	796	804	PF00400	0.552
DEG_Nend_UBRbox_3	1	3	PF02207	0.496
DEG_SPOP_SBC_1	313	317	PF00917	0.510
DEG_SPOP_SBC_1	786	790	PF00917	0.705
DOC_ANK_TNKS_1	216	223	PF00023	0.529
DOC_CKS1_1	701	706	PF01111	0.467
DOC_CYCLIN_RxL_1	752	761	PF00134	0.562
DOC_CYCLIN_yClb5_NLxxxL_5	554	563	PF00134	0.586
DOC_CYCLIN_yCln2_LP_2	296	302	PF00134	0.636
DOC_MAPK_gen_1	97	104	PF00069	0.516
DOC_MAPK_MEF2A_6	589	596	PF00069	0.548
DOC_MAPK_MEF2A_6	97	106	PF00069	0.498
DOC_PP1_RVXF_1	73	79	PF00149	0.461
DOC_PP2B_LxvP_1	296	299	PF13499	0.619
DOC_USP7_MATH_1	114	118	PF00917	0.496
DOC_USP7_MATH_1	24	28	PF00917	0.561
DOC_USP7_MATH_1	313	317	PF00917	0.676
DOC_USP7_MATH_1	479	483	PF00917	0.789
DOC_USP7_MATH_1	502	506	PF00917	0.625
DOC_USP7_MATH_1	521	525	PF00917	0.658
DOC_USP7_MATH_1	637	641	PF00917	0.599
DOC_USP7_MATH_1	691	695	PF00917	0.660
DOC_USP7_MATH_1	786	790	PF00917	0.485
DOC_USP7_MATH_1	86	90	PF00917	0.557
DOC_USP7_UBL2_3	434	438	PF12436	0.533
DOC_WW_Pin1_4	136	141	PF00397	0.562
DOC_WW_Pin1_4	700	705	PF00397	0.685
DOC_WW_Pin1_4	787	792	PF00397	0.667
LIG_14-3-3_CanoR_1	340	344	PF00244	0.659
LIG_14-3-3_CanoR_1	410	414	PF00244	0.524
LIG_14-3-3_CanoR_1	465	470	PF00244	0.650
LIG_14-3-3_CanoR_1	553	557	PF00244	0.565
LIG_14-3-3_CanoR_1	601	605	PF00244	0.591
LIG_14-3-3_CanoR_1	768	776	PF00244	0.559
LIG_14-3-3_CanoR_1	797	801	PF00244	0.701
LIG_APCC_ABBA_1	359	364	PF00400	0.544
LIG_APCC_ABBA_1	61	66	PF00400	0.482
LIG_APCC_ABBAyCdc20_2	358	364	PF00400	0.546
LIG_APCC_Cbox_2	633	639	PF00515	0.586
LIG_BIR_III_4	155	159	PF00653	0.488
LIG_BIR_III_4	690	694	PF00653	0.683
LIG_FHA_1	188	194	PF00498	0.466
LIG_FHA_1	223	229	PF00498	0.457
LIG_FHA_1	248	254	PF00498	0.494
LIG_FHA_1	285	291	PF00498	0.433
LIG_FHA_1	313	319	PF00498	0.718
LIG_FHA_1	4	10	PF00498	0.552
LIG_FHA_1	659	665	PF00498	0.666
LIG_FHA_1	752	758	PF00498	0.587
LIG_FHA_1	816	822	PF00498	0.554
LIG_FHA_2	448	454	PF00498	0.607
LIG_FHA_2	492	498	PF00498	0.611
LIG_FHA_2	580	586	PF00498	0.680
LIG_FHA_2	601	607	PF00498	0.584
LIG_FHA_2	709	715	PF00498	0.728
LIG_FHA_2	744	750	PF00498	0.574
LIG_LIR_Gen_1	145	156	PF02991	0.360
LIG_LIR_Gen_1	633	639	PF02991	0.571
LIG_LIR_Gen_1	746	752	PF02991	0.531
LIG_LIR_Nem_3	145	151	PF02991	0.313
LIG_LIR_Nem_3	606	611	PF02991	0.524
LIG_LIR_Nem_3	633	638	PF02991	0.566
LIG_LIR_Nem_3	746	751	PF02991	0.530
LIG_LRP6_Inhibitor_1	736	742	PF00058	0.677
LIG_MYND_1	304	308	PF01753	0.729
LIG_NRBOX	538	544	PF00104	0.621
LIG_NRBOX	558	564	PF00104	0.325
LIG_PCNA_yPIPBox_3	629	641	PF02747	0.587
LIG_PCNA_yPIPBox_3	742	751	PF02747	0.638
LIG_Pex14_2	64	68	PF04695	0.476
LIG_PTB_Apo_2	100	107	PF02174	0.547
LIG_Rb_LxCxE_1	575	588	PF01857	0.700
LIG_RPA_C_Fungi	346	358	PF08784	0.529
