Radial spoke head protein 9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ALB0_LEIMU

TriTrypDb:

LmxM.07.0930

Length:

330

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1
GO:0001534	radial spoke	2	4
GO:0032991	protein-containing complex	1	4

Expansion

Sequence features

E9ALB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALB0

Function

Biological processes
Term	Name	Level	Count
GO:0000226	microtubule cytoskeleton organization	3	1
GO:0001578	microtubule bundle formation	4	1
GO:0003341	cilium movement	4	5
GO:0006996	organelle organization	4	5
GO:0007010	cytoskeleton organization	5	1
GO:0007017	microtubule-based process	2	5
GO:0007018	microtubule-based movement	3	5
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	5
GO:0022607	cellular component assembly	4	5
GO:0030030	cell projection organization	4	5
GO:0030031	cell projection assembly	5	5
GO:0035082	axoneme assembly	5	1
GO:0044458	motile cilium assembly	7	1
GO:0044782	cilium organization	5	5
GO:0060271	cilium assembly	6	5
GO:0060294	cilium movement involved in cell motility	5	5
GO:0070925	organelle assembly	5	5
GO:0071840	cellular component organization or biogenesis	2	5
GO:0120031	plasma membrane bounded cell projection assembly	6	5
GO:0120036	plasma membrane bounded cell projection organization	5	5

