Lipoate-protein ligase-like (Putative lipoyl ligase) (Putative lipoyltransferase) (Putative lipoate biosynthesis protein)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

lipoyltransferase, putative

Species:

Leishmania mexicana

UniProt:

E9ALC5_LEIMU

TriTrypDb:

LmxM.07.1060

Length:

514

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALC5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALC5

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009249	protein lipoylation	5	10
GO:0018193	peptidyl-amino acid modification	5	10
GO:0018205	peptidyl-lysine modification	6	10
GO:0019538	protein metabolic process	3	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044238	primary metabolic process	2	10
GO:0051604	protein maturation	4	10
GO:0071704	organic substance metabolic process	2	10
GO:1901564	organonitrogen compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0016740	transferase activity	2	6
GO:0016874	ligase activity	2	10
GO:0016746	acyltransferase activity	3	1
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	1
GO:0017118	lipoyltransferase activity	5	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1
GO:0016779	nucleotidyltransferase activity	4	1
GO:0016879	ligase activity, forming carbon-nitrogen bonds	3	1
GO:0016979	lipoate-protein ligase activity	3	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	99	103	PF00656	0.362
CLV_NRD_NRD_1	108	110	PF00675	0.210
CLV_NRD_NRD_1	170	172	PF00675	0.367
CLV_NRD_NRD_1	310	312	PF00675	0.438
CLV_NRD_NRD_1	352	354	PF00675	0.408
CLV_NRD_NRD_1	417	419	PF00675	0.482
CLV_NRD_NRD_1	7	9	PF00675	0.532
CLV_NRD_NRD_1	97	99	PF00675	0.250
CLV_PCSK_KEX2_1	108	110	PF00082	0.210
CLV_PCSK_KEX2_1	245	247	PF00082	0.453
CLV_PCSK_KEX2_1	310	312	PF00082	0.494
CLV_PCSK_KEX2_1	351	353	PF00082	0.425
CLV_PCSK_KEX2_1	417	419	PF00082	0.486
CLV_PCSK_KEX2_1	7	9	PF00082	0.532
CLV_PCSK_KEX2_1	97	99	PF00082	0.250
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.453
CLV_PCSK_SKI1_1	171	175	PF00082	0.259
CLV_PCSK_SKI1_1	352	356	PF00082	0.478
CLV_PCSK_SKI1_1	409	413	PF00082	0.349
CLV_PCSK_SKI1_1	498	502	PF00082	0.363
CLV_PCSK_SKI1_1	507	511	PF00082	0.325
DEG_APCC_DBOX_1	350	358	PF00400	0.484
DEG_Nend_Nbox_1	1	3	PF02207	0.637
DEG_SCF_FBW7_1	192	199	PF00400	0.492
DOC_ANK_TNKS_1	97	104	PF00023	0.483
DOC_CKS1_1	193	198	PF01111	0.565
DOC_CKS1_1	213	218	PF01111	0.251
DOC_CYCLIN_RxL_1	495	502	PF00134	0.431
DOC_CYCLIN_RxL_1	59	69	PF00134	0.464
DOC_MAPK_gen_1	351	359	PF00069	0.412
DOC_MAPK_gen_1	505	514	PF00069	0.322
DOC_MAPK_MEF2A_6	138	147	PF00069	0.464
DOC_MIT_MIM_1	349	357	PF04212	0.406
DOC_PP4_FxxP_1	213	216	PF00568	0.280
DOC_USP7_MATH_1	196	200	PF00917	0.442
DOC_USP7_MATH_1	224	228	PF00917	0.415
DOC_USP7_MATH_1	424	428	PF00917	0.687
