WD domain, G-beta repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALB4_LEIMU

TriTrypDb:

LmxM.07.0970

Length:

879

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALB4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	788	792	PF00656	0.565
CLV_C14_Caspase3-7	873	877	PF00656	0.495
CLV_NRD_NRD_1	116	118	PF00675	0.618
CLV_NRD_NRD_1	139	141	PF00675	0.503
CLV_NRD_NRD_1	229	231	PF00675	0.659
CLV_NRD_NRD_1	237	239	PF00675	0.732
CLV_NRD_NRD_1	557	559	PF00675	0.492
CLV_NRD_NRD_1	575	577	PF00675	0.361
CLV_NRD_NRD_1	628	630	PF00675	0.735
CLV_NRD_NRD_1	665	667	PF00675	0.568
CLV_NRD_NRD_1	755	757	PF00675	0.768
CLV_NRD_NRD_1	763	765	PF00675	0.788
CLV_PCSK_FUR_1	113	117	PF00082	0.626
CLV_PCSK_KEX2_1	115	117	PF00082	0.605
CLV_PCSK_KEX2_1	139	141	PF00082	0.503
CLV_PCSK_KEX2_1	229	231	PF00082	0.674
CLV_PCSK_KEX2_1	237	239	PF00082	0.522
CLV_PCSK_KEX2_1	24	26	PF00082	0.554
CLV_PCSK_KEX2_1	575	577	PF00082	0.620
CLV_PCSK_KEX2_1	628	630	PF00082	0.740
CLV_PCSK_KEX2_1	665	667	PF00082	0.568
CLV_PCSK_KEX2_1	742	744	PF00082	0.734
CLV_PCSK_KEX2_1	754	756	PF00082	0.741
CLV_PCSK_KEX2_1	762	764	PF00082	0.490
CLV_PCSK_PC1ET2_1	24	26	PF00082	0.601
CLV_PCSK_PC1ET2_1	742	744	PF00082	0.734
CLV_PCSK_PC1ET2_1	754	756	PF00082	0.741
CLV_PCSK_PC1ET2_1	762	764	PF00082	0.490
CLV_PCSK_PC7_1	233	239	PF00082	0.485
CLV_PCSK_SKI1_1	150	154	PF00082	0.615
CLV_PCSK_SKI1_1	233	237	PF00082	0.530
CLV_PCSK_SKI1_1	238	242	PF00082	0.564
CLV_PCSK_SKI1_1	323	327	PF00082	0.531
CLV_PCSK_SKI1_1	356	360	PF00082	0.575
CLV_PCSK_SKI1_1	417	421	PF00082	0.444
CLV_PCSK_SKI1_1	558	562	PF00082	0.524
CLV_PCSK_SKI1_1	644	648	PF00082	0.567
CLV_PCSK_SKI1_1	694	698	PF00082	0.752
DEG_APCC_DBOX_1	149	157	PF00400	0.704
DEG_MDM2_SWIB_1	335	343	PF02201	0.465
DEG_SPOP_SBC_1	307	311	PF00917	0.537
DEG_SPOP_SBC_1	688	692	PF00917	0.547
DOC_ANK_TNKS_1	471	478	PF00023	0.454
DOC_CKS1_1	173	178	PF01111	0.549
DOC_CKS1_1	695	700	PF01111	0.548
DOC_CKS1_1	850	855	PF01111	0.595
DOC_CYCLIN_RxL_1	233	246	PF00134	0.574
DOC_CYCLIN_RxL_1	556	567	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	604	610	PF00134	0.589
DOC_MAPK_DCC_7	150	158	PF00069	0.713
DOC_MAPK_gen_1	115	127	PF00069	0.548
DOC_MAPK_gen_1	139	145	PF00069	0.463
DOC_MAPK_gen_1	558	565	PF00069	0.469
DOC_MAPK_MEF2A_6	150	158	PF00069	0.713
DOC_MAPK_MEF2A_6	404	411	PF00069	0.446
DOC_MAPK_MEF2A_6	558	565	PF00069	0.569
DOC_MAPK_MEF2A_6	603	611	PF00069	0.592
