RRM domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL96_LEIMU

TriTrypDb:

LmxM.07.0802

Length:

353

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9AL96

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL96

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	6
GO:0003723	RNA binding	4	6
GO:0005488	binding	1	6
GO:0097159	organic cyclic compound binding	2	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	166	168	PF00675	0.699
CLV_NRD_NRD_1	351	353	PF00675	0.793
CLV_PCSK_KEX2_1	123	125	PF00082	0.726
CLV_PCSK_KEX2_1	166	168	PF00082	0.568
CLV_PCSK_KEX2_1	351	353	PF00082	0.793
CLV_PCSK_KEX2_1	43	45	PF00082	0.511
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.807
CLV_PCSK_PC1ET2_1	43	45	PF00082	0.511
CLV_PCSK_PC7_1	39	45	PF00082	0.527
DEG_SCF_FBW7_2	305	311	PF00400	0.536
DOC_CKS1_1	234	239	PF01111	0.766
DOC_CKS1_1	305	310	PF01111	0.536
DOC_MAPK_gen_1	43	51	PF00069	0.623
DOC_PP2B_LxvP_1	280	283	PF13499	0.743
DOC_PP4_FxxP_1	342	345	PF00568	0.762
DOC_USP7_MATH_1	157	161	PF00917	0.640
DOC_USP7_MATH_1	276	280	PF00917	0.738
DOC_USP7_MATH_1	284	288	PF00917	0.742
DOC_USP7_MATH_1	330	334	PF00917	0.623
DOC_USP7_UBL2_3	86	90	PF12436	0.783
DOC_WW_Pin1_4	116	121	PF00397	0.548
DOC_WW_Pin1_4	170	175	PF00397	0.810
DOC_WW_Pin1_4	185	190	PF00397	0.580
DOC_WW_Pin1_4	233	238	PF00397	0.662
DOC_WW_Pin1_4	272	277	PF00397	0.812
DOC_WW_Pin1_4	289	294	PF00397	0.487
DOC_WW_Pin1_4	304	309	PF00397	0.536
DOC_WW_Pin1_4	5	10	PF00397	0.688
DOC_WW_Pin1_4	73	78	PF00397	0.589
DOC_WW_Pin1_4	85	90	PF00397	0.777
LIG_14-3-3_CanoR_1	65	73	PF00244	0.627
LIG_BIR_II_1	1	5	PF00653	0.670
LIG_EVH1_1	342	346	PF00568	0.762
LIG_FHA_1	304	310	PF00498	0.536
LIG_LIR_Gen_1	57	66	PF02991	0.598
LIG_LIR_Gen_1	8	19	PF02991	0.600
LIG_LIR_Nem_3	264	269	PF02991	0.828
LIG_LIR_Nem_3	28	34	PF02991	0.462
LIG_LIR_Nem_3	50	56	PF02991	0.482
LIG_LIR_Nem_3	57	61	PF02991	0.484
LIG_LIR_Nem_3	8	14	PF02991	0.621
LIG_PROFILIN_1	293	299	PF00235	0.746
LIG_PROFILIN_1	319	325	PF00235	0.743
LIG_PROFILIN_1	96	102	PF00235	0.692
LIG_SH2_CRK	266	270	PF00017	0.831
LIG_SH2_NCK_1	266	270	PF00017	0.770
LIG_SH2_PTP2	253	256	PF00017	0.639
LIG_SH2_SRC	82	85	PF00017	0.524
LIG_SH2_STAT3	118	121	PF00017	0.719
LIG_SH2_STAT5	253	256	PF00017	0.667
LIG_SH2_STAT5	30	33	PF00017	0.517
LIG_SH3_1	146	152	PF00018	0.531
LIG_SH3_1	253	259	PF00018	0.636
LIG_SH3_1	90	96	PF00018	0.714
LIG_SH3_2	346	351	PF14604	0.755
LIG_SH3_3	146	152	PF00018	0.645
LIG_SH3_3	188	194	PF00018	0.798
LIG_SH3_3	198	204	PF00018	0.518
