Putative RNA-editing complex protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA-editing complex protein, putative

Species:

Leishmania mexicana

UniProt:

E9ALC6_LEIMU

TriTrypDb:

LmxM.07.1070

Length:

502

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0031019	mitochondrial mRNA editing complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0045293	mRNA editing complex	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9ALC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALC6

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0010035	response to inorganic substance	3	1
GO:0010038	response to metal ion	4	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016556	mRNA modification	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0042221	response to chemical	2	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0050896	response to stimulus	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000175	3'-5'-RNA exonuclease activity	7	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0004521	RNA endonuclease activity	5	1
GO:0004527	exonuclease activity	5	1
GO:0004532	RNA exonuclease activity	5	1
GO:0004540	RNA nuclease activity	4	1
GO:0005488	binding	1	3
GO:0008270	zinc ion binding	6	1
GO:0008408	3'-5' exonuclease activity	6	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016796	exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	1
GO:0016896	RNA exonuclease activity, producing 5'-phosphomonoesters	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1
GO:0140098	catalytic activity, acting on RNA	3	1
GO:0140640	catalytic activity, acting on a nucleic acid	2	1
GO:0003676	nucleic acid binding	3	2
GO:0003677	DNA binding	4	2
GO:0003697	single-stranded DNA binding	5	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.730
CLV_NRD_NRD_1	23	25	PF00675	0.483
CLV_NRD_NRD_1	59	61	PF00675	0.599
CLV_NRD_NRD_1	68	70	PF00675	0.570
CLV_PCSK_KEX2_1	23	25	PF00082	0.448
CLV_PCSK_KEX2_1	267	269	PF00082	0.567
CLV_PCSK_KEX2_1	59	61	PF00082	0.576
CLV_PCSK_KEX2_1	68	70	PF00082	0.552
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.566
CLV_PCSK_SKI1_1	267	271	PF00082	0.482
DEG_Nend_UBRbox_1	1	4	PF02207	0.428
DEG_SCF_FBW7_1	226	233	PF00400	0.595
DEG_SPOP_SBC_1	192	196	PF00917	0.728
DOC_CKS1_1	429	434	PF01111	0.497
DOC_CYCLIN_yCln2_LP_2	238	244	PF00134	0.576
DOC_MAPK_gen_1	14	21	PF00069	0.427
DOC_MAPK_gen_1	152	160	PF00069	0.578
DOC_MAPK_MEF2A_6	14	21	PF00069	0.427
DOC_MAPK_MEF2A_6	396	404	PF00069	0.523
DOC_MAPK_MEF2A_6	483	492	PF00069	0.353
DOC_PP2B_LxvP_1	238	241	PF13499	0.574
DOC_PP2B_PxIxI_1	487	493	PF00149	0.353
DOC_PP4_FxxP_1	210	213	PF00568	0.621
DOC_PP4_FxxP_1	228	231	PF00568	0.473
DOC_PP4_FxxP_1	429	432	PF00568	0.434
DOC_PP4_FxxP_1	451	454	PF00568	0.492
DOC_SPAK_OSR1_1	464	468	PF12202	0.376
DOC_USP7_MATH_1	179	183	PF00917	0.579
DOC_USP7_MATH_1	191	195	PF00917	0.579
DOC_USP7_MATH_1	217	221	PF00917	0.689
DOC_USP7_MATH_1	319	323	PF00917	0.726
DOC_USP7_MATH_1	353	357	PF00917	0.586
DOC_USP7_UBL2_3	148	152	PF12436	0.529
DOC_WW_Pin1_4	193	198	PF00397	0.626
DOC_WW_Pin1_4	201	206	PF00397	0.508
DOC_WW_Pin1_4	226	231	PF00397	0.673
DOC_WW_Pin1_4	300	305	PF00397	0.694
DOC_WW_Pin1_4	32	37	PF00397	0.465
DOC_WW_Pin1_4	320	325	PF00397	0.754
DOC_WW_Pin1_4	428	433	PF00397	0.418
DOC_WW_Pin1_4	43	48	PF00397	0.469
LIG_14-3-3_CanoR_1	107	115	PF00244	0.583
LIG_14-3-3_CanoR_1	16	22	PF00244	0.428
LIG_14-3-3_CanoR_1	69	77	PF00244	0.662
LIG_CaM_IQ_9	272	288	PF13499	0.409