DOC_MAPK_NFAT4_5	558	566	PF00069	0.485
DOC_PP1_RVXF_1	334	340	PF00149	0.444
DOC_PP1_RVXF_1	601	607	PF00149	0.313
DOC_PP2B_LxvP_1	360	363	PF13499	0.522
DOC_PP4_FxxP_1	177	180	PF00568	0.704
DOC_PP4_FxxP_1	236	239	PF00568	0.492
DOC_PP4_FxxP_1	415	418	PF00568	0.477
DOC_USP7_MATH_1	224	228	PF00917	0.603
DOC_USP7_MATH_1	274	278	PF00917	0.620
DOC_USP7_MATH_1	289	293	PF00917	0.802
DOC_USP7_MATH_1	302	306	PF00917	0.597
DOC_USP7_MATH_1	308	312	PF00917	0.637
DOC_USP7_MATH_1	375	379	PF00917	0.725
DOC_USP7_MATH_1	440	444	PF00917	0.451
DOC_USP7_MATH_1	5	9	PF00917	0.541
DOC_USP7_MATH_1	638	642	PF00917	0.496
DOC_USP7_MATH_1	677	681	PF00917	0.817
DOC_USP7_MATH_1	748	752	PF00917	0.849
DOC_USP7_MATH_1	806	810	PF00917	0.656
DOC_USP7_MATH_1	856	860	PF00917	0.715
DOC_WW_Pin1_4	106	111	PF00397	0.653
DOC_WW_Pin1_4	143	148	PF00397	0.493
DOC_WW_Pin1_4	172	177	PF00397	0.539
DOC_WW_Pin1_4	253	258	PF00397	0.788
DOC_WW_Pin1_4	282	287	PF00397	0.557
DOC_WW_Pin1_4	3	8	PF00397	0.556
DOC_WW_Pin1_4	303	308	PF00397	0.744
DOC_WW_Pin1_4	373	378	PF00397	0.770
DOC_WW_Pin1_4	611	616	PF00397	0.425
DOC_WW_Pin1_4	694	699	PF00397	0.699
DOC_WW_Pin1_4	724	729	PF00397	0.695
DOC_WW_Pin1_4	731	736	PF00397	0.698
DOC_WW_Pin1_4	794	799	PF00397	0.730
DOC_WW_Pin1_4	849	854	PF00397	0.676
LIG_14-3-3_CanoR_1	15	20	PF00244	0.586
LIG_14-3-3_CanoR_1	244	248	PF00244	0.577
LIG_14-3-3_CanoR_1	250	258	PF00244	0.583
LIG_14-3-3_CanoR_1	338	347	PF00244	0.536
LIG_14-3-3_CanoR_1	356	361	PF00244	0.459
LIG_14-3-3_CanoR_1	396	401	PF00244	0.353
LIG_14-3-3_CanoR_1	446	451	PF00244	0.472
LIG_14-3-3_CanoR_1	593	601	PF00244	0.425
LIG_14-3-3_CanoR_1	628	632	PF00244	0.543
LIG_14-3-3_CanoR_1	650	657	PF00244	0.464
LIG_Actin_WH2_2	549	566	PF00022	0.570
LIG_AP2alpha_2	130	132	PF02296	0.512
LIG_BIR_II_1	1	5	PF00653	0.808
LIG_BIR_III_1	1	5	PF00653	0.721
LIG_BIR_III_2	795	799	PF00653	0.817
LIG_BIR_III_3	1	5	PF00653	0.721
LIG_BRCT_BRCA1_1	128	132	PF00533	0.502
LIG_BRCT_BRCA1_1	15	19	PF00533	0.643
LIG_BRCT_BRCA1_1	411	415	PF00533	0.549
LIG_BRCT_BRCA1_1	5	9	PF00533	0.797
LIG_CaM_IQ_9	438	453	PF13499	0.588
LIG_deltaCOP1_diTrp_1	36	41	PF00928	0.533
LIG_FHA_1	120	126	PF00498	0.493
LIG_FHA_1	136	142	PF00498	0.440
LIG_FHA_1	285	291	PF00498	0.554
LIG_FHA_1	386	392	PF00498	0.681
LIG_FHA_1	436	442	PF00498	0.447
LIG_FHA_1	510	516	PF00498	0.572
LIG_FHA_1	658	664	PF00498	0.603
LIG_FHA_1	843	849	PF00498	0.509
LIG_FHA_2	535	541	PF00498	0.487
LIG_FHA_2	88	94	PF00498	0.718
