LeishMANIAdb
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Putative 40S ribosomal protein S9

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative 40S ribosomal protein S9
Gene product:
40S ribosomal protein S9, putative
Species:
Leishmania mexicana
UniProt:
E9AL81_LEIMU
TriTrypDb:
LmxM.07.0680
Length:
189

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. yes yes: 32
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 6
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 12
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 14
NetGPI no yes: 0, no: 14
Cellular components
Term Name Level Count
GO:0015935 small ribosomal subunit 4 15
GO:0032991 protein-containing complex 1 15
GO:0044391 ribosomal subunit 3 15
GO:1990904 ribonucleoprotein complex 2 15
GO:0005730 nucleolus 5 1
GO:0005737 cytoplasm 2 1
GO:0022627 cytosolic small ribosomal subunit 5 2
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043226 organelle 2 1
GO:0043228 non-membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043232 intracellular non-membrane-bounded organelle 4 1
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

E9AL81
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9AL81

PDB structure(s): 6az1_D

Function

Biological processes
Term Name Level Count
GO:0006412 translation 4 15
GO:0006518 peptide metabolic process 4 15
GO:0006807 nitrogen compound metabolic process 2 15
GO:0008152 metabolic process 1 15
GO:0009058 biosynthetic process 2 15
GO:0009059 macromolecule biosynthetic process 4 15
GO:0009987 cellular process 1 15
GO:0019538 protein metabolic process 3 15
GO:0034641 cellular nitrogen compound metabolic process 3 15
GO:0034645 obsolete cellular macromolecule biosynthetic process 4 15
GO:0043043 peptide biosynthetic process 5 15
GO:0043170 macromolecule metabolic process 3 15
GO:0043603 amide metabolic process 3 15
GO:0043604 amide biosynthetic process 4 15
GO:0044237 cellular metabolic process 2 15
GO:0044238 primary metabolic process 2 15
GO:0044249 cellular biosynthetic process 3 15
GO:0044260 obsolete cellular macromolecule metabolic process 3 15
GO:0044271 cellular nitrogen compound biosynthetic process 4 15
GO:0071704 organic substance metabolic process 2 15
GO:1901564 organonitrogen compound metabolic process 3 15
GO:1901566 organonitrogen compound biosynthetic process 4 15
GO:1901576 organic substance biosynthetic process 3 15
GO:0006417 regulation of translation 6 2
GO:0006450 regulation of translational fidelity 3 2
GO:0009889 regulation of biosynthetic process 4 2
GO:0009891 positive regulation of biosynthetic process 5 2
GO:0009893 positive regulation of metabolic process 4 2
GO:0010468 regulation of gene expression 5 2
GO:0010556 regulation of macromolecule biosynthetic process 5 2
GO:0010557 positive regulation of macromolecule biosynthetic process 6 2
GO:0010604 positive regulation of macromolecule metabolic process 5 2
GO:0010608 post-transcriptional regulation of gene expression 6 2
GO:0010628 positive regulation of gene expression 6 2
GO:0019222 regulation of metabolic process 3 2
GO:0031323 regulation of cellular metabolic process 4 2
GO:0031325 positive regulation of cellular metabolic process 5 2
GO:0031326 regulation of cellular biosynthetic process 5 2
GO:0031328 positive regulation of cellular biosynthetic process 6 2
GO:0034248 regulation of amide metabolic process 5 2
GO:0034250 positive regulation of amide metabolic process 6 2
GO:0045727 positive regulation of translation 7 2
GO:0045903 positive regulation of translational fidelity 4 2
GO:0048518 positive regulation of biological process 3 2
GO:0048522 positive regulation of cellular process 4 2
GO:0050789 regulation of biological process 2 2
GO:0050794 regulation of cellular process 3 2
GO:0051171 regulation of nitrogen compound metabolic process 4 2
GO:0051173 positive regulation of nitrogen compound metabolic process 5 2
GO:0051246 regulation of protein metabolic process 5 2
GO:0051247 positive regulation of protein metabolic process 6 2
GO:0060255 regulation of macromolecule metabolic process 4 2
GO:0065007 biological regulation 1 2
GO:0065008 regulation of biological quality 2 2
GO:0080090 regulation of primary metabolic process 4 2
GO:2000112 obsolete regulation of cellular macromolecule biosynthetic process 6 2
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 15
GO:0003723 RNA binding 4 15
GO:0003735 structural constituent of ribosome 2 15
GO:0005198 structural molecule activity 1 15
GO:0005488 binding 1 15
GO:0019843 rRNA binding 5 15
GO:0097159 organic cyclic compound binding 2 15
GO:1901363 heterocyclic compound binding 2 15

