Importin N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9AL86_LEIMU

TriTrypDb:

LmxM.07.0720

Length:

1259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0005737	cytoplasm	2	11
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

E9AL86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL86

Function

Biological processes
Term	Name	Level	Count
GO:0006606	protein import into nucleus	5	11
GO:0006810	transport	3	11
GO:0006886	intracellular protein transport	4	11
GO:0006913	nucleocytoplasmic transport	5	11
GO:0008104	protein localization	4	11
GO:0009987	cellular process	1	11
GO:0015031	protein transport	4	11
GO:0033036	macromolecule localization	2	11
GO:0033365	protein localization to organelle	5	11
GO:0034504	protein localization to nucleus	6	11
GO:0045184	establishment of protein localization	3	11
GO:0046907	intracellular transport	3	11
GO:0051169	nuclear transport	4	11
GO:0051170	import into nucleus	6	11
GO:0051179	localization	1	11
GO:0051234	establishment of localization	2	11
GO:0051641	cellular localization	2	11
GO:0051649	establishment of localization in cell	3	11
GO:0070727	cellular macromolecule localization	3	11
GO:0071702	organic substance transport	4	11
GO:0071705	nitrogen compound transport	4	11
GO:0072594	establishment of protein localization to organelle	4	11

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0005515	protein binding	2	11
GO:0019899	enzyme binding	3	11
GO:0031267	small GTPase binding	5	11
GO:0051020	GTPase binding	4	11
GO:0005048	signal sequence binding	4	1
GO:0008139	nuclear localization sequence binding	5	1
GO:0033218	amide binding	2	1
GO:0042277	peptide binding	3	1
GO:0061608	nuclear import signal receptor activity	3	1
GO:0140104	molecular carrier activity	1	1
GO:0140142	nucleocytoplasmic carrier activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1129	1133	PF00656	0.521
CLV_C14_Caspase3-7	734	738	PF00656	0.584
CLV_C14_Caspase3-7	844	848	PF00656	0.549
CLV_MEL_PAP_1	418	424	PF00089	0.515
CLV_NRD_NRD_1	30	32	PF00675	0.483
CLV_NRD_NRD_1	399	401	PF00675	0.381
CLV_NRD_NRD_1	420	422	PF00675	0.447
CLV_NRD_NRD_1	483	485	PF00675	0.335
CLV_NRD_NRD_1	76	78	PF00675	0.392
CLV_NRD_NRD_1	865	867	PF00675	0.713
CLV_PCSK_KEX2_1	259	261	PF00082	0.324
CLV_PCSK_KEX2_1	29	31	PF00082	0.492
CLV_PCSK_KEX2_1	419	421	PF00082	0.461
CLV_PCSK_KEX2_1	482	484	PF00082	0.335
CLV_PCSK_KEX2_1	78	80	PF00082	0.503
CLV_PCSK_KEX2_1	865	867	PF00082	0.701
CLV_PCSK_PC1ET2_1	259	261	PF00082	0.358
CLV_PCSK_PC1ET2_1	78	80	PF00082	0.503
CLV_PCSK_SKI1_1	121	125	PF00082	0.493
CLV_PCSK_SKI1_1	1251	1255	PF00082	0.520
CLV_PCSK_SKI1_1	214	218	PF00082	0.454
CLV_PCSK_SKI1_1	375	379	PF00082	0.398
CLV_PCSK_SKI1_1	400	404	PF00082	0.443
CLV_PCSK_SKI1_1	430	434	PF00082	0.458
