Neuron navigator 2

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Neuron navigator 2

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ALA6_LEIMU

TriTrypDb:

LmxM.07.0890

Length:

626

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ALA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALA6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.626
CLV_C14_Caspase3-7	486	490	PF00656	0.601
CLV_C14_Caspase3-7	72	76	PF00656	0.604
CLV_NRD_NRD_1	139	141	PF00675	0.682
CLV_NRD_NRD_1	172	174	PF00675	0.635
CLV_NRD_NRD_1	435	437	PF00675	0.660
CLV_NRD_NRD_1	596	598	PF00675	0.587
CLV_PCSK_FUR_1	594	598	PF00082	0.712
CLV_PCSK_KEX2_1	138	140	PF00082	0.686
CLV_PCSK_KEX2_1	172	174	PF00082	0.635
CLV_PCSK_KEX2_1	414	416	PF00082	0.664
CLV_PCSK_KEX2_1	596	598	PF00082	0.581
CLV_PCSK_PC1ET2_1	414	416	PF00082	0.534
CLV_PCSK_SKI1_1	140	144	PF00082	0.676
CLV_PCSK_SKI1_1	437	441	PF00082	0.511
CLV_PCSK_SKI1_1	54	58	PF00082	0.522
CLV_PCSK_SKI1_1	61	65	PF00082	0.516
CLV_PCSK_SKI1_1	89	93	PF00082	0.551
DEG_SIAH_1	419	427	PF03145	0.510
DEG_SPOP_SBC_1	484	488	PF00917	0.546
DOC_CDC14_PxL_1	421	429	PF14671	0.658
DOC_CKS1_1	254	259	PF01111	0.646
DOC_CYCLIN_yCln2_LP_2	52	58	PF00134	0.516
DOC_MAPK_gen_1	159	167	PF00069	0.693
DOC_PP4_FxxP_1	57	60	PF00568	0.502
DOC_USP7_MATH_1	154	158	PF00917	0.700
DOC_USP7_MATH_1	362	366	PF00917	0.553
DOC_USP7_MATH_1	474	478	PF00917	0.639
DOC_USP7_MATH_1	531	535	PF00917	0.690
DOC_USP7_MATH_1	546	550	PF00917	0.540
DOC_USP7_MATH_1	565	569	PF00917	0.590
DOC_USP7_MATH_1	588	592	PF00917	0.684
DOC_USP7_MATH_1	63	67	PF00917	0.574
DOC_USP7_MATH_1	73	77	PF00917	0.558
DOC_USP7_UBL2_3	404	408	PF12436	0.542
DOC_USP7_UBL2_3	440	444	PF12436	0.674
DOC_USP7_UBL2_3	537	541	PF12436	0.551
DOC_WW_Pin1_4	224	229	PF00397	0.758
DOC_WW_Pin1_4	250	255	PF00397	0.644
DOC_WW_Pin1_4	293	298	PF00397	0.692
LIG_14-3-3_CanoR_1	172	178	PF00244	0.795
LIG_14-3-3_CanoR_1	195	204	PF00244	0.612
LIG_14-3-3_CanoR_1	230	236	PF00244	0.572
LIG_14-3-3_CanoR_1	378	383	PF00244	0.558
LIG_14-3-3_CanoR_1	41	51	PF00244	0.617
LIG_14-3-3_CanoR_1	436	440	PF00244	0.511
LIG_14-3-3_CanoR_1	545	553	PF00244	0.654
LIG_14-3-3_CanoR_1	7	13	PF00244	0.597
LIG_14-3-3_CanoR_1	89	97	PF00244	0.577
LIG_BIR_II_1	1	5	PF00653	0.670
LIG_BIR_III_2	304	308	PF00653	0.519
LIG_BRCT_BRCA1_1	460	464	PF00533	0.532