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 106 108 PF00675 0.314
CLV_NRD_NRD_1 15 17 PF00675 0.325
CLV_NRD_NRD_1 181 183 PF00675 0.502
CLV_NRD_NRD_1 52 54 PF00675 0.314
CLV_NRD_NRD_1 67 69 PF00675 0.314
CLV_NRD_NRD_1 77 79 PF00675 0.314
CLV_PCSK_FUR_1 170 174 PF00082 0.523
CLV_PCSK_FUR_1 36 40 PF00082 0.314
CLV_PCSK_KEX2_1 106 108 PF00082 0.314
CLV_PCSK_KEX2_1 15 17 PF00082 0.325
CLV_PCSK_KEX2_1 172 174 PF00082 0.522
CLV_PCSK_KEX2_1 180 182 PF00082 0.550
CLV_PCSK_KEX2_1 38 40 PF00082 0.305
CLV_PCSK_KEX2_1 52 54 PF00082 0.311
CLV_PCSK_KEX2_1 67 69 PF00082 0.314
CLV_PCSK_KEX2_1 77 79 PF00082 0.314
CLV_PCSK_PC1ET2_1 172 174 PF00082 0.528
CLV_PCSK_PC1ET2_1 180 182 PF00082 0.541
CLV_PCSK_PC1ET2_1 38 40 PF00082 0.305
CLV_PCSK_SKI1_1 177 181 PF00082 0.562
CLV_PCSK_SKI1_1 25 29 PF00082 0.325
CLV_PCSK_SKI1_1 56 60 PF00082 0.314
CLV_PCSK_SKI1_1 67 71 PF00082 0.314
DEG_Nend_UBRbox_1 1 4 PF02207 0.550
DOC_CYCLIN_RxL_1 50 63 PF00134 0.514
DOC_CYCLIN_RxL_1 64 73 PF00134 0.514
DOC_MAPK_gen_1 106 113 PF00069 0.514
DOC_MAPK_gen_1 20 29 PF00069 0.523
DOC_MAPK_gen_1 50 59 PF00069 0.523
DOC_MAPK_gen_1 89 98 PF00069 0.521
DOC_MAPK_MEF2A_6 52 61 PF00069 0.523
DOC_MAPK_MEF2A_6 91 100 PF00069 0.514
DOC_PP1_RVXF_1 151 158 PF00149 0.532
DOC_PP2B_LxvP_1 59 62 PF13499 0.514
DOC_PP2B_LxvP_1 98 101 PF13499 0.514
DOC_WW_Pin1_4 158 163 PF00397 0.479
LIG_14-3-3_CanoR_1 148 157 PF00244 0.574
LIG_14-3-3_CanoR_1 43 49 PF00244 0.514
LIG_14-3-3_CanoR_1 52 59 PF00244 0.503
LIG_BIR_III_2 159 163 PF00653 0.506
LIG_FHA_1 52 58 PF00498 0.523
LIG_FHA_2 58 64 PF00498 0.511
LIG_FHA_2 97 103 PF00498 0.513
LIG_Integrin_isoDGR_2 165 167 PF01839 0.523
LIG_LIR_Nem_3 81 85 PF02991 0.555
LIG_Pex14_2 7 11 PF04695 0.382
LIG_SH2_STAT5 94 97 PF00017 0.514
LIG_SH3_3 11 17 PF00018 0.525
LIG_SH3_3 137 143 PF00018 0.514
LIG_SUMO_SIM_par_1 138 144 PF11976 0.514
LIG_SUMO_SIM_par_1 57 63 PF11976 0.514
LIG_SUMO_SIM_par_1 93 99 PF11976 0.514
LIG_WRC_WIRS_1 142 147 PF05994 0.514
MOD_CK2_1 57 63 PF00069 0.508
MOD_GlcNHglycan 71 75 PF01048 0.314
MOD_N-GLC_1 44 49 PF02516 0.314
MOD_NEK2_1 117 122 PF00069 0.514
MOD_NEK2_1 46 51 PF00069 0.520
MOD_NEK2_1 57 62 PF00069 0.502
MOD_NEK2_1 70 75 PF00069 0.514
MOD_NEK2_1 96 101 PF00069 0.514
MOD_PKA_2 147 153 PF00069 0.514
MOD_PKA_2 51 57 PF00069 0.525
MOD_Plk_1 44 50 PF00069 0.514
MOD_Plk_4 107 113 PF00069 0.514
MOD_Plk_4 141 147 PF00069 0.508
MOD_ProDKin_1 158 164 PF00069 0.479
MOD_SUMO_rev_2 21 29 PF00179 0.525
TRG_DiLeu_BaEn_4 87 93 PF01217 0.555
TRG_DiLeu_BaLyEn_6 53 58 PF01217 0.514
TRG_DiLeu_BaLyEn_6 65 70 PF01217 0.514
TRG_ENDOCYTIC_2 4 7 PF00928 0.524
TRG_ENDOCYTIC_2 82 85 PF00928 0.519
TRG_ER_diArg_1 106 108 PF00400 0.514
TRG_ER_diArg_1 14 16 PF00400 0.525
TRG_ER_diArg_1 51 53 PF00400 0.514
TRG_ER_diArg_1 66 68 PF00400 0.514
TRG_ER_diArg_1 76 78 PF00400 0.514
TRG_NES_CRM1_1 90 102 PF08389 0.514
TRG_NLS_MonoExtN_4 170 176 PF00514 0.539
TRG_NLS_MonoExtN_4 177 184 PF00514 0.557
TRG_Pf-PMV_PEXEL_1 125 129 PF00026 0.305
TRG_Pf-PMV_PEXEL_1 67 71 PF00026 0.339

