DNAJ-domain transmembrane-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNAJ-domain transmembrane-like protein

Species:

Leishmania mexicana

UniProt:

E9AL92_LEIMU

TriTrypDb:

LmxM.07.0770

Length:

407

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

E9AL92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL92

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	118	122	PF00656	0.793
CLV_C14_Caspase3-7	220	224	PF00656	0.636
CLV_C14_Caspase3-7	42	46	PF00656	0.684
CLV_NRD_NRD_1	64	66	PF00675	0.589
CLV_PCSK_KEX2_1	64	66	PF00082	0.505
CLV_PCSK_SKI1_1	372	376	PF00082	0.313
CLV_PCSK_SKI1_1	396	400	PF00082	0.355
DEG_COP1_1	143	153	PF00400	0.673
DEG_Nend_UBRbox_1	1	4	PF02207	0.677
DEG_SCF_FBW7_1	53	59	PF00400	0.688
DEG_SPOP_SBC_1	44	48	PF00917	0.811
DOC_CKS1_1	53	58	PF01111	0.691
DOC_CYCLIN_RxL_1	158	169	PF00134	0.545
DOC_MAPK_MEF2A_6	372	381	PF00069	0.313
DOC_PP2B_LxvP_1	325	328	PF13499	0.506
DOC_PP2B_LxvP_1	352	355	PF13499	0.568
DOC_USP7_MATH_1	105	109	PF00917	0.723
DOC_USP7_MATH_1	119	123	PF00917	0.696
DOC_USP7_MATH_1	149	153	PF00917	0.621
DOC_USP7_MATH_1	31	35	PF00917	0.775
DOC_USP7_MATH_1	332	336	PF00917	0.464
DOC_USP7_MATH_1	40	44	PF00917	0.684
DOC_USP7_MATH_1	56	60	PF00917	0.806
DOC_USP7_MATH_1	81	85	PF00917	0.821
DOC_USP7_MATH_1	97	101	PF00917	0.793
DOC_WW_Pin1_4	12	17	PF00397	0.756
DOC_WW_Pin1_4	21	26	PF00397	0.704
DOC_WW_Pin1_4	283	288	PF00397	0.494
DOC_WW_Pin1_4	52	57	PF00397	0.780
DOC_WW_Pin1_4	83	88	PF00397	0.760
LIG_14-3-3_CanoR_1	252	258	PF00244	0.705
LIG_14-3-3_CanoR_1	324	328	PF00244	0.559
LIG_14-3-3_CanoR_1	329	335	PF00244	0.501
LIG_CSL_BTD_1	352	355	PF09270	0.525
LIG_EH1_1	359	367	PF00400	0.457
LIG_FHA_1	13	19	PF00498	0.824
LIG_FHA_1	160	166	PF00498	0.510
LIG_FHA_1	283	289	PF00498	0.527
LIG_FHA_1	293	299	PF00498	0.435
LIG_FHA_1	385	391	PF00498	0.335
LIG_FHA_2	207	213	PF00498	0.605
LIG_FHA_2	229	235	PF00498	0.550
LIG_FHA_2	252	258	PF00498	0.709
LIG_FHA_2	40	46	PF00498	0.683
LIG_GBD_Chelix_1	377	385	PF00786	0.453
LIG_HP1_1	16	20	PF01393	0.671
LIG_LIR_Apic_2	350	356	PF02991	0.524
LIG_LIR_Gen_1	152	160	PF02991	0.542
LIG_LIR_Gen_1	209	219	PF02991	0.637
LIG_LIR_Gen_1	359	366	PF02991	0.545
LIG_LIR_Nem_3	152	156	PF02991	0.561
LIG_LIR_Nem_3	209	214	PF02991	0.631
LIG_LIR_Nem_3	271	276	PF02991	0.334
LIG_LIR_Nem_3	359	363	PF02991	0.548
LIG_Pex14_1	279	283	PF04695	0.502
LIG_SH2_CRK	185	189	PF00017	0.572
LIG_SH2_CRK	211	215	PF00017	0.547
LIG_SH2_CRK	342	346	PF00017	0.444
LIG_SH2_NCK_1	145	149	PF00017	0.575
LIG_SH2_NCK_1	67	71	PF00017	0.745
