Splicing factor ptsr1-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

splicing factor ptsr1-like protein

Species:

Leishmania mexicana

UniProt:

E9ALA4_LEIMU

TriTrypDb:

LmxM.07.0870

Length:

372

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 3
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ALA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ALA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	159	161	PF00675	0.704
CLV_NRD_NRD_1	214	216	PF00675	0.587
CLV_NRD_NRD_1	254	256	PF00675	0.728
CLV_NRD_NRD_1	269	271	PF00675	0.604
CLV_NRD_NRD_1	284	286	PF00675	0.634
CLV_NRD_NRD_1	293	295	PF00675	0.681
CLV_NRD_NRD_1	299	301	PF00675	0.634
CLV_NRD_NRD_1	323	325	PF00675	0.800
CLV_NRD_NRD_1	336	338	PF00675	0.641
CLV_NRD_NRD_1	339	341	PF00675	0.615
CLV_NRD_NRD_1	349	351	PF00675	0.795
CLV_NRD_NRD_1	360	362	PF00675	0.785
CLV_NRD_NRD_1	363	365	PF00675	0.748
CLV_NRD_NRD_1	368	370	PF00675	0.573
CLV_PCSK_FUR_1	297	301	PF00082	0.792
CLV_PCSK_FUR_1	321	325	PF00082	0.796
CLV_PCSK_FUR_1	334	338	PF00082	0.641
CLV_PCSK_FUR_1	361	365	PF00082	0.780
CLV_PCSK_KEX2_1	159	161	PF00082	0.704
CLV_PCSK_KEX2_1	214	216	PF00082	0.587
CLV_PCSK_KEX2_1	230	232	PF00082	0.443
CLV_PCSK_KEX2_1	256	258	PF00082	0.770
CLV_PCSK_KEX2_1	269	271	PF00082	0.625
CLV_PCSK_KEX2_1	283	285	PF00082	0.654
CLV_PCSK_KEX2_1	293	295	PF00082	0.701
CLV_PCSK_KEX2_1	299	301	PF00082	0.668
CLV_PCSK_KEX2_1	323	325	PF00082	0.800
CLV_PCSK_KEX2_1	336	338	PF00082	0.641
CLV_PCSK_KEX2_1	339	341	PF00082	0.615
CLV_PCSK_KEX2_1	348	350	PF00082	0.789
CLV_PCSK_KEX2_1	360	362	PF00082	0.785
CLV_PCSK_KEX2_1	363	365	PF00082	0.748
CLV_PCSK_KEX2_1	368	370	PF00082	0.573
CLV_PCSK_PC1ET2_1	159	161	PF00082	0.693
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.476
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.770
CLV_PCSK_PC7_1	265	271	PF00082	0.780
CLV_PCSK_PC7_1	289	295	PF00082	0.762
CLV_PCSK_PC7_1	356	362	PF00082	0.785
CLV_PCSK_PC7_1	364	370	PF00082	0.685
CLV_PCSK_SKI1_1	113	117	PF00082	0.562
CLV_PCSK_SKI1_1	181	185	PF00082	0.561
CLV_PCSK_SKI1_1	84	88	PF00082	0.609
DEG_APCC_KENBOX_2	155	159	PF00400	0.680
DEG_SPOP_SBC_1	117	121	PF00917	0.552
DOC_MAPK_gen_1	138	145	PF00069	0.595
DOC_MAPK_MEF2A_6	138	147	PF00069	0.596
DOC_MAPK_MEF2A_6	70	79	PF00069	0.604
DOC_USP7_MATH_1	15	19	PF00917	0.795
DOC_USP7_MATH_1	23	27	PF00917	0.761
DOC_WW_Pin1_4	257	262	PF00397	0.829
DOC_WW_Pin1_4	300	305	PF00397	0.785
DOC_WW_Pin1_4	324	329	PF00397	0.807
DOC_WW_Pin1_4	54	59	PF00397	0.793
LIG_14-3-3_CanoR_1	27	35	PF00244	0.782
LIG_14-3-3_CanoR_1	297	303	PF00244	0.841
LIG_14-3-3_CanoR_1	307	313	PF00244	0.833
LIG_14-3-3_CanoR_1	321	327	PF00244	0.585
LIG_14-3-3_CanoR_1	84	89	PF00244	0.609
LIG_BIR_II_1	1	5	PF00653	0.770
LIG_FHA_1	117	123	PF00498	0.565
LIG_FHA_1	227	233	PF00498	0.597
LIG_FHA_1	55	61	PF00498	0.598
LIG_FHA_1	90	96	PF00498	0.507
LIG_FHA_2	119	125	PF00498	0.533
LIG_FHA_2	149	155	PF00498	0.671
LIG_FHA_2	223	229	PF00498	0.545
LIG_FHA_2	42	48	PF00498	0.783
LIG_FHA_2	85	91	PF00498	0.593
LIG_GBD_Chelix_1	232	240	PF00786	0.602
LIG_Integrin_RGD_1	364	366	PF01839	0.723
LIG_NRP_CendR_1	369	372	PF00754	0.760
LIG_PTB_Apo_2	131	138	PF02174	0.585