CLV_PCSK_SKI1_1	583	587	PF00082	0.450
CLV_PCSK_SKI1_1	652	656	PF00082	0.377
CLV_PCSK_SKI1_1	754	758	PF00082	0.452
CLV_PCSK_SKI1_1	78	82	PF00082	0.415
CLV_PCSK_SKI1_1	85	89	PF00082	0.439
CLV_PCSK_SKI1_1	96	100	PF00082	0.313
CLV_Separin_Metazoa	550	554	PF03568	0.560
DEG_COP1_1	498	507	PF00400	0.536
DEG_MDM2_SWIB_1	1113	1120	PF02201	0.504
DEG_Nend_UBRbox_3	1	3	PF02207	0.734
DEG_ODPH_VHL_1	1060	1072	PF01847	0.504
DEG_SCF_FBW7_1	53	60	PF00400	0.552
DOC_ANK_TNKS_1	1091	1098	PF00023	0.465
DOC_CDC14_PxL_1	201	209	PF14671	0.545
DOC_CDC14_PxL_1	303	311	PF14671	0.458
DOC_CKS1_1	558	563	PF01111	0.514
DOC_CYCLIN_RxL_1	1140	1148	PF00134	0.428
DOC_CYCLIN_RxL_1	646	658	PF00134	0.365
DOC_CYCLIN_yCln2_LP_2	1001	1007	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	507	513	PF00134	0.457
DOC_CYCLIN_yCln2_LP_2	552	558	PF00134	0.435
DOC_MAPK_gen_1	398	407	PF00069	0.381
DOC_MAPK_gen_1	419	428	PF00069	0.407
DOC_MAPK_gen_1	799	808	PF00069	0.515
DOC_MAPK_HePTP_8	798	810	PF00069	0.543
DOC_MAPK_MEF2A_6	238	245	PF00069	0.426
DOC_MAPK_MEF2A_6	453	461	PF00069	0.257
DOC_MAPK_MEF2A_6	801	810	PF00069	0.543
DOC_MAPK_RevD_3	468	484	PF00069	0.447
DOC_PP1_RVXF_1	107	114	PF00149	0.442
DOC_PP2B_LxvP_1	1059	1062	PF13499	0.530
DOC_PP2B_LxvP_1	794	797	PF13499	0.547
DOC_PP2B_LxvP_1	963	966	PF13499	0.657
DOC_SPAK_OSR1_1	112	116	PF12202	0.439
DOC_USP7_MATH_1	1040	1044	PF00917	0.533
DOC_USP7_MATH_1	1137	1141	PF00917	0.395
DOC_USP7_MATH_1	1192	1196	PF00917	0.636
DOC_USP7_MATH_1	177	181	PF00917	0.525
DOC_USP7_MATH_1	447	451	PF00917	0.433
DOC_USP7_MATH_1	516	520	PF00917	0.494
DOC_USP7_MATH_1	540	544	PF00917	0.567
DOC_USP7_MATH_1	756	760	PF00917	0.429
DOC_USP7_MATH_1	782	786	PF00917	0.704
DOC_USP7_MATH_1	925	929	PF00917	0.660
DOC_WW_Pin1_4	1050	1055	PF00397	0.639
DOC_WW_Pin1_4	53	58	PF00397	0.560
DOC_WW_Pin1_4	557	562	PF00397	0.485
LIG_14-3-3_CanoR_1	1244	1253	PF00244	0.383
LIG_14-3-3_CanoR_1	387	395	PF00244	0.583
LIG_14-3-3_CanoR_1	400	405	PF00244	0.181
LIG_14-3-3_CanoR_1	567	577	PF00244	0.405
LIG_14-3-3_CanoR_1	79	84	PF00244	0.460
LIG_Actin_WH2_2	795	813	PF00022	0.525
LIG_AP2alpha_1	586	590	PF02296	0.249
LIG_AP2alpha_2	913	915	PF02296	0.682
LIG_APCC_ABBA_1	1013	1018	PF00400	0.531
LIG_APCC_ABBA_1	1060	1065	PF00400	0.517
LIG_APCC_ABBA_1	459	464	PF00400	0.509
LIG_APCC_ABBA_1	710	715	PF00400	0.475
LIG_APCC_Cbox_2	501	507	PF00515	0.559
LIG_BIR_III_2	435	439	PF00653	0.523
LIG_BIR_III_4	1045	1049	PF00653	0.537
LIG_BRCT_BRCA1_1	373	377	PF00533	0.533
LIG_BRCT_BRCA1_1	537	541	PF00533	0.499
LIG_BRCT_BRCA1_1	611	615	PF00533	0.372
LIG_Clathr_ClatBox_1	1149	1153	PF01394	0.502
LIG_CORNRBOX	13	21	PF00104	0.522
LIG_DLG_GKlike_1	609	616	PF00625	0.373
LIG_eIF4E_1	1089	1095	PF01652	0.401
LIG_eIF4E_1	649	655	PF01652	0.406
LIG_FHA_1	106	112	PF00498	0.487
