Phosphoacetylglucosamine mutase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoacetylglucosamine mutase-like protein

Species:

Leishmania mexicana

UniProt:

E9AL97_LEIMU

TriTrypDb:

LmxM.07.0805

Length:

597

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AL97

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL97

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	12
GO:0006040	amino sugar metabolic process	4	11
GO:0006047	UDP-N-acetylglucosamine metabolic process	4	11
GO:0006048	UDP-N-acetylglucosamine biosynthetic process	5	11
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	12
GO:0009058	biosynthetic process	2	11
GO:0009225	nucleotide-sugar metabolic process	4	11
GO:0009226	nucleotide-sugar biosynthetic process	5	11
GO:0009987	cellular process	1	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0044281	small molecule metabolic process	2	11
GO:0046349	amino sugar biosynthetic process	5	11
GO:0046483	heterocycle metabolic process	3	11
GO:0055086	nucleobase-containing small molecule metabolic process	3	11
GO:0071704	organic substance metabolic process	2	12
GO:1901135	carbohydrate derivative metabolic process	3	11
GO:1901137	carbohydrate derivative biosynthetic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11
GO:0006041	glucosamine metabolic process	6	1
GO:1901071	glucosamine-containing compound metabolic process	5	1

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	7
GO:0003824	catalytic activity	1	12
GO:0004610	phosphoacetylglucosamine mutase activity	5	11
GO:0005488	binding	1	12
GO:0016853	isomerase activity	2	12
GO:0016866	intramolecular transferase activity	3	12
GO:0016868	intramolecular transferase activity, phosphotransferases	4	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12
GO:0046872	metal ion binding	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	25	29	PF00656	0.294
CLV_C14_Caspase3-7	267	271	PF00656	0.252
CLV_C14_Caspase3-7	540	544	PF00656	0.380
CLV_MEL_PAP_1	59	65	PF00089	0.355
CLV_NRD_NRD_1	376	378	PF00675	0.237
CLV_NRD_NRD_1	470	472	PF00675	0.494
CLV_NRD_NRD_1	530	532	PF00675	0.491
CLV_PCSK_KEX2_1	470	472	PF00082	0.494
CLV_PCSK_KEX2_1	530	532	PF00082	0.480
CLV_PCSK_KEX2_1	77	79	PF00082	0.441
CLV_PCSK_PC1ET2_1	77	79	PF00082	0.441
CLV_PCSK_SKI1_1	359	363	PF00082	0.392
CLV_PCSK_SKI1_1	450	454	PF00082	0.499
CLV_PCSK_SKI1_1	462	466	PF00082	0.388
CLV_PCSK_SKI1_1	511	515	PF00082	0.406
CLV_PCSK_SKI1_1	530	534	PF00082	0.390
DEG_Nend_UBRbox_2	1	3	PF02207	0.619