LIG_SH2_STAP1	145	149	PF00017	0.575
LIG_SH2_STAP1	211	215	PF00017	0.631
LIG_SH2_STAP1	373	377	PF00017	0.453
LIG_SH2_STAP1	67	71	PF00017	0.745
LIG_SH3_3	50	56	PF00018	0.753
LIG_SUMO_SIM_anti_2	15	22	PF11976	0.669
LIG_SUMO_SIM_par_1	15	22	PF11976	0.669
LIG_SUMO_SIM_par_1	34	39	PF11976	0.585
LIG_TRAF2_1	136	139	PF00917	0.776
LIG_TYR_ITIM	340	345	PF00017	0.552
LIG_WRC_WIRS_1	150	155	PF05994	0.498
MOD_CK1_1	100	106	PF00069	0.652
MOD_CK1_1	122	128	PF00069	0.694
MOD_CK1_1	251	257	PF00069	0.647
MOD_CK1_1	34	40	PF00069	0.689
MOD_CK1_1	43	49	PF00069	0.645
MOD_CK1_1	59	65	PF00069	0.781
MOD_CK2_1	127	133	PF00069	0.651
MOD_CK2_1	149	155	PF00069	0.539
MOD_CK2_1	228	234	PF00069	0.425
MOD_CK2_1	251	257	PF00069	0.647
MOD_GlcNHglycan	116	120	PF01048	0.579
MOD_GlcNHglycan	121	125	PF01048	0.702
MOD_GlcNHglycan	21	24	PF01048	0.603
MOD_GlcNHglycan	217	220	PF01048	0.550
MOD_GlcNHglycan	270	273	PF01048	0.507
MOD_GlcNHglycan	300	303	PF01048	0.703
MOD_GlcNHglycan	349	352	PF01048	0.677
MOD_GlcNHglycan	38	41	PF01048	0.670
MOD_GlcNHglycan	42	45	PF01048	0.782
MOD_GlcNHglycan	83	86	PF01048	0.752
MOD_GlcNHglycan	99	102	PF01048	0.753
MOD_GSK3_1	115	122	PF00069	0.745
MOD_GSK3_1	123	130	PF00069	0.619
MOD_GSK3_1	21	28	PF00069	0.786
MOD_GSK3_1	228	235	PF00069	0.319
MOD_GSK3_1	248	255	PF00069	0.588
MOD_GSK3_1	288	295	PF00069	0.583
MOD_GSK3_1	343	350	PF00069	0.555
MOD_GSK3_1	36	43	PF00069	0.540
MOD_GSK3_1	52	59	PF00069	0.723
MOD_GSK3_1	77	84	PF00069	0.689
MOD_N-GLC_1	207	212	PF02516	0.532
MOD_NEK2_1	19	24	PF00069	0.720
MOD_NEK2_1	248	253	PF00069	0.656
MOD_NEK2_1	282	287	PF00069	0.700
MOD_NEK2_1	365	370	PF00069	0.561
MOD_NEK2_2	56	61	PF00069	0.605
MOD_PIKK_1	7	13	PF00454	0.734
MOD_PKA_2	251	257	PF00069	0.647
MOD_PKA_2	323	329	PF00069	0.715
MOD_Plk_1	207	213	PF00069	0.532
MOD_Plk_4	31	37	PF00069	0.598
MOD_Plk_4	384	390	PF00069	0.340
MOD_ProDKin_1	12	18	PF00069	0.707
MOD_ProDKin_1	21	27	PF00069	0.632
MOD_ProDKin_1	283	289	PF00069	0.622
MOD_ProDKin_1	52	58	PF00069	0.737
MOD_ProDKin_1	83	89	PF00069	0.704
MOD_SUMO_rev_2	133	141	PF00179	0.732
TRG_DiLeu_BaEn_1	257	262	PF01217	0.570
TRG_ENDOCYTIC_2	157	160	PF00928	0.392
TRG_ENDOCYTIC_2	185	188	PF00928	0.450
TRG_ENDOCYTIC_2	211	214	PF00928	0.411
TRG_ENDOCYTIC_2	342	345	PF00928	0.548
TRG_NES_CRM1_1	154	169	PF08389	0.532
TRG_Pf-PMV_PEXEL_1	186	191	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILA2	Leptomonas seymouri	51%	88%
A0A3S7WPX9	Leishmania donovani	89%	98%
A4H529	Leishmania braziliensis	70%	100%
A4HTA3	Leishmania infantum	89%	67%
Q4QIL2	Leishmania major	88%	100%