J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL90_LEIMU

TriTrypDb:

LmxM.07.0750

Length:

295

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9AL90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL90

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.592
CLV_C14_Caspase3-7	152	156	PF00656	0.510
CLV_NRD_NRD_1	101	103	PF00675	0.640
CLV_NRD_NRD_1	118	120	PF00675	0.681
CLV_NRD_NRD_1	12	14	PF00675	0.649
CLV_NRD_NRD_1	287	289	PF00675	0.461
CLV_NRD_NRD_1	68	70	PF00675	0.765
CLV_PCSK_FUR_1	284	288	PF00082	0.355
CLV_PCSK_FUR_1	64	68	PF00082	0.749
CLV_PCSK_KEX2_1	100	102	PF00082	0.646
CLV_PCSK_KEX2_1	117	119	PF00082	0.653
CLV_PCSK_KEX2_1	12	14	PF00082	0.649
CLV_PCSK_KEX2_1	286	288	PF00082	0.454
CLV_PCSK_KEX2_1	66	68	PF00082	0.752
CLV_PCSK_PC7_1	64	70	PF00082	0.711
CLV_PCSK_SKI1_1	250	254	PF00082	0.480
DEG_APCC_DBOX_1	249	257	PF00400	0.340
DEG_Nend_UBRbox_1	1	4	PF02207	0.464
DOC_MAPK_HePTP_8	243	255	PF00069	0.430
DOC_MAPK_JIP1_4	250	256	PF00069	0.296
DOC_MAPK_MEF2A_6	171	180	PF00069	0.526
DOC_MAPK_MEF2A_6	246	255	PF00069	0.421
DOC_PP4_FxxP_1	38	41	PF00568	0.476
DOC_USP7_MATH_1	140	144	PF00917	0.507
DOC_USP7_MATH_1	146	150	PF00917	0.588
DOC_USP7_MATH_1	80	84	PF00917	0.435
LIG_14-3-3_CanoR_1	171	178	PF00244	0.390
LIG_Actin_WH2_2	176	191	PF00022	0.465
LIG_BRCT_BRCA1_1	176	180	PF00533	0.387
LIG_FHA_1	171	177	PF00498	0.480
LIG_FHA_1	183	189	PF00498	0.432
LIG_FHA_2	137	143	PF00498	0.523
LIG_FHA_2	45	51	PF00498	0.509
LIG_LIR_Apic_2	207	212	PF02991	0.506
LIG_LIR_Gen_1	260	270	PF02991	0.214
LIG_LIR_Gen_1	5	16	PF02991	0.477
LIG_LIR_Gen_1	50	60	PF02991	0.505
LIG_LIR_Nem_3	177	183	PF02991	0.425
LIG_LIR_Nem_3	5	11	PF02991	0.414
LIG_LIR_Nem_3	50	56	PF02991	0.500
LIG_NRBOX	252	258	PF00104	0.342
LIG_SH2_CRK	209	213	PF00017	0.504
LIG_SH2_CRK	53	57	PF00017	0.496
LIG_SH2_CRK	8	12	PF00017	0.411
LIG_SH2_GRB2like	209	212	PF00017	0.455
LIG_SH2_NCK_1	53	57	PF00017	0.496
LIG_SH2_SRC	209	212	PF00017	0.455
LIG_SH2_STAT3	236	239	PF00017	0.369
LIG_SH2_STAT5	231	234	PF00017	0.458
LIG_SH3_3	245	251	PF00018	0.435
LIG_TRAF2_1	49	52	PF00917	0.517
MOD_CK1_1	144	150	PF00069	0.815
MOD_CK1_1	174	180	PF00069	0.488
MOD_CK2_1	44	50	PF00069	0.642
MOD_Cter_Amidation	98	101	PF01082	0.542
MOD_GlcNHglycan	144	147	PF01048	0.737
MOD_GlcNHglycan	148	151	PF01048	0.779
MOD_GlcNHglycan	213	216	PF01048	0.557
MOD_GlcNHglycan	28	31	PF01048	0.543
MOD_GSK3_1	136	143	PF00069	0.798
MOD_GSK3_1	146	153	PF00069	0.559
MOD_GSK3_1	170	177	PF00069	0.479
MOD_N-GLC_1	171	176	PF02516	0.541
MOD_N-GLC_1	181	186	PF02516	0.608
MOD_N-GLC_1	44	49	PF02516	0.595
MOD_NEK2_1	181	186	PF00069	0.606
MOD_NEK2_1	194	199	PF00069	0.510
MOD_NEK2_1	204	209	PF00069	0.503
MOD_NEK2_1	257	262	PF00069	0.402
MOD_NEK2_1	268	273	PF00069	0.280
MOD_PKA_2	170	176	PF00069	0.609
MOD_Plk_1	171	177	PF00069	0.472
MOD_Plk_1	44	50	PF00069	0.598
MOD_Plk_2-3	93	99	PF00069	0.629
MOD_Plk_4	204	210	PF00069	0.469
MOD_Plk_4	257	263	PF00069	0.214
TRG_DiLeu_BaEn_1	6	11	PF01217	0.498
TRG_DiLeu_BaLyEn_6	248	253	PF01217	0.513
TRG_ENDOCYTIC_2	231	234	PF00928	0.683
TRG_ENDOCYTIC_2	53	56	PF00928	0.618
TRG_ENDOCYTIC_2	8	11	PF00928	0.495
TRG_ER_diArg_1	100	102	PF00400	0.561
TRG_ER_diArg_1	11	13	PF00400	0.551
TRG_ER_diArg_1	116	119	PF00400	0.616
TRG_ER_diArg_1	18	21	PF00400	0.635
TRG_ER_diArg_1	195	198	PF00400	0.650
TRG_ER_diArg_1	276	279	PF00400	0.495
TRG_ER_diArg_1	284	287	PF00400	0.511
TRG_ER_diArg_1	34	37	PF00400	0.700
TRG_ER_diArg_1	64	67	PF00400	0.692
TRG_ER_diArg_1	68	71	PF00400	0.682
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	21	25	PF00026	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H5Z9	Leishmania donovani	88%	100%
A4H527	Leishmania braziliensis	67%	100%
A4HTA1	Leishmania infantum	88%	100%
Q4QIL4	Leishmania major	87%	100%
V5B888	Trypanosoma cruzi	26%	78%