LIG_FXI_DFP_1	479	483	PF00024	0.748
LIG_IRF3_LxIS_1	406	412	PF10401	0.461
LIG_LIR_Apic_2	175	180	PF02991	0.600
LIG_LIR_Apic_2	36	42	PF02991	0.542
LIG_LIR_Apic_2	399	403	PF02991	0.586
LIG_LIR_Apic_2	412	418	PF02991	0.466
LIG_LIR_Gen_1	416	425	PF02991	0.448
LIG_LIR_Gen_1	527	535	PF02991	0.536
LIG_LIR_LC3C_4	204	207	PF02991	0.452
LIG_LIR_Nem_3	327	333	PF02991	0.564
LIG_LIR_Nem_3	38	44	PF02991	0.591
LIG_LIR_Nem_3	416	422	PF02991	0.451
LIG_LIR_Nem_3	527	532	PF02991	0.526
LIG_LIR_Nem_3	605	609	PF02991	0.482
LIG_LIR_Nem_3	803	807	PF02991	0.748
LIG_LYPXL_SIV_4	871	879	PF13949	0.498
LIG_Pex14_1	173	177	PF04695	0.594
LIG_Pex14_2	123	127	PF04695	0.317
LIG_Pex14_2	335	339	PF04695	0.464
LIG_Pex14_2	35	39	PF04695	0.517
LIG_Pex14_2	415	419	PF04695	0.469
LIG_Rb_LxCxE_1	350	359	PF01857	0.471
LIG_SH2_CRK	105	109	PF00017	0.568
LIG_SH2_CRK	118	122	PF00017	0.586
LIG_SH2_CRK	331	335	PF00017	0.517
LIG_SH2_CRK	400	404	PF00017	0.605
LIG_SH2_NCK_1	105	109	PF00017	0.499
LIG_SH2_NCK_1	331	335	PF00017	0.475
LIG_SH2_NCK_1	872	876	PF00017	0.500
LIG_SH2_STAP1	509	513	PF00017	0.407
LIG_SH2_STAP1	631	635	PF00017	0.530
LIG_SH2_STAT5	201	204	PF00017	0.534
LIG_SH2_STAT5	331	334	PF00017	0.467
LIG_SH2_STAT5	625	628	PF00017	0.635
LIG_SH2_STAT5	631	634	PF00017	0.543
LIG_SH2_STAT5	655	658	PF00017	0.495
LIG_SH3_3	1	7	PF00018	0.578
LIG_SH3_3	173	179	PF00018	0.421
LIG_SH3_3	268	274	PF00018	0.726
LIG_SH3_3	34	40	PF00018	0.519
LIG_SH3_3	346	352	PF00018	0.446
LIG_SH3_3	480	486	PF00018	0.716
LIG_SH3_3	848	854	PF00018	0.581
LIG_SUMO_SIM_anti_2	839	845	PF11976	0.571
LIG_SUMO_SIM_par_1	154	160	PF11976	0.635
LIG_SUMO_SIM_par_1	407	413	PF11976	0.422
LIG_SUMO_SIM_par_1	536	542	PF11976	0.489
LIG_SUMO_SIM_par_1	644	649	PF11976	0.372
LIG_TRAF2_1	278	281	PF00917	0.587
LIG_TRAF2_1	352	355	PF00917	0.461
LIG_TRAF2_1	669	672	PF00917	0.567
LIG_TRAF2_1	701	704	PF00917	0.739
LIG_TRAF2_1	781	784	PF00917	0.720
LIG_TRAF2_2	161	166	PF00917	0.667
LIG_WRC_WIRS_1	325	330	PF05994	0.555
LIG_WRC_WIRS_1	618	623	PF05994	0.551
LIG_WRC_WIRS_1	801	806	PF05994	0.678
LIG_WW_1	198	201	PF00397	0.507
MOD_CDC14_SPxK_1	797	800	PF00782	0.807
MOD_CDK_SPxK_1	172	178	PF00069	0.415
MOD_CDK_SPxK_1	794	800	PF00069	0.819
MOD_CDK_SPxxK_3	106	113	PF00069	0.674
MOD_CDK_SPxxK_3	143	150	PF00069	0.517
MOD_CK1_1	106	112	PF00069	0.508
MOD_CK1_1	186	192	PF00069	0.800
MOD_CK1_1	243	249	PF00069	0.630
MOD_CK1_1	272	278	PF00069	0.656
MOD_CK1_1	3	9	PF00069	0.719