DOC_USP7_MATH_1	56	60	PF00917	0.502
DOC_USP7_UBL2_3	326	330	PF12436	0.420
DOC_WW_Pin1_4	192	197	PF00397	0.551
DOC_WW_Pin1_4	212	217	PF00397	0.356
DOC_WW_Pin1_4	220	225	PF00397	0.417
DOC_WW_Pin1_4	261	266	PF00397	0.414
LIG_14-3-3_CanoR_1	157	166	PF00244	0.452
LIG_14-3-3_CanoR_1	274	278	PF00244	0.364
LIG_14-3-3_CanoR_1	283	288	PF00244	0.292
LIG_14-3-3_CanoR_1	351	360	PF00244	0.412
LIG_14-3-3_CanoR_1	409	415	PF00244	0.349
LIG_14-3-3_CanoR_1	442	449	PF00244	0.468
LIG_14-3-3_CanoR_1	62	67	PF00244	0.464
LIG_14-3-3_CanoR_1	97	104	PF00244	0.378
LIG_APCC_ABBAyCdc20_2	163	169	PF00400	0.433
LIG_BRCT_BRCA1_1	364	368	PF00533	0.259
LIG_Clathr_ClatBox_1	289	293	PF01394	0.397
LIG_deltaCOP1_diTrp_1	331	339	PF00928	0.418
LIG_deltaCOP1_diTrp_1	502	510	PF00928	0.429
LIG_eIF4E_1	186	192	PF01652	0.528
LIG_FHA_1	137	143	PF00498	0.488
LIG_FHA_1	188	194	PF00498	0.433
LIG_FHA_1	213	219	PF00498	0.379
LIG_FHA_1	29	35	PF00498	0.543
LIG_FHA_1	338	344	PF00498	0.369
LIG_FHA_1	410	416	PF00498	0.478
LIG_FHA_1	43	49	PF00498	0.340
LIG_FHA_1	464	470	PF00498	0.513
LIG_FHA_1	495	501	PF00498	0.281
LIG_FHA_2	262	268	PF00498	0.480
LIG_FHA_2	317	323	PF00498	0.408
LIG_FHA_2	402	408	PF00498	0.548
LIG_FHA_2	97	103	PF00498	0.362
LIG_Integrin_RGD_1	314	316	PF01839	0.479
LIG_LIR_Apic_2	201	206	PF02991	0.438
LIG_LIR_Apic_2	331	337	PF02991	0.420
LIG_LIR_Gen_1	207	218	PF02991	0.436
LIG_LIR_Gen_1	49	56	PF02991	0.360
LIG_LIR_LC3C_4	38	42	PF02991	0.414
LIG_LIR_Nem_3	207	213	PF02991	0.377
LIG_LIR_Nem_3	49	54	PF02991	0.362
LIG_NRBOX	443	449	PF00104	0.463
LIG_PCNA_yPIPBox_3	408	418	PF02747	0.378
LIG_PDZ_Class_2	509	514	PF00595	0.347
LIG_SH2_GRB2like	76	79	PF00017	0.305
LIG_SH2_NCK_1	334	338	PF00017	0.473
LIG_SH2_STAT3	9	12	PF00017	0.567
LIG_SH2_STAT5	203	206	PF00017	0.365
LIG_SH2_STAT5	210	213	PF00017	0.355
LIG_SH2_STAT5	76	79	PF00017	0.323
LIG_SH3_3	190	196	PF00018	0.506
LIG_SH3_3	218	224	PF00018	0.403
LIG_SH3_3	23	29	PF00018	0.461
LIG_SH3_3	446	452	PF00018	0.562
LIG_SH3_3	476	482	PF00018	0.489
LIG_SH3_3	74	80	PF00018	0.341
LIG_SH3_5	206	210	PF00018	0.485
LIG_SUMO_SIM_anti_2	371	379	PF11976	0.378
LIG_SUMO_SIM_anti_2	490	497	PF11976	0.337
LIG_SUMO_SIM_par_1	189	195	PF11976	0.433
LIG_SUMO_SIM_par_1	340	346	PF11976	0.324
LIG_SUMO_SIM_par_1	492	497	PF11976	0.528
LIG_TRAF2_1	370	373	PF00917	0.396
LIG_TRAF2_1	55	58	PF00917	0.286
LIG_TRFH_1	9	13	PF08558	0.549
LIG_UBA3_1	60	68	PF00899	0.361
MOD_CK1_1	126	132	PF00069	0.433
MOD_CK1_1	217	223	PF00069	0.405
MOD_CK1_1	276	282	PF00069	0.407
MOD_CK1_1	432	438	PF00069	0.576
MOD_CK2_1	224	230	PF00069	0.426
MOD_CK2_1	261	267	PF00069	0.452
MOD_CK2_1	316	322	PF00069	0.378
MOD_CK2_1	343	349	PF00069	0.416
MOD_CK2_1	401	407	PF00069	0.479
MOD_CK2_1	46	52	PF00069	0.432
