Flavoprotein subunit-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

flavoprotein subunit-like protein

Species:

Leishmania mexicana

UniProt:

E9AL95_LEIMU

TriTrypDb:

LmxM.07.0800

Length:

672

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9AL95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL95

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0016491	oxidoreductase activity	2	7
GO:0020037	heme binding	4	6
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046906	tetrapyrrole binding	3	6
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0000166	nucleotide binding	3	1
GO:0010181	FMN binding	4	1
GO:0032553	ribonucleotide binding	3	1
GO:0036094	small molecule binding	2	1
GO:0043168	anion binding	3	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	476	480	PF00656	0.400
CLV_C14_Caspase3-7	577	581	PF00656	0.588
CLV_NRD_NRD_1	312	314	PF00675	0.346
CLV_NRD_NRD_1	403	405	PF00675	0.304
CLV_PCSK_KEX2_1	312	314	PF00082	0.387
CLV_PCSK_KEX2_1	403	405	PF00082	0.439
CLV_PCSK_KEX2_1	416	418	PF00082	0.359
CLV_PCSK_KEX2_1	596	598	PF00082	0.594
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.288
CLV_PCSK_PC1ET2_1	596	598	PF00082	0.594
CLV_PCSK_SKI1_1	170	174	PF00082	0.400
CLV_PCSK_SKI1_1	404	408	PF00082	0.395
CLV_PCSK_SKI1_1	438	442	PF00082	0.400
CLV_PCSK_SKI1_1	526	530	PF00082	0.505
CLV_PCSK_SKI1_1	592	596	PF00082	0.621
CLV_PCSK_SKI1_1	76	80	PF00082	0.392
DEG_APCC_DBOX_1	403	411	PF00400	0.192
DEG_ODPH_VHL_1	458	471	PF01847	0.467
DOC_CYCLIN_RxL_1	401	409	PF00134	0.192
DOC_CYCLIN_RxL_1	523	531	PF00134	0.482
DOC_CYCLIN_RxL_1	614	625	PF00134	0.467
DOC_MAPK_gen_1	142	150	PF00069	0.400
DOC_PP1_RVXF_1	124	130	PF00149	0.467
DOC_PP4_MxPP_1	1	4	PF00568	0.535
DOC_USP7_MATH_1	100	104	PF00917	0.406
DOC_USP7_MATH_1	27	31	PF00917	0.379
DOC_USP7_UBL2_3	592	596	PF12436	0.409
DOC_WW_Pin1_4	324	329	PF00397	0.403
DOC_WW_Pin1_4	429	434	PF00397	0.435
DOC_WW_Pin1_4	579	584	PF00397	0.774
DOC_WW_Pin1_4	58	63	PF00397	0.304
DOC_WW_Pin1_4	659	664	PF00397	0.400
DOC_WW_Pin1_4	96	101	PF00397	0.381
LIG_14-3-3_CanoR_1	118	127	PF00244	0.348
LIG_14-3-3_CanoR_1	404	413	PF00244	0.467
LIG_APCC_ABBA_1	75	80	PF00400	0.392
LIG_BIR_III_2	580	584	PF00653	0.767
LIG_BRCT_BRCA1_1	407	411	PF00533	0.342
LIG_Clathr_ClatBox_1	260	264	PF01394	0.467
LIG_deltaCOP1_diTrp_1	114	120	PF00928	0.346
LIG_eIF4E_1	348	354	PF01652	0.346
LIG_EVH1_1	553	557	PF00568	0.496
LIG_FHA_1	13	19	PF00498	0.192
LIG_FHA_1	149	155	PF00498	0.346
LIG_FHA_1	188	194	PF00498	0.384
LIG_FHA_1	523	529	PF00498	0.468
LIG_FHA_1	622	628	PF00498	0.400
LIG_FHA_2	238	244	PF00498	0.346
LIG_FHA_2	367	373	PF00498	0.412
LIG_FHA_2	547	553	PF00498	0.347
LIG_FHA_2	575	581	PF00498	0.587
LIG_FHA_2	597	603	PF00498	0.312
LIG_GBD_Chelix_1	615	623	PF00786	0.467