LIG_RPA_C_Fungi	751	763	PF08784	0.625
LIG_SH2_CRK	148	152	PF00017	0.550
LIG_SH2_CRK	608	612	PF00017	0.623
LIG_SH2_NCK_1	79	83	PF00017	0.570
LIG_SH2_SRC	121	124	PF00017	0.541
LIG_SH2_STAP1	148	152	PF00017	0.550
LIG_SH2_STAT5	121	124	PF00017	0.508
LIG_SH2_STAT5	161	164	PF00017	0.486
LIG_SH2_STAT5	527	530	PF00017	0.562
LIG_SH2_STAT5	614	617	PF00017	0.539
LIG_SH2_STAT5	700	703	PF00017	0.476
LIG_SH2_STAT5	740	743	PF00017	0.544
LIG_SH2_STAT5	825	828	PF00017	0.494
LIG_SH3_3	119	125	PF00018	0.540
LIG_SH3_3	296	302	PF00018	0.642
LIG_SH3_3	551	557	PF00018	0.584
LIG_SH3_3	698	704	PF00018	0.770
LIG_SUMO_SIM_anti_2	179	187	PF11976	0.543
LIG_SUMO_SIM_anti_2	538	544	PF11976	0.654
LIG_SUMO_SIM_anti_2	760	766	PF11976	0.529
LIG_SUMO_SIM_par_1	225	231	PF11976	0.447
LIG_TRAF2_1	17	20	PF00917	0.577
LIG_TRAF2_1	350	353	PF00917	0.559
LIG_TRAF2_1	716	719	PF00917	0.666
LIG_UBA3_1	747	753	PF00899	0.634
LIG_WRC_WIRS_1	147	152	PF05994	0.547
MOD_CDK_SPxK_1	700	706	PF00069	0.470
MOD_CDK_SPxK_1	791	797	PF00069	0.755
MOD_CDK_SPxxK_3	791	798	PF00069	0.730
MOD_CK1_1	135	141	PF00069	0.563
MOD_CK1_1	339	345	PF00069	0.569
MOD_CK1_1	34	40	PF00069	0.540
MOD_CK1_1	790	796	PF00069	0.626
MOD_CK1_1	799	805	PF00069	0.541
MOD_CK2_1	174	180	PF00069	0.567
MOD_CK2_1	436	442	PF00069	0.552
MOD_CK2_1	491	497	PF00069	0.609
MOD_CK2_1	579	585	PF00069	0.618
MOD_CK2_1	600	606	PF00069	0.582
MOD_CK2_1	67	73	PF00069	0.526
MOD_CK2_1	713	719	PF00069	0.720
MOD_CK2_1	743	749	PF00069	0.604
MOD_CK2_1	824	830	PF00069	0.497
MOD_GlcNHglycan	116	119	PF01048	0.514
MOD_GlcNHglycan	155	159	PF01048	0.400
MOD_GlcNHglycan	174	177	PF01048	0.280
MOD_GlcNHglycan	218	221	PF01048	0.482
MOD_GlcNHglycan	230	233	PF01048	0.345
MOD_GlcNHglycan	26	29	PF01048	0.533
MOD_GlcNHglycan	33	36	PF01048	0.451
MOD_GlcNHglycan	481	484	PF01048	0.732
MOD_GlcNHglycan	504	507	PF01048	0.629
MOD_GlcNHglycan	519	522	PF01048	0.690
MOD_GlcNHglycan	559	562	PF01048	0.648
MOD_GlcNHglycan	679	682	PF01048	0.595
MOD_GlcNHglycan	693	696	PF01048	0.703
MOD_GlcNHglycan	770	773	PF01048	0.554
MOD_GlcNHglycan	807	810	PF01048	0.566
MOD_GlcNHglycan	826	829	PF01048	0.533
MOD_GSK3_1	112	119	PF00069	0.509
MOD_GSK3_1	130	137	PF00069	0.404
MOD_GSK3_1	142	149	PF00069	0.455
MOD_GSK3_1	172	179	PF00069	0.364
MOD_GSK3_1	189	196	PF00069	0.438
MOD_GSK3_1	230	237	PF00069	0.432
MOD_GSK3_1	247	254	PF00069	0.401
MOD_GSK3_1	394	401	PF00069	0.480
MOD_GSK3_1	422	429	PF00069	0.605
MOD_GSK3_1	447	454	PF00069	0.556
MOD_GSK3_1	487	494	PF00069	0.664
MOD_GSK3_1	517	524	PF00069	0.531
MOD_GSK3_1	596	603	PF00069	0.619
MOD_GSK3_1	781	788	PF00069	0.624
MOD_LATS_1	128	134	PF00433	0.566
MOD_LATS_1	766	772	PF00433	0.546
MOD_N-GLC_1	102	107	PF02516	0.547