LIG_FHA_1	1183	1189	PF00498	0.553
LIG_FHA_1	324	330	PF00498	0.496
LIG_FHA_1	35	41	PF00498	0.531
LIG_FHA_1	376	382	PF00498	0.398
LIG_FHA_1	475	481	PF00498	0.442
LIG_FHA_1	561	567	PF00498	0.464
LIG_FHA_1	569	575	PF00498	0.382
LIG_FHA_1	695	701	PF00498	0.456
LIG_FHA_2	1211	1217	PF00498	0.488
LIG_FHA_2	146	152	PF00498	0.543
LIG_FHA_2	204	210	PF00498	0.558
LIG_FHA_2	489	495	PF00498	0.335
LIG_FHA_2	639	645	PF00498	0.435
LIG_FHA_2	7	13	PF00498	0.501
LIG_FHA_2	732	738	PF00498	0.491
LIG_FHA_2	810	816	PF00498	0.512
LIG_FHA_2	899	905	PF00498	0.798
LIG_GBD_Chelix_1	264	272	PF00786	0.488
LIG_GBD_Chelix_1	853	861	PF00786	0.581
LIG_Integrin_RGD_1	866	868	PF01839	0.685
LIG_LIR_Gen_1	1071	1076	PF02991	0.508
LIG_LIR_Gen_1	633	642	PF02991	0.243
LIG_LIR_Gen_1	727	736	PF02991	0.390
LIG_LIR_Nem_3	132	137	PF02991	0.513
LIG_LIR_Nem_3	162	166	PF02991	0.533
LIG_LIR_Nem_3	250	256	PF02991	0.496
LIG_LIR_Nem_3	588	593	PF02991	0.390
LIG_LIR_Nem_3	610	616	PF02991	0.369
LIG_LIR_Nem_3	625	630	PF02991	0.365
LIG_LIR_Nem_3	633	639	PF02991	0.373
LIG_LIR_Nem_3	727	733	PF02991	0.389
LIG_LIR_Nem_3	738	744	PF02991	0.474
LIG_LIR_Nem_3	82	87	PF02991	0.404
LIG_LIR_Nem_3	886	890	PF02991	0.710
LIG_LYPXL_yS_3	741	744	PF13949	0.554
LIG_MYND_1	1007	1011	PF01753	0.446
LIG_MYND_1	505	509	PF01753	0.517
LIG_MYND_3	471	475	PF01753	0.402
LIG_NRBOX	1178	1184	PF00104	0.426
LIG_NRBOX	804	810	PF00104	0.484
LIG_NRBOX	94	100	PF00104	0.502
LIG_PCNA_yPIPBox_3	85	99	PF02747	0.530
LIG_Pex14_2	1113	1117	PF04695	0.504
LIG_Pex14_2	163	167	PF04695	0.543
LIG_Pex14_2	586	590	PF04695	0.419
LIG_Pex14_2	623	627	PF04695	0.513
LIG_PTB_Apo_2	2	9	PF02174	0.580
LIG_PTB_Phospho_1	2	8	PF10480	0.590
LIG_REV1ctd_RIR_1	913	922	PF16727	0.691
LIG_SH2_CRK	261	265	PF00017	0.541
LIG_SH2_CRK	890	894	PF00017	0.750
LIG_SH2_CRK	961	965	PF00017	0.640
LIG_SH2_CRK	998	1002	PF00017	0.508
LIG_SH2_NCK_1	961	965	PF00017	0.596
LIG_SH2_STAP1	961	965	PF00017	0.420
LIG_SH2_STAT5	1008	1011	PF00017	0.462
LIG_SH2_STAT5	1089	1092	PF00017	0.438
LIG_SH2_STAT5	1181	1184	PF00017	0.462
LIG_SH2_STAT5	384	387	PF00017	0.514
LIG_SH2_STAT5	417	420	PF00017	0.404
LIG_SH2_STAT5	424	427	PF00017	0.367
LIG_SH2_STAT5	503	506	PF00017	0.455
LIG_SH2_STAT5	589	592	PF00017	0.457
LIG_SH2_STAT5	630	633	PF00017	0.412
LIG_SH2_STAT5	636	639	PF00017	0.388
LIG_SH2_STAT5	708	711	PF00017	0.391
LIG_SH2_STAT5	8	11	PF00017	0.564
LIG_SH2_STAT5	836	839	PF00017	0.446
LIG_SH2_STAT5	961	964	PF00017	0.600
LIG_SH3_3	1001	1007	PF00018	0.464
LIG_SH3_3	199	205	PF00018	0.428
LIG_SH3_3	301	307	PF00018	0.515
LIG_SH3_3	840	846	PF00018	0.262
LIG_SH3_3	970	976	PF00018	0.705
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.326
LIG_SUMO_SIM_anti_2	547	553	PF11976	0.467
LIG_SUMO_SIM_anti_2	828	835	PF11976	0.450
LIG_SUMO_SIM_par_1	156	162	PF11976	0.482