LIG_PTB_Phospho_1	131	137	PF10480	0.568
LIG_SH2_GRB2like	176	179	PF00017	0.641
LIG_SH2_NCK_1	220	224	PF00017	0.443
LIG_SH2_SRC	220	223	PF00017	0.548
LIG_SH2_STAT5	176	179	PF00017	0.641
LIG_SH2_STAT5	217	220	PF00017	0.562
LIG_SH2_STAT5	302	305	PF00017	0.783
LIG_SH2_STAT5	94	97	PF00017	0.655
LIG_SH3_2	65	70	PF14604	0.743
LIG_SH3_3	62	68	PF00018	0.758
MOD_CDC14_SPxK_1	260	263	PF00782	0.774
MOD_CDK_SPxK_1	257	263	PF00069	0.769
MOD_CDK_SPxxK_3	300	307	PF00069	0.787
MOD_CK1_1	148	154	PF00069	0.659
MOD_CK1_1	26	32	PF00069	0.872
MOD_CK1_1	298	304	PF00069	0.820
MOD_CK1_1	305	311	PF00069	0.838
MOD_CK1_1	313	319	PF00069	0.683
MOD_CK1_1	327	333	PF00069	0.619
MOD_CK1_1	354	360	PF00069	0.598
MOD_CK2_1	118	124	PF00069	0.624
MOD_CK2_1	148	154	PF00069	0.654
MOD_CK2_1	198	204	PF00069	0.581
MOD_CK2_1	41	47	PF00069	0.738
MOD_CK2_1	84	90	PF00069	0.611
MOD_Cter_Amidation	321	324	PF01082	0.797
MOD_DYRK1A_RPxSP_1	300	304	PF00069	0.785
MOD_DYRK1A_RPxSP_1	324	328	PF00069	0.794
MOD_GlcNHglycan	17	20	PF01048	0.668
MOD_GlcNHglycan	21	24	PF01048	0.626
MOD_GlcNHglycan	355	359	PF01048	0.655
MOD_GlcNHglycan	41	44	PF01048	0.749
MOD_GlcNHglycan	7	10	PF01048	0.772
MOD_GSK3_1	1	8	PF00069	0.815
MOD_GSK3_1	13	20	PF00069	0.740
MOD_GSK3_1	21	28	PF00069	0.650
MOD_GSK3_1	222	229	PF00069	0.635
MOD_GSK3_1	298	305	PF00069	0.787
MOD_GSK3_1	306	313	PF00069	0.793
MOD_LATS_1	281	287	PF00433	0.791
MOD_N-GLC_1	195	200	PF02516	0.481
MOD_N-GLC_1	84	89	PF02516	0.443
MOD_NEK2_1	1	6	PF00069	0.799
MOD_NEK2_1	116	121	PF00069	0.553
MOD_NEK2_2	195	200	PF00069	0.481
MOD_PIKK_1	7	13	PF00454	0.725
MOD_PKA_1	283	289	PF00069	0.793
MOD_PKA_2	165	171	PF00069	0.788
MOD_PKA_2	26	32	PF00069	0.854
MOD_PKA_2	283	289	PF00069	0.727
MOD_PKA_2	298	304	PF00069	0.644
MOD_PKA_2	306	312	PF00069	0.834
MOD_PKA_2	322	328	PF00069	0.795
MOD_PKA_2	335	341	PF00069	0.643
MOD_PKB_1	283	291	PF00069	0.792
MOD_PKB_1	315	323	PF00069	0.793
MOD_Plk_1	117	123	PF00069	0.609
MOD_Plk_1	195	201	PF00069	0.490
MOD_Plk_1	84	90	PF00069	0.418
MOD_Plk_2-3	118	124	PF00069	0.566
MOD_Plk_4	249	255	PF00069	0.605
MOD_Plk_4	71	77	PF00069	0.618
MOD_ProDKin_1	257	263	PF00069	0.831
MOD_ProDKin_1	300	306	PF00069	0.785
MOD_ProDKin_1	324	330	PF00069	0.807
MOD_ProDKin_1	54	60	PF00069	0.794
MOD_SUMO_rev_2	222	232	PF00179	0.451
TRG_DiLeu_BaEn_1	124	129	PF01217	0.681
TRG_DiLeu_BaEn_1	243	248	PF01217	0.548
TRG_ENDOCYTIC_2	220	223	PF00928	0.548
TRG_ER_diArg_1	108	111	PF00400	0.584
TRG_ER_diArg_1	254	257	PF00400	0.738
TRG_ER_diArg_1	268	270	PF00400	0.613
TRG_ER_diArg_1	283	285	PF00400	0.638
TRG_ER_diArg_1	297	300	PF00400	0.645
TRG_ER_diArg_1	321	324	PF00400	0.797
TRG_ER_diArg_1	336	339	PF00400	0.622
TRG_ER_diArg_1	348	350	PF00400	0.742
TRG_ER_diArg_1	368	371	PF00400	0.755
TRG_NLS_MonoCore_2	158	163	PF00514	0.694
TRG_NLS_MonoExtC_3	158	164	PF00514	0.694
TRG_NLS_MonoExtN_4	156	163	PF00514	0.693
TRG_Pf-PMV_PEXEL_1	126	131	PF00026	0.547
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.546

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPZ1	Leishmania donovani	93%	99%
A4H537	Leishmania braziliensis	79%	100%
A4HTB3	Leishmania infantum	93%	99%
Q4QIK0	Leishmania major	93%	100%