LIG_SH3_3	238	244	PF00018	0.602
LIG_SH3_3	253	259	PF00018	0.771
LIG_SH3_3	288	294	PF00018	0.604
LIG_SH3_3	295	301	PF00018	0.641
LIG_SH3_3	310	316	PF00018	0.713
LIG_SH3_3	317	323	PF00018	0.631
LIG_SH3_3	340	346	PF00018	0.773
LIG_SH3_3	90	96	PF00018	0.784
LIG_SH3_3	99	105	PF00018	0.663
LIG_SH3_4	175	182	PF00018	0.555
LIG_SH3_CIN85_PxpxPR_1	346	351	PF14604	0.755
LIG_TRAF2_1	190	193	PF00917	0.622
LIG_TYR_ITIM	51	56	PF00017	0.578
LIG_WW_3	348	352	PF00397	0.766
MOD_CDK_SPK_2	170	175	PF00069	0.553
MOD_CDK_SPK_2	235	240	PF00069	0.516
MOD_CDK_SPK_2	5	10	PF00069	0.601
MOD_CDK_SPK_2	85	90	PF00069	0.777
MOD_CDK_SPxK_1	304	310	PF00069	0.536
MOD_CDK_SPxxK_3	116	123	PF00069	0.547
MOD_CDK_SPxxK_3	233	240	PF00069	0.504
MOD_CK1_1	187	193	PF00069	0.546
MOD_CK1_1	333	339	PF00069	0.783
MOD_CK1_1	88	94	PF00069	0.730
MOD_CK2_1	187	193	PF00069	0.696
MOD_CK2_1	66	72	PF00069	0.631
MOD_Cter_Amidation	84	87	PF01082	0.688
MOD_GlcNHglycan	15	18	PF01048	0.520
MOD_GlcNHglycan	22	25	PF01048	0.464
MOD_GlcNHglycan	286	289	PF01048	0.778
MOD_GlcNHglycan	335	338	PF01048	0.798
MOD_GlcNHglycan	35	38	PF01048	0.612
MOD_GSK3_1	1	8	PF00069	0.734
MOD_GSK3_1	219	226	PF00069	0.516
MOD_GSK3_1	229	236	PF00069	0.641
MOD_GSK3_1	261	268	PF00069	0.819
MOD_GSK3_1	272	279	PF00069	0.635
MOD_GSK3_1	328	335	PF00069	0.788
MOD_NEK2_1	1	6	PF00069	0.693
MOD_NEK2_1	13	18	PF00069	0.450
MOD_NEK2_1	309	314	PF00069	0.724
MOD_PIKK_1	100	106	PF00454	0.573
MOD_PIKK_1	107	113	PF00454	0.704
MOD_PIKK_1	223	229	PF00454	0.529
MOD_PIKK_1	66	72	PF00454	0.631
MOD_PIKK_1	88	94	PF00454	0.792
MOD_PKA_2	309	315	PF00069	0.748
MOD_PKB_1	124	132	PF00069	0.796
MOD_Plk_1	126	132	PF00069	0.804
MOD_Plk_4	229	235	PF00069	0.583
MOD_Plk_4	335	341	PF00069	0.538
MOD_ProDKin_1	116	122	PF00069	0.547
MOD_ProDKin_1	170	176	PF00069	0.811
MOD_ProDKin_1	185	191	PF00069	0.577
MOD_ProDKin_1	233	239	PF00069	0.666
MOD_ProDKin_1	272	278	PF00069	0.813
MOD_ProDKin_1	289	295	PF00069	0.485
MOD_ProDKin_1	304	310	PF00069	0.536
MOD_ProDKin_1	5	11	PF00069	0.675
MOD_ProDKin_1	73	79	PF00069	0.595
MOD_ProDKin_1	85	91	PF00069	0.776
TRG_ENDOCYTIC_2	11	14	PF00928	0.587
TRG_ENDOCYTIC_2	266	269	PF00928	0.832
TRG_ENDOCYTIC_2	53	56	PF00928	0.582
TRG_ER_diArg_1	166	168	PF00400	0.568
TRG_ER_diArg_1	350	352	PF00400	0.778

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H600	Leishmania donovani	81%	95%
A4HTA7	Leishmania infantum	84%	100%
C9ZUL7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
Q4QIK8	Leishmania major	84%	100%