Sel1 repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALC2_LEIMU

TriTrypDb:

LmxM.07.1040

Length:

324

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALC2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	166	170	PF00656	0.428
CLV_C14_Caspase3-7	93	97	PF00656	0.567
CLV_NRD_NRD_1	85	87	PF00675	0.588
CLV_PCSK_KEX2_1	297	299	PF00082	0.417
CLV_PCSK_KEX2_1	316	318	PF00082	0.388
CLV_PCSK_KEX2_1	85	87	PF00082	0.600
CLV_PCSK_PC1ET2_1	297	299	PF00082	0.394
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.610
CLV_PCSK_SKI1_1	269	273	PF00082	0.460
CLV_PCSK_SKI1_1	313	317	PF00082	0.487
DEG_SPOP_SBC_1	33	37	PF00917	0.522
DOC_CKS1_1	56	61	PF01111	0.334
DOC_CYCLIN_RxL_1	266	276	PF00134	0.466
DOC_CYCLIN_yCln2_LP_2	134	140	PF00134	0.405
DOC_MAPK_MEF2A_6	62	70	PF00069	0.259
DOC_USP7_MATH_1	11	15	PF00917	0.665
DOC_USP7_MATH_1	17	21	PF00917	0.669
DOC_USP7_MATH_1	179	183	PF00917	0.401
DOC_USP7_MATH_1	208	212	PF00917	0.397
DOC_USP7_MATH_1	229	233	PF00917	0.639
DOC_USP7_MATH_1	34	38	PF00917	0.544
DOC_WW_Pin1_4	133	138	PF00397	0.593
DOC_WW_Pin1_4	15	20	PF00397	0.718
DOC_WW_Pin1_4	55	60	PF00397	0.454
LIG_14-3-3_CanoR_1	206	215	PF00244	0.410
LIG_14-3-3_CanoR_1	86	92	PF00244	0.572
LIG_Actin_WH2_2	191	208	PF00022	0.551
LIG_BRCT_BRCA1_1	34	38	PF00533	0.508
LIG_deltaCOP1_diTrp_1	244	251	PF00928	0.396
LIG_FHA_1	189	195	PF00498	0.469
LIG_FHA_1	34	40	PF00498	0.429
LIG_FHA_2	304	310	PF00498	0.462
LIG_FHA_2	91	97	PF00498	0.591
LIG_LIR_Gen_1	117	127	PF02991	0.368
LIG_LIR_Nem_3	117	122	PF02991	0.357
LIG_NRBOX	266	272	PF00104	0.334
LIG_NRP_CendR_1	321	324	PF00754	0.400
LIG_PCNA_PIPBox_1	161	170	PF02747	0.360
LIG_SH2_SRC	213	216	PF00017	0.331
LIG_SH2_STAT5	213	216	PF00017	0.466
LIG_SH3_3	171	177	PF00018	0.413
LIG_SUMO_SIM_anti_2	135	142	PF11976	0.384
LIG_WRC_WIRS_1	164	169	PF05994	0.400
MOD_CDK_SPxxK_3	55	62	PF00069	0.349
MOD_CK1_1	200	206	PF00069	0.414
MOD_CK1_1	280	286	PF00069	0.579
MOD_CK1_1	32	38	PF00069	0.515
MOD_CK1_1	90	96	PF00069	0.513
MOD_CK2_1	303	309	PF00069	0.441
MOD_CK2_1	34	40	PF00069	0.403
MOD_GlcNHglycan	119	122	PF01048	0.433
MOD_GlcNHglycan	210	213	PF01048	0.427
MOD_GlcNHglycan	281	285	PF01048	0.595
MOD_GlcNHglycan	31	34	PF01048	0.509
MOD_GlcNHglycan	5	8	PF01048	0.740
MOD_GlcNHglycan	9	12	PF01048	0.697
MOD_GSK3_1	11	18	PF00069	0.478
MOD_GSK3_1	128	135	PF00069	0.419
MOD_GSK3_1	29	36	PF00069	0.582
MOD_GSK3_1	3	10	PF00069	0.512
MOD_GSK3_1	51	58	PF00069	0.615
MOD_NEK2_1	128	133	PF00069	0.368
MOD_PIKK_1	260	266	PF00454	0.472
MOD_PKA_1	85	91	PF00069	0.582
MOD_PKA_2	85	91	PF00069	0.582
MOD_Plk_1	51	57	PF00069	0.345
MOD_Plk_2-3	163	169	PF00069	0.426
MOD_Plk_4	108	114	PF00069	0.417
MOD_Plk_4	129	135	PF00069	0.597
MOD_Plk_4	163	169	PF00069	0.402
MOD_Plk_4	200	206	PF00069	0.405
MOD_Plk_4	34	40	PF00069	0.507
MOD_ProDKin_1	133	139	PF00069	0.585
MOD_ProDKin_1	15	21	PF00069	0.716
MOD_ProDKin_1	55	61	PF00069	0.453
TRG_DiLeu_BaEn_1	310	315	PF01217	0.378
TRG_DiLeu_BaEn_2	162	168	PF01217	0.358
TRG_Pf-PMV_PEXEL_1	69	73	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBF0	Leptomonas seymouri	49%	71%
A0A1X0NPV5	Trypanosomatidae	36%	95%
A0A3R7RGL1	Trypanosoma rangeli	32%	100%
A0A3S7WQ08	Leishmania donovani	88%	100%
A4HTC9	Leishmania infantum	88%	100%
E9AI29	Leishmania braziliensis	77%	100%
Q4QII3	Leishmania major	89%	100%
V5BYB8	Trypanosoma cruzi	36%	100%