DOC_CKS1_1	195	200	PF01111	0.363
DOC_CYCLIN_yCln2_LP_2	55	58	PF00134	0.361
DOC_MAPK_gen_1	508	517	PF00069	0.494
DOC_MAPK_MEF2A_6	508	517	PF00069	0.460
DOC_PP1_RVXF_1	344	351	PF00149	0.304
DOC_PP2B_LxvP_1	55	58	PF13499	0.361
DOC_PP4_FxxP_1	559	562	PF00568	0.300
DOC_USP7_MATH_1	127	131	PF00917	0.440
DOC_USP7_MATH_1	213	217	PF00917	0.608
DOC_USP7_MATH_1	313	317	PF00917	0.541
DOC_USP7_MATH_1	321	325	PF00917	0.580
DOC_USP7_MATH_1	355	359	PF00917	0.299
DOC_USP7_MATH_1	544	548	PF00917	0.434
DOC_USP7_MATH_1	61	65	PF00917	0.397
DOC_USP7_MATH_1	68	72	PF00917	0.349
DOC_WW_Pin1_4	194	199	PF00397	0.330
DOC_WW_Pin1_4	215	220	PF00397	0.451
DOC_WW_Pin1_4	311	316	PF00397	0.466
DOC_WW_Pin1_4	37	42	PF00397	0.399
DOC_WW_Pin1_4	523	528	PF00397	0.420
DOC_WW_Pin1_4	531	536	PF00397	0.418
LIG_14-3-3_CanoR_1	185	194	PF00244	0.548
LIG_14-3-3_CanoR_1	273	281	PF00244	0.500
LIG_14-3-3_CanoR_1	62	66	PF00244	0.391
LIG_Actin_WH2_2	11	26	PF00022	0.533
LIG_Actin_WH2_2	171	187	PF00022	0.391
LIG_APCC_ABBA_1	433	438	PF00400	0.323
LIG_APCC_ABBA_1	569	574	PF00400	0.300
LIG_BRCT_BRCA1_1	16	20	PF00533	0.407
LIG_BRCT_BRCA1_1	401	405	PF00533	0.425
LIG_deltaCOP1_diTrp_1	117	122	PF00928	0.306
LIG_FHA_1	178	184	PF00498	0.529
LIG_FHA_1	401	407	PF00498	0.339
LIG_FHA_1	442	448	PF00498	0.383
LIG_FHA_1	501	507	PF00498	0.528
LIG_FHA_1	563	569	PF00498	0.300
LIG_FHA_1	574	580	PF00498	0.263
LIG_FHA_1	86	92	PF00498	0.453
LIG_FHA_2	262	268	PF00498	0.315
LIG_FHA_2	281	287	PF00498	0.405
LIG_FHA_2	456	462	PF00498	0.426
LIG_FHA_2	495	501	PF00498	0.433
LIG_FHA_2	524	530	PF00498	0.437
LIG_IBAR_NPY_1	98	100	PF08397	0.349
LIG_LIR_Gen_1	156	162	PF02991	0.578
LIG_LIR_Gen_1	17	27	PF02991	0.487
LIG_LIR_Gen_1	220	229	PF02991	0.425
LIG_LIR_Gen_1	276	285	PF02991	0.404
LIG_LIR_Gen_1	307	315	PF02991	0.276
LIG_LIR_Gen_1	358	368	PF02991	0.402
LIG_LIR_Gen_1	369	380	PF02991	0.389
LIG_LIR_Gen_1	500	509	PF02991	0.394
LIG_LIR_Nem_3	102	108	PF02991	0.430
LIG_LIR_Nem_3	156	160	PF02991	0.590
LIG_LIR_Nem_3	17	23	PF02991	0.501
LIG_LIR_Nem_3	191	195	PF02991	0.439
LIG_LIR_Nem_3	220	225	PF02991	0.372
LIG_LIR_Nem_3	276	281	PF02991	0.455
LIG_LIR_Nem_3	283	287	PF02991	0.373
LIG_LIR_Nem_3	307	311	PF02991	0.274
LIG_LIR_Nem_3	335	340	PF02991	0.332
LIG_LIR_Nem_3	358	363	PF02991	0.411
LIG_LIR_Nem_3	369	375	PF02991	0.398
LIG_LIR_Nem_3	500	504	PF02991	0.429
LIG_LYPXL_yS_3	192	195	PF13949	0.436
LIG_MAD2	346	354	PF02301	0.464
LIG_MLH1_MIPbox_1	16	20	PF16413	0.407
LIG_Pex14_1	501	505	PF04695	0.342
LIG_Pex14_2	15	19	PF04695	0.472