LIG_LIR_Apic_2	531	535	PF02991	0.568
LIG_LIR_Gen_1	151	160	PF02991	0.407
LIG_LIR_Gen_1	327	338	PF02991	0.467
LIG_LIR_Gen_1	543	553	PF02991	0.567
LIG_LIR_Gen_1	610	621	PF02991	0.403
LIG_LIR_Gen_1	646	657	PF02991	0.400
LIG_LIR_Nem_3	151	155	PF02991	0.467
LIG_LIR_Nem_3	327	333	PF02991	0.400
LIG_LIR_Nem_3	377	381	PF02991	0.346
LIG_LIR_Nem_3	439	444	PF02991	0.448
LIG_LIR_Nem_3	543	548	PF02991	0.531
LIG_LIR_Nem_3	610	616	PF02991	0.403
LIG_LIR_Nem_3	646	652	PF02991	0.400
LIG_LIR_Nem_3	85	89	PF02991	0.381
LIG_MAD2	176	184	PF02301	0.410
LIG_PCNA_yPIPBox_3	502	515	PF02747	0.350
LIG_Pex14_1	115	119	PF04695	0.467
LIG_Pex14_2	215	219	PF04695	0.400
LIG_SH2_CRK	152	156	PF00017	0.467
LIG_SH2_CRK	516	520	PF00017	0.494
LIG_SH2_CRK	532	536	PF00017	0.543
LIG_SH2_NCK_1	152	156	PF00017	0.467
LIG_SH2_NCK_1	598	602	PF00017	0.467
LIG_SH2_STAT5	119	122	PF00017	0.467
LIG_SH2_STAT5	330	333	PF00017	0.453
LIG_SH2_STAT5	348	351	PF00017	0.185
LIG_SH2_STAT5	454	457	PF00017	0.370
LIG_SH2_STAT5	464	467	PF00017	0.311
LIG_SH2_STAT5	490	493	PF00017	0.467
LIG_SH2_STAT5	527	530	PF00017	0.451
LIG_SH2_STAT5	598	601	PF00017	0.467
LIG_SH2_STAT5	661	664	PF00017	0.400
LIG_SH3_1	94	100	PF00018	0.392
LIG_SH3_3	1	7	PF00018	0.527
LIG_SH3_3	178	184	PF00018	0.426
LIG_SH3_3	273	279	PF00018	0.400
LIG_SH3_3	551	557	PF00018	0.545
LIG_SH3_3	559	565	PF00018	0.615
LIG_SH3_3	580	586	PF00018	0.486
LIG_SH3_3	625	631	PF00018	0.400
LIG_SH3_3	649	655	PF00018	0.467
LIG_SH3_3	94	100	PF00018	0.392
LIG_SUMO_SIM_anti_2	37	42	PF11976	0.323
LIG_SUMO_SIM_par_1	37	42	PF11976	0.323
LIG_TYR_ITIM	150	155	PF00017	0.467
LIG_TYR_ITIM	514	519	PF00017	0.496
LIG_UBA3_1	154	163	PF00899	0.346
MOD_CK1_1	109	115	PF00069	0.346
MOD_CK1_1	429	435	PF00069	0.418
MOD_CK1_1	546	552	PF00069	0.415
MOD_CK1_1	576	582	PF00069	0.745
MOD_CK1_1	643	649	PF00069	0.342
MOD_CK2_1	153	159	PF00069	0.467
MOD_CK2_1	334	340	PF00069	0.467
MOD_CK2_1	356	362	PF00069	0.346
MOD_CK2_1	366	372	PF00069	0.346
MOD_CK2_1	596	602	PF00069	0.367
MOD_GlcNHglycan	108	111	PF01048	0.346
MOD_GlcNHglycan	155	158	PF01048	0.338
MOD_GlcNHglycan	270	273	PF01048	0.442
MOD_GlcNHglycan	29	32	PF01048	0.394
MOD_GlcNHglycan	316	319	PF01048	0.400
MOD_GlcNHglycan	324	327	PF01048	0.400
MOD_GlcNHglycan	335	339	PF01048	0.400
MOD_GlcNHglycan	358	361	PF01048	0.346
MOD_GlcNHglycan	395	398	PF01048	0.414
MOD_GlcNHglycan	55	58	PF01048	0.351
MOD_GlcNHglycan	93	97	PF01048	0.255
MOD_GSK3_1	118	125	PF00069	0.416
MOD_GSK3_1	131	138	PF00069	0.392
MOD_GSK3_1	232	239	PF00069	0.467
MOD_GSK3_1	48	55	PF00069	0.323
MOD_GSK3_1	92	99	PF00069	0.442
MOD_LATS_1	133	139	PF00433	0.467
MOD_N-GLC_1	12	17	PF02516	0.304
MOD_N-GLC_1	49	54	PF02516	0.323
MOD_N-GLC_1	621	626	PF02516	0.467
MOD_N-GLC_1	82	87	PF02516	0.323