MOD_CK1_1	306	312	PF00069	0.697
MOD_CK1_1	385	391	PF00069	0.662
MOD_CK1_1	627	633	PF00069	0.555
MOD_CK1_1	65	71	PF00069	0.817
MOD_CK1_1	727	733	PF00069	0.801
MOD_CK1_1	842	848	PF00069	0.431
MOD_CK1_1	98	104	PF00069	0.718
MOD_CK2_1	208	214	PF00069	0.420
MOD_CK2_1	289	295	PF00069	0.791
MOD_CK2_1	504	510	PF00069	0.421
MOD_CK2_1	565	571	PF00069	0.641
MOD_CK2_1	617	623	PF00069	0.640
MOD_CK2_1	665	671	PF00069	0.534
MOD_CK2_1	687	693	PF00069	0.549
MOD_CK2_1	87	93	PF00069	0.758
MOD_GlcNHglycan	193	196	PF01048	0.733
MOD_GlcNHglycan	209	213	PF01048	0.347
MOD_GlcNHglycan	253	256	PF01048	0.740
MOD_GlcNHglycan	266	269	PF01048	0.696
MOD_GlcNHglycan	276	279	PF01048	0.549
MOD_GlcNHglycan	291	294	PF01048	0.679
MOD_GlcNHglycan	311	314	PF01048	0.710
MOD_GlcNHglycan	317	320	PF01048	0.704
MOD_GlcNHglycan	369	372	PF01048	0.795
MOD_GlcNHglycan	53	56	PF01048	0.707
MOD_GlcNHglycan	540	544	PF01048	0.582
MOD_GlcNHglycan	567	570	PF01048	0.672
MOD_GlcNHglycan	667	670	PF01048	0.644
MOD_GlcNHglycan	684	687	PF01048	0.697
MOD_GlcNHglycan	750	753	PF01048	0.843
MOD_GlcNHglycan	771	774	PF01048	0.772
MOD_GlcNHglycan	808	811	PF01048	0.616
MOD_GlcNHglycan	817	820	PF01048	0.465
MOD_GlcNHglycan	858	861	PF01048	0.809
MOD_GlcNHglycan	868	871	PF01048	0.638
MOD_GlcNHglycan	99	103	PF01048	0.650
MOD_GSK3_1	13	20	PF00069	0.639
MOD_GSK3_1	183	190	PF00069	0.733
MOD_GSK3_1	23	30	PF00069	0.656
MOD_GSK3_1	284	291	PF00069	0.668
MOD_GSK3_1	302	309	PF00069	0.679
MOD_GSK3_1	311	318	PF00069	0.749
MOD_GSK3_1	382	389	PF00069	0.707
MOD_GSK3_1	392	399	PF00069	0.500
MOD_GSK3_1	47	54	PF00069	0.687
MOD_GSK3_1	61	68	PF00069	0.530
MOD_GSK3_1	684	691	PF00069	0.629
MOD_GSK3_1	723	730	PF00069	0.704
MOD_GSK3_1	806	813	PF00069	0.691
MOD_GSK3_1	856	863	PF00069	0.701
MOD_N-GLC_1	264	269	PF02516	0.548
MOD_N-GLC_1	367	372	PF02516	0.522
MOD_N-GLC_1	66	71	PF02516	0.534
MOD_N-GLC_1	688	693	PF02516	0.623
MOD_NEK2_1	187	192	PF00069	0.616
MOD_NEK2_1	240	245	PF00069	0.506
MOD_NEK2_1	329	334	PF00069	0.437
MOD_NEK2_1	35	40	PF00069	0.623
MOD_NEK2_1	392	397	PF00069	0.407
MOD_NEK2_1	434	439	PF00069	0.509
MOD_NEK2_1	503	508	PF00069	0.455
MOD_NEK2_1	539	544	PF00069	0.549
MOD_NEK2_1	552	557	PF00069	0.375
MOD_NEK2_1	62	67	PF00069	0.622
MOD_NEK2_1	648	653	PF00069	0.478
MOD_NEK2_2	453	458	PF00069	0.619
MOD_PIKK_1	248	254	PF00454	0.792
MOD_PIKK_1	272	278	PF00454	0.620
MOD_PIKK_1	311	317	PF00454	0.827
MOD_PIKK_1	338	344	PF00454	0.468