LIG_Clathr_ClatBox_1	157	161	PF01394	0.563
LIG_FHA_1	126	132	PF00498	0.522
LIG_FHA_1	16	22	PF00498	0.428
LIG_FHA_1	160	166	PF00498	0.635
LIG_FHA_1	276	282	PF00498	0.420
LIG_FHA_1	39	45	PF00498	0.486
LIG_FHA_1	441	447	PF00498	0.361
LIG_FHA_1	466	472	PF00498	0.362
LIG_FHA_1	98	104	PF00498	0.588
LIG_FHA_2	321	327	PF00498	0.677
LIG_LIR_Apic_2	227	231	PF02991	0.584
LIG_LIR_Apic_2	427	432	PF02991	0.437
LIG_LIR_Apic_2	450	454	PF02991	0.492
LIG_LIR_Gen_1	438	447	PF02991	0.375
LIG_LIR_Nem_3	128	132	PF02991	0.499
LIG_LIR_Nem_3	438	444	PF02991	0.403
LIG_LIR_Nem_3	450	455	PF02991	0.390
LIG_LYPXL_yS_3	487	490	PF13949	0.356
LIG_PDZ_Class_2	497	502	PF00595	0.380
LIG_Pex14_2	206	210	PF04695	0.660
LIG_SH2_CRK	485	489	PF00017	0.376
LIG_SH2_STAT3	363	366	PF00017	0.687
LIG_SH2_STAT5	11	14	PF00017	0.427
LIG_SH2_STAT5	363	366	PF00017	0.554
LIG_SH2_STAT5	414	417	PF00017	0.473
LIG_SH3_3	321	327	PF00018	0.787
LIG_SH3_3	369	375	PF00018	0.481
LIG_SH3_3	380	386	PF00018	0.466
LIG_SH3_3	41	47	PF00018	0.469
LIG_SH3_3	431	437	PF00018	0.440
LIG_Sin3_3	72	79	PF02671	0.427
LIG_TRAF2_1	261	264	PF00917	0.684
LIG_TRAF2_1	385	388	PF00917	0.447
MOD_CK1_1	173	179	PF00069	0.606
MOD_CK1_1	182	188	PF00069	0.627
MOD_CK1_1	196	202	PF00069	0.760
MOD_CK1_1	300	306	PF00069	0.586
MOD_CK1_1	320	326	PF00069	0.770
MOD_CK1_1	87	93	PF00069	0.694
MOD_CK1_1	98	104	PF00069	0.729
MOD_CK2_1	320	326	PF00069	0.792
MOD_GlcNHglycan	182	185	PF01048	0.624
MOD_GlcNHglycan	198	201	PF01048	0.732
MOD_GlcNHglycan	299	302	PF01048	0.585
MOD_GlcNHglycan	319	322	PF01048	0.683
MOD_GlcNHglycan	333	336	PF01048	0.726
MOD_GlcNHglycan	495	498	PF01048	0.469
MOD_GlcNHglycan	54	57	PF01048	0.502
MOD_GlcNHglycan	72	75	PF01048	0.515
MOD_GlcNHglycan	86	89	PF01048	0.703
MOD_GSK3_1	170	177	PF00069	0.598
MOD_GSK3_1	192	199	PF00069	0.664
MOD_GSK3_1	226	233	PF00069	0.610
MOD_GSK3_1	296	303	PF00069	0.523
MOD_GSK3_1	309	316	PF00069	0.637
MOD_GSK3_1	32	39	PF00069	0.519
MOD_GSK3_1	424	431	PF00069	0.475
MOD_GSK3_1	43	50	PF00069	0.713
MOD_GSK3_1	84	91	PF00069	0.579
MOD_N-GLC_1	353	358	PF02516	0.608
MOD_N-GLC_2	26	28	PF02516	0.450
MOD_N-GLC_2	399	401	PF02516	0.372
MOD_NEK2_1	270	275	PF00069	0.416
MOD_NEK2_1	421	426	PF00069	0.431
MOD_NEK2_1	465	470	PF00069	0.423
MOD_NEK2_2	125	130	PF00069	0.521
MOD_NEK2_2	275	280	PF00069	0.405
MOD_PIKK_1	476	482	PF00454	0.507
MOD_PKA_2	106	112	PF00069	0.672
MOD_PKA_2	15	21	PF00069	0.427
MOD_Plk_1	353	359	PF00069	0.605
MOD_Plk_1	88	94	PF00069	0.725
MOD_Plk_4	47	53	PF00069	0.542
MOD_Plk_4	88	94	PF00069	0.748
MOD_ProDKin_1	193	199	PF00069	0.627
MOD_ProDKin_1	201	207	PF00069	0.503
MOD_ProDKin_1	226	232	PF00069	0.676
MOD_ProDKin_1	300	306	PF00069	0.695
MOD_ProDKin_1	32	38	PF00069	0.468
MOD_ProDKin_1	320	326	PF00069	0.755
MOD_ProDKin_1	428	434	PF00069	0.423
MOD_ProDKin_1	43	49	PF00069	0.470
TRG_DiLeu_BaEn_2	265	271	PF01217	0.629
TRG_ENDOCYTIC_2	487	490	PF00928	0.356
TRG_ER_diArg_1	1	4	PF00400	0.448
TRG_ER_diArg_1	22	24	PF00400	0.518
TRG_ER_diArg_1	58	60	PF00400	0.596
TRG_ER_diArg_1	68	70	PF00400	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1P1	Leptomonas seymouri	56%	100%
A0A0S4IKI2	Bodo saltans	45%	100%
A0A1X0NPK8	Trypanosomatidae	48%	100%
A0A3S5H616	Leishmania donovani	89%	100%
A0A422N9Y4	Trypanosoma rangeli	50%	100%
A4H556	Leishmania braziliensis	72%	97%
A4HTD3	Leishmania infantum	89%	100%
C9ZUI1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
Q4QIH9	Leishmania major	90%	100%
V5DQ35	Trypanosoma cruzi	46%	100%