MOD_NEK2_1	148	153	PF00069	0.315
MOD_NEK2_1	237	242	PF00069	0.355
MOD_NEK2_1	406	411	PF00069	0.342
MOD_NEK2_1	41	46	PF00069	0.392
MOD_NEK2_1	436	441	PF00069	0.453
MOD_NEK2_1	528	533	PF00069	0.466
MOD_PIKK_1	60	66	PF00454	0.323
MOD_PKA_1	596	602	PF00069	0.346
MOD_PKA_2	106	112	PF00069	0.346
MOD_PKA_2	235	241	PF00069	0.192
MOD_PKA_2	596	602	PF00069	0.467
MOD_Plk_1	12	18	PF00069	0.294
MOD_Plk_1	221	227	PF00069	0.360
MOD_Plk_1	41	47	PF00069	0.323
MOD_Plk_1	82	88	PF00069	0.323
MOD_Plk_2-3	445	451	PF00069	0.467
MOD_Plk_4	222	228	PF00069	0.360
MOD_Plk_4	34	40	PF00069	0.351
MOD_Plk_4	406	412	PF00069	0.342
MOD_Plk_4	42	48	PF00069	0.380
MOD_Plk_4	436	442	PF00069	0.378
MOD_Plk_4	506	512	PF00069	0.346
MOD_Plk_4	528	534	PF00069	0.491
MOD_Plk_4	540	546	PF00069	0.567
MOD_Plk_4	633	639	PF00069	0.400
MOD_ProDKin_1	324	330	PF00069	0.403
MOD_ProDKin_1	429	435	PF00069	0.435
MOD_ProDKin_1	579	585	PF00069	0.771
MOD_ProDKin_1	58	64	PF00069	0.304
MOD_ProDKin_1	659	665	PF00069	0.400
MOD_ProDKin_1	96	102	PF00069	0.381
MOD_SUMO_rev_2	473	482	PF00179	0.467
MOD_SUMO_rev_2	588	594	PF00179	0.618
TRG_ENDOCYTIC_2	152	155	PF00928	0.400
TRG_ENDOCYTIC_2	330	333	PF00928	0.467
TRG_ENDOCYTIC_2	516	519	PF00928	0.498
TRG_ENDOCYTIC_2	545	548	PF00928	0.522
TRG_NES_CRM1_1	66	81	PF08389	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5C0	Leptomonas seymouri	38%	100%
A0A0S4IHN0	Bodo saltans	39%	100%
A0A0S4KND3	Bodo saltans	52%	100%
A0A1X0NPF8	Trypanosomatidae	57%	100%
A0A3S7WPX2	Leishmania donovani	93%	100%
A0A3S7X915	Leishmania donovani	36%	100%
A0A422MX37	Trypanosoma rangeli	35%	100%
A4HME0	Leishmania braziliensis	36%	94%
A4HME1	Leishmania braziliensis	34%	100%
A4HTA6	Leishmania infantum	93%	100%
A4IB13	Leishmania infantum	36%	100%
B2GCE0	Limosilactobacillus fermentum (strain NBRC 3956 / LMG 18251)	27%	100%
B5XRB0	Klebsiella pneumoniae (strain 342)	31%	73%
C8WLE3	Eggerthella lenta (strain ATCC 25559 / DSM 2243 / CCUG 17323 / JCM 9979 / KCTC 3265 / NCTC 11813 / VPI 0255 / 1899 B)	26%	100%
C9ZQ34	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	74%
E9AEU2	Leishmania major	36%	92%
E9B5Z8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	37%	100%
O06913	Helicobacter pylori (strain ATCC 700392 / 26695)	24%	94%
O13755	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
P0C278	Shewanella frigidimarina	31%	100%
P0DW92	Vibrio harveyi	26%	67%
P21375	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	34%	100%
P32614	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
P83223	Shewanella oneidensis (strain MR-1)	33%	100%
Q07WU7	Shewanella frigidimarina (strain NCIMB 400)	31%	100%
Q4QIK9	Leishmania major	93%	100%
Q8CVD0	Shewanella oneidensis (strain MR-1)	30%	100%
Q9Z4P0	Shewanella frigidimarina (strain NCIMB 400)	32%	100%