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HRV0 Leptomonas seymouri 97% 99%
A0A0S4J7G8 Bodo saltans 86% 100%
A0A1D8PGY8 Candida albicans (strain SC5314 / ATCC MYA-2876) 61% 100%
A0A1X0NPG8 Trypanosomatidae 91% 99%
A0A3R7M4J3 Trypanosoma rangeli 90% 99%
A0A3S5H5Z2 Leishmania donovani 98% 99%
A0B9L2 Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT) 39% 100%
A0RY02 Cenarchaeum symbiosum (strain A) 36% 92%
A0T0W7 Thalassiosira pseudonana 30% 92%
A1RT03 Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3) 42% 100%
A1RWT8 Thermofilum pendens (strain DSM 2475 / Hrk 5) 43% 100%
A2BK77 Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5) 43% 100%
A2SSV9 Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z) 40% 100%
A3CWH7 Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1) 38% 100%
A3DMQ4 Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1) 46% 100%
A3MUS9 Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1) 43% 100%
A4FWL4 Methanococcus maripaludis (strain C5 / ATCC BAA-1333) 36% 100%
A4H519 Leishmania braziliensis 98% 100%
A4HNY5 Leishmania braziliensis 98% 100%
A4HT92 Leishmania infantum 98% 99%
A4WM27 Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6) 44% 100%
A4YIN4 Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) 39% 100%
A5UN53 Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS) 36% 100%
A6QLG5 Bos taurus 64% 97%
A6UPW5 Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB) 37% 100%
A6UW05 Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3) 35% 100%
A6VGQ7 Methanococcus maripaludis (strain C7 / ATCC BAA-1331) 37% 100%
A7IAH7 Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8) 40% 100%
A8A8W3 Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125) 50% 100%
A8MDS5 Caldivirga maquilingensis (strain ATCC 700844 / DSM 13496 / JCM 10307 / IC-167) 36% 100%
A9A436 Nitrosopumilus maritimus (strain SCM1) 39% 94%
A9A9Z3 Methanococcus maripaludis (strain C6 / ATCC BAA-1332) 36% 100%
A9L913 Papio anubis 64% 97%
B0R4Y0 Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1) 39% 100%
B1L795 Korarchaeum cryptofilum (strain OPF8) 38% 100%
B1Y9B8 Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta) 42% 100%
B4PEU8 Drosophila yakuba 62% 97%
B6YSQ1 Thermococcus onnurineus (strain NA1) 42% 100%
B8GEG7 Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c) 36% 100%
C3MJP5 Sulfolobus islandicus (strain L.S.2.15 / Lassen #1) 40% 100%
C3MZ03 Sulfolobus islandicus (strain M.14.25 / Kamchatka #1) 40% 100%
C3N052 Sulfolobus islandicus (strain M.16.27) 40% 100%
C3N8R6 Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1) 40% 100%
C3NMQ2 Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2) 40% 100%
C4KJ91 Sulfolobus islandicus (strain M.16.4 / Kamchatka #3) 40% 100%
C5A251 Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3) 43% 100%
C6A1B1 Thermococcus sibiricus (strain DSM 12597 / MM 739) 43% 100%
C9ZUM9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 93% 99%
D0A2V2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 93% 93%
E9ASP5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 99% 100%
