Putative nucleolar RNA-binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

nucleolar RNA-binding protein, putative

Species:

Leishmania mexicana

UniProt:

E9ALB6_LEIMU

TriTrypDb:

LmxM.07.0990

Length:

341

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 3
NetGPI	no	yes: 0, no: 3

Cellular components
Term	Name	Level	Count
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:1990904	ribonucleoprotein complex	2	1

Expansion

Sequence features

E9ALB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALB6

Function

Biological processes
Term	Name	Level	Count
GO:0000027	ribosomal large subunit assembly	7	1
GO:0009987	cellular process	1	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0022618	ribonucleoprotein complex assembly	6	1
GO:0043933	protein-containing complex organization	4	1
GO:0065003	protein-containing complex assembly	5	1
GO:0071826	ribonucleoprotein complex subunit organization	5	1
GO:0071840	cellular component organization or biogenesis	2	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0019843	rRNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	230	232	PF00675	0.745
CLV_PCSK_KEX2_1	337	339	PF00082	0.717
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.717
CLV_PCSK_SKI1_1	13	17	PF00082	0.570
CLV_PCSK_SKI1_1	49	53	PF00082	0.425
DEG_Nend_UBRbox_2	1	3	PF02207	0.713
DOC_CYCLIN_yCln2_LP_2	30	36	PF00134	0.425
DOC_PP2B_LxvP_1	30	33	PF13499	0.425
DOC_USP7_MATH_1	107	111	PF00917	0.729
DOC_USP7_MATH_1	144	148	PF00917	0.762
LIG_14-3-3_CanoR_1	26	33	PF00244	0.425
LIG_Actin_WH2_2	12	28	PF00022	0.425
LIG_FHA_1	65	71	PF00498	0.439
LIG_FHA_1	88	94	PF00498	0.526
LIG_Integrin_RGD_1	238	240	PF01839	0.745
LIG_Integrin_RGD_1	279	281	PF01839	0.618
LIG_LIR_Apic_2	90	95	PF02991	0.425
LIG_LIR_LC3C_4	41	44	PF02991	0.425
LIG_LIR_Nem_3	2	7	PF02991	0.425
LIG_SH2_PTP2	92	95	PF00017	0.562
LIG_SH2_STAT5	92	95	PF00017	0.707
LIG_TRAF2_1	110	113	PF00917	0.786
LIG_TRAF2_1	147	150	PF00917	0.758
LIG_WRC_WIRS_1	43	48	PF05994	0.425
MOD_CK2_1	107	113	PF00069	0.734
MOD_CK2_1	123	129	PF00069	0.607
MOD_CK2_1	144	150	PF00069	0.761
MOD_Cter_Amidation	335	338	PF01082	0.724
MOD_GlcNHglycan	109	112	PF01048	0.740
MOD_GlcNHglycan	138	141	PF01048	0.694
MOD_GlcNHglycan	79	82	PF01048	0.512
MOD_GSK3_1	123	130	PF00069	0.755
MOD_GSK3_1	38	45	PF00069	0.541
MOD_NEK2_1	25	30	PF00069	0.570
MOD_PIKK_1	25	31	PF00454	0.570
MOD_PKA_2	25	31	PF00069	0.425
MOD_Plk_1	75	81	PF00069	0.425
MOD_Plk_2-3	113	119	PF00069	0.754
MOD_Plk_2-3	123	129	PF00069	0.659
MOD_Plk_2-3	212	218	PF00069	0.610
MOD_Plk_4	38	44	PF00069	0.505
MOD_SUMO_rev_2	41	51	PF00179	0.425
TRG_ER_diArg_1	338	341	PF00400	0.720
TRG_NLS_MonoExtN_4	334	341	PF00514	0.724

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H611	Leishmania donovani	84%	100%
Q4QII8	Leishmania major	73%	97%