LIG_FHA_1	230	236	PF00498	0.604
LIG_FHA_1	440	446	PF00498	0.607
LIG_FHA_1	47	53	PF00498	0.566
LIG_FHA_1	486	492	PF00498	0.600
LIG_FHA_1	62	68	PF00498	0.632
LIG_FHA_2	290	296	PF00498	0.694
LIG_FHA_2	356	362	PF00498	0.554
LIG_Integrin_isoDGR_2	570	572	PF01839	0.550
LIG_Integrin_isoDGR_2	602	604	PF01839	0.574
LIG_LIR_Apic_2	308	312	PF02991	0.501
LIG_LIR_Gen_1	330	338	PF02991	0.499
LIG_LIR_Nem_3	199	204	PF02991	0.538
LIG_LIR_Nem_3	330	336	PF02991	0.503
LIG_Pex14_2	329	333	PF04695	0.495
LIG_PTAP_UEV_1	532	537	PF05743	0.554
LIG_RPA_C_Fungi	395	407	PF08784	0.537
LIG_SH2_CRK	201	205	PF00017	0.539
LIG_SH2_CRK	263	267	PF00017	0.537
LIG_SH2_CRK	543	547	PF00017	0.547
LIG_SH2_PTP2	309	312	PF00017	0.497
LIG_SH2_STAT3	320	323	PF00017	0.504
LIG_SH2_STAT5	309	312	PF00017	0.497
LIG_SH3_3	248	254	PF00018	0.724
LIG_SH3_3	442	448	PF00018	0.673
LIG_SH3_3	527	533	PF00018	0.558
LIG_SH3_3	99	105	PF00018	0.544
LIG_SUMO_SIM_anti_2	64	69	PF11976	0.653
LIG_SUMO_SIM_par_1	425	431	PF11976	0.664
LIG_TRAF2_1	244	247	PF00917	0.520
MOD_CAAXbox	623	626	PF01239	0.654
MOD_CDC14_SPxK_1	227	230	PF00782	0.539
MOD_CDK_SPxK_1	224	230	PF00069	0.547
MOD_CDK_SPxxK_3	253	260	PF00069	0.513
MOD_CK1_1	108	114	PF00069	0.542
MOD_CK1_1	175	181	PF00069	0.743
MOD_CK1_1	229	235	PF00069	0.607
MOD_CK1_1	25	31	PF00069	0.679
MOD_CK1_1	253	259	PF00069	0.647
MOD_CK1_1	365	371	PF00069	0.638
MOD_CK1_1	459	465	PF00069	0.670
MOD_CK1_1	46	52	PF00069	0.534
MOD_CK1_1	485	491	PF00069	0.547
MOD_CK1_1	492	498	PF00069	0.531
MOD_CK1_1	8	14	PF00069	0.528
MOD_CK1_1	93	99	PF00069	0.679
MOD_CK2_1	123	129	PF00069	0.691
MOD_CK2_1	154	160	PF00069	0.555
MOD_CK2_1	241	247	PF00069	0.607
MOD_CK2_1	355	361	PF00069	0.558
MOD_CK2_1	457	463	PF00069	0.674
MOD_GlcNHglycan	162	165	PF01048	0.646
MOD_GlcNHglycan	191	194	PF01048	0.654
MOD_GlcNHglycan	213	216	PF01048	0.690
MOD_GlcNHglycan	222	225	PF01048	0.660
MOD_GlcNHglycan	235	238	PF01048	0.659
MOD_GlcNHglycan	239	242	PF01048	0.636
MOD_GlcNHglycan	274	277	PF01048	0.599
MOD_GlcNHglycan	364	367	PF01048	0.642
MOD_GlcNHglycan	501	505	PF01048	0.611
MOD_GlcNHglycan	533	536	PF01048	0.690
MOD_GlcNHglycan	614	617	PF01048	0.548
MOD_GlcNHglycan	75	78	PF01048	0.546
MOD_GSK3_1	1	8	PF00069	0.527
MOD_GSK3_1	123	130	PF00069	0.752
MOD_GSK3_1	155	162	PF00069	0.635
MOD_GSK3_1	168	175	PF00069	0.696