O13516 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 60% 96%
O13835 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 100%
O15612 Entamoeba histolytica 48% 100%
O26142 Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H) 37% 100%
O28000 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) 42% 100%
O59306 Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3) 43% 100%
O59675 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 63% 98%
P05755 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 62% 97%
P14132 Dictyostelium discoideum 53% 100%
P17959 Trypanosoma brucei brucei 93% 99%
P29314 Rattus norvegicus 64% 97%
P32899 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 23% 100%
P39467 Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770) 39% 100%
P46781 Homo sapiens 64% 97%
P52810 Podospora anserina 63% 99%
P54020 Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) 45% 100%
P55935 Drosophila melanogaster 62% 97%
P61992 Pyrococcus abyssi (strain GE5 / Orsay) 42% 100%
P61993 Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1) 42% 100%
P95987 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) 42% 100%
Q00862 Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809) 38% 100%
Q09757 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 64% 99%
Q0W1V5 Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50) 35% 92%
Q12ZR5 Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M) 33% 100%
Q18G54 Haloquadratum walsbyi (strain DSM 16790 / HBSQ001) 38% 100%
Q20228 Caenorhabditis elegans 62% 100%
Q25555 Naegleria fowleri 56% 100%
Q2FT97 Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1) 36% 100%
Q2NFZ4 Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3) 32% 100%
Q3IQT8 Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara) 38% 100%
Q3T0M3 Bos taurus 28% 100%
Q46GC8 Methanosarcina barkeri (strain Fusaro / DSM 804) 38% 88%
Q4Q1V1 Leishmania major 98% 100%
Q4QIM3 Leishmania major 98% 100%
Q5JJF2 Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1) 41% 100%
Q6KZP7 Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) 41% 100%
Q6LXN0 Methanococcus maripaludis (strain S2 / LL) 37% 100%
Q6ZWN5 Mus musculus 64% 97%
Q74NF7 Nanoarchaeum equitans (strain Kin4-M) 38% 100%
Q8PV18 Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) 35% 86%
Q8SRW6 Encephalitozoon cuniculi (strain GB-M1) 45% 100%
Q8TRR1 Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A) 35% 87%
Q8TVC0 Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938) 42% 100%
Q8ZTV1 Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2) 43% 100%
Q921Y2 Mus musculus 28% 100%
Q96YV8 Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) 39% 100%
Q97B95 Thermoplasma volcanium (strain ATCC 51530 / DSM 4299 / JCM 9571 / NBRC 15438 / GSS1) 44% 94%
Q9FLF0 Arabidopsis thaliana 63% 96%
Q9HJD7 Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165) 45% 95%
Q9HQJ6 Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1) 39% 100%
Q9LXG1 Arabidopsis thaliana 63% 95%
Q9NV31 Homo sapiens 26% 100%
Q9YB58 Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1) 42% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS