Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL93_LEIMU

TriTrypDb:

LmxM.07.0780

Length:

299

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9AL93

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL93

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	160	162	PF00675	0.495
CLV_NRD_NRD_1	206	208	PF00675	0.494
CLV_NRD_NRD_1	213	215	PF00675	0.471
CLV_NRD_NRD_1	294	296	PF00675	0.521
CLV_PCSK_FUR_1	158	162	PF00082	0.496
CLV_PCSK_KEX2_1	160	162	PF00082	0.495
CLV_PCSK_KEX2_1	193	195	PF00082	0.510
CLV_PCSK_KEX2_1	212	214	PF00082	0.511
CLV_PCSK_PC1ET2_1	193	195	PF00082	0.510
CLV_PCSK_SKI1_1	190	194	PF00082	0.490
CLV_PCSK_SKI1_1	288	292	PF00082	0.458
DEG_Nend_Nbox_1	1	3	PF02207	0.477
DEG_SPOP_SBC_1	226	230	PF00917	0.662
DOC_ANK_TNKS_1	58	65	PF00023	0.422
DOC_PP4_FxxP_1	60	63	PF00568	0.428
DOC_USP7_MATH_1	135	139	PF00917	0.623
DOC_USP7_MATH_1	226	230	PF00917	0.706
DOC_USP7_MATH_1	250	254	PF00917	0.775
DOC_USP7_MATH_1	256	260	PF00917	0.737
DOC_USP7_MATH_1	267	271	PF00917	0.642
DOC_USP7_MATH_1	276	280	PF00917	0.570
DOC_USP7_MATH_1	42	46	PF00917	0.560
DOC_USP7_MATH_1	84	88	PF00917	0.591
DOC_WW_Pin1_4	145	150	PF00397	0.724
DOC_WW_Pin1_4	230	235	PF00397	0.762
DOC_WW_Pin1_4	44	49	PF00397	0.454
LIG_14-3-3_CanoR_1	227	236	PF00244	0.758
LIG_14-3-3_CanoR_1	46	52	PF00244	0.497
LIG_14-3-3_CterR_2	295	299	PF00244	0.729
LIG_BRCT_BRCA1_1	34	38	PF00533	0.540
LIG_BRCT_BRCA1_1	77	81	PF00533	0.433
LIG_deltaCOP1_diTrp_1	23	29	PF00928	0.389
LIG_deltaCOP1_diTrp_1	90	97	PF00928	0.679
LIG_EH_1	40	44	PF12763	0.521
LIG_FHA_1	77	83	PF00498	0.526
LIG_LIR_Nem_3	23	29	PF02991	0.389
LIG_LIR_Nem_3	47	52	PF02991	0.445
LIG_SH2_GRB2like	25	28	PF00017	0.528
LIG_SH2_NCK_1	52	56	PF00017	0.486
LIG_SH2_SRC	154	157	PF00017	0.646
LIG_SH2_STAT3	156	159	PF00017	0.694
LIG_SH2_STAT3	5	8	PF00017	0.517
LIG_SH2_STAT5	144	147	PF00017	0.740
LIG_SH2_STAT5	74	77	PF00017	0.433
LIG_SH3_3	200	206	PF00018	0.565
LIG_SH3_3	258	264	PF00018	0.766
LIG_SH3_3	270	276	PF00018	0.669
LIG_TRAF2_1	279	282	PF00917	0.718
LIG_TYR_ITIM	72	77	PF00017	0.433
LIG_UBA3_1	290	296	PF00899	0.713
MOD_CDK_SPxxK_3	145	152	PF00069	0.720
MOD_CK1_1	138	144	PF00069	0.696
MOD_CK1_1	230	236	PF00069	0.821
MOD_CK1_1	259	265	PF00069	0.683
MOD_CK1_1	47	53	PF00069	0.485
MOD_CK2_1	171	177	PF00069	0.607
MOD_CK2_1	226	232	PF00069	0.766
MOD_CK2_1	276	282	PF00069	0.730
MOD_GlcNHglycan	222	225	PF01048	0.447
MOD_GlcNHglycan	32	35	PF01048	0.725
MOD_GSK3_1	226	233	PF00069	0.722
MOD_LATS_1	30	36	PF00433	0.534
MOD_N-GLC_1	267	272	PF02516	0.564
MOD_N-GLC_1	30	35	PF02516	0.600
MOD_NEK2_1	220	225	PF00069	0.630
MOD_NEK2_1	75	80	PF00069	0.433
MOD_NEK2_1	99	104	PF00069	0.677
MOD_PKA_2	220	226	PF00069	0.726
MOD_PKA_2	97	103	PF00069	0.682
MOD_Plk_1	257	263	PF00069	0.708
MOD_Plk_1	267	273	PF00069	0.747
MOD_Plk_4	268	274	PF00069	0.764
MOD_Plk_4	62	68	PF00069	0.433
MOD_Plk_4	76	82	PF00069	0.433
MOD_ProDKin_1	145	151	PF00069	0.720
MOD_ProDKin_1	230	236	PF00069	0.763
MOD_ProDKin_1	44	50	PF00069	0.448
TRG_ENDOCYTIC_2	74	77	PF00928	0.526
TRG_ER_diArg_1	139	142	PF00400	0.706
TRG_ER_diArg_1	158	161	PF00400	0.587
TRG_ER_diArg_1	212	214	PF00400	0.711
TRG_ER_diArg_1	57	60	PF00400	0.490

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WPX5	Leishmania donovani	87%	98%
A4H530	Leishmania braziliensis	73%	100%
Q4QIL1	Leishmania major	90%	100%