MOD_Cter_Amidation	308	311	PF01082	0.472
MOD_GlcNHglycan	110	113	PF01048	0.242
MOD_GlcNHglycan	175	178	PF01048	0.233
MOD_GlcNHglycan	230	233	PF01048	0.404
MOD_GlcNHglycan	285	288	PF01048	0.356
MOD_GlcNHglycan	345	348	PF01048	0.355
MOD_GlcNHglycan	426	429	PF01048	0.747
MOD_GlcNHglycan	431	434	PF01048	0.566
MOD_GlcNHglycan	435	438	PF01048	0.598
MOD_GlcNHglycan	444	447	PF01048	0.315
MOD_GSK3_1	192	199	PF00069	0.538
MOD_GSK3_1	220	227	PF00069	0.390
MOD_GSK3_1	339	346	PF00069	0.397
MOD_GSK3_1	42	49	PF00069	0.371
MOD_GSK3_1	420	427	PF00069	0.652
MOD_GSK3_1	429	436	PF00069	0.583
MOD_GSK3_1	459	466	PF00069	0.477
MOD_GSK3_1	92	99	PF00069	0.506
MOD_N-GLC_2	122	124	PF02516	0.264
MOD_NEK2_1	1	6	PF00069	0.607
MOD_NEK2_1	123	128	PF00069	0.475
MOD_NEK2_1	147	152	PF00069	0.463
MOD_NEK2_1	158	163	PF00069	0.428
MOD_NEK2_1	19	24	PF00069	0.569
MOD_NEK2_1	228	233	PF00069	0.366
MOD_NEK2_1	273	278	PF00069	0.470
MOD_NEK2_1	339	344	PF00069	0.421
MOD_NEK2_1	410	415	PF00069	0.476
MOD_NEK2_1	463	468	PF00069	0.448
MOD_NEK2_1	494	499	PF00069	0.409
MOD_NEK2_1	96	101	PF00069	0.362
MOD_PKA_1	108	114	PF00069	0.440
MOD_PKA_1	171	177	PF00069	0.459
MOD_PKA_1	352	358	PF00069	0.256
MOD_PKA_2	108	114	PF00069	0.437
MOD_PKA_2	156	162	PF00069	0.433
MOD_PKA_2	273	279	PF00069	0.559
MOD_PKA_2	35	41	PF00069	0.467
MOD_PKA_2	352	358	PF00069	0.378
MOD_PKA_2	96	102	PF00069	0.426
MOD_PKB_1	281	289	PF00069	0.304
MOD_Plk_1	136	142	PF00069	0.502
MOD_Plk_1	464	470	PF00069	0.551
MOD_Plk_1	56	62	PF00069	0.343
MOD_Plk_1	92	98	PF00069	0.516
MOD_Plk_2-3	316	322	PF00069	0.517
MOD_Plk_4	1	7	PF00069	0.689
MOD_Plk_4	187	193	PF00069	0.446
MOD_Plk_4	339	345	PF00069	0.381
MOD_Plk_4	410	416	PF00069	0.454
MOD_Plk_4	46	52	PF00069	0.402
MOD_Plk_4	469	475	PF00069	0.392
MOD_Plk_4	56	62	PF00069	0.408
MOD_ProDKin_1	192	198	PF00069	0.559
MOD_ProDKin_1	212	218	PF00069	0.360
MOD_ProDKin_1	220	226	PF00069	0.409
MOD_ProDKin_1	261	267	PF00069	0.419
TRG_DiLeu_BaEn_1	69	74	PF01217	0.273
TRG_ENDOCYTIC_2	210	213	PF00928	0.374
TRG_ER_diArg_1	131	134	PF00400	0.506
TRG_ER_diArg_1	310	312	PF00400	0.463
TRG_ER_diArg_1	350	353	PF00400	0.411
TRG_ER_diArg_1	416	418	PF00400	0.472
TRG_ER_diArg_1	6	8	PF00400	0.624
TRG_ER_diArg_1	96	98	PF00400	0.491
TRG_NES_CRM1_1	349	361	PF08389	0.451
TRG_Pf-PMV_PEXEL_1	202	207	PF00026	0.496
TRG_Pf-PMV_PEXEL_1	498	502	PF00026	0.348
TRG_Pf-PMV_PEXEL_1	62	67	PF00026	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I310	Leptomonas seymouri	59%	100%
A0A0S4IZJ4	Bodo saltans	39%	82%
A0A1X0NQ94	Trypanosomatidae	39%	100%
A0A3R7MGW3	Trypanosoma rangeli	40%	99%
A0A3S5H615	Leishmania donovani	90%	100%
A4H555	Leishmania braziliensis	79%	100%
C9ZUI2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4QII0	Leishmania major	89%	100%