MOD_N-GLC_1	557	562	PF02516	0.543
MOD_N-GLC_1	786	791	PF02516	0.674
MOD_NEK2_1	134	139	PF00069	0.559
MOD_NEK2_1	422	427	PF00069	0.624
MOD_NEK2_1	517	522	PF00069	0.565
MOD_NEK2_1	525	530	PF00069	0.548
MOD_NEK2_1	563	568	PF00069	0.494
MOD_NEK2_1	596	601	PF00069	0.582
MOD_NEK2_1	653	658	PF00069	0.540
MOD_NEK2_1	660	665	PF00069	0.574
MOD_NEK2_1	758	763	PF00069	0.566
MOD_NEK2_1	781	786	PF00069	0.600
MOD_NEK2_2	116	121	PF00069	0.534
MOD_PIKK_1	142	148	PF00454	0.244
MOD_PIKK_1	415	421	PF00454	0.525
MOD_PKA_2	216	222	PF00069	0.449
MOD_PKA_2	339	345	PF00069	0.563
MOD_PKA_2	409	415	PF00069	0.425
MOD_PKA_2	448	454	PF00069	0.462
MOD_PKA_2	464	470	PF00069	0.602
MOD_PKA_2	552	558	PF00069	0.566
MOD_PKA_2	600	606	PF00069	0.617
MOD_PKA_2	796	802	PF00069	0.641
MOD_Plk_1	102	108	PF00069	0.551
MOD_Plk_1	284	290	PF00069	0.354
MOD_Plk_1	415	421	PF00069	0.579
MOD_Plk_1	525	531	PF00069	0.558
MOD_Plk_1	557	563	PF00069	0.627
MOD_Plk_1	713	719	PF00069	0.543
MOD_Plk_2-3	743	749	PF00069	0.595
MOD_Plk_4	116	122	PF00069	0.482
MOD_Plk_4	146	152	PF00069	0.476
MOD_Plk_4	189	195	PF00069	0.426
MOD_Plk_4	230	236	PF00069	0.441
MOD_Plk_4	563	569	PF00069	0.502
MOD_Plk_4	743	749	PF00069	0.562
MOD_Plk_4	86	92	PF00069	0.503
MOD_ProDKin_1	136	142	PF00069	0.554
MOD_ProDKin_1	700	706	PF00069	0.686
MOD_ProDKin_1	787	793	PF00069	0.669
MOD_SUMO_for_1	362	365	PF00179	0.625
MOD_SUMO_rev_2	339	348	PF00179	0.567
MOD_SUMO_rev_2	372	381	PF00179	0.381
TRG_DiLeu_BaEn_1	180	185	PF01217	0.547
TRG_DiLeu_BaEn_1	365	370	PF01217	0.610
TRG_DiLeu_BaEn_1	535	540	PF01217	0.656
TRG_DiLeu_BaEn_3	365	371	PF01217	0.532
TRG_DiLeu_BaEn_4	352	358	PF01217	0.553
TRG_DiLeu_BaLyEn_6	703	708	PF01217	0.677
TRG_DiLeu_BaLyEn_6	753	758	PF01217	0.637
TRG_ENDOCYTIC_2	148	151	PF00928	0.563
TRG_ENDOCYTIC_2	608	611	PF00928	0.516
TRG_ER_diArg_1	357	360	PF00400	0.504
TRG_ER_diArg_1	367	369	PF00400	0.468
TRG_ER_diArg_1	474	476	PF00400	0.684
TRG_ER_diArg_1	529	532	PF00400	0.568
TRG_ER_diArg_1	546	549	PF00400	0.502
TRG_ER_diArg_1	755	757	PF00400	0.629
TRG_Pf-PMV_PEXEL_1	367	372	PF00026	0.559
TRG_Pf-PMV_PEXEL_1	379	384	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	443	447	PF00026	0.656
TRG_Pf-PMV_PEXEL_1	728	733	PF00026	0.700
TRG_Pf-PMV_PEXEL_1	734	738	PF00026	0.596
TRG_Pf-PMV_PEXEL_1	755	760	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HV16	Leptomonas seymouri	56%	95%
A0A1X0NPL3	Trypanosomatidae	37%	91%
A0A3S5H617	Leishmania donovani	90%	100%
A0A3S5IQT7	Trypanosoma rangeli	38%	92%
A4H557	Leishmania braziliensis	75%	98%
A4HTD4	Leishmania infantum	90%	100%
C9ZUI0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	95%
Q4QIH8	Leishmania major	88%	100%
V5BTL6	Trypanosoma cruzi	35%	92%