LIG_Rb_pABgroove_1	346	354	PF01858	0.383
LIG_SH2_CRK	157	161	PF00017	0.367
LIG_SH2_CRK	308	312	PF00017	0.275
LIG_SH2_CRK	372	376	PF00017	0.361
LIG_SH2_GRB2like	221	224	PF00017	0.369
LIG_SH2_GRB2like	397	400	PF00017	0.319
LIG_SH2_NCK_1	415	419	PF00017	0.369
LIG_SH2_NCK_1	572	576	PF00017	0.403
LIG_SH2_SRC	352	355	PF00017	0.257
LIG_SH2_SRC	397	400	PF00017	0.319
LIG_SH2_SRC	572	575	PF00017	0.344
LIG_SH2_STAP1	372	376	PF00017	0.317
LIG_SH2_STAT5	100	103	PF00017	0.306
LIG_SH2_STAT5	157	160	PF00017	0.403
LIG_SH2_STAT5	415	418	PF00017	0.342
LIG_SH2_STAT5	436	439	PF00017	0.353
LIG_SH2_STAT5	505	508	PF00017	0.342
LIG_SH2_STAT5	73	76	PF00017	0.503
LIG_SH3_3	146	152	PF00018	0.562
LIG_SH3_3	192	198	PF00018	0.372
LIG_SH3_3	35	41	PF00018	0.591
LIG_SH3_3	503	509	PF00018	0.372
LIG_SH3_3	514	520	PF00018	0.331
LIG_SUMO_SIM_anti_2	366	372	PF11976	0.273
LIG_SUMO_SIM_anti_2	389	395	PF11976	0.389
LIG_SUMO_SIM_par_1	106	111	PF11976	0.321
LIG_SUMO_SIM_par_1	443	449	PF11976	0.397
LIG_TRAF2_1	169	172	PF00917	0.388
LIG_TYR_ITIM	370	375	PF00017	0.357
LIG_UBA3_1	370	378	PF00899	0.484
LIG_WRC_WIRS_1	281	286	PF05994	0.452
MOD_CDK_SPxxK_3	523	530	PF00069	0.438
MOD_CK1_1	130	136	PF00069	0.567
MOD_CK1_1	163	169	PF00069	0.436
MOD_CK1_1	237	243	PF00069	0.511
MOD_CK1_1	40	46	PF00069	0.389
MOD_CK2_1	130	136	PF00069	0.310
MOD_CK2_1	145	151	PF00069	0.388
MOD_CK2_1	166	172	PF00069	0.464
MOD_CK2_1	261	267	PF00069	0.374
MOD_CK2_1	280	286	PF00069	0.405
MOD_CK2_1	455	461	PF00069	0.552
MOD_CK2_1	523	529	PF00069	0.413
MOD_CK2_1	548	554	PF00069	0.509
MOD_CK2_1	560	566	PF00069	0.224
MOD_CMANNOS	119	122	PF00535	0.430
MOD_Cter_Amidation	75	78	PF01082	0.381
MOD_DYRK1A_RPxSP_1	531	535	PF00069	0.392
MOD_GlcNHglycan	130	133	PF01048	0.445
MOD_GlcNHglycan	168	171	PF01048	0.397
MOD_GlcNHglycan	236	239	PF01048	0.450
MOD_GlcNHglycan	319	322	PF01048	0.421
MOD_GlcNHglycan	416	419	PF01048	0.466
MOD_GlcNHglycan	562	565	PF01048	0.348
MOD_GlcNHglycan	584	587	PF01048	0.349
MOD_GlcNHglycan	59	62	PF01048	0.291
MOD_GSK3_1	184	191	PF00069	0.407
MOD_GSK3_1	213	220	PF00069	0.646
MOD_GSK3_1	22	29	PF00069	0.397
MOD_GSK3_1	269	276	PF00069	0.474
MOD_GSK3_1	295	302	PF00069	0.567
MOD_GSK3_1	313	320	PF00069	0.430
MOD_GSK3_1	332	339	PF00069	0.435
MOD_GSK3_1	441	448	PF00069	0.413
MOD_GSK3_1	450	457	PF00069	0.423
MOD_GSK3_1	544	551	PF00069	0.396
MOD_GSK3_1	57	64	PF00069	0.264
MOD_N-GLC_1	127	132	PF02516	0.412
MOD_N-GLC_1	185	190	PF02516	0.457
MOD_N-GLC_1	494	499	PF02516	0.549
MOD_NEK2_1	184	189	PF00069	0.475