LIG_SUMO_SIM_par_1	200	206	PF11976	0.515
LIG_SUMO_SIM_par_1	244	250	PF11976	0.364
LIG_SUMO_SIM_par_1	322	331	PF11976	0.498
LIG_SUMO_SIM_par_1	424	429	PF11976	0.529
LIG_TRAF2_1	763	766	PF00917	0.397
LIG_TRAF2_1	812	815	PF00917	0.557
LIG_UBA3_1	1159	1166	PF00899	0.525
LIG_UBA3_1	252	259	PF00899	0.513
LIG_Vh1_VBS_1	515	533	PF01044	0.496
LIG_WRC_WIRS_1	160	165	PF05994	0.519
LIG_WRC_WIRS_1	448	453	PF05994	0.443
LIG_WW_1	958	961	PF00397	0.666
MOD_CK1_1	1053	1059	PF00069	0.536
MOD_CK1_1	1078	1084	PF00069	0.525
MOD_CK1_1	1100	1106	PF00069	0.472
MOD_CK1_1	386	392	PF00069	0.478
MOD_CK1_1	519	525	PF00069	0.404
MOD_CK1_1	62	68	PF00069	0.581
MOD_CK1_1	785	791	PF00069	0.585
MOD_CK2_1	145	151	PF00069	0.498
MOD_CK2_1	159	165	PF00069	0.354
MOD_CK2_1	203	209	PF00069	0.549
MOD_CK2_1	488	494	PF00069	0.335
MOD_CK2_1	515	521	PF00069	0.466
MOD_CK2_1	6	12	PF00069	0.558
MOD_CK2_1	638	644	PF00069	0.418
MOD_CK2_1	809	815	PF00069	0.493
MOD_GlcNHglycan	1086	1089	PF01048	0.412
MOD_GlcNHglycan	1135	1138	PF01048	0.366
MOD_GlcNHglycan	173	176	PF01048	0.529
MOD_GlcNHglycan	230	233	PF01048	0.495
MOD_GlcNHglycan	333	336	PF01048	0.742
MOD_GlcNHglycan	355	358	PF01048	0.501
MOD_GlcNHglycan	365	368	PF01048	0.452
MOD_GlcNHglycan	578	581	PF01048	0.524
MOD_GlcNHglycan	64	67	PF01048	0.509
MOD_GlcNHglycan	704	707	PF01048	0.371
MOD_GlcNHglycan	758	761	PF01048	0.504
MOD_GlcNHglycan	784	788	PF01048	0.699
MOD_GlcNHglycan	901	904	PF01048	0.792
MOD_GlcNHglycan	927	930	PF01048	0.656
MOD_GlcNHglycan	952	955	PF01048	0.745
MOD_GSK3_1	1026	1033	PF00069	0.481
MOD_GSK3_1	1075	1082	PF00069	0.458
MOD_GSK3_1	1133	1140	PF00069	0.380
MOD_GSK3_1	1188	1195	PF00069	0.616
MOD_GSK3_1	228	235	PF00069	0.448
MOD_GSK3_1	319	326	PF00069	0.454
MOD_GSK3_1	327	334	PF00069	0.595
MOD_GSK3_1	363	370	PF00069	0.377
MOD_GSK3_1	371	378	PF00069	0.513
MOD_GSK3_1	396	403	PF00069	0.482
MOD_GSK3_1	515	522	PF00069	0.435
MOD_GSK3_1	53	60	PF00069	0.607
MOD_GSK3_1	536	543	PF00069	0.305
MOD_GSK3_1	731	738	PF00069	0.511
MOD_GSK3_1	946	953	PF00069	0.761
MOD_LATS_1	692	698	PF00433	0.522
MOD_N-GLC_1	883	888	PF02516	0.736
MOD_N-GLC_1	898	903	PF02516	0.541
MOD_N-GLC_2	618	620	PF02516	0.364
MOD_NEK2_1	1	6	PF00069	0.601
MOD_NEK2_1	1070	1075	PF00069	0.516
MOD_NEK2_1	159	164	PF00069	0.390
MOD_NEK2_1	228	233	PF00069	0.521
MOD_NEK2_1	241	246	PF00069	0.341
MOD_NEK2_1	352	357	PF00069	0.538
MOD_NEK2_1	368	373	PF00069	0.289
MOD_NEK2_1	426	431	PF00069	0.435
MOD_NEK2_1	446	451	PF00069	0.182
MOD_NEK2_1	535	540	PF00069	0.472
MOD_NEK2_1	631	636	PF00069	0.448
MOD_NEK2_1	857	862	PF00069	0.502
MOD_NEK2_1	990	995	PF00069	0.443
MOD_PIKK_1	1100	1106	PF00454	0.514
MOD_PIKK_1	519	525	PF00454	0.396
MOD_PIKK_1	836	842	PF00454	0.451
MOD_PIKK_1	946	952	PF00454	0.593
MOD_PKA_1	400	406	PF00069	0.439