MOD_GSK3_1	22	29	PF00069	0.679
MOD_GSK3_1	220	227	PF00069	0.691
MOD_GSK3_1	229	236	PF00069	0.583
MOD_GSK3_1	237	244	PF00069	0.528
MOD_GSK3_1	246	253	PF00069	0.560
MOD_GSK3_1	289	296	PF00069	0.608
MOD_GSK3_1	351	358	PF00069	0.622
MOD_GSK3_1	39	46	PF00069	0.541
MOD_GSK3_1	396	403	PF00069	0.542
MOD_GSK3_1	435	442	PF00069	0.727
MOD_GSK3_1	458	465	PF00069	0.671
MOD_GSK3_1	480	487	PF00069	0.544
MOD_GSK3_1	553	560	PF00069	0.599
MOD_N-GLC_1	115	120	PF02516	0.588
MOD_N-GLC_1	167	172	PF02516	0.600
MOD_N-GLC_1	173	178	PF02516	0.614
MOD_N-GLC_1	25	30	PF02516	0.677
MOD_N-GLC_1	468	473	PF02516	0.673
MOD_N-GLC_1	492	497	PF02516	0.538
MOD_N-GLC_1	523	528	PF02516	0.620
MOD_N-GLC_1	553	558	PF02516	0.650
MOD_NEK2_1	1	6	PF00069	0.666
MOD_NEK2_1	39	44	PF00069	0.680
MOD_NEK2_1	396	401	PF00069	0.536
MOD_NEK2_1	464	469	PF00069	0.544
MOD_NEK2_1	553	558	PF00069	0.603
MOD_NEK2_2	128	133	PF00069	0.598
MOD_PIKK_1	196	202	PF00454	0.627
MOD_PIKK_1	26	32	PF00454	0.680
MOD_PIKK_1	265	271	PF00454	0.524
MOD_PIKK_1	355	361	PF00454	0.597
MOD_PIKK_1	367	373	PF00454	0.674
MOD_PIKK_1	39	45	PF00454	0.574
MOD_PIKK_1	557	563	PF00454	0.675
MOD_PIKK_1	90	96	PF00454	0.544
MOD_PK_1	173	179	PF00069	0.559
MOD_PKA_1	172	178	PF00069	0.557
MOD_PKA_2	160	166	PF00069	0.660
MOD_PKA_2	172	178	PF00069	0.768
MOD_PKA_2	229	235	PF00069	0.524
MOD_PKA_2	241	247	PF00069	0.508
MOD_PKA_2	377	383	PF00069	0.552
MOD_PKA_2	435	441	PF00069	0.649
MOD_PKA_2	571	577	PF00069	0.631
MOD_PKA_2	595	601	PF00069	0.633
MOD_PKA_2	603	609	PF00069	0.591
MOD_PKA_2	73	79	PF00069	0.544
MOD_PKA_2	8	14	PF00069	0.576
MOD_Plk_1	128	134	PF00069	0.595
MOD_Plk_1	173	179	PF00069	0.621
MOD_Plk_1	468	474	PF00069	0.674
MOD_Plk_1	480	486	PF00069	0.584
MOD_Plk_2-3	289	295	PF00069	0.751
MOD_Plk_4	63	69	PF00069	0.644
MOD_ProDKin_1	224	230	PF00069	0.757
MOD_ProDKin_1	250	256	PF00069	0.646
MOD_ProDKin_1	293	299	PF00069	0.687
MOD_SUMO_rev_2	501	509	PF00179	0.602
TRG_DiLeu_BaEn_2	52	58	PF01217	0.516
TRG_ENDOCYTIC_2	201	204	PF00928	0.539
TRG_ENDOCYTIC_2	263	266	PF00928	0.539
TRG_ER_diArg_1	138	140	PF00400	0.686
TRG_ER_diArg_1	594	597	PF00400	0.732
TRG_ER_diArg_1	99	102	PF00400	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WQ13	Leishmania donovani	55%	99%
A4HTE6	Leishmania infantum	55%	99%
Q4QIJ8	Leishmania major	53%	99%