MOD_PIKK_1	650	656	PF00454	0.524
MOD_PIKK_1	66	72	PF00454	0.537
MOD_PKA_1	665	671	PF00069	0.622
MOD_PKA_1	754	760	PF00069	0.829
MOD_PKA_2	119	125	PF00069	0.529
MOD_PKA_2	222	228	PF00069	0.582
MOD_PKA_2	243	249	PF00069	0.684
MOD_PKA_2	272	278	PF00069	0.571
MOD_PKA_2	315	321	PF00069	0.728
MOD_PKA_2	627	633	PF00069	0.609
MOD_PKA_2	665	671	PF00069	0.739
MOD_PKA_2	754	760	PF00069	0.769
MOD_PKB_1	336	344	PF00069	0.466
MOD_PKB_1	49	57	PF00069	0.710
MOD_Plk_1	35	41	PF00069	0.627
MOD_Plk_1	47	53	PF00069	0.595
MOD_Plk_1	527	533	PF00069	0.534
MOD_Plk_1	648	654	PF00069	0.519
MOD_Plk_2-3	77	83	PF00069	0.692
MOD_Plk_2-3	87	93	PF00069	0.538
MOD_Plk_4	119	125	PF00069	0.655
MOD_Plk_4	321	327	PF00069	0.585
MOD_Plk_4	375	381	PF00069	0.740
MOD_Plk_4	387	393	PF00069	0.433
MOD_Plk_4	453	459	PF00069	0.612
MOD_Plk_4	504	510	PF00069	0.379
MOD_Plk_4	534	540	PF00069	0.459
MOD_Plk_4	677	683	PF00069	0.675
MOD_Plk_4	800	806	PF00069	0.583
MOD_ProDKin_1	106	112	PF00069	0.649
MOD_ProDKin_1	143	149	PF00069	0.502
MOD_ProDKin_1	172	178	PF00069	0.546
MOD_ProDKin_1	253	259	PF00069	0.789
MOD_ProDKin_1	282	288	PF00069	0.558
MOD_ProDKin_1	3	9	PF00069	0.553
MOD_ProDKin_1	303	309	PF00069	0.746
MOD_ProDKin_1	373	379	PF00069	0.769
MOD_ProDKin_1	611	617	PF00069	0.424
MOD_ProDKin_1	694	700	PF00069	0.700
MOD_ProDKin_1	724	730	PF00069	0.697
MOD_ProDKin_1	731	737	PF00069	0.691
MOD_ProDKin_1	794	800	PF00069	0.727
MOD_ProDKin_1	849	855	PF00069	0.678
MOD_SUMO_for_1	278	281	PF00179	0.784
MOD_SUMO_for_1	74	77	PF00179	0.758
MOD_SUMO_for_1	781	784	PF00179	0.714
TRG_DiLeu_BaEn_1	426	431	PF01217	0.454
TRG_DiLeu_BaEn_4	703	709	PF01217	0.639
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.581
TRG_DiLeu_BaLyEn_6	604	609	PF01217	0.480
TRG_ENDOCYTIC_2	105	108	PF00928	0.505
TRG_ER_diArg_1	115	117	PF00400	0.605
TRG_ER_diArg_1	139	141	PF00400	0.425
TRG_ER_diArg_1	217	220	PF00400	0.522
TRG_ER_diArg_1	236	238	PF00400	0.647
TRG_ER_diArg_1	335	338	PF00400	0.432
TRG_ER_diArg_1	49	52	PF00400	0.747
TRG_ER_diArg_1	561	564	PF00400	0.564
TRG_ER_diArg_1	591	594	PF00400	0.384
TRG_ER_diArg_1	743	746	PF00400	0.831
TRG_NLS_MonoCore_2	741	746	PF00514	0.749
TRG_NLS_MonoExtC_3	741	746	PF00514	0.836
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZN7	Leptomonas seymouri	42%	100%
A0A3S5H609	Leishmania donovani	81%	100%
A4H545	Leishmania braziliensis	72%	100%
A4HTC1	Leishmania infantum	82%	100%
Q4QIJ0	Leishmania major	84%	100%