MOD_PKA_2	386	392	PF00069	0.569
MOD_PKA_2	857	863	PF00069	0.568
MOD_PKB_1	398	406	PF00069	0.489
MOD_PKB_1	77	85	PF00069	0.510
MOD_Plk_1	145	151	PF00069	0.469
MOD_Plk_1	323	329	PF00069	0.496
MOD_Plk_1	609	615	PF00069	0.376
MOD_Plk_1	883	889	PF00069	0.732
MOD_Plk_2-3	640	646	PF00069	0.550
MOD_Plk_2-3	677	683	PF00069	0.729
MOD_Plk_2-3	874	880	PF00069	0.779
MOD_Plk_2-3	883	889	PF00069	0.762
MOD_Plk_4	1033	1039	PF00069	0.412
MOD_Plk_4	1097	1103	PF00069	0.439
MOD_Plk_4	1137	1143	PF00069	0.355
MOD_Plk_4	1145	1151	PF00069	0.407
MOD_Plk_4	1193	1199	PF00069	0.529
MOD_Plk_4	12	18	PF00069	0.481
MOD_Plk_4	1225	1231	PF00069	0.480
MOD_Plk_4	177	183	PF00069	0.472
MOD_Plk_4	187	193	PF00069	0.425
MOD_Plk_4	241	247	PF00069	0.420
MOD_Plk_4	400	406	PF00069	0.438
MOD_Plk_4	413	419	PF00069	0.407
MOD_Plk_4	462	468	PF00069	0.368
MOD_Plk_4	48	54	PF00069	0.487
MOD_Plk_4	503	509	PF00069	0.481
MOD_Plk_4	631	637	PF00069	0.405
MOD_Plk_4	785	791	PF00069	0.586
MOD_Plk_4	828	834	PF00069	0.463
MOD_Plk_4	959	965	PF00069	0.507
MOD_ProDKin_1	1050	1056	PF00069	0.628
MOD_ProDKin_1	53	59	PF00069	0.570
MOD_ProDKin_1	557	563	PF00069	0.479
MOD_SUMO_rev_2	230	240	PF00179	0.497
MOD_SUMO_rev_2	699	705	PF00179	0.395
TRG_DiLeu_BaEn_1	1055	1060	PF01217	0.295
TRG_DiLeu_BaEn_1	804	809	PF01217	0.521
TRG_DiLeu_BaLyEn_6	1008	1013	PF01217	0.457
TRG_DiLeu_BaLyEn_6	469	474	PF01217	0.339
TRG_ENDOCYTIC_2	1041	1044	PF00928	0.530
TRG_ENDOCYTIC_2	261	264	PF00928	0.549
TRG_ENDOCYTIC_2	589	592	PF00928	0.468
TRG_ENDOCYTIC_2	636	639	PF00928	0.400
TRG_ENDOCYTIC_2	741	744	PF00928	0.521
TRG_ENDOCYTIC_2	890	893	PF00928	0.659
TRG_ENDOCYTIC_2	961	964	PF00928	0.643
TRG_ENDOCYTIC_2	998	1001	PF00928	0.510
TRG_ER_diArg_1	283	286	PF00400	0.438
TRG_ER_diArg_1	29	31	PF00400	0.559
TRG_ER_diArg_1	418	421	PF00400	0.425
TRG_ER_diArg_1	481	484	PF00400	0.335
TRG_ER_diArg_1	693	696	PF00400	0.609
TRG_ER_diArg_1	76	79	PF00400	0.503
TRG_NES_CRM1_1	11	25	PF08389	0.409
TRG_NES_CRM1_1	1153	1168	PF08389	0.532
TRG_NES_CRM1_1	800	814	PF08389	0.554
TRG_Pf-PMV_PEXEL_1	1092	1096	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	1244	1248	PF00026	0.334
TRG_Pf-PMV_PEXEL_1	183	187	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	453	458	PF00026	0.474
TRG_Pf-PMV_PEXEL_1	811	815	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	85	90	PF00026	0.511
TRG_Pf-PMV_PEXEL_1	96	101	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4K3	Leptomonas seymouri	74%	100%
A0A0S4J3W9	Bodo saltans	41%	100%
A0A1X0NRZ8	Trypanosomatidae	45%	100%
A0A3S5H5Z4	Leishmania donovani	94%	99%
A0A422P327	Trypanosoma rangeli	45%	100%
A4H524	Leishmania braziliensis	84%	100%
A4HT97	Leishmania infantum	94%	100%
D0AAL4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q4QIL9	Leishmania major	94%	100%