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	178	182	PF00082	0.635
CLV_PCSK_SKI1_1	294	298	PF00082	0.376
DOC_MAPK_gen_1	178	187	PF00069	0.420
DOC_MAPK_gen_1	34	42	PF00069	0.444
DOC_USP7_MATH_1	148	152	PF00917	0.535
DOC_USP7_MATH_1	66	70	PF00917	0.430
DOC_WW_Pin1_4	124	129	PF00397	0.506
LIG_14-3-3_CanoR_1	176	185	PF00244	0.595
LIG_14-3-3_CanoR_1	205	209	PF00244	0.343
LIG_14-3-3_CanoR_1	223	228	PF00244	0.565
LIG_BIR_II_1	1	5	PF00653	0.329
LIG_FHA_1	263	269	PF00498	0.396
LIG_FHA_1	285	291	PF00498	0.407
LIG_FHA_2	15	21	PF00498	0.477
LIG_LIR_Apic_2	265	270	PF02991	0.469
LIG_LIR_Apic_2	301	307	PF02991	0.313
LIG_LIR_Gen_1	105	114	PF02991	0.396
LIG_LIR_Gen_1	239	247	PF02991	0.338
LIG_LIR_Gen_1	77	85	PF02991	0.520
LIG_LIR_Nem_3	179	185	PF02991	0.355
LIG_LIR_Nem_3	69	73	PF02991	0.361
LIG_LIR_Nem_3	77	82	PF02991	0.410
LIG_PDZ_Class_2	325	330	PF00595	0.349
LIG_Pex14_1	280	284	PF04695	0.349
LIG_Pex14_2	324	328	PF04695	0.385
LIG_PTB_Apo_2	2	9	PF02174	0.350
LIG_PTB_Apo_2	221	228	PF02174	0.379
LIG_PTB_Apo_2	292	299	PF02174	0.297
LIG_PTB_Apo_2	58	65	PF02174	0.486
LIG_PTB_Phospho_1	2	8	PF10480	0.356
LIG_PTB_Phospho_1	292	298	PF10480	0.334
LIG_SH2_CRK	100	104	PF00017	0.349
LIG_SH2_STAP1	106	110	PF00017	0.488
LIG_SH2_STAT3	212	215	PF00017	0.406
LIG_SH2_STAT5	212	215	PF00017	0.384
LIG_SH2_STAT5	241	244	PF00017	0.317
LIG_SH2_STAT5	267	270	PF00017	0.490
LIG_SH2_STAT5	316	319	PF00017	0.318
LIG_SH2_STAT5	8	11	PF00017	0.415
LIG_SH3_3	120	126	PF00018	0.553
LIG_SH3_3	169	175	PF00018	0.589
LIG_SH3_5	263	267	PF00018	0.490
LIG_SUMO_SIM_par_1	183	189	PF11976	0.406
MOD_CAAXbox	327	330	PF01239	0.390
MOD_CK1_1	14	20	PF00069	0.476
MOD_CK1_1	69	75	PF00069	0.375
MOD_CK1_1	77	83	PF00069	0.449
MOD_CK2_1	124	130	PF00069	0.390
MOD_CK2_1	14	20	PF00069	0.362
MOD_CK2_1	148	154	PF00069	0.485
MOD_CK2_1	183	189	PF00069	0.416
MOD_GlcNHglycan	276	279	PF01048	0.380
MOD_GlcNHglycan	318	321	PF01048	0.419
MOD_GSK3_1	274	281	PF00069	0.427
MOD_N-GLC_1	176	181	PF02516	0.370
MOD_N-GLC_1	223	228	PF02516	0.509
MOD_N-GLC_1	284	289	PF02516	0.360
MOD_NEK2_1	11	16	PF00069	0.434
MOD_NEK2_1	24	29	PF00069	0.333
MOD_NEK2_1	92	97	PF00069	0.479
MOD_NEK2_2	204	209	PF00069	0.419
MOD_NEK2_2	278	283	PF00069	0.463
MOD_NEK2_2	298	303	PF00069	0.392
MOD_NEK2_2	66	71	PF00069	0.425
MOD_PIKK_1	29	35	PF00454	0.487
MOD_PK_1	183	189	PF00069	0.493
MOD_PKA_1	236	242	PF00069	0.471
MOD_PKA_2	204	210	PF00069	0.349
MOD_PKA_2	222	228	PF00069	0.565
MOD_PKA_2	35	41	PF00069	0.325
MOD_Plk_1	19	25	PF00069	0.414
MOD_Plk_1	223	229	PF00069	0.548
MOD_Plk_2-3	150	156	PF00069	0.574
MOD_Plk_4	298	304	PF00069	0.318
MOD_Plk_4	66	72	PF00069	0.396
MOD_ProDKin_1	124	130	PF00069	0.502
TRG_DiLeu_BaEn_3	250	256	PF01217	0.500
TRG_DiLeu_BaEn_4	87	93	PF01217	0.388
TRG_DiLeu_BaLyEn_6	26	31	PF01217	0.326
TRG_DiLeu_BaLyEn_6	7	12	PF01217	0.512
TRG_ENDOCYTIC_2	100	103	PF00928	0.453
TRG_ENDOCYTIC_2	106	109	PF00928	0.449
TRG_ENDOCYTIC_2	241	244	PF00928	0.342
TRG_ENDOCYTIC_2	8	11	PF00928	0.446
TRG_ER_diArg_1	175	178	PF00400	0.517
TRG_ER_diArg_1	252	255	PF00400	0.432
TRG_Pf-PMV_PEXEL_1	294	299	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E1	Leptomonas seymouri	25%	100%
A0A0N1IL99	Leptomonas seymouri	69%	97%
A0A0S4J8G1	Bodo saltans	39%	100%
A0A1X0NQ76	Trypanosomatidae	47%	99%
A0A3Q8IKD9	Leishmania donovani	27%	100%
A0A3R7MSU5	Trypanosoma rangeli	48%	98%
A0A3S7WQ16	Leishmania donovani	94%	99%
A4H541	Leishmania braziliensis	85%	100%
A4HLW1	Leishmania braziliensis	24%	100%
A4HTB7	Leishmania infantum	89%	98%
C9ZUK2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	99%
D0A660	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AHR8	Leishmania infantum	27%	100%
E9B489	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
Q2KIU7	Bos taurus	24%	100%
Q4Q3T7	Leishmania major	26%	100%
Q4QIJ4	Leishmania major	92%	100%
Q5TYW6	Danio rerio	27%	100%
Q6DFN5	Xenopus tropicalis	25%	100%
Q9D9V4	Mus musculus	26%	100%
Q9H1X1	Homo sapiens	24%	100%
V5B8M6	Trypanosoma cruzi	27%	100%