MOD_NEK2_1	299	304	PF00069	0.429
MOD_NEK2_1	494	499	PF00069	0.467
MOD_NEK2_1	548	553	PF00069	0.505
MOD_NEK2_2	177	182	PF00069	0.420
MOD_NEK2_2	261	266	PF00069	0.305
MOD_NEK2_2	280	285	PF00069	0.404
MOD_NEK2_2	68	73	PF00069	0.332
MOD_PIKK_1	237	243	PF00454	0.560
MOD_PIKK_1	471	477	PF00454	0.329
MOD_PKA_2	163	169	PF00069	0.350
MOD_PKA_2	184	190	PF00069	0.545
MOD_PKA_2	355	361	PF00069	0.483
MOD_PKA_2	366	372	PF00069	0.306
MOD_PKA_2	521	527	PF00069	0.495
MOD_PKA_2	560	566	PF00069	0.300
MOD_PKA_2	61	67	PF00069	0.399
MOD_Plk_1	295	301	PF00069	0.520
MOD_Plk_1	494	500	PF00069	0.521
MOD_Plk_2-3	22	28	PF00069	0.235
MOD_Plk_4	14	20	PF00069	0.447
MOD_Plk_4	145	151	PF00069	0.566
MOD_Plk_4	217	223	PF00069	0.539
MOD_Plk_4	22	28	PF00069	0.417
MOD_Plk_4	280	286	PF00069	0.420
MOD_Plk_4	295	301	PF00069	0.566
MOD_Plk_4	441	447	PF00069	0.350
MOD_Plk_4	500	506	PF00069	0.328
MOD_Plk_4	61	67	PF00069	0.386
MOD_ProDKin_1	194	200	PF00069	0.327
MOD_ProDKin_1	215	221	PF00069	0.437
MOD_ProDKin_1	311	317	PF00069	0.472
MOD_ProDKin_1	37	43	PF00069	0.399
MOD_ProDKin_1	523	529	PF00069	0.419
MOD_ProDKin_1	531	537	PF00069	0.414
MOD_SUMO_for_1	51	54	PF00179	0.324
MOD_SUMO_rev_2	17	26	PF00179	0.432
TRG_ENDOCYTIC_2	157	160	PF00928	0.403
TRG_ENDOCYTIC_2	192	195	PF00928	0.465
TRG_ENDOCYTIC_2	222	225	PF00928	0.492
TRG_ENDOCYTIC_2	308	311	PF00928	0.274
TRG_ENDOCYTIC_2	372	375	PF00928	0.387
TRG_ER_diArg_1	469	471	PF00400	0.405
TRG_NES_CRM1_1	21	36	PF08389	0.405
TRG_Pf-PMV_PEXEL_1	378	382	PF00026	0.411
TRG_Pf-PMV_PEXEL_1	450	454	PF00026	0.502
TRG_Pf-PMV_PEXEL_1	470	475	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5G0	Leptomonas seymouri	53%	100%
A0A0S4KHH8	Bodo saltans	38%	100%
A0A1X0NPH2	Trypanosomatidae	44%	99%
A0A3R7KD29	Trypanosoma rangeli	45%	98%
A0A3S5H601	Leishmania donovani	92%	100%
A4H3S0	Leishmania braziliensis	85%	100%
A4HTA8	Leishmania infantum	92%	100%
C9ZUL6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	99%
F1RQM2	Sus scrofa	37%	100%
O95394	Homo sapiens	37%	100%
P38628	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	100%
P57750	Arabidopsis thaliana	35%	100%
Q09687	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	36%	100%
Q09770	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	31%	100%
Q4QIK7	Leishmania major	91%	100%
Q6ZDQ1	Oryza sativa subsp. japonica	35%	100%
Q8SSL7	Encephalitozoon cuniculi (strain GB-M1)	32%	100%
Q9CYR6	Mus musculus	35%	100%
Q9P4V2	Candida albicans	34%	100%
V5B892	Trypanosoma cruzi	44%	98%